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The toxicology of ion-shedding zinc oxide nanoparticles

Zinc oxide nanoparticles (ZnO NPs) are nanomaterials that are widely used in many fields. ZnO NPs are ion-shedding particles, and zinc ions produce important and potent effects that differ from those of other metal or metal oxide NPs. Several studies have reported the toxicological effects of ZnO NP... Full description

Journal Title: Critical reviews in toxicology 2016, Vol.46 (4), p.348-384
Main Author: Liu, Jia
Other Authors: Feng, Xiaoli , Wei, Limin , Chen, Liangjiao , Song, Bin , Shao, Longquan
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: England: Taylor & Francis
ID: ISSN: 1040-8444
Link: https://www.ncbi.nlm.nih.gov/pubmed/26963861
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recordid: cdi_informaworld_taylorfrancis_310_3109_10408444_2015_1137864
title: The toxicology of ion-shedding zinc oxide nanoparticles
format: Article
creator:
  • Liu, Jia
  • Feng, Xiaoli
  • Wei, Limin
  • Chen, Liangjiao
  • Song, Bin
  • Shao, Longquan
subjects:
  • Animals
  • Humans
  • Inflammatory response
  • nanoparticle
  • Nanoparticles - chemistry
  • Nanoparticles - metabolism
  • Nanoparticles - poisoning
  • Nanoparticles - toxicity
  • oxidative stress
  • physicochemical property
  • toxicokinetics
  • toxicology
  • zinc oxide
  • Zinc Oxide - chemistry
  • Zinc Oxide - pharmacokinetics
  • Zinc Oxide - poisoning
  • Zinc Oxide - toxicity
ispartof: Critical reviews in toxicology, 2016, Vol.46 (4), p.348-384
description: Zinc oxide nanoparticles (ZnO NPs) are nanomaterials that are widely used in many fields. ZnO NPs are ion-shedding particles, and zinc ions produce important and potent effects that differ from those of other metal or metal oxide NPs. Several studies have reported the toxicological effects of ZnO NPs administered via several different routes, including orally, dermally, by pulmonary absorption, intraperitoneally, and intravenously. Some potential routes for human exposure have produced various toxic effects in animal models. Moreover, several in vitro studies using a range of cell lines have reported the mechanisms underlying ZnO NP toxicity. Zinc ions play a very important role in ZnO NP toxicity, although the effects of the particulate form cannot be excluded. A crucial determinant of toxicity is the solubility of ZnO NPs, which is influenced by various factors, including the pH of the environment in tissues, cells, and organelles. In addition to the inflammatory responses and oxidative stress known to be induced by ZnO NPs, these NPs also exhibit some positive anti-inflammatory, anti-diabetic, and pro-coagulant effects at sub-toxic doses; these effects are probably induced by zinc ions, which are an essential element in cell homeostasis. It is highly likely that there are additional distinct mechanisms at sub-toxic doses and concentrations, which may be concealed or altered by the toxic effects observed at higher levels of ZnO NPs. Furthermore, many signaling pathway molecules associated with necrosis and apoptosis can be activated, leading to cell death. This review presents the status of ZnO NP toxicology and highlights areas requiring further investigation.
language: eng
source:
identifier: ISSN: 1040-8444
fulltext: no_fulltext
issn:
  • 1040-8444
  • 1547-6898
url: Link


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titleThe toxicology of ion-shedding zinc oxide nanoparticles
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descriptionZinc oxide nanoparticles (ZnO NPs) are nanomaterials that are widely used in many fields. ZnO NPs are ion-shedding particles, and zinc ions produce important and potent effects that differ from those of other metal or metal oxide NPs. Several studies have reported the toxicological effects of ZnO NPs administered via several different routes, including orally, dermally, by pulmonary absorption, intraperitoneally, and intravenously. Some potential routes for human exposure have produced various toxic effects in animal models. Moreover, several in vitro studies using a range of cell lines have reported the mechanisms underlying ZnO NP toxicity. Zinc ions play a very important role in ZnO NP toxicity, although the effects of the particulate form cannot be excluded. A crucial determinant of toxicity is the solubility of ZnO NPs, which is influenced by various factors, including the pH of the environment in tissues, cells, and organelles. In addition to the inflammatory responses and oxidative stress known to be induced by ZnO NPs, these NPs also exhibit some positive anti-inflammatory, anti-diabetic, and pro-coagulant effects at sub-toxic doses; these effects are probably induced by zinc ions, which are an essential element in cell homeostasis. It is highly likely that there are additional distinct mechanisms at sub-toxic doses and concentrations, which may be concealed or altered by the toxic effects observed at higher levels of ZnO NPs. Furthermore, many signaling pathway molecules associated with necrosis and apoptosis can be activated, leading to cell death. This review presents the status of ZnO NP toxicology and highlights areas requiring further investigation.
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subjectAnimals ; Humans ; Inflammatory response ; nanoparticle ; Nanoparticles - chemistry ; Nanoparticles - metabolism ; Nanoparticles - poisoning ; Nanoparticles - toxicity ; oxidative stress ; physicochemical property ; toxicokinetics ; toxicology ; zinc oxide ; Zinc Oxide - chemistry ; Zinc Oxide - pharmacokinetics ; Zinc Oxide - poisoning ; Zinc Oxide - toxicity
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abstractZinc oxide nanoparticles (ZnO NPs) are nanomaterials that are widely used in many fields. ZnO NPs are ion-shedding particles, and zinc ions produce important and potent effects that differ from those of other metal or metal oxide NPs. Several studies have reported the toxicological effects of ZnO NPs administered via several different routes, including orally, dermally, by pulmonary absorption, intraperitoneally, and intravenously. Some potential routes for human exposure have produced various toxic effects in animal models. Moreover, several in vitro studies using a range of cell lines have reported the mechanisms underlying ZnO NP toxicity. Zinc ions play a very important role in ZnO NP toxicity, although the effects of the particulate form cannot be excluded. A crucial determinant of toxicity is the solubility of ZnO NPs, which is influenced by various factors, including the pH of the environment in tissues, cells, and organelles. In addition to the inflammatory responses and oxidative stress known to be induced by ZnO NPs, these NPs also exhibit some positive anti-inflammatory, anti-diabetic, and pro-coagulant effects at sub-toxic doses; these effects are probably induced by zinc ions, which are an essential element in cell homeostasis. It is highly likely that there are additional distinct mechanisms at sub-toxic doses and concentrations, which may be concealed or altered by the toxic effects observed at higher levels of ZnO NPs. Furthermore, many signaling pathway molecules associated with necrosis and apoptosis can be activated, leading to cell death. This review presents the status of ZnO NP toxicology and highlights areas requiring further investigation.
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