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Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure

Summary Patients with chronic kidney failure—defined as a glomerular filtration rate persistently below 15 mL/min per 1·73 m2 —have an unacceptably high mortality rate. In developing countries, mortality results primarily from an absence of access to renal replacement therapy. Additionally, cardiova... Full description

Journal Title: The Lancet (British edition) 2014, Vol.383 (9931), p.1831-1843
Main Author: Ortiz, Alberto, Prof
Other Authors: Covic, Adrian, MD , Fliser, Danilo, MD , Fouque, Denis, MD , Goldsmith, David, Prof , Kanbay, Mehmet, MD , Mallamaci, Francesca, MD , Massy, Ziad A, MD , Rossignol, Patrick, MD , Vanholder, Raymond, MD , Wiecek, Andrzej, MD , Zoccali, Carmine, MD , London, Gérard M, MD
Format: Electronic Article Electronic Article
Language: English
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Quelle: Alma/SFX Local Collection
Publisher: Kidlington: Elsevier Ltd
ID: ISSN: 0140-6736
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recordid: cdi_hal_primary_oai_HAL_hal_01858997v1
title: Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure
format: Article
creator:
  • Ortiz, Alberto, Prof
  • Covic, Adrian, MD
  • Fliser, Danilo, MD
  • Fouque, Denis, MD
  • Goldsmith, David, Prof
  • Kanbay, Mehmet, MD
  • Mallamaci, Francesca, MD
  • Massy, Ziad A, MD
  • Rossignol, Patrick, MD
  • Vanholder, Raymond, MD
  • Wiecek, Andrzej, MD
  • Zoccali, Carmine, MD
  • London, Gérard M, MD
subjects:
  • Abridged Index Medicus
  • Analysis as Topic
  • Biological and medical sciences
  • Care and treatment
  • Chronic
  • Chronic kidney failure
  • Epidemiology
  • etiology
  • General aspects
  • Health risk assessment
  • Humans
  • Internal Medicine
  • Kidney diseases
  • Kidney Failure
  • Kidney Failure, Chronic - etiology
  • Kidney Failure, Chronic - mortality
  • Kidney Failure, Chronic - therapy
  • Life Sciences
  • male genital diseases
  • Medical sciences
  • Meta
  • Meta-Analysis as Topic
  • methods
  • Miscellaneous
  • Mortality
  • omized Controlled Trials as Topic
  • Patient outcomes
  • Peritoneal dialysis
  • Public health. Hygiene
  • Public health. Hygiene-occupational medicine
  • Randomized Controlled Trials as Topic - methods
  • Renal Replacement Therapy
  • Renal Replacement Therapy - methods
  • Renal Replacement Therapy - mortality
  • Research
  • Risk Factors
  • therapy
  • Transplants & implants
  • urologic
ispartof: The Lancet (British edition), 2014, Vol.383 (9931), p.1831-1843
description: Summary Patients with chronic kidney failure—defined as a glomerular filtration rate persistently below 15 mL/min per 1·73 m2 —have an unacceptably high mortality rate. In developing countries, mortality results primarily from an absence of access to renal replacement therapy. Additionally, cardiovascular and non-cardiovascular mortality are several times higher in patients on dialysis or post-renal transplantation than in the general population. Mortality of patients on renal replacement therapy is affected by a combination of socioeconomic factors, pre-existing medical disorders, renal replacement treatment modalities, and kidney failure itself. Characterisation of the key pathophysiological contributors to increased mortality and cardiorenal risk staging systems are needed for the rational design of clinical trials aimed at decreasing mortality. Policy changes to improve access to renal replacement therapy should be combined with research into low-cost renal replacement therapy and optimum clinical care, which should include multifaceted approaches simultaneously targeting several of the putative contributors to increased mortality.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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creatorOrtiz, Alberto, Prof ; Covic, Adrian, MD ; Fliser, Danilo, MD ; Fouque, Denis, MD ; Goldsmith, David, Prof ; Kanbay, Mehmet, MD ; Mallamaci, Francesca, MD ; Massy, Ziad A, MD ; Rossignol, Patrick, MD ; Vanholder, Raymond, MD ; Wiecek, Andrzej, MD ; Zoccali, Carmine, MD ; London, Gérard M, MD
creatorcontribOrtiz, Alberto, Prof ; Covic, Adrian, MD ; Fliser, Danilo, MD ; Fouque, Denis, MD ; Goldsmith, David, Prof ; Kanbay, Mehmet, MD ; Mallamaci, Francesca, MD ; Massy, Ziad A, MD ; Rossignol, Patrick, MD ; Vanholder, Raymond, MD ; Wiecek, Andrzej, MD ; Zoccali, Carmine, MD ; London, Gérard M, MD ; for the Board of the EURECA-m Working Group of ERA-EDTA ; Board of the EURECA-m Working Group of ERA-EDTA
descriptionSummary Patients with chronic kidney failure—defined as a glomerular filtration rate persistently below 15 mL/min per 1·73 m2 —have an unacceptably high mortality rate. In developing countries, mortality results primarily from an absence of access to renal replacement therapy. Additionally, cardiovascular and non-cardiovascular mortality are several times higher in patients on dialysis or post-renal transplantation than in the general population. Mortality of patients on renal replacement therapy is affected by a combination of socioeconomic factors, pre-existing medical disorders, renal replacement treatment modalities, and kidney failure itself. Characterisation of the key pathophysiological contributors to increased mortality and cardiorenal risk staging systems are needed for the rational design of clinical trials aimed at decreasing mortality. Policy changes to improve access to renal replacement therapy should be combined with research into low-cost renal replacement therapy and optimum clinical care, which should include multifaceted approaches simultaneously targeting several of the putative contributors to increased mortality.
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subjectAbridged Index Medicus ; Analysis as Topic ; Biological and medical sciences ; Care and treatment ; Chronic ; Chronic kidney failure ; Epidemiology ; etiology ; General aspects ; Health risk assessment ; Humans ; Internal Medicine ; Kidney diseases ; Kidney Failure ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - mortality ; Kidney Failure, Chronic - therapy ; Life Sciences ; male genital diseases ; Medical sciences ; Meta ; Meta-Analysis as Topic ; methods ; Miscellaneous ; Mortality ; omized Controlled Trials as Topic ; Patient outcomes ; Peritoneal dialysis ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Randomized Controlled Trials as Topic - methods ; Renal Replacement Therapy ; Renal Replacement Therapy - methods ; Renal Replacement Therapy - mortality ; Research ; Risk Factors ; therapy ; Transplants & implants ; urologic
ispartofThe Lancet (British edition), 2014, Vol.383 (9931), p.1831-1843
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descriptionSummary Patients with chronic kidney failure—defined as a glomerular filtration rate persistently below 15 mL/min per 1·73 m2 —have an unacceptably high mortality rate. In developing countries, mortality results primarily from an absence of access to renal replacement therapy. Additionally, cardiovascular and non-cardiovascular mortality are several times higher in patients on dialysis or post-renal transplantation than in the general population. Mortality of patients on renal replacement therapy is affected by a combination of socioeconomic factors, pre-existing medical disorders, renal replacement treatment modalities, and kidney failure itself. Characterisation of the key pathophysiological contributors to increased mortality and cardiorenal risk staging systems are needed for the rational design of clinical trials aimed at decreasing mortality. Policy changes to improve access to renal replacement therapy should be combined with research into low-cost renal replacement therapy and optimum clinical care, which should include multifaceted approaches simultaneously targeting several of the putative contributors to increased mortality.
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titleEpidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure
authorOrtiz, Alberto, Prof ; Covic, Adrian, MD ; Fliser, Danilo, MD ; Fouque, Denis, MD ; Goldsmith, David, Prof ; Kanbay, Mehmet, MD ; Mallamaci, Francesca, MD ; Massy, Ziad A, MD ; Rossignol, Patrick, MD ; Vanholder, Raymond, MD ; Wiecek, Andrzej, MD ; Zoccali, Carmine, MD ; London, Gérard M, MD
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6Epidemiology
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8General aspects
9Health risk assessment
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13Kidney Failure
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17Life Sciences
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26Patient outcomes
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31Renal Replacement Therapy
32Renal Replacement Therapy - methods
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34Research
35Risk Factors
36therapy
37Transplants & implants
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abstractSummary Patients with chronic kidney failure—defined as a glomerular filtration rate persistently below 15 mL/min per 1·73 m2 —have an unacceptably high mortality rate. In developing countries, mortality results primarily from an absence of access to renal replacement therapy. Additionally, cardiovascular and non-cardiovascular mortality are several times higher in patients on dialysis or post-renal transplantation than in the general population. Mortality of patients on renal replacement therapy is affected by a combination of socioeconomic factors, pre-existing medical disorders, renal replacement treatment modalities, and kidney failure itself. Characterisation of the key pathophysiological contributors to increased mortality and cardiorenal risk staging systems are needed for the rational design of clinical trials aimed at decreasing mortality. Policy changes to improve access to renal replacement therapy should be combined with research into low-cost renal replacement therapy and optimum clinical care, which should include multifaceted approaches simultaneously targeting several of the putative contributors to increased mortality.
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