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Effects of Interferon-γ and Tumor Necrosis Factor-α on Macrophage Enzyme Levels

Murine peritoneal macrophages were treated with interferon-γ (IFN-γ) or tumor necrosis factor-α (TNF). Measurements of changes in acid phosphatase and β-glucuronidase levels were made as an indication of activation by cytokine treatment. IFN-γ or TNF-γ treatment resulted in a significant increase in... Full description

Journal Title: Journal of Interferon Research 1989-02, Vol.9 (1), p.1-9
Main Author: Pierangeli, Silvia S.
Other Authors: Sonnenfeld, Gerald
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Legacy CDMS: Liebert
ID: ISSN: 0197-8357
Zum Text:
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recordid: cdi_maryannliebert_primary_10_1089_jir_1989_9_1
title: Effects of Interferon-γ and Tumor Necrosis Factor-α on Macrophage Enzyme Levels
format: Article
creator:
  • Pierangeli, Silvia S.
  • Sonnenfeld, Gerald
subjects:
  • Acid Phosphatase - metabolism
  • Analysis of the immune response. Humoral and cellular immunity
  • Animals
  • Antibodies, Monoclonal - immunology
  • Antigen-Antibody Reactions
  • Biological and medical sciences
  • Fundamental and applied biological sciences. Psychology
  • Fundamental immunology
  • Glucuronidase - metabolism
  • Immunobiology
  • Interferon-gamma - pharmacology
  • LIFE SCIENCES (GENERAL)
  • Macrophages - drug effects
  • Macrophages - enzymology
  • Mice
  • Mice, Inbred C57BL
  • Miscellaneous
  • Regulatory factors and their cellular receptors
  • Space life sciences
  • Time Factors
  • Tumor Necrosis Factor-alpha - pharmacology
ispartof: Journal of Interferon Research, 1989-02, Vol.9 (1), p.1-9
description: Murine peritoneal macrophages were treated with interferon-γ (IFN-γ) or tumor necrosis factor-α (TNF). Measurements of changes in acid phosphatase and β-glucuronidase levels were made as an indication of activation by cytokine treatment. IFN-γ or TNF-γ treatment resulted in a significant increase in the activities of both enzymes measured in the cell lysates. This increase was observable after 6 h of incubation, but reached its maximum level after 24 h of incubation. The effect of the treatment of the cells with both cytokines together was additive. No synergistic effect of addition of both cytokines on the enzyme levels was observed.
language: eng
source:
identifier: ISSN: 0197-8357
fulltext: no_fulltext
issn:
  • 0197-8357
  • 1557-7465
  • 2332-4007
url: Link


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titleEffects of Interferon-γ and Tumor Necrosis Factor-α on Macrophage Enzyme Levels
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descriptionMurine peritoneal macrophages were treated with interferon-γ (IFN-γ) or tumor necrosis factor-α (TNF). Measurements of changes in acid phosphatase and β-glucuronidase levels were made as an indication of activation by cytokine treatment. IFN-γ or TNF-γ treatment resulted in a significant increase in the activities of both enzymes measured in the cell lysates. This increase was observable after 6 h of incubation, but reached its maximum level after 24 h of incubation. The effect of the treatment of the cells with both cytokines together was additive. No synergistic effect of addition of both cytokines on the enzyme levels was observed.
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subjectAcid Phosphatase - metabolism ; Analysis of the immune response. Humoral and cellular immunity ; Animals ; Antibodies, Monoclonal - immunology ; Antigen-Antibody Reactions ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Glucuronidase - metabolism ; Immunobiology ; Interferon-gamma - pharmacology ; LIFE SCIENCES (GENERAL) ; Macrophages - drug effects ; Macrophages - enzymology ; Mice ; Mice, Inbred C57BL ; Miscellaneous ; Regulatory factors and their cellular receptors ; Space life sciences ; Time Factors ; Tumor Necrosis Factor-alpha - pharmacology
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descriptionMurine peritoneal macrophages were treated with interferon-γ (IFN-γ) or tumor necrosis factor-α (TNF). Measurements of changes in acid phosphatase and β-glucuronidase levels were made as an indication of activation by cytokine treatment. IFN-γ or TNF-γ treatment resulted in a significant increase in the activities of both enzymes measured in the cell lysates. This increase was observable after 6 h of incubation, but reached its maximum level after 24 h of incubation. The effect of the treatment of the cells with both cytokines together was additive. No synergistic effect of addition of both cytokines on the enzyme levels was observed.
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titleEffects of Interferon-γ and Tumor Necrosis Factor-α on Macrophage Enzyme Levels
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abstractMurine peritoneal macrophages were treated with interferon-γ (IFN-γ) or tumor necrosis factor-α (TNF). Measurements of changes in acid phosphatase and β-glucuronidase levels were made as an indication of activation by cytokine treatment. IFN-γ or TNF-γ treatment resulted in a significant increase in the activities of both enzymes measured in the cell lysates. This increase was observable after 6 h of incubation, but reached its maximum level after 24 h of incubation. The effect of the treatment of the cells with both cytokines together was additive. No synergistic effect of addition of both cytokines on the enzyme levels was observed.
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