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Detection of Mammaglobin in the Sera of Patients with Breast Cancer

Current procedures for the diagnosis of breast cancer are cumbersome and invasive, making detection of this disease difficult. A rapid screening test for early detection of breast cancer would allow for better management of this deadly disease. In this report, we show that, with the exception of the... Full description

Journal Title: Tumor biology 2002-12, Vol.23 (4), p.212-221
Main Author: Fanger, Gary R
Other Authors: Houghton, Raymond L , Retter, Marc W , Hendrickson, Ron C , Babcook, John , Dillon, Davin C , Durham, Margarita D , Reynolds, Lisa D , Johnson, Jeffrey C , Carter, Darrick , Fleming, Timothy P , Roche, Patrick C , Persing, David H , Reed, Steven G
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: Karger
ID: ISSN: 1010-4283
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recordid: cdi_pascalfrancis_primary_14409911
title: Detection of Mammaglobin in the Sera of Patients with Breast Cancer
format: Article
creator:
  • Fanger, Gary R
  • Houghton, Raymond L
  • Retter, Marc W
  • Hendrickson, Ron C
  • Babcook, John
  • Dillon, Davin C
  • Durham, Margarita D
  • Reynolds, Lisa D
  • Johnson, Jeffrey C
  • Carter, Darrick
  • Fleming, Timothy P
  • Roche, Patrick C
  • Persing, David H
  • Reed, Steven G
subjects:
  • Adult
  • Biological and medical sciences
  • Biomarkers, Tumor - metabolism
  • Blotting, Western
  • Breast Neoplasms - blood
  • Breast Neoplasms - diagnosis
  • DNA, Complementary - metabolism
  • Dose-Response Relationship, Drug
  • Enzyme-Linked Immunosorbent Assay
  • Epitopes
  • Female
  • Gynecology. Andrology. Obstetrics
  • Humans
  • Immunohistochemistry
  • Mammaglobin A
  • Mammary gland diseases
  • Mass Screening
  • Medical sciences
  • Middle Aged
  • Neoplasm Proteins - blood
  • Neoplasm Proteins - metabolism
  • Polymerase Chain Reaction
  • Research Article
  • RNA - metabolism
  • RNA, Messenger - metabolism
  • Tissue Distribution
  • Tumors
  • Uteroglobin - blood
  • Uteroglobin - metabolism
ispartof: Tumor biology, 2002-12, Vol.23 (4), p.212-221
description: Current procedures for the diagnosis of breast cancer are cumbersome and invasive, making detection of this disease difficult. A rapid screening test for early detection of breast cancer would allow for better management of this deadly disease. In this report, we show that, with the exception of the skin, mammaglobin mRNA is specifically expressed in mammary tissue and commonly overexpressed in breast cancer. Mammaglobin is not expressed in other types of cancer including colon, lung, ovarian, and prostate cancer. Breast-specific expression of mammaglobin protein was shown using immunohistochemical methods. Mammaglobin is secreted from both established breast cancer cell lines and primary breast carcinoma cells cultured in vitro. Using a monoclonal antibody-based assay for monitoring the presence of mammaglobin in serum, elevated levels of mammaglobin were detected in sera of patients with breast cancer, but not in healthy women. Thus, mammaglobin, which is overexpressed and secreted from breast carcinoma cells, is detectable in sera of patients with breast cancer and may provide a rapid screening test for the diagnosis and management of breast cancer.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1010-4283
fulltext: fulltext
issn:
  • 1010-4283
  • 1423-0380
url: Link


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titleDetection of Mammaglobin in the Sera of Patients with Breast Cancer
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creatorFanger, Gary R ; Houghton, Raymond L ; Retter, Marc W ; Hendrickson, Ron C ; Babcook, John ; Dillon, Davin C ; Durham, Margarita D ; Reynolds, Lisa D ; Johnson, Jeffrey C ; Carter, Darrick ; Fleming, Timothy P ; Roche, Patrick C ; Persing, David H ; Reed, Steven G
creatorcontribFanger, Gary R ; Houghton, Raymond L ; Retter, Marc W ; Hendrickson, Ron C ; Babcook, John ; Dillon, Davin C ; Durham, Margarita D ; Reynolds, Lisa D ; Johnson, Jeffrey C ; Carter, Darrick ; Fleming, Timothy P ; Roche, Patrick C ; Persing, David H ; Reed, Steven G
descriptionCurrent procedures for the diagnosis of breast cancer are cumbersome and invasive, making detection of this disease difficult. A rapid screening test for early detection of breast cancer would allow for better management of this deadly disease. In this report, we show that, with the exception of the skin, mammaglobin mRNA is specifically expressed in mammary tissue and commonly overexpressed in breast cancer. Mammaglobin is not expressed in other types of cancer including colon, lung, ovarian, and prostate cancer. Breast-specific expression of mammaglobin protein was shown using immunohistochemical methods. Mammaglobin is secreted from both established breast cancer cell lines and primary breast carcinoma cells cultured in vitro. Using a monoclonal antibody-based assay for monitoring the presence of mammaglobin in serum, elevated levels of mammaglobin were detected in sera of patients with breast cancer, but not in healthy women. Thus, mammaglobin, which is overexpressed and secreted from breast carcinoma cells, is detectable in sera of patients with breast cancer and may provide a rapid screening test for the diagnosis and management of breast cancer.
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languageeng
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subjectAdult ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Blotting, Western ; Breast Neoplasms - blood ; Breast Neoplasms - diagnosis ; DNA, Complementary - metabolism ; Dose-Response Relationship, Drug ; Enzyme-Linked Immunosorbent Assay ; Epitopes ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Mammaglobin A ; Mammary gland diseases ; Mass Screening ; Medical sciences ; Middle Aged ; Neoplasm Proteins - blood ; Neoplasm Proteins - metabolism ; Polymerase Chain Reaction ; Research Article ; RNA - metabolism ; RNA, Messenger - metabolism ; Tissue Distribution ; Tumors ; Uteroglobin - blood ; Uteroglobin - metabolism
ispartofTumor biology, 2002-12, Vol.23 (4), p.212-221
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7Reynolds, Lisa D
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descriptionCurrent procedures for the diagnosis of breast cancer are cumbersome and invasive, making detection of this disease difficult. A rapid screening test for early detection of breast cancer would allow for better management of this deadly disease. In this report, we show that, with the exception of the skin, mammaglobin mRNA is specifically expressed in mammary tissue and commonly overexpressed in breast cancer. Mammaglobin is not expressed in other types of cancer including colon, lung, ovarian, and prostate cancer. Breast-specific expression of mammaglobin protein was shown using immunohistochemical methods. Mammaglobin is secreted from both established breast cancer cell lines and primary breast carcinoma cells cultured in vitro. Using a monoclonal antibody-based assay for monitoring the presence of mammaglobin in serum, elevated levels of mammaglobin were detected in sera of patients with breast cancer, but not in healthy women. Thus, mammaglobin, which is overexpressed and secreted from breast carcinoma cells, is detectable in sera of patients with breast cancer and may provide a rapid screening test for the diagnosis and management of breast cancer.
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2Biomarkers, Tumor - metabolism
3Blotting, Western
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6DNA, Complementary - metabolism
7Dose-Response Relationship, Drug
8Enzyme-Linked Immunosorbent Assay
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12Humans
13Immunohistochemistry
14Mammaglobin A
15Mammary gland diseases
16Mass Screening
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21Polymerase Chain Reaction
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23RNA - metabolism
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titleDetection of Mammaglobin in the Sera of Patients with Breast Cancer
authorFanger, Gary R ; Houghton, Raymond L ; Retter, Marc W ; Hendrickson, Ron C ; Babcook, John ; Dillon, Davin C ; Durham, Margarita D ; Reynolds, Lisa D ; Johnson, Jeffrey C ; Carter, Darrick ; Fleming, Timothy P ; Roche, Patrick C ; Persing, David H ; Reed, Steven G
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7Dose-Response Relationship, Drug
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2Retter, Marc W
3Hendrickson, Ron C
4Babcook, John
5Dillon, Davin C
6Durham, Margarita D
7Reynolds, Lisa D
8Johnson, Jeffrey C
9Carter, Darrick
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atitleDetection of Mammaglobin in the Sera of Patients with Breast Cancer
jtitleTumor biology
addtitleTumor Biol
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pages212-221
issn1010-4283
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abstractCurrent procedures for the diagnosis of breast cancer are cumbersome and invasive, making detection of this disease difficult. A rapid screening test for early detection of breast cancer would allow for better management of this deadly disease. In this report, we show that, with the exception of the skin, mammaglobin mRNA is specifically expressed in mammary tissue and commonly overexpressed in breast cancer. Mammaglobin is not expressed in other types of cancer including colon, lung, ovarian, and prostate cancer. Breast-specific expression of mammaglobin protein was shown using immunohistochemical methods. Mammaglobin is secreted from both established breast cancer cell lines and primary breast carcinoma cells cultured in vitro. Using a monoclonal antibody-based assay for monitoring the presence of mammaglobin in serum, elevated levels of mammaglobin were detected in sera of patients with breast cancer, but not in healthy women. Thus, mammaglobin, which is overexpressed and secreted from breast carcinoma cells, is detectable in sera of patients with breast cancer and may provide a rapid screening test for the diagnosis and management of breast cancer.
copBasel, Switzerland
pubKarger
pmid12499777
doi10.1159/000067251
tpages10
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