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Prognostic value of the baseline 18F-FDG PET/CT metabolic tumour volume and further stratification in low-intermediate risk NCCNIPI subgroup by MTV in DLBCL MTV predict prognosis in DLBCL

Keywords: PET/CT; Diffuse large B-cell lymphoma; Metabolic tumour volume; Prognosis Introduction In the era of rituximab, the NCCNIPI is widely used in clinical practice as a tool for the prognosis and risk stratification of diffuse large B-cell lymphoma (DLBCL). In recent years, FDG PET/CT has also... Full description

Journal Title: Annals of nuclear medicine 2021-01-01, Vol.35 (1), p.24
Main Author: Zhao, Peng
Other Authors: Yu, Tao , Pan, Zheng
Format: Electronic Article Electronic Article
Language: English
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Publisher: Springer
ID: ISSN: 0914-7187
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title: Prognostic value of the baseline 18F-FDG PET/CT metabolic tumour volume and further stratification in low-intermediate risk NCCNIPI subgroup by MTV in DLBCL MTV predict prognosis in DLBCL
format: Article
creator:
  • Zhao, Peng
  • Yu, Tao
  • Pan, Zheng
subjects:
  • Lymphomas
  • PET imaging
  • Prognosis
ispartof: Annals of nuclear medicine, 2021-01-01, Vol.35 (1), p.24
description: Keywords: PET/CT; Diffuse large B-cell lymphoma; Metabolic tumour volume; Prognosis Introduction In the era of rituximab, the NCCNIPI is widely used in clinical practice as a tool for the prognosis and risk stratification of diffuse large B-cell lymphoma (DLBCL). In recent years, FDG PET/CT has also shown unique prognostic value. We try to further confirm the prognostic role of metabolic parameters in the overall and subgroups patients. Methods We retrospectively analysed 87 DLBCL patients who underwent baseline FDG PET/CT and followed the R-CHOP or R-CHOP-like strategy. The clinical parameters and PET-related metabolic parameters were evaluated. Results For all patients, the 2-year PFS rate was 65.5% and the 2-year OS rate was 66.7%. According to Cox multivariate analysis, a high NCCNIPI score (4--8 points) and an MTV greater than 64.1 cm.sup.3 (defined by ROC) were independent prognostic factors for PFS and OS. The patients were divided into low, low-intermediate, high-intermediate and high-risk groups by NCCNIPI score. The 2-year PFS rates in each group were 90.9%, 71.3%, 33.2% and 16.7%, and the 2-year OS rates were 100%, 81.6%, 48.4% and 16.7%. In the subsequent subgroup analysis by MTV, it could further stratified low-intermediate and high-intermediate NCCNIPI groups, the P value was 0.068 and 0.069 for PFS, 0.078 and 0.036 for OS. Conclusions MTV, as a tumor metabolic volume parameter, and the NCCNIPI score were independent predictors of prognosis in general DLBCL patients. In the low-intermediate and high-intermediate NCCNIPI subgroup, we further confirm the risk stratification abilities of MTV, which could add the prognostic value of NCCNIPI. Author Affiliation: (1) Cancer Hospital of China Medical University, Liaoning Cancer Hospital &Institute, Shenyang, Liaoning, People's Republic of China (2) Cancer Hospital of China Medical University, Liaoning Cancer Hospital &Institute, No. 44 Xiaoheyan Road, Dadong District, 110042, Shenyang, Liaoning, People's Republic of China (b) yutao@cancerhosp-ln-cmu.com Article History: Registration Date: 09/17/2020 Received Date: 08/03/2020 Accepted Date: 09/16/2020 Online Date: 10/01/2020 Byline:
language: eng
source:
identifier: ISSN: 0914-7187
fulltext: no_fulltext
issn:
  • 0914-7187
  • 1864-6433
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titlePrognostic value of the baseline 18F-FDG PET/CT metabolic tumour volume and further stratification in low-intermediate risk NCCNIPI subgroup by MTV in DLBCL MTV predict prognosis in DLBCL
creatorZhao, Peng ; Yu, Tao ; Pan, Zheng
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descriptionKeywords: PET/CT; Diffuse large B-cell lymphoma; Metabolic tumour volume; Prognosis Introduction In the era of rituximab, the NCCNIPI is widely used in clinical practice as a tool for the prognosis and risk stratification of diffuse large B-cell lymphoma (DLBCL). In recent years, FDG PET/CT has also shown unique prognostic value. We try to further confirm the prognostic role of metabolic parameters in the overall and subgroups patients. Methods We retrospectively analysed 87 DLBCL patients who underwent baseline FDG PET/CT and followed the R-CHOP or R-CHOP-like strategy. The clinical parameters and PET-related metabolic parameters were evaluated. Results For all patients, the 2-year PFS rate was 65.5% and the 2-year OS rate was 66.7%. According to Cox multivariate analysis, a high NCCNIPI score (4--8 points) and an MTV greater than 64.1 cm.sup.3 (defined by ROC) were independent prognostic factors for PFS and OS. The patients were divided into low, low-intermediate, high-intermediate and high-risk groups by NCCNIPI score. The 2-year PFS rates in each group were 90.9%, 71.3%, 33.2% and 16.7%, and the 2-year OS rates were 100%, 81.6%, 48.4% and 16.7%. In the subsequent subgroup analysis by MTV, it could further stratified low-intermediate and high-intermediate NCCNIPI groups, the P value was 0.068 and 0.069 for PFS, 0.078 and 0.036 for OS. Conclusions MTV, as a tumor metabolic volume parameter, and the NCCNIPI score were independent predictors of prognosis in general DLBCL patients. In the low-intermediate and high-intermediate NCCNIPI subgroup, we further confirm the risk stratification abilities of MTV, which could add the prognostic value of NCCNIPI. Author Affiliation: (1) Cancer Hospital of China Medical University, Liaoning Cancer Hospital &Institute, Shenyang, Liaoning, People's Republic of China (2) Cancer Hospital of China Medical University, Liaoning Cancer Hospital &Institute, No. 44 Xiaoheyan Road, Dadong District, 110042, Shenyang, Liaoning, People's Republic of China (b) yutao@cancerhosp-ln-cmu.com Article History: Registration Date: 09/17/2020 Received Date: 08/03/2020 Accepted Date: 09/16/2020 Online Date: 10/01/2020 Byline:
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descriptionKeywords: PET/CT; Diffuse large B-cell lymphoma; Metabolic tumour volume; Prognosis Introduction In the era of rituximab, the NCCNIPI is widely used in clinical practice as a tool for the prognosis and risk stratification of diffuse large B-cell lymphoma (DLBCL). In recent years, FDG PET/CT has also shown unique prognostic value. We try to further confirm the prognostic role of metabolic parameters in the overall and subgroups patients. Methods We retrospectively analysed 87 DLBCL patients who underwent baseline FDG PET/CT and followed the R-CHOP or R-CHOP-like strategy. The clinical parameters and PET-related metabolic parameters were evaluated. Results For all patients, the 2-year PFS rate was 65.5% and the 2-year OS rate was 66.7%. According to Cox multivariate analysis, a high NCCNIPI score (4--8 points) and an MTV greater than 64.1 cm.sup.3 (defined by ROC) were independent prognostic factors for PFS and OS. The patients were divided into low, low-intermediate, high-intermediate and high-risk groups by NCCNIPI score. The 2-year PFS rates in each group were 90.9%, 71.3%, 33.2% and 16.7%, and the 2-year OS rates were 100%, 81.6%, 48.4% and 16.7%. In the subsequent subgroup analysis by MTV, it could further stratified low-intermediate and high-intermediate NCCNIPI groups, the P value was 0.068 and 0.069 for PFS, 0.078 and 0.036 for OS. Conclusions MTV, as a tumor metabolic volume parameter, and the NCCNIPI score were independent predictors of prognosis in general DLBCL patients. In the low-intermediate and high-intermediate NCCNIPI subgroup, we further confirm the risk stratification abilities of MTV, which could add the prognostic value of NCCNIPI. Author Affiliation: (1) Cancer Hospital of China Medical University, Liaoning Cancer Hospital &Institute, Shenyang, Liaoning, People's Republic of China (2) Cancer Hospital of China Medical University, Liaoning Cancer Hospital &Institute, No. 44 Xiaoheyan Road, Dadong District, 110042, Shenyang, Liaoning, People's Republic of China (b) yutao@cancerhosp-ln-cmu.com Article History: Registration Date: 09/17/2020 Received Date: 08/03/2020 Accepted Date: 09/16/2020 Online Date: 10/01/2020 Byline:
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abstractKeywords: PET/CT; Diffuse large B-cell lymphoma; Metabolic tumour volume; Prognosis Introduction In the era of rituximab, the NCCNIPI is widely used in clinical practice as a tool for the prognosis and risk stratification of diffuse large B-cell lymphoma (DLBCL). In recent years, FDG PET/CT has also shown unique prognostic value. We try to further confirm the prognostic role of metabolic parameters in the overall and subgroups patients. Methods We retrospectively analysed 87 DLBCL patients who underwent baseline FDG PET/CT and followed the R-CHOP or R-CHOP-like strategy. The clinical parameters and PET-related metabolic parameters were evaluated. Results For all patients, the 2-year PFS rate was 65.5% and the 2-year OS rate was 66.7%. According to Cox multivariate analysis, a high NCCNIPI score (4--8 points) and an MTV greater than 64.1 cm.sup.3 (defined by ROC) were independent prognostic factors for PFS and OS. The patients were divided into low, low-intermediate, high-intermediate and high-risk groups by NCCNIPI score. The 2-year PFS rates in each group were 90.9%, 71.3%, 33.2% and 16.7%, and the 2-year OS rates were 100%, 81.6%, 48.4% and 16.7%. In the subsequent subgroup analysis by MTV, it could further stratified low-intermediate and high-intermediate NCCNIPI groups, the P value was 0.068 and 0.069 for PFS, 0.078 and 0.036 for OS. Conclusions MTV, as a tumor metabolic volume parameter, and the NCCNIPI score were independent predictors of prognosis in general DLBCL patients. In the low-intermediate and high-intermediate NCCNIPI subgroup, we further confirm the risk stratification abilities of MTV, which could add the prognostic value of NCCNIPI. Author Affiliation: (1) Cancer Hospital of China Medical University, Liaoning Cancer Hospital &Institute, Shenyang, Liaoning, People's Republic of China (2) Cancer Hospital of China Medical University, Liaoning Cancer Hospital &Institute, No. 44 Xiaoheyan Road, Dadong District, 110042, Shenyang, Liaoning, People's Republic of China (b) yutao@cancerhosp-ln-cmu.com Article History: Registration Date: 09/17/2020 Received Date: 08/03/2020 Accepted Date: 09/16/2020 Online Date: 10/01/2020 Byline:
pubSpringer
doi10.1007/s12149-020-01531-1