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Changes in Cognitive Function over 3 Years after First-Ever Stroke and Predictors of Cognitive Impairment and Long-Term Cognitive Stability: The Erlangen Stroke Project

Background and Purpose: Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. Methods: Data were collected from the E... Full description

Journal Title: Dementia and geriatric cognitive disorders 2011, Vol.31 (4), p.291-299
Main Author: Liman, T.G
Other Authors: Heuschmann, P.U , Endres, M , Flöel, A , Schwab, S , Kolominsky-Rabas, P.L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: Karger
ID: ISSN: 1420-8008
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recordid: cdi_karger_primary_DEM2011031004291
title: Changes in Cognitive Function over 3 Years after First-Ever Stroke and Predictors of Cognitive Impairment and Long-Term Cognitive Stability: The Erlangen Stroke Project
format: Article
creator:
  • Liman, T.G
  • Heuschmann, P.U
  • Endres, M
  • Flöel, A
  • Schwab, S
  • Kolominsky-Rabas, P.L
subjects:
  • Aged
  • Aged, 80 and over
  • Aphasia - diagnosis
  • Aphasia - physiopathology
  • Biological and medical sciences
  • Cognition - physiology
  • Cognition Disorders - diagnosis
  • Cognition Disorders - physiopathology
  • Cohort Studies
  • Consciousness Disorders - diagnosis
  • Consciousness Disorders - physiopathology
  • Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Medical sciences
  • Middle Aged
  • Neurology
  • Neuropsychological Tests
  • Original Research Article
  • Predictive Value of Tests
  • Recovery of Function - physiology
  • Registries
  • Stroke - diagnosis
  • Stroke - physiopathology
  • Time Factors
  • Vascular diseases and vascular malformations of the nervous system
ispartof: Dementia and geriatric cognitive disorders, 2011, Vol.31 (4), p.291-299
description: Background and Purpose: Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. Methods: Data were collected from the Erlangen Stroke Project, an ongoing population-based stroke registry. The Mini-Mental State Examination (MMSE) for assessing global cognitive function was used; CI was defined as an MMSE score
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1420-8008
fulltext: fulltext
issn:
  • 1420-8008
  • 1421-9824
url: Link


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titleChanges in Cognitive Function over 3 Years after First-Ever Stroke and Predictors of Cognitive Impairment and Long-Term Cognitive Stability: The Erlangen Stroke Project
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creatorLiman, T.G ; Heuschmann, P.U ; Endres, M ; Flöel, A ; Schwab, S ; Kolominsky-Rabas, P.L
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descriptionBackground and Purpose: Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. Methods: Data were collected from the Erlangen Stroke Project, an ongoing population-based stroke registry. The Mini-Mental State Examination (MMSE) for assessing global cognitive function was used; CI was defined as an MMSE score <24. Results: From February 1998 to January 2006, 630 patients with first-ever stroke were included. Prevalence rates of CI at 3 months, 1 and 3 years were 15, 13, and 12%. In multivariable analysis, stroke severity, i.e. Barthel index (p < 0.001), age (OR = 1.03; 95% CI = 1.00–1.05) and diabetes mellitus (OR = 2.03; 95% CI = 1.13–3.67) were associated with CI at 3 months. Recovery rate from CI at 3 months after stroke was found to be 31% over the following 3 years. Intact cognitive function rate was 71% over 3 years and inversely associated with age (OR = 0.96; 95% CI = 0.96–0.94) and stroke severity (p < 0.001). Conclusion: CI is frequent among stroke survivors and associated with age, stroke severity, and diabetes mellitus, but recovery occurs in approximately one third of the patients over the course of 3 years. Factors affecting intact cognitive function over time are increasing age and stroke severity.
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subjectAged ; Aged, 80 and over ; Aphasia - diagnosis ; Aphasia - physiopathology ; Biological and medical sciences ; Cognition - physiology ; Cognition Disorders - diagnosis ; Cognition Disorders - physiopathology ; Cohort Studies ; Consciousness Disorders - diagnosis ; Consciousness Disorders - physiopathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Neuropsychological Tests ; Original Research Article ; Predictive Value of Tests ; Recovery of Function - physiology ; Registries ; Stroke - diagnosis ; Stroke - physiopathology ; Time Factors ; Vascular diseases and vascular malformations of the nervous system
ispartofDementia and geriatric cognitive disorders, 2011, Vol.31 (4), p.291-299
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descriptionBackground and Purpose: Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. Methods: Data were collected from the Erlangen Stroke Project, an ongoing population-based stroke registry. The Mini-Mental State Examination (MMSE) for assessing global cognitive function was used; CI was defined as an MMSE score <24. Results: From February 1998 to January 2006, 630 patients with first-ever stroke were included. Prevalence rates of CI at 3 months, 1 and 3 years were 15, 13, and 12%. In multivariable analysis, stroke severity, i.e. Barthel index (p < 0.001), age (OR = 1.03; 95% CI = 1.00–1.05) and diabetes mellitus (OR = 2.03; 95% CI = 1.13–3.67) were associated with CI at 3 months. Recovery rate from CI at 3 months after stroke was found to be 31% over the following 3 years. Intact cognitive function rate was 71% over 3 years and inversely associated with age (OR = 0.96; 95% CI = 0.96–0.94) and stroke severity (p < 0.001). Conclusion: CI is frequent among stroke survivors and associated with age, stroke severity, and diabetes mellitus, but recovery occurs in approximately one third of the patients over the course of 3 years. Factors affecting intact cognitive function over time are increasing age and stroke severity.
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2Aphasia - diagnosis
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4Biological and medical sciences
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11Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
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17Medical sciences
18Middle Aged
19Neurology
20Neuropsychological Tests
21Original Research Article
22Predictive Value of Tests
23Recovery of Function - physiology
24Registries
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26Stroke - physiopathology
27Time Factors
28Vascular diseases and vascular malformations of the nervous system
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titleChanges in Cognitive Function over 3 Years after First-Ever Stroke and Predictors of Cognitive Impairment and Long-Term Cognitive Stability: The Erlangen Stroke Project
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atitleChanges in Cognitive Function over 3 Years after First-Ever Stroke and Predictors of Cognitive Impairment and Long-Term Cognitive Stability: The Erlangen Stroke Project
jtitleDementia and geriatric cognitive disorders
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abstractBackground and Purpose: Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. Methods: Data were collected from the Erlangen Stroke Project, an ongoing population-based stroke registry. The Mini-Mental State Examination (MMSE) for assessing global cognitive function was used; CI was defined as an MMSE score <24. Results: From February 1998 to January 2006, 630 patients with first-ever stroke were included. Prevalence rates of CI at 3 months, 1 and 3 years were 15, 13, and 12%. In multivariable analysis, stroke severity, i.e. Barthel index (p < 0.001), age (OR = 1.03; 95% CI = 1.00–1.05) and diabetes mellitus (OR = 2.03; 95% CI = 1.13–3.67) were associated with CI at 3 months. Recovery rate from CI at 3 months after stroke was found to be 31% over the following 3 years. Intact cognitive function rate was 71% over 3 years and inversely associated with age (OR = 0.96; 95% CI = 0.96–0.94) and stroke severity (p < 0.001). Conclusion: CI is frequent among stroke survivors and associated with age, stroke severity, and diabetes mellitus, but recovery occurs in approximately one third of the patients over the course of 3 years. Factors affecting intact cognitive function over time are increasing age and stroke severity.
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doi10.1159/000327358
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