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A short leucocyte telomere length is associated with development of insulin resistance

Aims/hypothesis A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance o... Full description

Journal Title: Diabetologia 2016, Vol.59 (6), p.1258-1265
Main Author: Verhulst, Simon
Other Authors: Dalgard, Christine , Labat, Carlos , Kark, Jeremy D , Kimura, Masayuki , Christensen, Kaare , Toupance, Simon , Aviv, Abraham , Kyvik, Kirsten O , Benetos, Athanase
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
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recordid: cdi_hal_primary_oai_HAL_hal_01759676v1
title: A short leucocyte telomere length is associated with development of insulin resistance
format: Article
creator:
  • Verhulst, Simon
  • Dalgard, Christine
  • Labat, Carlos
  • Kark, Jeremy D
  • Kimura, Masayuki
  • Christensen, Kaare
  • Toupance, Simon
  • Aviv, Abraham
  • Kyvik, Kirsten O
  • Benetos, Athanase
subjects:
  • Adult
  • ADULTS
  • Age Factors
  • AMERICAN-INDIANS
  • Article
  • BIOLOGY
  • Body Mass Index
  • Cardiology
  • Cardiology and cardiovascular system
  • Cardiovascular Diseases
  • Cardiovascular Diseases - genetics
  • Cardiovascular Diseases - physiopathology
  • cardiovascular system
  • epidemiology (all)
  • Female
  • Genetics
  • Genetics/epidemiology (all)
  • GLUCOSE
  • GLYCEMIA
  • Human
  • Human health
  • Human health and pathology
  • Human Physiology
  • Humans
  • INFLAMMATION
  • Insulin Resistance
  • Insulin Resistance - genetics
  • Insulin Resistance - physiology
  • Insulin sensitivity
  • Insulin sensitivity and resistance
  • Internal Medicine
  • Leukocytes
  • Leukocytes - metabolism
  • Life Sciences
  • Male
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • METABOLIC SYNDROME
  • Middle Aged
  • OBESITY
  • OXIDATIVE STRESS
  • pathology
  • resistance
  • Resveratrol
  • Risk Factors
  • Sex Factors
  • STRONG HEART FAMILY
  • Telomere
  • Telomere - genetics
  • Type 2 diabetes
ispartof: Diabetologia, 2016, Vol.59 (6), p.1258-1265
description: Aims/hypothesis A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof. Methods Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs. Results Age at baseline examination was 37.4 +/- 9.6 (mean +/- SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleA short leucocyte telomere length is associated with development of insulin resistance
creatorVerhulst, Simon ; Dalgard, Christine ; Labat, Carlos ; Kark, Jeremy D ; Kimura, Masayuki ; Christensen, Kaare ; Toupance, Simon ; Aviv, Abraham ; Kyvik, Kirsten O ; Benetos, Athanase
creatorcontribVerhulst, Simon ; Dalgard, Christine ; Labat, Carlos ; Kark, Jeremy D ; Kimura, Masayuki ; Christensen, Kaare ; Toupance, Simon ; Aviv, Abraham ; Kyvik, Kirsten O ; Benetos, Athanase
descriptionAims/hypothesis A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof. Methods Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs. Results Age at baseline examination was 37.4 +/- 9.6 (mean +/- SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p <0.001); this effect was additive to that of BMI. The co-twin with the shorter baseline LTL displayed higher insulin resistance at follow-up than the co-twin with the longer LTL. Conclusions/interpretation These findings suggest that individuals with short LTL are more likely to develop insulin resistance later in life. By contrast, presence of insulin resistance does not accelerate LTL attrition.
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subjectAdult ; ADULTS ; Age Factors ; AMERICAN-INDIANS ; Article ; BIOLOGY ; Body Mass Index ; Cardiology ; Cardiology and cardiovascular system ; Cardiovascular Diseases ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - physiopathology ; cardiovascular system ; epidemiology (all) ; Female ; Genetics ; Genetics/epidemiology (all) ; GLUCOSE ; GLYCEMIA ; Human ; Human health ; Human health and pathology ; Human Physiology ; Humans ; INFLAMMATION ; Insulin Resistance ; Insulin Resistance - genetics ; Insulin Resistance - physiology ; Insulin sensitivity ; Insulin sensitivity and resistance ; Internal Medicine ; Leukocytes ; Leukocytes - metabolism ; Life Sciences ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; METABOLIC SYNDROME ; Middle Aged ; OBESITY ; OXIDATIVE STRESS ; pathology ; resistance ; Resveratrol ; Risk Factors ; Sex Factors ; STRONG HEART FAMILY ; Telomere ; Telomere - genetics ; Type 2 diabetes
ispartofDiabetologia, 2016, Vol.59 (6), p.1258-1265
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8Kyvik, Kirsten O
9Benetos, Athanase
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descriptionAims/hypothesis A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof. Methods Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs. Results Age at baseline examination was 37.4 +/- 9.6 (mean +/- SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p <0.001); this effect was additive to that of BMI. The co-twin with the shorter baseline LTL displayed higher insulin resistance at follow-up than the co-twin with the longer LTL. Conclusions/interpretation These findings suggest that individuals with short LTL are more likely to develop insulin resistance later in life. By contrast, presence of insulin resistance does not accelerate LTL attrition.
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abstractAims/hypothesis A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof. Methods Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs. Results Age at baseline examination was 37.4 +/- 9.6 (mean +/- SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p <0.001); this effect was additive to that of BMI. The co-twin with the shorter baseline LTL displayed higher insulin resistance at follow-up than the co-twin with the longer LTL. Conclusions/interpretation These findings suggest that individuals with short LTL are more likely to develop insulin resistance later in life. By contrast, presence of insulin resistance does not accelerate LTL attrition.
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