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Effect of Treatment with Interferon-γ and Concanavalin A on the Course of Infection of Mice with Salmonella typhimurium Strain LT-2

Lymphokines have been shown to affect the resistance of mice to bacterial infections. To explore this effect further, mice were pretreated with 34 units per day for 5 days of a hybridoma supernatant containing primarily interferon-γ activity. Then, the mice were infected with one LD 50 of Salmonella... Full description

Journal Title: Journal of Interferon Research 1987-06, Vol.7 (3), p.255-260
Main Author: Gould, Cheryl L.
Other Authors: Sonnenfeld, Gerald
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Legacy CDMS: Liebert
ID: ISSN: 0197-8357
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recordid: cdi_maryannliebert_primary_10_1089_jir_1987_7_255
title: Effect of Treatment with Interferon-γ and Concanavalin A on the Course of Infection of Mice with Salmonella typhimurium Strain LT-2
format: Article
creator:
  • Gould, Cheryl L.
  • Sonnenfeld, Gerald
subjects:
  • Animals
  • Biological and medical sciences
  • Concanavalin A - pharmacology
  • Female
  • Immunomodulators
  • Interferon-gamma - immunology
  • Interferon-gamma - isolation & purification
  • Interferon-gamma - pharmacology
  • LIFE SCIENCES (GENERAL)
  • Medical sciences
  • Mice
  • Pharmacology. Drug treatments
  • Salmonella Infections, Animal - immunology
  • Salmonella Infections, Animal - therapy
  • Salmonella typhimurium
  • Space life sciences
ispartof: Journal of Interferon Research, 1987-06, Vol.7 (3), p.255-260
description: Lymphokines have been shown to affect the resistance of mice to bacterial infections. To explore this effect further, mice were pretreated with 34 units per day for 5 days of a hybridoma supernatant containing primarily interferon-γ activity. Then, the mice were infected with one LD 50 of Salmonella typhimurium strain LT-2. The hybridoma supernatant fluid-treated mice were not protected; in fact, they died faster than did mice only infected with S typhimurium . When mice were pretreated under the same regimen with pure murine IFN-γ produced by recombinant DNA technology prior to infection, the mice were protected and 95% survived the infection. The hybridomas had been treated with concanavalin A (ConA) to induce IFN-γ. When mice were directly treated with ConA prior to infection with S. typhimurium , they also died more quickly than untreated controls. These data suggest that IFN-γ pretreatment can protect mice against infection with S. typhimurium , but that ConA pretreatment can counteract that effect.
language: eng
source:
identifier: ISSN: 0197-8357
fulltext: no_fulltext
issn:
  • 0197-8357
  • 1557-7465
  • 2332-4007
url: Link


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titleEffect of Treatment with Interferon-γ and Concanavalin A on the Course of Infection of Mice with Salmonella typhimurium Strain LT-2
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descriptionLymphokines have been shown to affect the resistance of mice to bacterial infections. To explore this effect further, mice were pretreated with 34 units per day for 5 days of a hybridoma supernatant containing primarily interferon-γ activity. Then, the mice were infected with one LD 50 of Salmonella typhimurium strain LT-2. The hybridoma supernatant fluid-treated mice were not protected; in fact, they died faster than did mice only infected with S typhimurium . When mice were pretreated under the same regimen with pure murine IFN-γ produced by recombinant DNA technology prior to infection, the mice were protected and 95% survived the infection. The hybridomas had been treated with concanavalin A (ConA) to induce IFN-γ. When mice were directly treated with ConA prior to infection with S. typhimurium , they also died more quickly than untreated controls. These data suggest that IFN-γ pretreatment can protect mice against infection with S. typhimurium , but that ConA pretreatment can counteract that effect.
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subjectAnimals ; Biological and medical sciences ; Concanavalin A - pharmacology ; Female ; Immunomodulators ; Interferon-gamma - immunology ; Interferon-gamma - isolation & purification ; Interferon-gamma - pharmacology ; LIFE SCIENCES (GENERAL) ; Medical sciences ; Mice ; Pharmacology. Drug treatments ; Salmonella Infections, Animal - immunology ; Salmonella Infections, Animal - therapy ; Salmonella typhimurium ; Space life sciences
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descriptionLymphokines have been shown to affect the resistance of mice to bacterial infections. To explore this effect further, mice were pretreated with 34 units per day for 5 days of a hybridoma supernatant containing primarily interferon-γ activity. Then, the mice were infected with one LD 50 of Salmonella typhimurium strain LT-2. The hybridoma supernatant fluid-treated mice were not protected; in fact, they died faster than did mice only infected with S typhimurium . When mice were pretreated under the same regimen with pure murine IFN-γ produced by recombinant DNA technology prior to infection, the mice were protected and 95% survived the infection. The hybridomas had been treated with concanavalin A (ConA) to induce IFN-γ. When mice were directly treated with ConA prior to infection with S. typhimurium , they also died more quickly than untreated controls. These data suggest that IFN-γ pretreatment can protect mice against infection with S. typhimurium , but that ConA pretreatment can counteract that effect.
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abstractLymphokines have been shown to affect the resistance of mice to bacterial infections. To explore this effect further, mice were pretreated with 34 units per day for 5 days of a hybridoma supernatant containing primarily interferon-γ activity. Then, the mice were infected with one LD 50 of Salmonella typhimurium strain LT-2. The hybridoma supernatant fluid-treated mice were not protected; in fact, they died faster than did mice only infected with S typhimurium . When mice were pretreated under the same regimen with pure murine IFN-γ produced by recombinant DNA technology prior to infection, the mice were protected and 95% survived the infection. The hybridomas had been treated with concanavalin A (ConA) to induce IFN-γ. When mice were directly treated with ConA prior to infection with S. typhimurium , they also died more quickly than untreated controls. These data suggest that IFN-γ pretreatment can protect mice against infection with S. typhimurium , but that ConA pretreatment can counteract that effect.
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doi10.1089/jir.1987.7.255