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AT.sub.2 and MAS angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats

Byline: Willian Costa-Ferreira (1,2), Lucas Gomes-de-Souza (1,2), Carlos C. Crestani (1,2) Keywords: Amygdala; Losartan; PD123319; A-779; AT.sub.2 receptor; MAS receptor; Blood pressure; Heart rate The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the... Full description

Journal Title: Pflügers Archiv 2019, Vol.471 (9), p.1173
Main Author: Costa-Ferreira, Willian
Other Authors: Gomes-de-Souza, Lucas , Crestani, Carlos C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Springer
ID: ISSN: 0031-6768
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title: AT.sub.2 and MAS angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats
format: Article
creator:
  • Costa-Ferreira, Willian
  • Gomes-de-Souza, Lucas
  • Crestani, Carlos C
subjects:
  • Heart beat
  • Physiological aspects
ispartof: Pflügers Archiv, 2019, Vol.471 (9), p.1173
description: Byline: Willian Costa-Ferreira (1,2), Lucas Gomes-de-Souza (1,2), Carlos C. Crestani (1,2) Keywords: Amygdala; Losartan; PD123319; A-779; AT.sub.2 receptor; MAS receptor; Blood pressure; Heart rate The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the central circuitry regulating baroreflex function. However, the local neurochemical mechanisms involved in baroreflex control by this forebrain structure is poorly understood. Thus, in the present study, we investigated the specific role of AT.sub.1, AT.sub.2, and MAS angiotensinergic receptors within the MeA in baroreflex responses in unanesthetized rats. For this, the baroreflex function was assessed using both the pharmacological approach via intravenous infusion of vasoactive agents and the sequence analysis technique. Using the pharmacological approach, we observed that bilateral microinjection of the selective AT.sub.2 receptor antagonist PD123319 into the MeA increased the tachycardia evoked by blood pressure decrease, but without affecting the reflex bradycardia caused by blood pressure increase. Besides, bilateral microinjection of the selective MAS receptor antagonist A-779 decreased both tachycardic and bradycardic responses of the baroreflex. The sequence analysis technique indicated that PD123319 into the MeA increased baroreflex effectiveness index while A-779 had an opposite effect. Treatment of the MeA with the selective AT.sub.1 receptor antagonist losartan did not affect baroreflex function assessed by either the pharmacological approach or sequence analysis technique. Overall, these findings provide evidence that MAS receptor within the MeA plays a facilitatory role in baroreflex function, whereas local AT.sub.2 receptor inhibits cardiac baroreflex responses. Results also indicate that AT.sub.1 receptor within the MeA is not involved in the control of baroreflex function. Author Affiliation: (1) 0000 0001 2188 478X, grid.410543.7, Laboratory of Pharmacology, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitario), Campus Ville, Araraquara, SP, 14800-903, Brazil (2) Joint UFSCar-UNESP Graduate Program in Physiological Sciences, Sao Carlos, SP, Brazil Article History: Registration Date: 01/08/2019 Received Date: 08/05/2019 Accepted Date: 01/08/2019 Online Date: 08/08/2019
language: eng
source:
identifier: ISSN: 0031-6768
fulltext: no_fulltext
issn:
  • 0031-6768
  • 1432-2013
url: Link


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titleAT.sub.2 and MAS angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats
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descriptionByline: Willian Costa-Ferreira (1,2), Lucas Gomes-de-Souza (1,2), Carlos C. Crestani (1,2) Keywords: Amygdala; Losartan; PD123319; A-779; AT.sub.2 receptor; MAS receptor; Blood pressure; Heart rate The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the central circuitry regulating baroreflex function. However, the local neurochemical mechanisms involved in baroreflex control by this forebrain structure is poorly understood. Thus, in the present study, we investigated the specific role of AT.sub.1, AT.sub.2, and MAS angiotensinergic receptors within the MeA in baroreflex responses in unanesthetized rats. For this, the baroreflex function was assessed using both the pharmacological approach via intravenous infusion of vasoactive agents and the sequence analysis technique. Using the pharmacological approach, we observed that bilateral microinjection of the selective AT.sub.2 receptor antagonist PD123319 into the MeA increased the tachycardia evoked by blood pressure decrease, but without affecting the reflex bradycardia caused by blood pressure increase. Besides, bilateral microinjection of the selective MAS receptor antagonist A-779 decreased both tachycardic and bradycardic responses of the baroreflex. The sequence analysis technique indicated that PD123319 into the MeA increased baroreflex effectiveness index while A-779 had an opposite effect. Treatment of the MeA with the selective AT.sub.1 receptor antagonist losartan did not affect baroreflex function assessed by either the pharmacological approach or sequence analysis technique. Overall, these findings provide evidence that MAS receptor within the MeA plays a facilitatory role in baroreflex function, whereas local AT.sub.2 receptor inhibits cardiac baroreflex responses. Results also indicate that AT.sub.1 receptor within the MeA is not involved in the control of baroreflex function. Author Affiliation: (1) 0000 0001 2188 478X, grid.410543.7, Laboratory of Pharmacology, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitario), Campus Ville, Araraquara, SP, 14800-903, Brazil (2) Joint UFSCar-UNESP Graduate Program in Physiological Sciences, Sao Carlos, SP, Brazil Article History: Registration Date: 01/08/2019 Received Date: 08/05/2019 Accepted Date: 01/08/2019 Online Date: 08/08/2019
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abstractByline: Willian Costa-Ferreira (1,2), Lucas Gomes-de-Souza (1,2), Carlos C. Crestani (1,2) Keywords: Amygdala; Losartan; PD123319; A-779; AT.sub.2 receptor; MAS receptor; Blood pressure; Heart rate The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the central circuitry regulating baroreflex function. However, the local neurochemical mechanisms involved in baroreflex control by this forebrain structure is poorly understood. Thus, in the present study, we investigated the specific role of AT.sub.1, AT.sub.2, and MAS angiotensinergic receptors within the MeA in baroreflex responses in unanesthetized rats. For this, the baroreflex function was assessed using both the pharmacological approach via intravenous infusion of vasoactive agents and the sequence analysis technique. Using the pharmacological approach, we observed that bilateral microinjection of the selective AT.sub.2 receptor antagonist PD123319 into the MeA increased the tachycardia evoked by blood pressure decrease, but without affecting the reflex bradycardia caused by blood pressure increase. Besides, bilateral microinjection of the selective MAS receptor antagonist A-779 decreased both tachycardic and bradycardic responses of the baroreflex. The sequence analysis technique indicated that PD123319 into the MeA increased baroreflex effectiveness index while A-779 had an opposite effect. Treatment of the MeA with the selective AT.sub.1 receptor antagonist losartan did not affect baroreflex function assessed by either the pharmacological approach or sequence analysis technique. Overall, these findings provide evidence that MAS receptor within the MeA plays a facilitatory role in baroreflex function, whereas local AT.sub.2 receptor inhibits cardiac baroreflex responses. Results also indicate that AT.sub.1 receptor within the MeA is not involved in the control of baroreflex function. Author Affiliation: (1) 0000 0001 2188 478X, grid.410543.7, Laboratory of Pharmacology, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitario), Campus Ville, Araraquara, SP, 14800-903, Brazil (2) Joint UFSCar-UNESP Graduate Program in Physiological Sciences, Sao Carlos, SP, Brazil Article History: Registration Date: 01/08/2019 Received Date: 08/05/2019 Accepted Date: 01/08/2019 Online Date: 08/08/2019
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doi10.1007/s00424-019-02301-3