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Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage

Background: This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage... Full description

Journal Title: Cerebrovascular diseases (Basel Switzerland), 2016-02, Vol.41 (1-2), p.80-86
Main Author: Sato, Shoichiro
Other Authors: Delcourt, Candice , Zhang, Shihong , Arima, Hisatomi , Heeley, Emma , Zheng, Danni , Al-Shahi Salman, Rustam , Stapf, Christian , Tzourio, Christophe , Robinson, Thompson , Lindley, Richard I , Chalmers, John , Anderson, Craig S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Aged
Aged, 80 and over
Anticoagulants - therapeutic use
Antihypertensive Agents - therapeutic use
Blood coagulation factors
Cerebral Hemorrhage - complications
Cerebral Hemorrhage - diagnostic imaging
Cerebral Hemorrhage - therapy
Disease Management
Female
Hematoma
Hematoma - diagnostic imaging
Hematoma - etiology
Humans
Hypertension - complications
Hypertension - therapy
Intracerebral hemorrhage
Logistic Models
Male
Middle Aged
Multivariate Analysis
Original Paper
Prognosis
Risk Factors
Tomography, X-Ray Computed
Warfarin
Warfarin - therapeutic use
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: S. Karger AG
ID: ISSN: 1015-9770
Link: https://www.ncbi.nlm.nih.gov/pubmed/26671408
Zum Text:
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title: Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage
format: Article
creator:
  • Sato, Shoichiro
  • Delcourt, Candice
  • Zhang, Shihong
  • Arima, Hisatomi
  • Heeley, Emma
  • Zheng, Danni
  • Al-Shahi Salman, Rustam
  • Stapf, Christian
  • Tzourio, Christophe
  • Robinson, Thompson
  • Lindley, Richard I
  • Chalmers, John
  • Anderson, Craig S
subjects:
  • Aged
  • Aged, 80 and over
  • Anticoagulants - therapeutic use
  • Antihypertensive Agents - therapeutic use
  • Blood coagulation factors
  • Cerebral Hemorrhage - complications
  • Cerebral Hemorrhage - diagnostic imaging
  • Cerebral Hemorrhage - therapy
  • Disease Management
  • Female
  • Hematoma
  • Hematoma - diagnostic imaging
  • Hematoma - etiology
  • Humans
  • Hypertension - complications
  • Hypertension - therapy
  • Intracerebral hemorrhage
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Original Paper
  • Prognosis
  • Risk Factors
  • Tomography, X-Ray Computed
  • Warfarin
  • Warfarin - therapeutic use
ispartof: Cerebrovascular diseases (Basel, Switzerland), 2016-02, Vol.41 (1-2), p.80-86
description: Background: This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Post-hoc analysis of the INTERACT2 dataset, a randomized controlled trial of patients with acute ICH with elevated systolic blood pressure (SBP), randomly assigned to intensive (target SBP
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1015-9770
fulltext: fulltext
issn:
  • 1015-9770
  • 1421-9786
url: Link


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titleDeterminants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage
sourceAlma/SFX Local Collection
creatorSato, Shoichiro ; Delcourt, Candice ; Zhang, Shihong ; Arima, Hisatomi ; Heeley, Emma ; Zheng, Danni ; Al-Shahi Salman, Rustam ; Stapf, Christian ; Tzourio, Christophe ; Robinson, Thompson ; Lindley, Richard I ; Chalmers, John ; Anderson, Craig S
creatorcontribSato, Shoichiro ; Delcourt, Candice ; Zhang, Shihong ; Arima, Hisatomi ; Heeley, Emma ; Zheng, Danni ; Al-Shahi Salman, Rustam ; Stapf, Christian ; Tzourio, Christophe ; Robinson, Thompson ; Lindley, Richard I ; Chalmers, John ; Anderson, Craig S ; INTERACT2 Investigators ; for the INTERACT2 Investigators
descriptionBackground: This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Post-hoc analysis of the INTERACT2 dataset, a randomized controlled trial of patients with acute ICH with elevated systolic blood pressure (SBP), randomly assigned to intensive (target SBP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Patients with a sedimentation level at baseline assessment on CT, and modified Rankin Scale score at 90-day, were included in these analyses. Factors associated with a sedimentation level and its significance in relation to 90-day clinical outcomes were assessed in univariable and multivariable logistic regression models. Results: Of 2,065 participants, 19 (1%) had sedimentation level on baseline CT, which was independently associated with warfarin use (p = 0.006) and lobar ICH (p = 0.025). Sedimentation level was also associated with death or major disability at 90-day in both crude (84 vs. 53%; p = 0.014) and multivariable analyses adjusted for age, gender, Chinese region, warfarin use, baseline National Institutes of Health Stroke Scale score, onset to CT time, volume and location of ICH, intraventricular extension, and randomized intensive BP lowering (OR 3.94, 95% CI 1.01-15.37; p = 0.049). Conclusions: The presence of hematoma sedimentation level on baseline CT is associated with warfarin use and lobar location of ICH, and predicts a worse outcome. Although uncommon, sedimentation level is an easily detectable prognostic factor in acute ICH.
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subjectAged ; Aged, 80 and over ; Anticoagulants - therapeutic use ; Antihypertensive Agents - therapeutic use ; Blood coagulation factors ; Cerebral Hemorrhage - complications ; Cerebral Hemorrhage - diagnostic imaging ; Cerebral Hemorrhage - therapy ; Disease Management ; Female ; Hematoma ; Hematoma - diagnostic imaging ; Hematoma - etiology ; Humans ; Hypertension - complications ; Hypertension - therapy ; Intracerebral hemorrhage ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Original Paper ; Prognosis ; Risk Factors ; Tomography, X-Ray Computed ; Warfarin ; Warfarin - therapeutic use
ispartofCerebrovascular diseases (Basel, Switzerland), 2016-02, Vol.41 (1-2), p.80-86
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1Delcourt, Candice
2Zhang, Shihong
3Arima, Hisatomi
4Heeley, Emma
5Zheng, Danni
6Al-Shahi Salman, Rustam
7Stapf, Christian
8Tzourio, Christophe
9Robinson, Thompson
10Lindley, Richard I
11Chalmers, John
12Anderson, Craig S
13INTERACT2 Investigators
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title
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descriptionBackground: This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Post-hoc analysis of the INTERACT2 dataset, a randomized controlled trial of patients with acute ICH with elevated systolic blood pressure (SBP), randomly assigned to intensive (target SBP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Patients with a sedimentation level at baseline assessment on CT, and modified Rankin Scale score at 90-day, were included in these analyses. Factors associated with a sedimentation level and its significance in relation to 90-day clinical outcomes were assessed in univariable and multivariable logistic regression models. Results: Of 2,065 participants, 19 (1%) had sedimentation level on baseline CT, which was independently associated with warfarin use (p = 0.006) and lobar ICH (p = 0.025). Sedimentation level was also associated with death or major disability at 90-day in both crude (84 vs. 53%; p = 0.014) and multivariable analyses adjusted for age, gender, Chinese region, warfarin use, baseline National Institutes of Health Stroke Scale score, onset to CT time, volume and location of ICH, intraventricular extension, and randomized intensive BP lowering (OR 3.94, 95% CI 1.01-15.37; p = 0.049). Conclusions: The presence of hematoma sedimentation level on baseline CT is associated with warfarin use and lobar location of ICH, and predicts a worse outcome. Although uncommon, sedimentation level is an easily detectable prognostic factor in acute ICH.
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2Anticoagulants - therapeutic use
3Antihypertensive Agents - therapeutic use
4Blood coagulation factors
5Cerebral Hemorrhage - complications
6Cerebral Hemorrhage - diagnostic imaging
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8Disease Management
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10Hematoma
11Hematoma - diagnostic imaging
12Hematoma - etiology
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14Hypertension - complications
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20Multivariate Analysis
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22Prognosis
23Risk Factors
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titleDeterminants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage
authorSato, Shoichiro ; Delcourt, Candice ; Zhang, Shihong ; Arima, Hisatomi ; Heeley, Emma ; Zheng, Danni ; Al-Shahi Salman, Rustam ; Stapf, Christian ; Tzourio, Christophe ; Robinson, Thompson ; Lindley, Richard I ; Chalmers, John ; Anderson, Craig S
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24Tomography, X-Ray Computed
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8Tzourio, Christophe
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volume41
issue1-2
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pages80-86
issn1015-9770
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abstractBackground: This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Post-hoc analysis of the INTERACT2 dataset, a randomized controlled trial of patients with acute ICH with elevated systolic blood pressure (SBP), randomly assigned to intensive (target SBP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Patients with a sedimentation level at baseline assessment on CT, and modified Rankin Scale score at 90-day, were included in these analyses. Factors associated with a sedimentation level and its significance in relation to 90-day clinical outcomes were assessed in univariable and multivariable logistic regression models. Results: Of 2,065 participants, 19 (1%) had sedimentation level on baseline CT, which was independently associated with warfarin use (p = 0.006) and lobar ICH (p = 0.025). Sedimentation level was also associated with death or major disability at 90-day in both crude (84 vs. 53%; p = 0.014) and multivariable analyses adjusted for age, gender, Chinese region, warfarin use, baseline National Institutes of Health Stroke Scale score, onset to CT time, volume and location of ICH, intraventricular extension, and randomized intensive BP lowering (OR 3.94, 95% CI 1.01-15.37; p = 0.049). Conclusions: The presence of hematoma sedimentation level on baseline CT is associated with warfarin use and lobar location of ICH, and predicts a worse outcome. Although uncommon, sedimentation level is an easily detectable prognostic factor in acute ICH.
copBasel, Switzerland
pubS. Karger AG
pmid26671408
doi10.1159/000442532
tpages7