schliessen

Filtern

 

Bibliotheken

Chemical Profile and Antinociceptive Efficacy of Rheedia longifolia Leaf Extract

Different species of the family Clusiaceae, including Rheedia longifolia , are used in folk medicine to treat inflammatory diseases. This family is largely distributed in tropical and subtropical areas of Brazil, but their chemical and pharmacological properties have been the subject of a few studie... Full description

Journal Title: Journal of Medicinal Food 14(9), pp.1039-1045
Main Author: Santos, José A.A.
Other Authors: Calheiros, Andrea , Nascimento, Diogo D. , Bérenger, Ana Luiza R. , Amendoeira, Fábio C. , Castro-Faria-Neto, Hugo C. , Figueiredo, Maria Raquel , Alves, Luiz A. , Frutuoso, Valber da Silva
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Mary Ann Liebert, Inc
ID: ISSN: 1096-620X
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_nrf_kci_oai_kci_go_kr_ARTI_742596
title: Chemical Profile and Antinociceptive Efficacy of Rheedia longifolia Leaf Extract
format: Article
creator:
  • Santos, José A.A.
  • Calheiros, Andrea
  • Nascimento, Diogo D.
  • Bérenger, Ana Luiza R.
  • Amendoeira, Fábio C.
  • Castro-Faria-Neto, Hugo C.
  • Figueiredo, Maria Raquel
  • Alves, Luiz A.
  • Frutuoso, Valber da Silva
subjects:
  • Analgesics, Non-Narcotic - chemistry
  • Analgesics, Non-Narcotic - therapeutic use
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal - chemistry
  • Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
  • Anti-Ulcer Agents - chemistry
  • Anti-Ulcer Agents - therapeutic use
  • Behavior, Animal - drug effects
  • Brazil
  • Care and treatment
  • Chemical Fractionation
  • Clusiaceae - chemistry
  • Flavonoids - analysis
  • Flavonoids - therapeutic use
  • Full Communications
  • Health aspects
  • Inflammation
  • Male
  • Materia medica, Vegetable
  • Medicine, Traditional
  • Methanol - chemistry
  • Mice
  • Neuralgia - drug therapy
  • Neurogenic Inflammation - drug therapy
  • Plant extracts
  • Plant Extracts - chemistry
  • Plant Extracts - therapeutic use
  • Plant Leaves - chemistry
  • Rats
  • Rats, Wistar
  • Solvents - chemistry
  • Ulcers
  • 식품과학
ispartof: Journal of Medicinal Food, 14(9), pp.1039-1045
description: Different species of the family Clusiaceae, including Rheedia longifolia , are used in folk medicine to treat inflammatory diseases. This family is largely distributed in tropical and subtropical areas of Brazil, but their chemical and pharmacological properties have been the subject of a few studies. In previous studies, we found that the aqueous extract from R. longifolia leaves presented important anti-inflammatory and analgesic activity. We investigated the chemical profile of R. longifolia and characterized the pharmacological effect of different chemically identified fractions in pharmacological models of neurogenic and inflammatory nociception. The pharmacological tests showed that oral treatment with aqueous crude extract and fractions of methanol extract of R. longifolia leaf induced a significant antinociceptive effect using von Frey filaments. In addition, the most polar fractions presented antinociceptive activity in a neurogenic model of nociception (capsaicin model). The chromatographic analysis indicated the presence of bisflavonoids in the fractions obtained from the methanol extract. These results suggest that bisflavonoids found in methanol-extracted fractions are involved in the inhibition of inflammatory and neurogenic nociception. It is important that the R. longifolia aqueous extract treatment inhibited ulcer formation induced by indomethacin, suggesting an anti-ulcerogenic activity closely associated with its analgesic effect.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1096-620X
fulltext: fulltext
issn:
  • 1096-620X
  • 1557-7600
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.17126
LOCALfalse
PrimoNMBib
record
control
sourceidgale_nrf_k
recordidTN_cdi_nrf_kci_oai_kci_go_kr_ARTI_742596
sourceformatXML
sourcesystemPC
galeidA265872153
sourcerecordidA265872153
originalsourceidFETCH-LOGICAL-c383t-ed2a31d268bdd9c9184f3642374b56c05ac8155205e1a3a9c02da8259dd25d823
addsrcrecordideNqFkU1r3DAQhkVpaNK0x16LoYfm4q0-LFk-LssmDSwkhBR6E1pptFEiS1vZG5p_H7lOC4VCmcOMhucdNPMi9IHgBcGy-3LfuwXF5YWJZK_QCeG8rVuB8etS407UguLvx-jtMNxjjFnD2jfomBJBaMPlCbpe3UHvjQ7VdU7OB6h0tNUyjj4m4w3sR_8I1dq5wpinKrnq5g7Ael2FFHfepVDKDWhXrX-OWZvxHTpyOgzw_iWfom_n69vV13pzdXG5Wm5qwyQba7BUM2KpkFtrO9MR2TgmGsraZsuFwVwbWVahmAPRTHcGU6sl5Z21lFtJ2Sk6m-fG7NSD8Spp_yvvknrIanlze6napghEQT_P6D6nHwcYRtX7wUAIOkI6DErKRjacCFnITzO50wGUjy5NO020WlLBZUsJZ4Va_IMqYadTpgjTHf8W1LPA5DQMGZzaZ9_r_KQIVpOLqrioJhfV5GLhP758-LDtwf6hf9tWADYDU1vHGDxsIY__GfsMHhCmMQ
sourcetypeOpen Website
isCDItrue
recordtypearticle
pqid884845168
display
typearticle
titleChemical Profile and Antinociceptive Efficacy of Rheedia longifolia Leaf Extract
sourceAlma/SFX Local Collection
creatorSantos, José A.A. ; Calheiros, Andrea ; Nascimento, Diogo D. ; Bérenger, Ana Luiza R. ; Amendoeira, Fábio C. ; Castro-Faria-Neto, Hugo C. ; Figueiredo, Maria Raquel ; Alves, Luiz A. ; Frutuoso, Valber da Silva
creatorcontribSantos, José A.A. ; Calheiros, Andrea ; Nascimento, Diogo D. ; Bérenger, Ana Luiza R. ; Amendoeira, Fábio C. ; Castro-Faria-Neto, Hugo C. ; Figueiredo, Maria Raquel ; Alves, Luiz A. ; Frutuoso, Valber da Silva
descriptionDifferent species of the family Clusiaceae, including Rheedia longifolia , are used in folk medicine to treat inflammatory diseases. This family is largely distributed in tropical and subtropical areas of Brazil, but their chemical and pharmacological properties have been the subject of a few studies. In previous studies, we found that the aqueous extract from R. longifolia leaves presented important anti-inflammatory and analgesic activity. We investigated the chemical profile of R. longifolia and characterized the pharmacological effect of different chemically identified fractions in pharmacological models of neurogenic and inflammatory nociception. The pharmacological tests showed that oral treatment with aqueous crude extract and fractions of methanol extract of R. longifolia leaf induced a significant antinociceptive effect using von Frey filaments. In addition, the most polar fractions presented antinociceptive activity in a neurogenic model of nociception (capsaicin model). The chromatographic analysis indicated the presence of bisflavonoids in the fractions obtained from the methanol extract. These results suggest that bisflavonoids found in methanol-extracted fractions are involved in the inhibition of inflammatory and neurogenic nociception. It is important that the R. longifolia aqueous extract treatment inhibited ulcer formation induced by indomethacin, suggesting an anti-ulcerogenic activity closely associated with its analgesic effect.
identifier
0ISSN: 1096-620X
1EISSN: 1557-7600
2DOI: 10.1089/jmf.2010.0183
3PMID: 21612458
languageeng
publisherUnited States: Mary Ann Liebert, Inc
subjectAnalgesics, Non-Narcotic - chemistry ; Analgesics, Non-Narcotic - therapeutic use ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Anti-Ulcer Agents - chemistry ; Anti-Ulcer Agents - therapeutic use ; Behavior, Animal - drug effects ; Brazil ; Care and treatment ; Chemical Fractionation ; Clusiaceae - chemistry ; Flavonoids - analysis ; Flavonoids - therapeutic use ; Full Communications ; Health aspects ; Inflammation ; Male ; Materia medica, Vegetable ; Medicine, Traditional ; Methanol - chemistry ; Mice ; Neuralgia - drug therapy ; Neurogenic Inflammation - drug therapy ; Plant extracts ; Plant Extracts - chemistry ; Plant Extracts - therapeutic use ; Plant Leaves - chemistry ; Rats ; Rats, Wistar ; Solvents - chemistry ; Ulcers ; 식품과학
ispartofJournal of Medicinal Food, 14(9), pp.1039-1045
rights
02011, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition
1COPYRIGHT 2011 Mary Ann Liebert, Inc.
2N
lds50peer_reviewed
oafree_for_read
citesFETCH-LOGICAL-c383t-ed2a31d268bdd9c9184f3642374b56c05ac8155205e1a3a9c02da8259dd25d823
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21612458$$D View this record in MEDLINE/PubMed
1$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001587409$$DAccess content in National Resesrch Foundation of Korea (NRF)
search
creatorcontrib
0Santos, José A.A.
1Calheiros, Andrea
2Nascimento, Diogo D.
3Bérenger, Ana Luiza R.
4Amendoeira, Fábio C.
5Castro-Faria-Neto, Hugo C.
6Figueiredo, Maria Raquel
7Alves, Luiz A.
8Frutuoso, Valber da Silva
title
0Chemical Profile and Antinociceptive Efficacy of Rheedia longifolia Leaf Extract
1Journal of medicinal food
addtitleJ Med Food
descriptionDifferent species of the family Clusiaceae, including Rheedia longifolia , are used in folk medicine to treat inflammatory diseases. This family is largely distributed in tropical and subtropical areas of Brazil, but their chemical and pharmacological properties have been the subject of a few studies. In previous studies, we found that the aqueous extract from R. longifolia leaves presented important anti-inflammatory and analgesic activity. We investigated the chemical profile of R. longifolia and characterized the pharmacological effect of different chemically identified fractions in pharmacological models of neurogenic and inflammatory nociception. The pharmacological tests showed that oral treatment with aqueous crude extract and fractions of methanol extract of R. longifolia leaf induced a significant antinociceptive effect using von Frey filaments. In addition, the most polar fractions presented antinociceptive activity in a neurogenic model of nociception (capsaicin model). The chromatographic analysis indicated the presence of bisflavonoids in the fractions obtained from the methanol extract. These results suggest that bisflavonoids found in methanol-extracted fractions are involved in the inhibition of inflammatory and neurogenic nociception. It is important that the R. longifolia aqueous extract treatment inhibited ulcer formation induced by indomethacin, suggesting an anti-ulcerogenic activity closely associated with its analgesic effect.
subject
0Analgesics, Non-Narcotic - chemistry
1Analgesics, Non-Narcotic - therapeutic use
2Animals
3Anti-Inflammatory Agents, Non-Steroidal - chemistry
4Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
5Anti-Ulcer Agents - chemistry
6Anti-Ulcer Agents - therapeutic use
7Behavior, Animal - drug effects
8Brazil
9Care and treatment
10Chemical Fractionation
11Clusiaceae - chemistry
12Flavonoids - analysis
13Flavonoids - therapeutic use
14Full Communications
15Health aspects
16Inflammation
17Male
18Materia medica, Vegetable
19Medicine, Traditional
20Methanol - chemistry
21Mice
22Neuralgia - drug therapy
23Neurogenic Inflammation - drug therapy
24Plant extracts
25Plant Extracts - chemistry
26Plant Extracts - therapeutic use
27Plant Leaves - chemistry
28Rats
29Rats, Wistar
30Solvents - chemistry
31Ulcers
32식품과학
issn
01096-620X
11557-7600
fulltexttrue
rsrctypearticle
creationdate2011
recordtypearticle
recordideNqFkU1r3DAQhkVpaNK0x16LoYfm4q0-LFk-LssmDSwkhBR6E1pptFEiS1vZG5p_H7lOC4VCmcOMhucdNPMi9IHgBcGy-3LfuwXF5YWJZK_QCeG8rVuB8etS407UguLvx-jtMNxjjFnD2jfomBJBaMPlCbpe3UHvjQ7VdU7OB6h0tNUyjj4m4w3sR_8I1dq5wpinKrnq5g7Ael2FFHfepVDKDWhXrX-OWZvxHTpyOgzw_iWfom_n69vV13pzdXG5Wm5qwyQba7BUM2KpkFtrO9MR2TgmGsraZsuFwVwbWVahmAPRTHcGU6sl5Z21lFtJ2Sk6m-fG7NSD8Spp_yvvknrIanlze6napghEQT_P6D6nHwcYRtX7wUAIOkI6DErKRjacCFnITzO50wGUjy5NO020WlLBZUsJZ4Va_IMqYadTpgjTHf8W1LPA5DQMGZzaZ9_r_KQIVpOLqrioJhfV5GLhP758-LDtwf6hf9tWADYDU1vHGDxsIY__GfsMHhCmMQ
startdate20110901
enddate20110901
creator
0Santos, José A.A.
1Calheiros, Andrea
2Nascimento, Diogo D.
3Bérenger, Ana Luiza R.
4Amendoeira, Fábio C.
5Castro-Faria-Neto, Hugo C.
6Figueiredo, Maria Raquel
7Alves, Luiz A.
8Frutuoso, Valber da Silva
general
0Mary Ann Liebert, Inc
1한국식품영양과학회
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
87X8
9ACYCR
sort
creationdate20110901
titleChemical Profile and Antinociceptive Efficacy of Rheedia longifolia Leaf Extract
authorSantos, José A.A. ; Calheiros, Andrea ; Nascimento, Diogo D. ; Bérenger, Ana Luiza R. ; Amendoeira, Fábio C. ; Castro-Faria-Neto, Hugo C. ; Figueiredo, Maria Raquel ; Alves, Luiz A. ; Frutuoso, Valber da Silva
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c383t-ed2a31d268bdd9c9184f3642374b56c05ac8155205e1a3a9c02da8259dd25d823
rsrctypearticles
prefilterarticles
languageeng
creationdate2011
topic
0Analgesics, Non-Narcotic - chemistry
1Analgesics, Non-Narcotic - therapeutic use
2Animals
3Anti-Inflammatory Agents, Non-Steroidal - chemistry
4Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
5Anti-Ulcer Agents - chemistry
6Anti-Ulcer Agents - therapeutic use
7Behavior, Animal - drug effects
8Brazil
9Care and treatment
10Chemical Fractionation
11Clusiaceae - chemistry
12Flavonoids - analysis
13Flavonoids - therapeutic use
14Full Communications
15Health aspects
16Inflammation
17Male
18Materia medica, Vegetable
19Medicine, Traditional
20Methanol - chemistry
21Mice
22Neuralgia - drug therapy
23Neurogenic Inflammation - drug therapy
24Plant extracts
25Plant Extracts - chemistry
26Plant Extracts - therapeutic use
27Plant Leaves - chemistry
28Rats
29Rats, Wistar
30Solvents - chemistry
31Ulcers
32식품과학
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Santos, José A.A.
1Calheiros, Andrea
2Nascimento, Diogo D.
3Bérenger, Ana Luiza R.
4Amendoeira, Fábio C.
5Castro-Faria-Neto, Hugo C.
6Figueiredo, Maria Raquel
7Alves, Luiz A.
8Frutuoso, Valber da Silva
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7MEDLINE - Academic
8Korean Citation Index
jtitleJournal of medicinal food
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Santos, José A.A.
1Calheiros, Andrea
2Nascimento, Diogo D.
3Bérenger, Ana Luiza R.
4Amendoeira, Fábio C.
5Castro-Faria-Neto, Hugo C.
6Figueiredo, Maria Raquel
7Alves, Luiz A.
8Frutuoso, Valber da Silva
formatjournal
genrearticle
ristypeJOUR
atitleChemical Profile and Antinociceptive Efficacy of Rheedia longifolia Leaf Extract
jtitleJournal of medicinal food
addtitleJ Med Food
date2011-09-01
risdate2011
volume14
issue9
spage139
epage1045
pages139-1045
issn1096-620X
eissn1557-7600
notesG704-001634.2011.14.9.015
abstractDifferent species of the family Clusiaceae, including Rheedia longifolia , are used in folk medicine to treat inflammatory diseases. This family is largely distributed in tropical and subtropical areas of Brazil, but their chemical and pharmacological properties have been the subject of a few studies. In previous studies, we found that the aqueous extract from R. longifolia leaves presented important anti-inflammatory and analgesic activity. We investigated the chemical profile of R. longifolia and characterized the pharmacological effect of different chemically identified fractions in pharmacological models of neurogenic and inflammatory nociception. The pharmacological tests showed that oral treatment with aqueous crude extract and fractions of methanol extract of R. longifolia leaf induced a significant antinociceptive effect using von Frey filaments. In addition, the most polar fractions presented antinociceptive activity in a neurogenic model of nociception (capsaicin model). The chromatographic analysis indicated the presence of bisflavonoids in the fractions obtained from the methanol extract. These results suggest that bisflavonoids found in methanol-extracted fractions are involved in the inhibition of inflammatory and neurogenic nociception. It is important that the R. longifolia aqueous extract treatment inhibited ulcer formation induced by indomethacin, suggesting an anti-ulcerogenic activity closely associated with its analgesic effect.
copUnited States
pubMary Ann Liebert, Inc
pmid21612458
doi10.1089/jmf.2010.0183
oafree_for_read