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Effects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women

Purpose Epidemiological studies suggest that a moderate consumption of wine is associated with a reduced risk of cardiovascular diseases and with a reduced mortality for all causes, possibly due to increased antioxidant defences. The present intervention study was undertaken to evaluate the in vivo... Full description

Journal Title: European journal of nutrition 2010-04-27, Vol.50 (1), p.19-29
Main Author: Giovannelli, Lisa
Other Authors: Pitozzi, Vanessa , Luceri, Cristina , Giannini, Lucia , Toti, Simona , Salvini, Simonetta , Sera, Francesco , Souquet, Jean-Marc , Cheynier, Veronique , Sofi, Francesco , Mannini, Lucia , Gori, Anna Maria , Abbate, Rosanna , Palli, Domenico , Dolara, Piero
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 1436-6207
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recordid: cdi_hal_primary_oai_HAL_hal_02644576v1
title: Effects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women
format: Article
creator:
  • Giovannelli, Lisa
  • Pitozzi, Vanessa
  • Luceri, Cristina
  • Giannini, Lucia
  • Toti, Simona
  • Salvini, Simonetta
  • Sera, Francesco
  • Souquet, Jean-Marc
  • Cheynier, Veronique
  • Sofi, Francesco
  • Mannini, Lucia
  • Gori, Anna Maria
  • Abbate, Rosanna
  • Palli, Domenico
  • Dolara, Piero
subjects:
  • Analysis
  • Anopheles
  • Antioxidants
  • Biological and medical sciences
  • Blood Viscosity
  • Cancer
  • Cardiovascular Diseases - epidemiology
  • Cardiovascular Diseases - immunology
  • Cardiovascular Diseases - prevention & control
  • Chemistry
  • Chemistry and Materials Science
  • Cross-Over Studies
  • Cytokines - blood
  • DNA
  • DNA Damage
  • DNA microarrays
  • Feeding. Feeding behavior
  • Female
  • Flavonoids - analysis
  • Flavonoids - therapeutic use
  • Fundamental and applied biological sciences. Psychology
  • Gene expression
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Genetic research
  • Humans
  • Life Sciences
  • Lymphocytes
  • Lymphocytes - metabolism
  • Middle Aged
  • Nutrition
  • Oligonucleotide Array Sequence Analysis
  • Oncology, Experimental
  • Original Contribution
  • Other
  • Oxidative Stress
  • Phenols - analysis
  • Phenols - therapeutic use
  • Platelet Aggregation
  • Polyphenols
  • Postmenopausal women
  • Postmenopause - blood
  • Postmenopause - immunology
  • Prevention
  • Proanthocyanidins - analysis
  • Proanthocyanidins - therapeutic use
  • Risk Factors
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vitaceae
  • Wine - analysis
ispartof: European journal of nutrition, 2010-04-27, Vol.50 (1), p.19-29
description: Purpose Epidemiological studies suggest that a moderate consumption of wine is associated with a reduced risk of cardiovascular diseases and with a reduced mortality for all causes, possibly due to increased antioxidant defences. The present intervention study was undertaken to evaluate the in vivo effects of wine polyphenols on gene expression in humans, along with their supposed antioxidant activity. Methods Blood haemorheology and platelet function were also evaluated. In order to avoid interferences from alcohol, we used de-alcoholised wine (DAW) with different polyphenol content. A randomised cross-over trial of high-proanthocyanidin (PA) red DAW (500 mL/die, PA dose = 7 mg/kg b.w.) vs. low-PA rosé DAW (500 mL/die, PA dose = 0.45 mg/kg) was conducted in 21 post-menopausal women in Florence, Italy. Oxidative DNA damage by the comet assay and gene expression by microarray was measured in peripheral blood lymphocytes, collected during the study period. Blood samples were also collected for the evaluation of haematological, haemostatic, haemorheological, and inflammatory parameters. Results The results of the present study provide evidence that consumption of substantial amounts of de-alcoholised wine for 1 month does not exert a protective activity towards oxidative DNA damage, nor modifies significantly the gene expression profile of peripheral lymphocytes, whereas it shows blood-fluidifying actions, expressed as a significant decrease in blood viscosity. However, this effect does not correlate with the dosage of polyphenols of the de-alcoholised wine. Conclusions More intervention studies are needed to provide further evidence of the health-protective effects of wine proanthocyanidins.
language: eng
source:
identifier: ISSN: 1436-6207
fulltext: no_fulltext
issn:
  • 1436-6207
  • 1436-6215
url: Link


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titleEffects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women
creatorGiovannelli, Lisa ; Pitozzi, Vanessa ; Luceri, Cristina ; Giannini, Lucia ; Toti, Simona ; Salvini, Simonetta ; Sera, Francesco ; Souquet, Jean-Marc ; Cheynier, Veronique ; Sofi, Francesco ; Mannini, Lucia ; Gori, Anna Maria ; Abbate, Rosanna ; Palli, Domenico ; Dolara, Piero
creatorcontribGiovannelli, Lisa ; Pitozzi, Vanessa ; Luceri, Cristina ; Giannini, Lucia ; Toti, Simona ; Salvini, Simonetta ; Sera, Francesco ; Souquet, Jean-Marc ; Cheynier, Veronique ; Sofi, Francesco ; Mannini, Lucia ; Gori, Anna Maria ; Abbate, Rosanna ; Palli, Domenico ; Dolara, Piero
descriptionPurpose Epidemiological studies suggest that a moderate consumption of wine is associated with a reduced risk of cardiovascular diseases and with a reduced mortality for all causes, possibly due to increased antioxidant defences. The present intervention study was undertaken to evaluate the in vivo effects of wine polyphenols on gene expression in humans, along with their supposed antioxidant activity. Methods Blood haemorheology and platelet function were also evaluated. In order to avoid interferences from alcohol, we used de-alcoholised wine (DAW) with different polyphenol content. A randomised cross-over trial of high-proanthocyanidin (PA) red DAW (500 mL/die, PA dose = 7 mg/kg b.w.) vs. low-PA rosé DAW (500 mL/die, PA dose = 0.45 mg/kg) was conducted in 21 post-menopausal women in Florence, Italy. Oxidative DNA damage by the comet assay and gene expression by microarray was measured in peripheral blood lymphocytes, collected during the study period. Blood samples were also collected for the evaluation of haematological, haemostatic, haemorheological, and inflammatory parameters. Results The results of the present study provide evidence that consumption of substantial amounts of de-alcoholised wine for 1 month does not exert a protective activity towards oxidative DNA damage, nor modifies significantly the gene expression profile of peripheral lymphocytes, whereas it shows blood-fluidifying actions, expressed as a significant decrease in blood viscosity. However, this effect does not correlate with the dosage of polyphenols of the de-alcoholised wine. Conclusions More intervention studies are needed to provide further evidence of the health-protective effects of wine proanthocyanidins.
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1EISSN: 1436-6215
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3PMID: 20422199
languageeng
publisherBerlin/Heidelberg: Springer-Verlag
subjectAnalysis ; Anopheles ; Antioxidants ; Biological and medical sciences ; Blood Viscosity ; Cancer ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - immunology ; Cardiovascular Diseases - prevention & control ; Chemistry ; Chemistry and Materials Science ; Cross-Over Studies ; Cytokines - blood ; DNA ; DNA Damage ; DNA microarrays ; Feeding. Feeding behavior ; Female ; Flavonoids - analysis ; Flavonoids - therapeutic use ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation ; Genetic research ; Humans ; Life Sciences ; Lymphocytes ; Lymphocytes - metabolism ; Middle Aged ; Nutrition ; Oligonucleotide Array Sequence Analysis ; Oncology, Experimental ; Original Contribution ; Other ; Oxidative Stress ; Phenols - analysis ; Phenols - therapeutic use ; Platelet Aggregation ; Polyphenols ; Postmenopausal women ; Postmenopause - blood ; Postmenopause - immunology ; Prevention ; Proanthocyanidins - analysis ; Proanthocyanidins - therapeutic use ; Risk Factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitaceae ; Wine - analysis
ispartofEuropean journal of nutrition, 2010-04-27, Vol.50 (1), p.19-29
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0Giovannelli, Lisa
1Pitozzi, Vanessa
2Luceri, Cristina
3Giannini, Lucia
4Toti, Simona
5Salvini, Simonetta
6Sera, Francesco
7Souquet, Jean-Marc
8Cheynier, Veronique
9Sofi, Francesco
10Mannini, Lucia
11Gori, Anna Maria
12Abbate, Rosanna
13Palli, Domenico
14Dolara, Piero
title
0Effects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women
1European journal of nutrition
addtitle
0Eur J Nutr
1Eur J Nutr
descriptionPurpose Epidemiological studies suggest that a moderate consumption of wine is associated with a reduced risk of cardiovascular diseases and with a reduced mortality for all causes, possibly due to increased antioxidant defences. The present intervention study was undertaken to evaluate the in vivo effects of wine polyphenols on gene expression in humans, along with their supposed antioxidant activity. Methods Blood haemorheology and platelet function were also evaluated. In order to avoid interferences from alcohol, we used de-alcoholised wine (DAW) with different polyphenol content. A randomised cross-over trial of high-proanthocyanidin (PA) red DAW (500 mL/die, PA dose = 7 mg/kg b.w.) vs. low-PA rosé DAW (500 mL/die, PA dose = 0.45 mg/kg) was conducted in 21 post-menopausal women in Florence, Italy. Oxidative DNA damage by the comet assay and gene expression by microarray was measured in peripheral blood lymphocytes, collected during the study period. Blood samples were also collected for the evaluation of haematological, haemostatic, haemorheological, and inflammatory parameters. Results The results of the present study provide evidence that consumption of substantial amounts of de-alcoholised wine for 1 month does not exert a protective activity towards oxidative DNA damage, nor modifies significantly the gene expression profile of peripheral lymphocytes, whereas it shows blood-fluidifying actions, expressed as a significant decrease in blood viscosity. However, this effect does not correlate with the dosage of polyphenols of the de-alcoholised wine. Conclusions More intervention studies are needed to provide further evidence of the health-protective effects of wine proanthocyanidins.
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0Analysis
1Anopheles
2Antioxidants
3Biological and medical sciences
4Blood Viscosity
5Cancer
6Cardiovascular Diseases - epidemiology
7Cardiovascular Diseases - immunology
8Cardiovascular Diseases - prevention & control
9Chemistry
10Chemistry and Materials Science
11Cross-Over Studies
12Cytokines - blood
13DNA
14DNA Damage
15DNA microarrays
16Feeding. Feeding behavior
17Female
18Flavonoids - analysis
19Flavonoids - therapeutic use
20Fundamental and applied biological sciences. Psychology
21Gene expression
22Gene Expression Profiling
23Gene Expression Regulation
24Genetic research
25Humans
26Life Sciences
27Lymphocytes
28Lymphocytes - metabolism
29Middle Aged
30Nutrition
31Oligonucleotide Array Sequence Analysis
32Oncology, Experimental
33Original Contribution
34Other
35Oxidative Stress
36Phenols - analysis
37Phenols - therapeutic use
38Platelet Aggregation
39Polyphenols
40Postmenopausal women
41Postmenopause - blood
42Postmenopause - immunology
43Prevention
44Proanthocyanidins - analysis
45Proanthocyanidins - therapeutic use
46Risk Factors
47Vertebrates: anatomy and physiology, studies on body, several organs or systems
48Vitaceae
49Wine - analysis
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9Sofi, Francesco
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titleEffects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women
authorGiovannelli, Lisa ; Pitozzi, Vanessa ; Luceri, Cristina ; Giannini, Lucia ; Toti, Simona ; Salvini, Simonetta ; Sera, Francesco ; Souquet, Jean-Marc ; Cheynier, Veronique ; Sofi, Francesco ; Mannini, Lucia ; Gori, Anna Maria ; Abbate, Rosanna ; Palli, Domenico ; Dolara, Piero
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1Anopheles
2Antioxidants
3Biological and medical sciences
4Blood Viscosity
5Cancer
6Cardiovascular Diseases - epidemiology
7Cardiovascular Diseases - immunology
8Cardiovascular Diseases - prevention & control
9Chemistry
10Chemistry and Materials Science
11Cross-Over Studies
12Cytokines - blood
13DNA
14DNA Damage
15DNA microarrays
16Feeding. Feeding behavior
17Female
18Flavonoids - analysis
19Flavonoids - therapeutic use
20Fundamental and applied biological sciences. Psychology
21Gene expression
22Gene Expression Profiling
23Gene Expression Regulation
24Genetic research
25Humans
26Life Sciences
27Lymphocytes
28Lymphocytes - metabolism
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30Nutrition
31Oligonucleotide Array Sequence Analysis
32Oncology, Experimental
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36Phenols - analysis
37Phenols - therapeutic use
38Platelet Aggregation
39Polyphenols
40Postmenopausal women
41Postmenopause - blood
42Postmenopause - immunology
43Prevention
44Proanthocyanidins - analysis
45Proanthocyanidins - therapeutic use
46Risk Factors
47Vertebrates: anatomy and physiology, studies on body, several organs or systems
48Vitaceae
49Wine - analysis
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1Pitozzi, Vanessa
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7Souquet, Jean-Marc
8Cheynier, Veronique
9Sofi, Francesco
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11Gori, Anna Maria
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8Cheynier, Veronique
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10Mannini, Lucia
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atitleEffects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women
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abstractPurpose Epidemiological studies suggest that a moderate consumption of wine is associated with a reduced risk of cardiovascular diseases and with a reduced mortality for all causes, possibly due to increased antioxidant defences. The present intervention study was undertaken to evaluate the in vivo effects of wine polyphenols on gene expression in humans, along with their supposed antioxidant activity. Methods Blood haemorheology and platelet function were also evaluated. In order to avoid interferences from alcohol, we used de-alcoholised wine (DAW) with different polyphenol content. A randomised cross-over trial of high-proanthocyanidin (PA) red DAW (500 mL/die, PA dose = 7 mg/kg b.w.) vs. low-PA rosé DAW (500 mL/die, PA dose = 0.45 mg/kg) was conducted in 21 post-menopausal women in Florence, Italy. Oxidative DNA damage by the comet assay and gene expression by microarray was measured in peripheral blood lymphocytes, collected during the study period. Blood samples were also collected for the evaluation of haematological, haemostatic, haemorheological, and inflammatory parameters. Results The results of the present study provide evidence that consumption of substantial amounts of de-alcoholised wine for 1 month does not exert a protective activity towards oxidative DNA damage, nor modifies significantly the gene expression profile of peripheral lymphocytes, whereas it shows blood-fluidifying actions, expressed as a significant decrease in blood viscosity. However, this effect does not correlate with the dosage of polyphenols of the de-alcoholised wine. Conclusions More intervention studies are needed to provide further evidence of the health-protective effects of wine proanthocyanidins.
copBerlin/Heidelberg
pubSpringer-Verlag
pmid20422199
doi10.1007/s00394-010-0111-1
orcididhttps://orcid.org/0000-0001-7759-284X