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Antigenotoxicity, Cytotoxicity, and Apoptosis Induction by Apigenin, Bisabolol, and Protocatechuic Acid

Medicinal plants represent an important resource in new drug research. Antioxidant properties of plants can help to scavenge reactive oxygen species. The objective of this work was to evaluate the genotoxic, antigenotoxic, tumoricidal, and apoptotic effect of some major phenols (apigenin, bisabolol,... Full description

Journal Title: Journal of Medicinal Food 14(3), pp.276-283
Main Author: Anter, Jaouad
Other Authors: Romero-Jiménez, Magdalena , Fernández-Bedmar, Zahira , Villatoro-Pulido, Myriam , Analla, Mohamed , Alonso-Moraga, Ángeles , Muñoz-Serrano, Andrés
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
Quelle: Alma/SFX Local Collection
Publisher: United States: Mary Ann Liebert, Inc
ID: ISSN: 1096-620X
Zum Text:
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recordid: cdi_nrf_kci_oai_kci_go_kr_ARTI_742816
title: Antigenotoxicity, Cytotoxicity, and Apoptosis Induction by Apigenin, Bisabolol, and Protocatechuic Acid
format: Article
creator:
  • Anter, Jaouad
  • Romero-Jiménez, Magdalena
  • Fernández-Bedmar, Zahira
  • Villatoro-Pulido, Myriam
  • Analla, Mohamed
  • Alonso-Moraga, Ángeles
  • Muñoz-Serrano, Andrés
subjects:
  • Animals
  • Antimutagenic Agents - pharmacology
  • Antimutagenic Agents - therapeutic use
  • Antineoplastic Agents, Phytogenic - pharmacology
  • Antineoplastic Agents, Phytogenic - therapeutic use
  • Antioxidants - pharmacology
  • Antioxidants - therapeutic use
  • Apigenin - pharmacology
  • Apigenin - therapeutic use
  • Apoptosis
  • Apoptosis - drug effects
  • DNA
  • DNA Fragmentation
  • Drosophila
  • Full Communications
  • Health aspects
  • HL-60 Cells
  • Humans
  • Hydrogen Peroxide
  • Hydroxybenzoates - pharmacology
  • Hydroxybenzoates - therapeutic use
  • Leukemia - drug therapy
  • Matricaria - chemistry
  • Phenols - pharmacology
  • Phenols - therapeutic use
  • Physiological aspects
  • Phytochemicals
  • Phytotherapy
  • Plant Extracts - pharmacology
  • Plant Extracts - therapeutic use
  • Sesquiterpenes - pharmacology
  • Sesquiterpenes - therapeutic use
  • Uncaria - chemistry
  • 식품과학
ispartof: Journal of Medicinal Food, 14(3), pp.276-283
description: Medicinal plants represent an important resource in new drug research. Antioxidant properties of plants can help to scavenge reactive oxygen species. The objective of this work was to evaluate the genotoxic, antigenotoxic, tumoricidal, and apoptotic effect of some major phenols (apigenin, bisabolol, and protocatechuic acid) from two medicinal plants, Matricaria chamomilla and Uncaria tomentosa . The wing spot test of Drosophila melanogaster was used to evaluate the genotoxicity and antigenotoxicity of the three phenols. The human model of HL-60 leukemia cells was used for the assessment of the cytotoxic effect, growth, and cellular viability. The apoptotic effect was evaluated using a DNA fragmentation assay based on the formation of internucleosomal units. Protocatechuic acid (0.25 and 1 m M ), apigenin (0.46 and 1.85 m M ), and bisabolol (0.56 and 2.24 m M ) did not exhibit any genotoxic effect. The three phenols showed an antigenotoxic effect against the hydrogen peroxide effect and also exhibited tumoricidal activity. Apigenin (2.24–35.96 m M ) showed a lower 50% inhibitory concentration (0.75 and 3.87 m M for the trypan blue test and WST-8 colorimetric assay, respectively) than bisabolol and protocatechuic acid. These phenolics also induced apoptosis in HL-60 leukemia cells. This study suggests that the antioxidant activity of Chamomilla and Uncaria could be partially responsible of their beneficial activity.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1096-620X
fulltext: fulltext
issn:
  • 1096-620X
  • 1557-7600
url: Link


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titleAntigenotoxicity, Cytotoxicity, and Apoptosis Induction by Apigenin, Bisabolol, and Protocatechuic Acid
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creatorAnter, Jaouad ; Romero-Jiménez, Magdalena ; Fernández-Bedmar, Zahira ; Villatoro-Pulido, Myriam ; Analla, Mohamed ; Alonso-Moraga, Ángeles ; Muñoz-Serrano, Andrés
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descriptionMedicinal plants represent an important resource in new drug research. Antioxidant properties of plants can help to scavenge reactive oxygen species. The objective of this work was to evaluate the genotoxic, antigenotoxic, tumoricidal, and apoptotic effect of some major phenols (apigenin, bisabolol, and protocatechuic acid) from two medicinal plants, Matricaria chamomilla and Uncaria tomentosa . The wing spot test of Drosophila melanogaster was used to evaluate the genotoxicity and antigenotoxicity of the three phenols. The human model of HL-60 leukemia cells was used for the assessment of the cytotoxic effect, growth, and cellular viability. The apoptotic effect was evaluated using a DNA fragmentation assay based on the formation of internucleosomal units. Protocatechuic acid (0.25 and 1 m M ), apigenin (0.46 and 1.85 m M ), and bisabolol (0.56 and 2.24 m M ) did not exhibit any genotoxic effect. The three phenols showed an antigenotoxic effect against the hydrogen peroxide effect and also exhibited tumoricidal activity. Apigenin (2.24–35.96 m M ) showed a lower 50% inhibitory concentration (0.75 and 3.87 m M for the trypan blue test and WST-8 colorimetric assay, respectively) than bisabolol and protocatechuic acid. These phenolics also induced apoptosis in HL-60 leukemia cells. This study suggests that the antioxidant activity of Chamomilla and Uncaria could be partially responsible of their beneficial activity.
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subjectAnimals ; Antimutagenic Agents - pharmacology ; Antimutagenic Agents - therapeutic use ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - therapeutic use ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Apigenin - pharmacology ; Apigenin - therapeutic use ; Apoptosis ; Apoptosis - drug effects ; DNA ; DNA Fragmentation ; Drosophila ; Full Communications ; Health aspects ; HL-60 Cells ; Humans ; Hydrogen Peroxide ; Hydroxybenzoates - pharmacology ; Hydroxybenzoates - therapeutic use ; Leukemia - drug therapy ; Matricaria - chemistry ; Phenols - pharmacology ; Phenols - therapeutic use ; Physiological aspects ; Phytochemicals ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Sesquiterpenes - pharmacology ; Sesquiterpenes - therapeutic use ; Uncaria - chemistry ; 식품과학
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1Romero-Jiménez, Magdalena
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6Muñoz-Serrano, Andrés
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descriptionMedicinal plants represent an important resource in new drug research. Antioxidant properties of plants can help to scavenge reactive oxygen species. The objective of this work was to evaluate the genotoxic, antigenotoxic, tumoricidal, and apoptotic effect of some major phenols (apigenin, bisabolol, and protocatechuic acid) from two medicinal plants, Matricaria chamomilla and Uncaria tomentosa . The wing spot test of Drosophila melanogaster was used to evaluate the genotoxicity and antigenotoxicity of the three phenols. The human model of HL-60 leukemia cells was used for the assessment of the cytotoxic effect, growth, and cellular viability. The apoptotic effect was evaluated using a DNA fragmentation assay based on the formation of internucleosomal units. Protocatechuic acid (0.25 and 1 m M ), apigenin (0.46 and 1.85 m M ), and bisabolol (0.56 and 2.24 m M ) did not exhibit any genotoxic effect. The three phenols showed an antigenotoxic effect against the hydrogen peroxide effect and also exhibited tumoricidal activity. Apigenin (2.24–35.96 m M ) showed a lower 50% inhibitory concentration (0.75 and 3.87 m M for the trypan blue test and WST-8 colorimetric assay, respectively) than bisabolol and protocatechuic acid. These phenolics also induced apoptosis in HL-60 leukemia cells. This study suggests that the antioxidant activity of Chamomilla and Uncaria could be partially responsible of their beneficial activity.
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1Antimutagenic Agents - pharmacology
2Antimutagenic Agents - therapeutic use
3Antineoplastic Agents, Phytogenic - pharmacology
4Antineoplastic Agents, Phytogenic - therapeutic use
5Antioxidants - pharmacology
6Antioxidants - therapeutic use
7Apigenin - pharmacology
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10Apoptosis - drug effects
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12DNA Fragmentation
13Drosophila
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27Phytotherapy
28Plant Extracts - pharmacology
29Plant Extracts - therapeutic use
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titleAntigenotoxicity, Cytotoxicity, and Apoptosis Induction by Apigenin, Bisabolol, and Protocatechuic Acid
authorAnter, Jaouad ; Romero-Jiménez, Magdalena ; Fernández-Bedmar, Zahira ; Villatoro-Pulido, Myriam ; Analla, Mohamed ; Alonso-Moraga, Ángeles ; Muñoz-Serrano, Andrés
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abstractMedicinal plants represent an important resource in new drug research. Antioxidant properties of plants can help to scavenge reactive oxygen species. The objective of this work was to evaluate the genotoxic, antigenotoxic, tumoricidal, and apoptotic effect of some major phenols (apigenin, bisabolol, and protocatechuic acid) from two medicinal plants, Matricaria chamomilla and Uncaria tomentosa . The wing spot test of Drosophila melanogaster was used to evaluate the genotoxicity and antigenotoxicity of the three phenols. The human model of HL-60 leukemia cells was used for the assessment of the cytotoxic effect, growth, and cellular viability. The apoptotic effect was evaluated using a DNA fragmentation assay based on the formation of internucleosomal units. Protocatechuic acid (0.25 and 1 m M ), apigenin (0.46 and 1.85 m M ), and bisabolol (0.56 and 2.24 m M ) did not exhibit any genotoxic effect. The three phenols showed an antigenotoxic effect against the hydrogen peroxide effect and also exhibited tumoricidal activity. Apigenin (2.24–35.96 m M ) showed a lower 50% inhibitory concentration (0.75 and 3.87 m M for the trypan blue test and WST-8 colorimetric assay, respectively) than bisabolol and protocatechuic acid. These phenolics also induced apoptosis in HL-60 leukemia cells. This study suggests that the antioxidant activity of Chamomilla and Uncaria could be partially responsible of their beneficial activity.
copUnited States
pubMary Ann Liebert, Inc
pmid21182433
doi10.1089/jmf.2010.0139