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Low Prevalence of Drug Resistance Transmitted Virus in HIV Type 1-Infected ARV-Naive Patients in Cambodia

Abstract Between November 2006 and June 2007, HIV-1 reverse transcriptase (RT) and protease (PR) genes of 67 ARV-naive Cambodian patients were amplified and sequenced. At inclusion, the median age and duration of HIV infection were 28 and 1.1 years, respectively. The median CD4 and HIV-1 RNA were 61... Full description

Journal Title: AIDS research and human retroviruses 2009, Vol.25 (5), p.543-545
Main Author: JANIN, Nouhin
Other Authors: SOPHEAK, Ngin , REGIS, Martin P , OLIVIER, Marcy , SIM, Kruy L , FREDERIC, Ariey , MARTINE, Peeters , MARIE-LAURE, Chaix , AHIDJO, Ayouba , ERIC, Nerrienet
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New Rochelle, NY: Liebert
ID: ISSN: 0889-2229
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recordid: cdi_hal_primary_oai_HAL_pasteur_00599052v1
title: Low Prevalence of Drug Resistance Transmitted Virus in HIV Type 1-Infected ARV-Naive Patients in Cambodia
format: Article
creator:
  • JANIN, Nouhin
  • SOPHEAK, Ngin
  • REGIS, Martin P
  • OLIVIER, Marcy
  • SIM, Kruy L
  • FREDERIC, Ariey
  • MARTINE, Peeters
  • MARIE-LAURE, Chaix
  • AHIDJO, Ayouba
  • ERIC, Nerrienet
subjects:
  • Adult
  • AIDS/HIV
  • Amino Acid Substitution
  • Amino Acid Substitution - genetics
  • Biological and medical sciences
  • Cambodia
  • CD4 Lymphocyte Count
  • Complications and side effects
  • Drug Resistance
  • Drug Resistance, Viral
  • Drug therapy
  • Epidemiology
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Genetic aspects
  • Genotype
  • Health aspects
  • Highly active antiretroviral therapy
  • HIV (Viruses)
  • HIV infection
  • HIV Infections
  • HIV Infections - transmission
  • HIV Infections - virology
  • HIV Protease
  • HIV Protease - genetics
  • HIV Reverse Transcriptase
  • HIV Reverse Transcriptase - genetics
  • HIV-1
  • HIV-1 - drug effects
  • HIV-1 - genetics
  • HIV-1 - isolation & purification
  • Human health
  • Human health and pathology
  • Human immunodeficiency virus 1
  • Human viral diseases
  • Humans
  • Infectious diseases
  • Life Sciences
  • Male
  • Medical sciences
  • Microbiology
  • Miscellaneous
  • Missense
  • Molecular Sequence Data
  • Mutation
  • Mutation, Missense
  • pathology
  • Properties
  • Retrovirus
  • RNA, Viral
  • RNA, Viral - blood
  • Sequence Analysis
  • Sequence Analysis, DNA
  • Viral
  • Viral diseases
  • Viral drug resistance
  • Viral Load
  • Virology
  • virus diseases
ispartof: AIDS research and human retroviruses, 2009, Vol.25 (5), p.543-545
description: Abstract Between November 2006 and June 2007, HIV-1 reverse transcriptase (RT) and protease (PR) genes of 67 ARV-naive Cambodian patients were amplified and sequenced. At inclusion, the median age and duration of HIV infection were 28 and 1.1 years, respectively. The median CD4 and HIV-1 RNA were 611 cells/ml [IQR: 525-759] and 4.0 log(10) copies/ml [IQR: 3.4-4.6]. Among 67 HIV-1 strains, 95.5% were CRF 01_AE viruses (n = 64) whereas three clustered with subtype B. RT analysis indicated that only 1 patient out of 67, presenting K103N and M184V mutations, was resistant to NVP/EFV and 3TC/FTC. No primary resistance to protease inhibitors was detected in 59 amplified protease genes. The 1.49% (IC 95%: 0.04-8.04%) prevalence of transmitted drug-resistant strains in drug-naive patients was low in our study. Surveys of drug-resistant transmitted viruses should be regularly performed regarding the increasing access to HAART in Cambodia.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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descriptionAbstract Between November 2006 and June 2007, HIV-1 reverse transcriptase (RT) and protease (PR) genes of 67 ARV-naive Cambodian patients were amplified and sequenced. At inclusion, the median age and duration of HIV infection were 28 and 1.1 years, respectively. The median CD4 and HIV-1 RNA were 611 cells/ml [IQR: 525-759] and 4.0 log(10) copies/ml [IQR: 3.4-4.6]. Among 67 HIV-1 strains, 95.5% were CRF 01_AE viruses (n = 64) whereas three clustered with subtype B. RT analysis indicated that only 1 patient out of 67, presenting K103N and M184V mutations, was resistant to NVP/EFV and 3TC/FTC. No primary resistance to protease inhibitors was detected in 59 amplified protease genes. The 1.49% (IC 95%: 0.04-8.04%) prevalence of transmitted drug-resistant strains in drug-naive patients was low in our study. Surveys of drug-resistant transmitted viruses should be regularly performed regarding the increasing access to HAART in Cambodia.
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subjectAdult ; AIDS/HIV ; Amino Acid Substitution ; Amino Acid Substitution - genetics ; Biological and medical sciences ; Cambodia ; CD4 Lymphocyte Count ; Complications and side effects ; Drug Resistance ; Drug Resistance, Viral ; Drug therapy ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic aspects ; Genotype ; Health aspects ; Highly active antiretroviral therapy ; HIV (Viruses) ; HIV infection ; HIV Infections ; HIV Infections - transmission ; HIV Infections - virology ; HIV Protease ; HIV Protease - genetics ; HIV Reverse Transcriptase ; HIV Reverse Transcriptase - genetics ; HIV-1 ; HIV-1 - drug effects ; HIV-1 - genetics ; HIV-1 - isolation & purification ; Human health ; Human health and pathology ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Life Sciences ; Male ; Medical sciences ; Microbiology ; Miscellaneous ; Missense ; Molecular Sequence Data ; Mutation ; Mutation, Missense ; pathology ; Properties ; Retrovirus ; RNA, Viral ; RNA, Viral - blood ; Sequence Analysis ; Sequence Analysis, DNA ; Viral ; Viral diseases ; Viral drug resistance ; Viral Load ; Virology ; virus diseases
ispartofAIDS research and human retroviruses, 2009, Vol.25 (5), p.543-545
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4SIM, Kruy L
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6MARTINE, Peeters
7MARIE-LAURE, Chaix
8AHIDJO, Ayouba
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0Low Prevalence of Drug Resistance Transmitted Virus in HIV Type 1-Infected ARV-Naive Patients in Cambodia
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descriptionAbstract Between November 2006 and June 2007, HIV-1 reverse transcriptase (RT) and protease (PR) genes of 67 ARV-naive Cambodian patients were amplified and sequenced. At inclusion, the median age and duration of HIV infection were 28 and 1.1 years, respectively. The median CD4 and HIV-1 RNA were 611 cells/ml [IQR: 525-759] and 4.0 log(10) copies/ml [IQR: 3.4-4.6]. Among 67 HIV-1 strains, 95.5% were CRF 01_AE viruses (n = 64) whereas three clustered with subtype B. RT analysis indicated that only 1 patient out of 67, presenting K103N and M184V mutations, was resistant to NVP/EFV and 3TC/FTC. No primary resistance to protease inhibitors was detected in 59 amplified protease genes. The 1.49% (IC 95%: 0.04-8.04%) prevalence of transmitted drug-resistant strains in drug-naive patients was low in our study. Surveys of drug-resistant transmitted viruses should be regularly performed regarding the increasing access to HAART in Cambodia.
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0Adult
1AIDS/HIV
2Amino Acid Substitution
3Amino Acid Substitution - genetics
4Biological and medical sciences
5Cambodia
6CD4 Lymphocyte Count
7Complications and side effects
8Drug Resistance
9Drug Resistance, Viral
10Drug therapy
11Epidemiology
12Female
13Fundamental and applied biological sciences. Psychology
14Genetic aspects
15Genotype
16Health aspects
17Highly active antiretroviral therapy
18HIV (Viruses)
19HIV infection
20HIV Infections
21HIV Infections - transmission
22HIV Infections - virology
23HIV Protease
24HIV Protease - genetics
25HIV Reverse Transcriptase
26HIV Reverse Transcriptase - genetics
27HIV-1
28HIV-1 - drug effects
29HIV-1 - genetics
30HIV-1 - isolation & purification
31Human health
32Human health and pathology
33Human immunodeficiency virus 1
34Human viral diseases
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36Infectious diseases
37Life Sciences
38Male
39Medical sciences
40Microbiology
41Miscellaneous
42Missense
43Molecular Sequence Data
44Mutation
45Mutation, Missense
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47Properties
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49RNA, Viral
50RNA, Viral - blood
51Sequence Analysis
52Sequence Analysis, DNA
53Viral
54Viral diseases
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56Viral Load
57Virology
58virus diseases
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titleLow Prevalence of Drug Resistance Transmitted Virus in HIV Type 1-Infected ARV-Naive Patients in Cambodia
authorJANIN, Nouhin ; SOPHEAK, Ngin ; REGIS, Martin P ; OLIVIER, Marcy ; SIM, Kruy L ; FREDERIC, Ariey ; MARTINE, Peeters ; MARIE-LAURE, Chaix ; AHIDJO, Ayouba ; ERIC, Nerrienet
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1AIDS/HIV
2Amino Acid Substitution
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6CD4 Lymphocyte Count
7Complications and side effects
8Drug Resistance
9Drug Resistance, Viral
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13Fundamental and applied biological sciences. Psychology
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15Genotype
16Health aspects
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20HIV Infections
21HIV Infections - transmission
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23HIV Protease
24HIV Protease - genetics
25HIV Reverse Transcriptase
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31Human health
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33Human immunodeficiency virus 1
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35Humans
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39Medical sciences
40Microbiology
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43Molecular Sequence Data
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50RNA, Viral - blood
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54Viral diseases
55Viral drug resistance
56Viral Load
57Virology
58virus diseases
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1SOPHEAK, Ngin
2REGIS, Martin P
3OLIVIER, Marcy
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7MARIE-LAURE, Chaix
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atitleLow Prevalence of Drug Resistance Transmitted Virus in HIV Type 1-Infected ARV-Naive Patients in Cambodia
jtitleAIDS research and human retroviruses
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date2009
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volume25
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pages543-545
issn0889-2229
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abstractAbstract Between November 2006 and June 2007, HIV-1 reverse transcriptase (RT) and protease (PR) genes of 67 ARV-naive Cambodian patients were amplified and sequenced. At inclusion, the median age and duration of HIV infection were 28 and 1.1 years, respectively. The median CD4 and HIV-1 RNA were 611 cells/ml [IQR: 525-759] and 4.0 log(10) copies/ml [IQR: 3.4-4.6]. Among 67 HIV-1 strains, 95.5% were CRF 01_AE viruses (n = 64) whereas three clustered with subtype B. RT analysis indicated that only 1 patient out of 67, presenting K103N and M184V mutations, was resistant to NVP/EFV and 3TC/FTC. No primary resistance to protease inhibitors was detected in 59 amplified protease genes. The 1.49% (IC 95%: 0.04-8.04%) prevalence of transmitted drug-resistant strains in drug-naive patients was low in our study. Surveys of drug-resistant transmitted viruses should be regularly performed regarding the increasing access to HAART in Cambodia.
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pmid19388823
doi10.1089/aid.2008.0305
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