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Postconditioning and Remote Postconditioning of Ischemic Rat Cardiac Grafts

Background: Global warm ischemia of transplanted cardiac grafts is associated with apoptosis and subsequent tissue necrosis. It is suggested that postconditioning (PostC) may ameliorate the early outcome of cardiac grafts after ischemia-reperfusion. We investigated whether PostC and remote postcondi... Full description

Journal Title: European surgical research 2010-09, Vol.45 (1), p.1-8
Main Author: Tang, Y
Other Authors: Mennander, A , Oksala, N , Atalay, M , Syvala, H , Lagerstedt, A , Kuuslahti, M , Nieminen, R , Anas, N , Moilanen, E , Tarkka, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: S. Karger AG
ID: ISSN: 0014-312X
Link: https://www.ncbi.nlm.nih.gov/pubmed/20628256
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recordid: cdi_karger_primary_ESR2010045001001
title: Postconditioning and Remote Postconditioning of Ischemic Rat Cardiac Grafts
format: Article
creator:
  • Tang, Y
  • Mennander, A
  • Oksala, N
  • Atalay, M
  • Syvala, H
  • Lagerstedt, A
  • Kuuslahti, M
  • Nieminen, R
  • Anas, N
  • Moilanen, E
  • Tarkka, M
subjects:
  • Animals
  • Apoptosis
  • Blood Coagulation
  • Heart Transplantation - methods
  • HSP70 Heat-Shock Proteins - metabolism
  • Ischemic Postconditioning - methods
  • Male
  • Myocardial Contraction - physiology
  • Myocardial Ischemia - etiology
  • Myocardial Ischemia - pathology
  • Necrosis
  • Original Paper
  • Oxidative Stress
  • Rats
  • Rats, Inbred F344
  • Reperfusion Injury - pathology
  • Transplantation, Isogeneic - methods
ispartof: European surgical research, 2010-09, Vol.45 (1), p.1-8
description: Background: Global warm ischemia of transplanted cardiac grafts is associated with apoptosis and subsequent tissue necrosis. It is suggested that postconditioning (PostC) may ameliorate the early outcome of cardiac grafts after ischemia-reperfusion. We investigated whether PostC and remote postconditioning (RPostC) have a histopathologic impact after transplantation of warm ischemic rat cardiac grafts. Materials and Methods: Thirteen rats were randomized to undergo either PostC or RPostC after heterotopic transplantation of ischemic cardiac grafts. Six rats without intervention besides transplantation served as controls (control). The recipient rats were sacrificed 24 h after transplantation to evaluate histopathology and apoptotic index. Results: No significant differences were observed between the study groups in terms of graft heat shock protein 70 and oxygen radical absorbing capacity, an indicator of antioxidant capacity. While apoptosis and PCARB, a marker of protein oxidation and oxidative stress, decreased after RPostC (p < 0.05), contraction band necrosis was less prominent in both PostC and RPostC. Conclusion: Both PostC and RPostC have a histopathologic impact after 24 h of reperfusion of warm ischemic rat cardiac grafts.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0014-312X
fulltext: fulltext
issn:
  • 0014-312X
  • 1421-9921
url: Link


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creatorTang, Y ; Mennander, A ; Oksala, N ; Atalay, M ; Syvala, H ; Lagerstedt, A ; Kuuslahti, M ; Nieminen, R ; Anas, N ; Moilanen, E ; Tarkka, M
creatorcontribTang, Y ; Mennander, A ; Oksala, N ; Atalay, M ; Syvala, H ; Lagerstedt, A ; Kuuslahti, M ; Nieminen, R ; Anas, N ; Moilanen, E ; Tarkka, M
descriptionBackground: Global warm ischemia of transplanted cardiac grafts is associated with apoptosis and subsequent tissue necrosis. It is suggested that postconditioning (PostC) may ameliorate the early outcome of cardiac grafts after ischemia-reperfusion. We investigated whether PostC and remote postconditioning (RPostC) have a histopathologic impact after transplantation of warm ischemic rat cardiac grafts. Materials and Methods: Thirteen rats were randomized to undergo either PostC or RPostC after heterotopic transplantation of ischemic cardiac grafts. Six rats without intervention besides transplantation served as controls (control). The recipient rats were sacrificed 24 h after transplantation to evaluate histopathology and apoptotic index. Results: No significant differences were observed between the study groups in terms of graft heat shock protein 70 and oxygen radical absorbing capacity, an indicator of antioxidant capacity. While apoptosis and PCARB, a marker of protein oxidation and oxidative stress, decreased after RPostC (p < 0.05), contraction band necrosis was less prominent in both PostC and RPostC. Conclusion: Both PostC and RPostC have a histopathologic impact after 24 h of reperfusion of warm ischemic rat cardiac grafts.
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subjectAnimals ; Apoptosis ; Blood Coagulation ; Heart Transplantation - methods ; HSP70 Heat-Shock Proteins - metabolism ; Ischemic Postconditioning - methods ; Male ; Myocardial Contraction - physiology ; Myocardial Ischemia - etiology ; Myocardial Ischemia - pathology ; Necrosis ; Original Paper ; Oxidative Stress ; Rats ; Rats, Inbred F344 ; Reperfusion Injury - pathology ; Transplantation, Isogeneic - methods
ispartofEuropean surgical research, 2010-09, Vol.45 (1), p.1-8
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descriptionBackground: Global warm ischemia of transplanted cardiac grafts is associated with apoptosis and subsequent tissue necrosis. It is suggested that postconditioning (PostC) may ameliorate the early outcome of cardiac grafts after ischemia-reperfusion. We investigated whether PostC and remote postconditioning (RPostC) have a histopathologic impact after transplantation of warm ischemic rat cardiac grafts. Materials and Methods: Thirteen rats were randomized to undergo either PostC or RPostC after heterotopic transplantation of ischemic cardiac grafts. Six rats without intervention besides transplantation served as controls (control). The recipient rats were sacrificed 24 h after transplantation to evaluate histopathology and apoptotic index. Results: No significant differences were observed between the study groups in terms of graft heat shock protein 70 and oxygen radical absorbing capacity, an indicator of antioxidant capacity. While apoptosis and PCARB, a marker of protein oxidation and oxidative stress, decreased after RPostC (p < 0.05), contraction band necrosis was less prominent in both PostC and RPostC. Conclusion: Both PostC and RPostC have a histopathologic impact after 24 h of reperfusion of warm ischemic rat cardiac grafts.
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date2010-09
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volume45
issue1
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abstractBackground: Global warm ischemia of transplanted cardiac grafts is associated with apoptosis and subsequent tissue necrosis. It is suggested that postconditioning (PostC) may ameliorate the early outcome of cardiac grafts after ischemia-reperfusion. We investigated whether PostC and remote postconditioning (RPostC) have a histopathologic impact after transplantation of warm ischemic rat cardiac grafts. Materials and Methods: Thirteen rats were randomized to undergo either PostC or RPostC after heterotopic transplantation of ischemic cardiac grafts. Six rats without intervention besides transplantation served as controls (control). The recipient rats were sacrificed 24 h after transplantation to evaluate histopathology and apoptotic index. Results: No significant differences were observed between the study groups in terms of graft heat shock protein 70 and oxygen radical absorbing capacity, an indicator of antioxidant capacity. While apoptosis and PCARB, a marker of protein oxidation and oxidative stress, decreased after RPostC (p < 0.05), contraction band necrosis was less prominent in both PostC and RPostC. Conclusion: Both PostC and RPostC have a histopathologic impact after 24 h of reperfusion of warm ischemic rat cardiac grafts.
copBasel, Switzerland
pubS. Karger AG
pmid20628256
doi10.1159/000315479
tpages8