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Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes

Purpose This study was conducted in order to study Sostdc1 expression in rat and human developing and adult eyes. Methods Using the yeast signal sequence trap screening method, we identified the Sostdc1 cDNA encoding a protein secreted by the adult rat retinal pigment epithelium. We determined by in... Full description

Journal Title: Graefe's archive for clinical and experimental ophthalmology 2019, Vol.257 (11), p.2401-2427
Main Author: Valensi, Maud
Other Authors: Goldman, Gabrielle , Marchant, Dominique , Van Den Berghe, Loïc , Jonet, Laurent , Daruich, Alejandra , Robert, Matthieu P , Krejci, Eric , Klein, Christophe , Mascarelli, Frédéric , Versaux-Botteri, Claudine , Moulin, Alexandre , Putterman, Marc , Guimiot, Fabien , Molina, Thierry , Terris, Benoît , Brémond-Gignac, Dominique , Behar-Cohen, Francine , Abitbol, Marc M
Format: Electronic Article Electronic Article
Language: English
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Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0721-832X
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title: Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes
format: Article
creator:
  • Valensi, Maud
  • Goldman, Gabrielle
  • Marchant, Dominique
  • Van Den Berghe, Loïc
  • Jonet, Laurent
  • Daruich, Alejandra
  • Robert, Matthieu P
  • Krejci, Eric
  • Klein, Christophe
  • Mascarelli, Frédéric
  • Versaux-Botteri, Claudine
  • Moulin, Alexandre
  • Putterman, Marc
  • Guimiot, Fabien
  • Molina, Thierry
  • Terris, Benoît
  • Brémond-Gignac, Dominique
  • Behar-Cohen, Francine
  • Abitbol, Marc M
subjects:
  • Adaptor Proteins, Signal Transducing - biosynthesis
  • Adaptor Proteins, Signal Transducing - genetics
  • Aged
  • Animals
  • Basic Science
  • Blotting, Western
  • Central nervous system
  • Child, Preschool
  • Developmental stages
  • Disease Models, Animal
  • Embryos
  • Epithelium
  • Eye diseases
  • Eye Diseases, Hereditary - genetics
  • Eye Diseases, Hereditary - metabolism
  • Female
  • Gene expression
  • Gene Expression Regulation, Developmental
  • Humans
  • Hybridization
  • Immunohistochemistry
  • In Situ Hybridization
  • Life Sciences
  • Localization
  • Male
  • Medicine
  • Medicine & Public Health
  • Ophthalmology
  • Otx2 protein
  • Pax6 protein
  • Polymerase chain reaction
  • Rats
  • Retina
  • Retinal pigment epithelium
  • Retinal Pigment Epithelium - cytology
  • Retinal Pigment Epithelium - growth & development
  • Retinal Pigment Epithelium - metabolism
  • RNA - genetics
  • Vascularization
  • Wnt protein
  • β-Catenin
ispartof: Graefe's archive for clinical and experimental ophthalmology, 2019, Vol.257 (11), p.2401-2427
description: Purpose This study was conducted in order to study Sostdc1 expression in rat and human developing and adult eyes. Methods Using the yeast signal sequence trap screening method, we identified the Sostdc1 cDNA encoding a protein secreted by the adult rat retinal pigment epithelium. We determined by in situ hybridization, RT-PCR, immunohistochemistry, and western blot analysis Sostdc1 gene and protein expression in developing and postnatal rat ocular tissue sections. We also investigated Sostdc1 immunohistolocalization in developing and adult human ocular tissues. Results We demonstrated a prominent Sostdc1 gene expression in the developing rat central nervous system (CNS) and eyes at early developmental stages from E10.5 days postconception (dpc) to E13 dpc. Specific Sostdc1 immunostaining was also detected in most adult cells of rat ocular tissue sections. We also identified the rat ocular embryonic compartments characterized by a specific Sostdc1 immunohistostaining and specific Pax6, Sox2, Otx2, and Vsx2 immunohistostaining from embryonic stages E10.5 to E13 dpc. Furthermore, we determined the localization of SOSTDC1 immunoreactivity in ocular tissue sections of developing and adult human eyes. Indeed, we detected SOSTDC1 immunostaining in developing and adult human retinal pigment epithelium (RPE) and neural retina (NR) as well as in several developing and adult human ocular compartments, including the walls of choroidal and scleral vessels. Of utmost importance, we observed a strong SOSTDC1 expression in a pathological ocular specimen of type 2 Peters' anomaly complicated by retinal neovascularization as well in the walls ofother pathological extra-ocular vessels.  Conclusion As rat Sostdc1 and human SOSTDC1 are dual antagonists of the Wnt/β-catenin and BMP signaling pathways, these results underscore the potential crucial roles of these pathways and their antagonists, such as Sostdc1 and SOSTDC1, in developing and adult mammalian normal eyes as well as in syndromic and nonsyndromic congenital eye diseases.
language: eng
source:
identifier: ISSN: 0721-832X
fulltext: no_fulltext
issn:
  • 0721-832X
  • 1435-702X
url: Link


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titleSostdc1 is expressed in all major compartments of developing and adult mammalian eyes
creatorValensi, Maud ; Goldman, Gabrielle ; Marchant, Dominique ; Van Den Berghe, Loïc ; Jonet, Laurent ; Daruich, Alejandra ; Robert, Matthieu P ; Krejci, Eric ; Klein, Christophe ; Mascarelli, Frédéric ; Versaux-Botteri, Claudine ; Moulin, Alexandre ; Putterman, Marc ; Guimiot, Fabien ; Molina, Thierry ; Terris, Benoît ; Brémond-Gignac, Dominique ; Behar-Cohen, Francine ; Abitbol, Marc M
creatorcontribValensi, Maud ; Goldman, Gabrielle ; Marchant, Dominique ; Van Den Berghe, Loïc ; Jonet, Laurent ; Daruich, Alejandra ; Robert, Matthieu P ; Krejci, Eric ; Klein, Christophe ; Mascarelli, Frédéric ; Versaux-Botteri, Claudine ; Moulin, Alexandre ; Putterman, Marc ; Guimiot, Fabien ; Molina, Thierry ; Terris, Benoît ; Brémond-Gignac, Dominique ; Behar-Cohen, Francine ; Abitbol, Marc M
descriptionPurpose This study was conducted in order to study Sostdc1 expression in rat and human developing and adult eyes. Methods Using the yeast signal sequence trap screening method, we identified the Sostdc1 cDNA encoding a protein secreted by the adult rat retinal pigment epithelium. We determined by in situ hybridization, RT-PCR, immunohistochemistry, and western blot analysis Sostdc1 gene and protein expression in developing and postnatal rat ocular tissue sections. We also investigated Sostdc1 immunohistolocalization in developing and adult human ocular tissues. Results We demonstrated a prominent Sostdc1 gene expression in the developing rat central nervous system (CNS) and eyes at early developmental stages from E10.5 days postconception (dpc) to E13 dpc. Specific Sostdc1 immunostaining was also detected in most adult cells of rat ocular tissue sections. We also identified the rat ocular embryonic compartments characterized by a specific Sostdc1 immunohistostaining and specific Pax6, Sox2, Otx2, and Vsx2 immunohistostaining from embryonic stages E10.5 to E13 dpc. Furthermore, we determined the localization of SOSTDC1 immunoreactivity in ocular tissue sections of developing and adult human eyes. Indeed, we detected SOSTDC1 immunostaining in developing and adult human retinal pigment epithelium (RPE) and neural retina (NR) as well as in several developing and adult human ocular compartments, including the walls of choroidal and scleral vessels. Of utmost importance, we observed a strong SOSTDC1 expression in a pathological ocular specimen of type 2 Peters' anomaly complicated by retinal neovascularization as well in the walls ofother pathological extra-ocular vessels.  Conclusion As rat Sostdc1 and human SOSTDC1 are dual antagonists of the Wnt/β-catenin and BMP signaling pathways, these results underscore the potential crucial roles of these pathways and their antagonists, such as Sostdc1 and SOSTDC1, in developing and adult mammalian normal eyes as well as in syndromic and nonsyndromic congenital eye diseases.
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0ISSN: 0721-832X
1EISSN: 1435-702X
2DOI: 10.1007/s00417-019-04462-4
3PMID: 31529323
languageeng
publisherBerlin/Heidelberg: Springer Berlin Heidelberg
subjectAdaptor Proteins, Signal Transducing - biosynthesis ; Adaptor Proteins, Signal Transducing - genetics ; Aged ; Animals ; Basic Science ; Blotting, Western ; Central nervous system ; Child, Preschool ; Developmental stages ; Disease Models, Animal ; Embryos ; Epithelium ; Eye diseases ; Eye Diseases, Hereditary - genetics ; Eye Diseases, Hereditary - metabolism ; Female ; Gene expression ; Gene Expression Regulation, Developmental ; Humans ; Hybridization ; Immunohistochemistry ; In Situ Hybridization ; Life Sciences ; Localization ; Male ; Medicine ; Medicine & Public Health ; Ophthalmology ; Otx2 protein ; Pax6 protein ; Polymerase chain reaction ; Rats ; Retina ; Retinal pigment epithelium ; Retinal Pigment Epithelium - cytology ; Retinal Pigment Epithelium - growth & development ; Retinal Pigment Epithelium - metabolism ; RNA - genetics ; Vascularization ; Wnt protein ; β-Catenin
ispartofGraefe's archive for clinical and experimental ophthalmology, 2019, Vol.257 (11), p.2401-2427
rights
0Springer-Verlag GmbH Germany, part of Springer Nature 2019
1Graefe's Archive for Clinical and Experimental Ophthalmology is a copyright of Springer, (2019). All Rights Reserved.
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1Goldman, Gabrielle
2Marchant, Dominique
3Van Den Berghe, Loïc
4Jonet, Laurent
5Daruich, Alejandra
6Robert, Matthieu P
7Krejci, Eric
8Klein, Christophe
9Mascarelli, Frédéric
10Versaux-Botteri, Claudine
11Moulin, Alexandre
12Putterman, Marc
13Guimiot, Fabien
14Molina, Thierry
15Terris, Benoît
16Brémond-Gignac, Dominique
17Behar-Cohen, Francine
18Abitbol, Marc M
title
0Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes
1Graefe's archive for clinical and experimental ophthalmology
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0Graefes Arch Clin Exp Ophthalmol
1Graefes Arch Clin Exp Ophthalmol
descriptionPurpose This study was conducted in order to study Sostdc1 expression in rat and human developing and adult eyes. Methods Using the yeast signal sequence trap screening method, we identified the Sostdc1 cDNA encoding a protein secreted by the adult rat retinal pigment epithelium. We determined by in situ hybridization, RT-PCR, immunohistochemistry, and western blot analysis Sostdc1 gene and protein expression in developing and postnatal rat ocular tissue sections. We also investigated Sostdc1 immunohistolocalization in developing and adult human ocular tissues. Results We demonstrated a prominent Sostdc1 gene expression in the developing rat central nervous system (CNS) and eyes at early developmental stages from E10.5 days postconception (dpc) to E13 dpc. Specific Sostdc1 immunostaining was also detected in most adult cells of rat ocular tissue sections. We also identified the rat ocular embryonic compartments characterized by a specific Sostdc1 immunohistostaining and specific Pax6, Sox2, Otx2, and Vsx2 immunohistostaining from embryonic stages E10.5 to E13 dpc. Furthermore, we determined the localization of SOSTDC1 immunoreactivity in ocular tissue sections of developing and adult human eyes. Indeed, we detected SOSTDC1 immunostaining in developing and adult human retinal pigment epithelium (RPE) and neural retina (NR) as well as in several developing and adult human ocular compartments, including the walls of choroidal and scleral vessels. Of utmost importance, we observed a strong SOSTDC1 expression in a pathological ocular specimen of type 2 Peters' anomaly complicated by retinal neovascularization as well in the walls ofother pathological extra-ocular vessels.  Conclusion As rat Sostdc1 and human SOSTDC1 are dual antagonists of the Wnt/β-catenin and BMP signaling pathways, these results underscore the potential crucial roles of these pathways and their antagonists, such as Sostdc1 and SOSTDC1, in developing and adult mammalian normal eyes as well as in syndromic and nonsyndromic congenital eye diseases.
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21In Situ Hybridization
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25Medicine
26Medicine & Public Health
27Ophthalmology
28Otx2 protein
29Pax6 protein
30Polymerase chain reaction
31Rats
32Retina
33Retinal pigment epithelium
34Retinal Pigment Epithelium - cytology
35Retinal Pigment Epithelium - growth & development
36Retinal Pigment Epithelium - metabolism
37RNA - genetics
38Vascularization
39Wnt protein
40β-Catenin
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12Putterman, Marc
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titleSostdc1 is expressed in all major compartments of developing and adult mammalian eyes
authorValensi, Maud ; Goldman, Gabrielle ; Marchant, Dominique ; Van Den Berghe, Loïc ; Jonet, Laurent ; Daruich, Alejandra ; Robert, Matthieu P ; Krejci, Eric ; Klein, Christophe ; Mascarelli, Frédéric ; Versaux-Botteri, Claudine ; Moulin, Alexandre ; Putterman, Marc ; Guimiot, Fabien ; Molina, Thierry ; Terris, Benoît ; Brémond-Gignac, Dominique ; Behar-Cohen, Francine ; Abitbol, Marc M
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3Animals
4Basic Science
5Blotting, Western
6Central nervous system
7Child, Preschool
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9Disease Models, Animal
10Embryos
11Epithelium
12Eye diseases
13Eye Diseases, Hereditary - genetics
14Eye Diseases, Hereditary - metabolism
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16Gene expression
17Gene Expression Regulation, Developmental
18Humans
19Hybridization
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30Polymerase chain reaction
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33Retinal pigment epithelium
34Retinal Pigment Epithelium - cytology
35Retinal Pigment Epithelium - growth & development
36Retinal Pigment Epithelium - metabolism
37RNA - genetics
38Vascularization
39Wnt protein
40β-Catenin
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8Klein, Christophe
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abstractPurpose This study was conducted in order to study Sostdc1 expression in rat and human developing and adult eyes. Methods Using the yeast signal sequence trap screening method, we identified the Sostdc1 cDNA encoding a protein secreted by the adult rat retinal pigment epithelium. We determined by in situ hybridization, RT-PCR, immunohistochemistry, and western blot analysis Sostdc1 gene and protein expression in developing and postnatal rat ocular tissue sections. We also investigated Sostdc1 immunohistolocalization in developing and adult human ocular tissues. Results We demonstrated a prominent Sostdc1 gene expression in the developing rat central nervous system (CNS) and eyes at early developmental stages from E10.5 days postconception (dpc) to E13 dpc. Specific Sostdc1 immunostaining was also detected in most adult cells of rat ocular tissue sections. We also identified the rat ocular embryonic compartments characterized by a specific Sostdc1 immunohistostaining and specific Pax6, Sox2, Otx2, and Vsx2 immunohistostaining from embryonic stages E10.5 to E13 dpc. Furthermore, we determined the localization of SOSTDC1 immunoreactivity in ocular tissue sections of developing and adult human eyes. Indeed, we detected SOSTDC1 immunostaining in developing and adult human retinal pigment epithelium (RPE) and neural retina (NR) as well as in several developing and adult human ocular compartments, including the walls of choroidal and scleral vessels. Of utmost importance, we observed a strong SOSTDC1 expression in a pathological ocular specimen of type 2 Peters' anomaly complicated by retinal neovascularization as well in the walls ofother pathological extra-ocular vessels.  Conclusion As rat Sostdc1 and human SOSTDC1 are dual antagonists of the Wnt/β-catenin and BMP signaling pathways, these results underscore the potential crucial roles of these pathways and their antagonists, such as Sostdc1 and SOSTDC1, in developing and adult mammalian normal eyes as well as in syndromic and nonsyndromic congenital eye diseases.
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