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Central complex substructures are required for the maintenance of locomotor activity in Drosophila melanogaster

In Drosophila melanogaster, former studies based on structural brain mutants have suggested that the central complex is a higher control center of locomotor behavior. Continuing this investigation we studied the effect of the central complex on the temporal structure of spontaneous locomotor activit... Full description

Journal Title: Journal of Comparative Physiology 1999, Vol.185 (3), p.277-288
Main Author: Martin, J.R
Other Authors: Raabe, T , Heisenberg, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
fan
Publisher: Germany: Springer Nature B.V
ID: ISSN: 0340-7594
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recordid: cdi_hal_primary_oai_HAL_hal_00140927v1
title: Central complex substructures are required for the maintenance of locomotor activity in Drosophila melanogaster
format: Article
creator:
  • Martin, J.R
  • Raabe, T
  • Heisenberg, M
subjects:
  • Animals
  • Brain
  • Brain - anatomy & histology
  • Brain - physiology
  • Circuits
  • Cognition
  • controls
  • Drosophila melanogaster
  • Drosophila melanogaster - physiology
  • ellipsoid body
  • fan
  • fan-shaped body
  • Insects
  • Life Sciences
  • locomotion
  • Locomotor activity
  • locomotor control
  • Motivational control
  • Motor Activity
  • Motor Activity - genetics
  • Motor Activity - physiology
  • Mutagenesis
  • Mutants
  • Mutation
  • Neurons
  • Neurons and Cognition
  • Neuropil
  • neurotoxins
  • Noduli
  • Protocerebral bridge
  • shape body
  • Spontaneous walking
  • Substructures
  • temporal variation
  • Tetanus
  • Tetanus toxin
  • transgenic animals
ispartof: Journal of Comparative Physiology, 1999, Vol.185 (3), p.277-288
description: In Drosophila melanogaster, former studies based on structural brain mutants have suggested that the central complex is a higher control center of locomotor behavior. Continuing this investigation we studied the effect of the central complex on the temporal structure of spontaneous locomotor activity in the time domain of a few hours. In an attempt to dissect the internal circuitry of the central complex we perturbed a putative local neuronal network connecting the four neuropil regions of the central complex, the protocerebral bridge, the fan-shape body, the noduli and the ellipsoid body. Two independent and non-invasive methods were applied: mutations affecting the neuroarchitecture of the protocerebral bridge, and the targeted expression of tetanus toxin in small subsets of central complex neurons using the binary enhancer trap P[GAL4] system. All groups of flies with a disturbed component of this network exhibited a common phenotype: a drastic decrease in locomotor activity. While locomotor activity was still clustered in bouts and these were initiated at the normal rate, their duration was reduced. This finding suggests that the bridge and some of its neural connections to the other neuropil regions of the central complex are required for the maintenance but not the initiation of walking.
language: eng
source:
identifier: ISSN: 0340-7594
fulltext: no_fulltext
issn:
  • 0340-7594
  • 1432-1351
url: Link


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descriptionIn Drosophila melanogaster, former studies based on structural brain mutants have suggested that the central complex is a higher control center of locomotor behavior. Continuing this investigation we studied the effect of the central complex on the temporal structure of spontaneous locomotor activity in the time domain of a few hours. In an attempt to dissect the internal circuitry of the central complex we perturbed a putative local neuronal network connecting the four neuropil regions of the central complex, the protocerebral bridge, the fan-shape body, the noduli and the ellipsoid body. Two independent and non-invasive methods were applied: mutations affecting the neuroarchitecture of the protocerebral bridge, and the targeted expression of tetanus toxin in small subsets of central complex neurons using the binary enhancer trap P[GAL4] system. All groups of flies with a disturbed component of this network exhibited a common phenotype: a drastic decrease in locomotor activity. While locomotor activity was still clustered in bouts and these were initiated at the normal rate, their duration was reduced. This finding suggests that the bridge and some of its neural connections to the other neuropil regions of the central complex are required for the maintenance but not the initiation of walking.
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subjectAnimals ; Brain ; Brain - anatomy & histology ; Brain - physiology ; Circuits ; Cognition ; controls ; Drosophila melanogaster ; Drosophila melanogaster - physiology ; ellipsoid body ; fan ; fan-shaped body ; Insects ; Life Sciences ; locomotion ; Locomotor activity ; locomotor control ; Motivational control ; Motor Activity ; Motor Activity - genetics ; Motor Activity - physiology ; Mutagenesis ; Mutants ; Mutation ; Neurons ; Neurons and Cognition ; Neuropil ; neurotoxins ; Noduli ; Protocerebral bridge ; shape body ; Spontaneous walking ; Substructures ; temporal variation ; Tetanus ; Tetanus toxin ; transgenic animals
ispartofJournal of Comparative Physiology, 1999, Vol.185 (3), p.277-288
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abstractIn Drosophila melanogaster, former studies based on structural brain mutants have suggested that the central complex is a higher control center of locomotor behavior. Continuing this investigation we studied the effect of the central complex on the temporal structure of spontaneous locomotor activity in the time domain of a few hours. In an attempt to dissect the internal circuitry of the central complex we perturbed a putative local neuronal network connecting the four neuropil regions of the central complex, the protocerebral bridge, the fan-shape body, the noduli and the ellipsoid body. Two independent and non-invasive methods were applied: mutations affecting the neuroarchitecture of the protocerebral bridge, and the targeted expression of tetanus toxin in small subsets of central complex neurons using the binary enhancer trap P[GAL4] system. All groups of flies with a disturbed component of this network exhibited a common phenotype: a drastic decrease in locomotor activity. While locomotor activity was still clustered in bouts and these were initiated at the normal rate, their duration was reduced. This finding suggests that the bridge and some of its neural connections to the other neuropil regions of the central complex are required for the maintenance but not the initiation of walking.
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