schliessen

Filtern

 

Bibliotheken

Cover Image

AT.sub.2 and MAS angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats

Byline: Willian Costa-Ferreira (1,2), Lucas Gomes-de-Souza (1,2), Carlos C. Crestani (1,2) Keywords: Amygdala; Losartan; PD123319; A-779; AT.sub.2 receptor; MAS receptor; Blood pressure; Heart rate The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the... Full description

Journal Title: Pflügers Archiv 2019, Vol.471 (9), p.1173
Main Author: Costa-Ferreira, Willian
Other Authors: Gomes-de-Souza, Lucas , Crestani, Carlos C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Heart beat
Physiological aspects
Publisher: Springer
ID: ISSN: 0031-6768
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_gale_infotracacademiconefile_A597517294
title: AT.sub.2 and MAS angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats
format: Article
creator:
  • Costa-Ferreira, Willian
  • Gomes-de-Souza, Lucas
  • Crestani, Carlos C
subjects:
  • Heart beat
  • Physiological aspects
ispartof: Pflügers Archiv, 2019, Vol.471 (9), p.1173
description: Byline: Willian Costa-Ferreira (1,2), Lucas Gomes-de-Souza (1,2), Carlos C. Crestani (1,2) Keywords: Amygdala; Losartan; PD123319; A-779; AT.sub.2 receptor; MAS receptor; Blood pressure; Heart rate The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the central circuitry regulating baroreflex function. However, the local neurochemical mechanisms involved in baroreflex control by this forebrain structure is poorly understood. Thus, in the present study, we investigated the specific role of AT.sub.1, AT.sub.2, and MAS angiotensinergic receptors within the MeA in baroreflex responses in unanesthetized rats. For this, the baroreflex function was assessed using both the pharmacological approach via intravenous infusion of vasoactive agents and the sequence analysis technique. Using the pharmacological approach, we observed that bilateral microinjection of the selective AT.sub.2 receptor antagonist PD123319 into the MeA increased the tachycardia evoked by blood pressure decrease, but without affecting the reflex bradycardia caused by blood pressure increase. Besides, bilateral microinjection of the selective MAS receptor antagonist A-779 decreased both tachycardic and bradycardic responses of the baroreflex. The sequence analysis technique indicated that PD123319 into the MeA increased baroreflex effectiveness index while A-779 had an opposite effect. Treatment of the MeA with the selective AT.sub.1 receptor antagonist losartan did not affect baroreflex function assessed by either the pharmacological approach or sequence analysis technique. Overall, these findings provide evidence that MAS receptor within the MeA plays a facilitatory role in baroreflex function, whereas local AT.sub.2 receptor inhibits cardiac baroreflex responses. Results also indicate that AT.sub.1 receptor within the MeA is not involved in the control of baroreflex function. Author Affiliation: (1) 0000 0001 2188 478X, grid.410543.7, Laboratory of Pharmacology, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitario), Campus Ville, Araraquara, SP, 14800-903, Brazil (2) Joint UFSCar-UNESP Graduate Program in Physiological Sciences, Sao Carlos, SP, Brazil Article History: Registration Date: 01/08/2019 Received Date: 08/05/2019 Accepted Date: 01/08/2019 Online Date: 08/08/2019
language: eng
source:
identifier: ISSN: 0031-6768
fulltext: no_fulltext
issn:
  • 0031-6768
  • 1432-2013
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.520902
LOCALfalse
PrimoNMBib
record
control
sourceidgale
recordidTN_cdi_gale_infotracacademiconefile_A597517294
sourceformatXML
sourcesystemPC
galeidA597517294
sourcerecordidA597517294
originalsourceidFETCH-LOGICAL-g674-c35b750d982d6ca398d5e8f4a27278066d4141030cbadf91ceb40cb7f5b2d8270
addsrcrecordideNptjMtLxDAYxIMouK7-A54CnlO_PNq0x7L4ghUP7n1Jk6810ockqbj_vfVx8CBzmGH4zRByySHjAPo6AiihGPCKgZDAmTwiK66kYAK4PCYrAMlZoYvylJzF-AoAQpViReZ6l8W5yQQ1o6OP9fPinZ8SjtGPGDpvaUCLb2kKkfqRphekAzpvemqGQ-dMP3lHx9n2OEc6TG7uTcJvrDFhCtj2-EGNTf7dp8PXQzApnpOT1vQRL359TXa3N7vNPds-3T1s6i3rCq2YlXmjc3BVKVxhjaxKl2PZKiO00CUUhVNccZBgG-Pailts1JJ1mzfClULDmlz93Hamx70f2ykFYwcf7b7OK51zLSq1UNk_1CKHg7fTiK1f-j-DT2DQbgI
sourcetypeAggregation Database
isCDItrue
recordtypearticle
display
typearticle
titleAT.sub.2 and MAS angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats
creatorCosta-Ferreira, Willian ; Gomes-de-Souza, Lucas ; Crestani, Carlos C
creatorcontribCosta-Ferreira, Willian ; Gomes-de-Souza, Lucas ; Crestani, Carlos C
descriptionByline: Willian Costa-Ferreira (1,2), Lucas Gomes-de-Souza (1,2), Carlos C. Crestani (1,2) Keywords: Amygdala; Losartan; PD123319; A-779; AT.sub.2 receptor; MAS receptor; Blood pressure; Heart rate The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the central circuitry regulating baroreflex function. However, the local neurochemical mechanisms involved in baroreflex control by this forebrain structure is poorly understood. Thus, in the present study, we investigated the specific role of AT.sub.1, AT.sub.2, and MAS angiotensinergic receptors within the MeA in baroreflex responses in unanesthetized rats. For this, the baroreflex function was assessed using both the pharmacological approach via intravenous infusion of vasoactive agents and the sequence analysis technique. Using the pharmacological approach, we observed that bilateral microinjection of the selective AT.sub.2 receptor antagonist PD123319 into the MeA increased the tachycardia evoked by blood pressure decrease, but without affecting the reflex bradycardia caused by blood pressure increase. Besides, bilateral microinjection of the selective MAS receptor antagonist A-779 decreased both tachycardic and bradycardic responses of the baroreflex. The sequence analysis technique indicated that PD123319 into the MeA increased baroreflex effectiveness index while A-779 had an opposite effect. Treatment of the MeA with the selective AT.sub.1 receptor antagonist losartan did not affect baroreflex function assessed by either the pharmacological approach or sequence analysis technique. Overall, these findings provide evidence that MAS receptor within the MeA plays a facilitatory role in baroreflex function, whereas local AT.sub.2 receptor inhibits cardiac baroreflex responses. Results also indicate that AT.sub.1 receptor within the MeA is not involved in the control of baroreflex function. Author Affiliation: (1) 0000 0001 2188 478X, grid.410543.7, Laboratory of Pharmacology, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitario), Campus Ville, Araraquara, SP, 14800-903, Brazil (2) Joint UFSCar-UNESP Graduate Program in Physiological Sciences, Sao Carlos, SP, Brazil Article History: Registration Date: 01/08/2019 Received Date: 08/05/2019 Accepted Date: 01/08/2019 Online Date: 08/08/2019
identifier
0ISSN: 0031-6768
1EISSN: 1432-2013
2DOI: 10.1007/s00424-019-02301-3
languageeng
publisherSpringer
subjectHeart beat ; Physiological aspects
ispartofPflügers Archiv, 2019, Vol.471 (9), p.1173
rightsCOPYRIGHT 2019 Springer
lds50peer_reviewed
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
search
creatorcontrib
0Costa-Ferreira, Willian
1Gomes-de-Souza, Lucas
2Crestani, Carlos C
title
0AT.sub.2 and MAS angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats
1Pflügers Archiv
descriptionByline: Willian Costa-Ferreira (1,2), Lucas Gomes-de-Souza (1,2), Carlos C. Crestani (1,2) Keywords: Amygdala; Losartan; PD123319; A-779; AT.sub.2 receptor; MAS receptor; Blood pressure; Heart rate The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the central circuitry regulating baroreflex function. However, the local neurochemical mechanisms involved in baroreflex control by this forebrain structure is poorly understood. Thus, in the present study, we investigated the specific role of AT.sub.1, AT.sub.2, and MAS angiotensinergic receptors within the MeA in baroreflex responses in unanesthetized rats. For this, the baroreflex function was assessed using both the pharmacological approach via intravenous infusion of vasoactive agents and the sequence analysis technique. Using the pharmacological approach, we observed that bilateral microinjection of the selective AT.sub.2 receptor antagonist PD123319 into the MeA increased the tachycardia evoked by blood pressure decrease, but without affecting the reflex bradycardia caused by blood pressure increase. Besides, bilateral microinjection of the selective MAS receptor antagonist A-779 decreased both tachycardic and bradycardic responses of the baroreflex. The sequence analysis technique indicated that PD123319 into the MeA increased baroreflex effectiveness index while A-779 had an opposite effect. Treatment of the MeA with the selective AT.sub.1 receptor antagonist losartan did not affect baroreflex function assessed by either the pharmacological approach or sequence analysis technique. Overall, these findings provide evidence that MAS receptor within the MeA plays a facilitatory role in baroreflex function, whereas local AT.sub.2 receptor inhibits cardiac baroreflex responses. Results also indicate that AT.sub.1 receptor within the MeA is not involved in the control of baroreflex function. Author Affiliation: (1) 0000 0001 2188 478X, grid.410543.7, Laboratory of Pharmacology, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitario), Campus Ville, Araraquara, SP, 14800-903, Brazil (2) Joint UFSCar-UNESP Graduate Program in Physiological Sciences, Sao Carlos, SP, Brazil Article History: Registration Date: 01/08/2019 Received Date: 08/05/2019 Accepted Date: 01/08/2019 Online Date: 08/08/2019
subject
0Heart beat
1Physiological aspects
issn
00031-6768
11432-2013
fulltextfalse
rsrctypearticle
creationdate2019
recordtypearticle
recordideNptjMtLxDAYxIMouK7-A54CnlO_PNq0x7L4ghUP7n1Jk6810ockqbj_vfVx8CBzmGH4zRByySHjAPo6AiihGPCKgZDAmTwiK66kYAK4PCYrAMlZoYvylJzF-AoAQpViReZ6l8W5yQQ1o6OP9fPinZ8SjtGPGDpvaUCLb2kKkfqRphekAzpvemqGQ-dMP3lHx9n2OEc6TG7uTcJvrDFhCtj2-EGNTf7dp8PXQzApnpOT1vQRL359TXa3N7vNPds-3T1s6i3rCq2YlXmjc3BVKVxhjaxKl2PZKiO00CUUhVNccZBgG-Pailts1JJ1mzfClULDmlz93Hamx70f2ykFYwcf7b7OK51zLSq1UNk_1CKHg7fTiK1f-j-DT2DQbgI
startdate20190901
enddate20190901
creator
0Costa-Ferreira, Willian
1Gomes-de-Souza, Lucas
2Crestani, Carlos C
generalSpringer
scopeBSHEE
sort
creationdate20190901
titleAT.sub.2 and MAS angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats
authorCosta-Ferreira, Willian ; Gomes-de-Souza, Lucas ; Crestani, Carlos C
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-g674-c35b750d982d6ca398d5e8f4a27278066d4141030cbadf91ceb40cb7f5b2d8270
rsrctypearticles
prefilterarticles
languageeng
creationdate2019
topic
0Heart beat
1Physiological aspects
toplevelpeer_reviewed
creatorcontrib
0Costa-Ferreira, Willian
1Gomes-de-Souza, Lucas
2Crestani, Carlos C
collectionAcademic OneFile (A&I only)
jtitlePflügers Archiv
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Costa-Ferreira, Willian
1Gomes-de-Souza, Lucas
2Crestani, Carlos C
formatjournal
genrearticle
ristypeJOUR
atitleAT.sub.2 and MAS angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats
jtitlePflügers Archiv
date2019-09-01
risdate2019
volume471
issue9
spage1173
pages1173-
issn0031-6768
eissn1432-2013
abstractByline: Willian Costa-Ferreira (1,2), Lucas Gomes-de-Souza (1,2), Carlos C. Crestani (1,2) Keywords: Amygdala; Losartan; PD123319; A-779; AT.sub.2 receptor; MAS receptor; Blood pressure; Heart rate The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the central circuitry regulating baroreflex function. However, the local neurochemical mechanisms involved in baroreflex control by this forebrain structure is poorly understood. Thus, in the present study, we investigated the specific role of AT.sub.1, AT.sub.2, and MAS angiotensinergic receptors within the MeA in baroreflex responses in unanesthetized rats. For this, the baroreflex function was assessed using both the pharmacological approach via intravenous infusion of vasoactive agents and the sequence analysis technique. Using the pharmacological approach, we observed that bilateral microinjection of the selective AT.sub.2 receptor antagonist PD123319 into the MeA increased the tachycardia evoked by blood pressure decrease, but without affecting the reflex bradycardia caused by blood pressure increase. Besides, bilateral microinjection of the selective MAS receptor antagonist A-779 decreased both tachycardic and bradycardic responses of the baroreflex. The sequence analysis technique indicated that PD123319 into the MeA increased baroreflex effectiveness index while A-779 had an opposite effect. Treatment of the MeA with the selective AT.sub.1 receptor antagonist losartan did not affect baroreflex function assessed by either the pharmacological approach or sequence analysis technique. Overall, these findings provide evidence that MAS receptor within the MeA plays a facilitatory role in baroreflex function, whereas local AT.sub.2 receptor inhibits cardiac baroreflex responses. Results also indicate that AT.sub.1 receptor within the MeA is not involved in the control of baroreflex function. Author Affiliation: (1) 0000 0001 2188 478X, grid.410543.7, Laboratory of Pharmacology, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitario), Campus Ville, Araraquara, SP, 14800-903, Brazil (2) Joint UFSCar-UNESP Graduate Program in Physiological Sciences, Sao Carlos, SP, Brazil Article History: Registration Date: 01/08/2019 Received Date: 08/05/2019 Accepted Date: 01/08/2019 Online Date: 08/08/2019
pubSpringer
doi10.1007/s00424-019-02301-3