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Amino acid supplementation decreases plasma and liver triacylglycerols in elderly

Abstract Objective Hypertriglyceridemia is a risk factor for coronary heart disease. The aim of this study was to determine the effect of amino acid (AA) supplementation on plasma, liver, and muscle lipid concentrations and insulin sensitivity in the elderly. Methods Twelve impaired glucose tolerant... Full description

Journal Title: Nutrition (Burbank Los Angeles County, Calif.), 2009, Vol.25 (3), p.281-288
Main Author: Børsheim, Elisabet, Ph.D
Other Authors: Bui, Quynh-Uyen T., M.D , Tissier, Sandrine, P.T , Cree, Melanie G., M.D., Ph.D , Rønsen, Ola, M.D., Ph.D , Morio, Beatrice, Ph.D , Ferrando, Arny A., Ph.D , Kobayashi, Hisamine, D.V.M , Newcomer, Bradley R., Ph.D , Wolfe, Robert R., Ph.D
Format: Electronic Article Electronic Article
Language: English
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Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0899-9007
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recordid: cdi_hal_primary_oai_HAL_hal_02666410v1
title: Amino acid supplementation decreases plasma and liver triacylglycerols in elderly
format: Article
creator:
  • Børsheim, Elisabet, Ph.D
  • Bui, Quynh-Uyen T., M.D
  • Tissier, Sandrine, P.T
  • Cree, Melanie G., M.D., Ph.D
  • Rønsen, Ola, M.D., Ph.D
  • Morio, Beatrice, Ph.D
  • Ferrando, Arny A., Ph.D
  • Kobayashi, Hisamine, D.V.M
  • Newcomer, Bradley R., Ph.D
  • Wolfe, Robert R., Ph.D
subjects:
  • Aged
  • Amino acids
  • Amino Acids, Essential - administration & dosage
  • Amino Acids, Essential - pharmacology
  • Arginine - administration & dosage
  • Arginine - pharmacology
  • Biological and medical sciences
  • Cholesterol
  • Cholesterol - blood
  • Cholesterol, VLDL - blood
  • Dietary Supplements
  • Elderly
  • Feeding. Feeding behavior
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Gastroenterology and Hepatology
  • Glucose
  • Glucose Intolerance - blood
  • Humans
  • Hypertriglyceridemia - blood
  • Hypertriglyceridemia - complications
  • Hypertriglyceridemia - drug therapy
  • Insulin
  • Insulin - metabolism
  • Insulin sensitivity
  • Life Sciences
  • Lipids
  • Liver - drug effects
  • Liver - metabolism
  • Liver lipids
  • Male
  • Muscle, Skeletal - drug effects
  • Muscle, Skeletal - metabolism
  • Muscle, Skeletal - pathology
  • Plasma
  • Plasma lipids
  • Treatment Outcome
  • Triglycerides - blood
  • Triglycerides - metabolism
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Weight control
ispartof: Nutrition (Burbank, Los Angeles County, Calif.), 2009, Vol.25 (3), p.281-288
description: Abstract Objective Hypertriglyceridemia is a risk factor for coronary heart disease. The aim of this study was to determine the effect of amino acid (AA) supplementation on plasma, liver, and muscle lipid concentrations and insulin sensitivity in the elderly. Methods Twelve impaired glucose tolerant elderly (mean ± SD 67.0 ± 5.6 y of age, seven women and five men) ingested 11 g of essential AAs plus arginine twice a day for 16 wk, after a 7-wk control run-in. Diet and activity were not otherwise modified. Plasma lipid concentrations and oral glucose tolerance were measured every fourth week and tissue lipid concentrations (magnetic resonance spectroscopy) every eighth week. Results No changes in plasma lipids were observed during the control run-in. AA supplementation lowered plasma triacylglycerol (TG; P < 0.001), total cholesterol ( P = 0.048), and very low-density lipoprotein cholesterol ( P < 0.001) concentrations. Plasma TG decreased ∼20% from the initial value of 1.45 ± 0.18 mmol/L (mean ± SE, 128 ± 16 mg/dL), with the greatest decrease in the subjects starting out with the highest concentrations ( r = −0.83). Similarly, liver fat content (liver TG/Intralipid standard) decreased ∼50% from the initial value of 0.34 ± 0.06 ( P = 0.021, n = 8), with the greatest decrease in the subjects who initially had the highest values ( r = −0.86). Intramuscular fat content and insulin sensitivity did not change. Conclusion Diet supplementation with AAs lowers plasma TG, total cholesterol, and very low-density lipoprotein cholesterol concentrations and liver lipid content in impaired glucose tolerant elderly. AA supplementation may have a potential role in the treatment of hypertriglyceridemia or hepatic steatosis.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0899-9007
fulltext: fulltext
issn:
  • 0899-9007
  • 1873-1244
url: Link


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titleAmino acid supplementation decreases plasma and liver triacylglycerols in elderly
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creatorBørsheim, Elisabet, Ph.D ; Bui, Quynh-Uyen T., M.D ; Tissier, Sandrine, P.T ; Cree, Melanie G., M.D., Ph.D ; Rønsen, Ola, M.D., Ph.D ; Morio, Beatrice, Ph.D ; Ferrando, Arny A., Ph.D ; Kobayashi, Hisamine, D.V.M ; Newcomer, Bradley R., Ph.D ; Wolfe, Robert R., Ph.D
creatorcontribBørsheim, Elisabet, Ph.D ; Bui, Quynh-Uyen T., M.D ; Tissier, Sandrine, P.T ; Cree, Melanie G., M.D., Ph.D ; Rønsen, Ola, M.D., Ph.D ; Morio, Beatrice, Ph.D ; Ferrando, Arny A., Ph.D ; Kobayashi, Hisamine, D.V.M ; Newcomer, Bradley R., Ph.D ; Wolfe, Robert R., Ph.D
descriptionAbstract Objective Hypertriglyceridemia is a risk factor for coronary heart disease. The aim of this study was to determine the effect of amino acid (AA) supplementation on plasma, liver, and muscle lipid concentrations and insulin sensitivity in the elderly. Methods Twelve impaired glucose tolerant elderly (mean ± SD 67.0 ± 5.6 y of age, seven women and five men) ingested 11 g of essential AAs plus arginine twice a day for 16 wk, after a 7-wk control run-in. Diet and activity were not otherwise modified. Plasma lipid concentrations and oral glucose tolerance were measured every fourth week and tissue lipid concentrations (magnetic resonance spectroscopy) every eighth week. Results No changes in plasma lipids were observed during the control run-in. AA supplementation lowered plasma triacylglycerol (TG; P < 0.001), total cholesterol ( P = 0.048), and very low-density lipoprotein cholesterol ( P < 0.001) concentrations. Plasma TG decreased ∼20% from the initial value of 1.45 ± 0.18 mmol/L (mean ± SE, 128 ± 16 mg/dL), with the greatest decrease in the subjects starting out with the highest concentrations ( r = −0.83). Similarly, liver fat content (liver TG/Intralipid standard) decreased ∼50% from the initial value of 0.34 ± 0.06 ( P = 0.021, n = 8), with the greatest decrease in the subjects who initially had the highest values ( r = −0.86). Intramuscular fat content and insulin sensitivity did not change. Conclusion Diet supplementation with AAs lowers plasma TG, total cholesterol, and very low-density lipoprotein cholesterol concentrations and liver lipid content in impaired glucose tolerant elderly. AA supplementation may have a potential role in the treatment of hypertriglyceridemia or hepatic steatosis.
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languageeng
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subjectAged ; Amino acids ; Amino Acids, Essential - administration & dosage ; Amino Acids, Essential - pharmacology ; Arginine - administration & dosage ; Arginine - pharmacology ; Biological and medical sciences ; Cholesterol ; Cholesterol - blood ; Cholesterol, VLDL - blood ; Dietary Supplements ; Elderly ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Glucose ; Glucose Intolerance - blood ; Humans ; Hypertriglyceridemia - blood ; Hypertriglyceridemia - complications ; Hypertriglyceridemia - drug therapy ; Insulin ; Insulin - metabolism ; Insulin sensitivity ; Life Sciences ; Lipids ; Liver - drug effects ; Liver - metabolism ; Liver lipids ; Male ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - pathology ; Plasma ; Plasma lipids ; Treatment Outcome ; Triglycerides - blood ; Triglycerides - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Weight control
ispartofNutrition (Burbank, Los Angeles County, Calif.), 2009, Vol.25 (3), p.281-288
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1Bui, Quynh-Uyen T., M.D
2Tissier, Sandrine, P.T
3Cree, Melanie G., M.D., Ph.D
4Rønsen, Ola, M.D., Ph.D
5Morio, Beatrice, Ph.D
6Ferrando, Arny A., Ph.D
7Kobayashi, Hisamine, D.V.M
8Newcomer, Bradley R., Ph.D
9Wolfe, Robert R., Ph.D
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0Amino acid supplementation decreases plasma and liver triacylglycerols in elderly
1Nutrition (Burbank, Los Angeles County, Calif.)
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descriptionAbstract Objective Hypertriglyceridemia is a risk factor for coronary heart disease. The aim of this study was to determine the effect of amino acid (AA) supplementation on plasma, liver, and muscle lipid concentrations and insulin sensitivity in the elderly. Methods Twelve impaired glucose tolerant elderly (mean ± SD 67.0 ± 5.6 y of age, seven women and five men) ingested 11 g of essential AAs plus arginine twice a day for 16 wk, after a 7-wk control run-in. Diet and activity were not otherwise modified. Plasma lipid concentrations and oral glucose tolerance were measured every fourth week and tissue lipid concentrations (magnetic resonance spectroscopy) every eighth week. Results No changes in plasma lipids were observed during the control run-in. AA supplementation lowered plasma triacylglycerol (TG; P < 0.001), total cholesterol ( P = 0.048), and very low-density lipoprotein cholesterol ( P < 0.001) concentrations. Plasma TG decreased ∼20% from the initial value of 1.45 ± 0.18 mmol/L (mean ± SE, 128 ± 16 mg/dL), with the greatest decrease in the subjects starting out with the highest concentrations ( r = −0.83). Similarly, liver fat content (liver TG/Intralipid standard) decreased ∼50% from the initial value of 0.34 ± 0.06 ( P = 0.021, n = 8), with the greatest decrease in the subjects who initially had the highest values ( r = −0.86). Intramuscular fat content and insulin sensitivity did not change. Conclusion Diet supplementation with AAs lowers plasma TG, total cholesterol, and very low-density lipoprotein cholesterol concentrations and liver lipid content in impaired glucose tolerant elderly. AA supplementation may have a potential role in the treatment of hypertriglyceridemia or hepatic steatosis.
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28Liver - metabolism
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31Muscle, Skeletal - drug effects
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34Plasma
35Plasma lipids
36Treatment Outcome
37Triglycerides - blood
38Triglycerides - metabolism
39Vertebrates: anatomy and physiology, studies on body, several organs or systems
40Weight control
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titleAmino acid supplementation decreases plasma and liver triacylglycerols in elderly
authorBørsheim, Elisabet, Ph.D ; Bui, Quynh-Uyen T., M.D ; Tissier, Sandrine, P.T ; Cree, Melanie G., M.D., Ph.D ; Rønsen, Ola, M.D., Ph.D ; Morio, Beatrice, Ph.D ; Ferrando, Arny A., Ph.D ; Kobayashi, Hisamine, D.V.M ; Newcomer, Bradley R., Ph.D ; Wolfe, Robert R., Ph.D
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31Muscle, Skeletal - drug effects
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38Triglycerides - metabolism
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40Weight control
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abstractAbstract Objective Hypertriglyceridemia is a risk factor for coronary heart disease. The aim of this study was to determine the effect of amino acid (AA) supplementation on plasma, liver, and muscle lipid concentrations and insulin sensitivity in the elderly. Methods Twelve impaired glucose tolerant elderly (mean ± SD 67.0 ± 5.6 y of age, seven women and five men) ingested 11 g of essential AAs plus arginine twice a day for 16 wk, after a 7-wk control run-in. Diet and activity were not otherwise modified. Plasma lipid concentrations and oral glucose tolerance were measured every fourth week and tissue lipid concentrations (magnetic resonance spectroscopy) every eighth week. Results No changes in plasma lipids were observed during the control run-in. AA supplementation lowered plasma triacylglycerol (TG; P < 0.001), total cholesterol ( P = 0.048), and very low-density lipoprotein cholesterol ( P < 0.001) concentrations. Plasma TG decreased ∼20% from the initial value of 1.45 ± 0.18 mmol/L (mean ± SE, 128 ± 16 mg/dL), with the greatest decrease in the subjects starting out with the highest concentrations ( r = −0.83). Similarly, liver fat content (liver TG/Intralipid standard) decreased ∼50% from the initial value of 0.34 ± 0.06 ( P = 0.021, n = 8), with the greatest decrease in the subjects who initially had the highest values ( r = −0.86). Intramuscular fat content and insulin sensitivity did not change. Conclusion Diet supplementation with AAs lowers plasma TG, total cholesterol, and very low-density lipoprotein cholesterol concentrations and liver lipid content in impaired glucose tolerant elderly. AA supplementation may have a potential role in the treatment of hypertriglyceridemia or hepatic steatosis.
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doi10.1016/j.nut.2008.09.001
orcididhttps://orcid.org/0000-0002-2418-1438