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Interindividual variability in the cholesterol-lowering effect of supplementation with plant sterols or stanols

Low-density lipoprotein cholesterol (LDL-C) plays a causal role in atherosclerosis. One way to reduce LDL-C levels is to inhibit cholesterol absorption. Plant sterols and stanols compete with cholesterol for absorption in the intestine and induce an average decrease in LDL-C by 5% to 15% in a dose-d... Full description

Journal Title: Nutrition reviews 2017-02-01, Vol.75 (2), p.134-145
Main Author: Fumeron, Frédéric
Other Authors: Bard, Jean-Marie , Lecerf, Jean-Michel
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Oxford University Press
ID: ISSN: 0029-6643
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recordid: cdi_hal_primary_oai_HAL_inserm_02452775v1
title: Interindividual variability in the cholesterol-lowering effect of supplementation with plant sterols or stanols
format: Article
creator:
  • Fumeron, Frédéric
  • Bard, Jean-Marie
  • Lecerf, Jean-Michel
subjects:
  • administration & dosage
  • Analysis as Topic
  • Anticholesteremic Agents
  • Anticholesteremic Agents - administration & dosage
  • Apolipoproteins E
  • Apolipoproteins E - blood
  • Apolipoproteins E - genetics
  • Atherosclerosis
  • ATP Binding Cassette Transporter
  • ATP Binding Cassette Transporter, Sub-Family G, Member 5 - blood
  • ATP Binding Cassette Transporter, Sub-Family G, Member 5 - genetics
  • ATP Binding Cassette Transporter, Sub-Family G, Member 8 - blood
  • ATP Binding Cassette Transporter, Sub-Family G, Member 8 - genetics
  • ATP Binding Cassette Transporter, Subfamily G, Member 5/blood
  • ATP Binding Cassette Transporter, Subfamily G, Member 5/genetics
  • ATP Binding Cassette Transporter, Subfamily G, Member 8/blood
  • ATP Binding Cassette Transporter, Subfamily G, Member 8/genetics
  • blood
  • chemistry
  • Cholesterol
  • Cholesterol - blood
  • cholesterol transporters
  • Diet
  • Dietary Supplements
  • Edible Grain
  • Edible Grain - chemistry
  • Food
  • Food and Nutrition
  • Fruit
  • Fruit - chemistry
  • Genetic
  • genetics
  • Health aspects
  • Humans
  • individual response
  • intestinal absorption
  • Life Sciences
  • lipids (amino acids
  • Lipoproteins
  • Lipoproteins - blood
  • Lipoproteins - genetics
  • Member 5
  • Member 8
  • Membrane Proteins
  • Membrane Proteins - blood
  • Membrane Proteins - genetics
  • Meta
  • Meta-Analysis as Topic
  • Nutrition
  • Nuts
  • Nuts - chemistry
  • omized Controlled Trials as Topic
  • peptides
  • Phytosterols
  • Phytosterols - administration & dosage
  • Plant Oils
  • Plant Oils - chemistry
  • plant sterols
  • Polymorphism
  • Polymorphism, Genetic
  • Prevention
  • proteins
  • Randomized Controlled Trials as Topic
  • Sitosterols
  • Sitosterols - administration & dosage
  • Subfamily G
  • Vegetables
  • Vegetables - chemistry
ispartof: Nutrition reviews, 2017-02-01, Vol.75 (2), p.134-145
description: Low-density lipoprotein cholesterol (LDL-C) plays a causal role in atherosclerosis. One way to reduce LDL-C levels is to inhibit cholesterol absorption. Plant sterols and stanols compete with cholesterol for absorption in the intestine and induce an average decrease in LDL-C by 5% to 15% in a dose-dependent manner, but not in all individuals. This review focuses on the interindividual variability in response to dietary supplementation with plant sterols and stanols. Dietary plant sterols and stanols have no significant effects on LDL-C in substantial numbers of individuals. Higher responses, in absolute value and percentage of LDL-C, are observed in individuals with higher cholesterol absorption and a lower rate of cholesterol synthesis. Some data provide evidence of the influence of genetics on the response to plant sterols and stanols. Further studies in large populations are required to extend these conclusions about genetic influences.
language: eng
source:
identifier: ISSN: 0029-6643
fulltext: no_fulltext
issn:
  • 0029-6643
  • 1753-4887
url: Link


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titleInterindividual variability in the cholesterol-lowering effect of supplementation with plant sterols or stanols
creatorFumeron, Frédéric ; Bard, Jean-Marie ; Lecerf, Jean-Michel
creatorcontribFumeron, Frédéric ; Bard, Jean-Marie ; Lecerf, Jean-Michel
descriptionLow-density lipoprotein cholesterol (LDL-C) plays a causal role in atherosclerosis. One way to reduce LDL-C levels is to inhibit cholesterol absorption. Plant sterols and stanols compete with cholesterol for absorption in the intestine and induce an average decrease in LDL-C by 5% to 15% in a dose-dependent manner, but not in all individuals. This review focuses on the interindividual variability in response to dietary supplementation with plant sterols and stanols. Dietary plant sterols and stanols have no significant effects on LDL-C in substantial numbers of individuals. Higher responses, in absolute value and percentage of LDL-C, are observed in individuals with higher cholesterol absorption and a lower rate of cholesterol synthesis. Some data provide evidence of the influence of genetics on the response to plant sterols and stanols. Further studies in large populations are required to extend these conclusions about genetic influences.
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0ISSN: 0029-6643
1EISSN: 1753-4887
2DOI: 10.1093/nutrit/nuw059
3PMID: 28158760
languageeng
publisherUnited States: Oxford University Press
subjectadministration & dosage ; Analysis as Topic ; Anticholesteremic Agents ; Anticholesteremic Agents - administration & dosage ; Apolipoproteins E ; Apolipoproteins E - blood ; Apolipoproteins E - genetics ; Atherosclerosis ; ATP Binding Cassette Transporter ; ATP Binding Cassette Transporter, Sub-Family G, Member 5 - blood ; ATP Binding Cassette Transporter, Sub-Family G, Member 5 - genetics ; ATP Binding Cassette Transporter, Sub-Family G, Member 8 - blood ; ATP Binding Cassette Transporter, Sub-Family G, Member 8 - genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 5/blood ; ATP Binding Cassette Transporter, Subfamily G, Member 5/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 8/blood ; ATP Binding Cassette Transporter, Subfamily G, Member 8/genetics ; blood ; chemistry ; Cholesterol ; Cholesterol - blood ; cholesterol transporters ; Diet ; Dietary Supplements ; Edible Grain ; Edible Grain - chemistry ; Food ; Food and Nutrition ; Fruit ; Fruit - chemistry ; Genetic ; genetics ; Health aspects ; Humans ; individual response ; intestinal absorption ; Life Sciences ; lipids (amino acids ; Lipoproteins ; Lipoproteins - blood ; Lipoproteins - genetics ; Member 5 ; Member 8 ; Membrane Proteins ; Membrane Proteins - blood ; Membrane Proteins - genetics ; Meta ; Meta-Analysis as Topic ; Nutrition ; Nuts ; Nuts - chemistry ; omized Controlled Trials as Topic ; peptides ; Phytosterols ; Phytosterols - administration & dosage ; Plant Oils ; Plant Oils - chemistry ; plant sterols ; Polymorphism ; Polymorphism, Genetic ; Prevention ; proteins ; Randomized Controlled Trials as Topic ; Sitosterols ; Sitosterols - administration & dosage ; Subfamily G ; Vegetables ; Vegetables - chemistry
ispartofNutrition reviews, 2017-02-01, Vol.75 (2), p.134-145
rights
0The Author(s) 2017. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. 2017
1The Author(s) 2017. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
2COPYRIGHT 2017 Oxford University Press
3Distributed under a Creative Commons Attribution 4.0 International License
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1Bard, Jean-Marie
2Lecerf, Jean-Michel
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0Interindividual variability in the cholesterol-lowering effect of supplementation with plant sterols or stanols
1Nutrition reviews
addtitleNutr Rev
descriptionLow-density lipoprotein cholesterol (LDL-C) plays a causal role in atherosclerosis. One way to reduce LDL-C levels is to inhibit cholesterol absorption. Plant sterols and stanols compete with cholesterol for absorption in the intestine and induce an average decrease in LDL-C by 5% to 15% in a dose-dependent manner, but not in all individuals. This review focuses on the interindividual variability in response to dietary supplementation with plant sterols and stanols. Dietary plant sterols and stanols have no significant effects on LDL-C in substantial numbers of individuals. Higher responses, in absolute value and percentage of LDL-C, are observed in individuals with higher cholesterol absorption and a lower rate of cholesterol synthesis. Some data provide evidence of the influence of genetics on the response to plant sterols and stanols. Further studies in large populations are required to extend these conclusions about genetic influences.
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0administration & dosage
1Analysis as Topic
2Anticholesteremic Agents
3Anticholesteremic Agents - administration & dosage
4Apolipoproteins E
5Apolipoproteins E - blood
6Apolipoproteins E - genetics
7Atherosclerosis
8ATP Binding Cassette Transporter
9ATP Binding Cassette Transporter, Sub-Family G, Member 5 - blood
10ATP Binding Cassette Transporter, Sub-Family G, Member 5 - genetics
11ATP Binding Cassette Transporter, Sub-Family G, Member 8 - blood
12ATP Binding Cassette Transporter, Sub-Family G, Member 8 - genetics
13ATP Binding Cassette Transporter, Subfamily G, Member 5/blood
14ATP Binding Cassette Transporter, Subfamily G, Member 5/genetics
15ATP Binding Cassette Transporter, Subfamily G, Member 8/blood
16ATP Binding Cassette Transporter, Subfamily G, Member 8/genetics
17blood
18chemistry
19Cholesterol
20Cholesterol - blood
21cholesterol transporters
22Diet
23Dietary Supplements
24Edible Grain
25Edible Grain - chemistry
26Food
27Food and Nutrition
28Fruit
29Fruit - chemistry
30Genetic
31genetics
32Health aspects
33Humans
34individual response
35intestinal absorption
36Life Sciences
37lipids (amino acids
38Lipoproteins
39Lipoproteins - blood
40Lipoproteins - genetics
41Member 5
42Member 8
43Membrane Proteins
44Membrane Proteins - blood
45Membrane Proteins - genetics
46Meta
47Meta-Analysis as Topic
48Nutrition
49Nuts
50Nuts - chemistry
51omized Controlled Trials as Topic
52peptides
53Phytosterols
54Phytosterols - administration & dosage
55Plant Oils
56Plant Oils - chemistry
57plant sterols
58Polymorphism
59Polymorphism, Genetic
60Prevention
61proteins
62Randomized Controlled Trials as Topic
63Sitosterols
64Sitosterols - administration & dosage
65Subfamily G
66Vegetables
67Vegetables - chemistry
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titleInterindividual variability in the cholesterol-lowering effect of supplementation with plant sterols or stanols
authorFumeron, Frédéric ; Bard, Jean-Marie ; Lecerf, Jean-Michel
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0administration & dosage
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2Anticholesteremic Agents
3Anticholesteremic Agents - administration & dosage
4Apolipoproteins E
5Apolipoproteins E - blood
6Apolipoproteins E - genetics
7Atherosclerosis
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9ATP Binding Cassette Transporter, Sub-Family G, Member 5 - blood
10ATP Binding Cassette Transporter, Sub-Family G, Member 5 - genetics
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12ATP Binding Cassette Transporter, Sub-Family G, Member 8 - genetics
13ATP Binding Cassette Transporter, Subfamily G, Member 5/blood
14ATP Binding Cassette Transporter, Subfamily G, Member 5/genetics
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21cholesterol transporters
22Diet
23Dietary Supplements
24Edible Grain
25Edible Grain - chemistry
26Food
27Food and Nutrition
28Fruit
29Fruit - chemistry
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31genetics
32Health aspects
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34individual response
35intestinal absorption
36Life Sciences
37lipids (amino acids
38Lipoproteins
39Lipoproteins - blood
40Lipoproteins - genetics
41Member 5
42Member 8
43Membrane Proteins
44Membrane Proteins - blood
45Membrane Proteins - genetics
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52peptides
53Phytosterols
54Phytosterols - administration & dosage
55Plant Oils
56Plant Oils - chemistry
57plant sterols
58Polymorphism
59Polymorphism, Genetic
60Prevention
61proteins
62Randomized Controlled Trials as Topic
63Sitosterols
64Sitosterols - administration & dosage
65Subfamily G
66Vegetables
67Vegetables - chemistry
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spage134
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pages134-145
issn0029-6643
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abstractLow-density lipoprotein cholesterol (LDL-C) plays a causal role in atherosclerosis. One way to reduce LDL-C levels is to inhibit cholesterol absorption. Plant sterols and stanols compete with cholesterol for absorption in the intestine and induce an average decrease in LDL-C by 5% to 15% in a dose-dependent manner, but not in all individuals. This review focuses on the interindividual variability in response to dietary supplementation with plant sterols and stanols. Dietary plant sterols and stanols have no significant effects on LDL-C in substantial numbers of individuals. Higher responses, in absolute value and percentage of LDL-C, are observed in individuals with higher cholesterol absorption and a lower rate of cholesterol synthesis. Some data provide evidence of the influence of genetics on the response to plant sterols and stanols. Further studies in large populations are required to extend these conclusions about genetic influences.
copUnited States
pubOxford University Press
pmid28158760
doi10.1093/nutrit/nuw059
oafree_for_read