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Serum and lipoprotein sitostanol and non-cholesterol sterols after an acute dose of plant stanol ester on its long-term consumption

Purpose Chronic inhibition of cholesterol absorption with large doses of plant stanol esters (staest) alters profoundly cholesterol metabolism, but it is unknown how an acute inhibition with a large staest dose alters the postprandial serum and lipoprotein cholesterol precursor, plant sterol, and si... Full description

Journal Title: European journal of nutrition 2011-09-23, Vol.51 (5), p.615-622
Main Author: Gylling, H
Other Authors: Hallikainen, M , Simonen, P , Miettinen, H. E , Nissinen, M. J , Miettinen, T. A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 1436-6207
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title: Serum and lipoprotein sitostanol and non-cholesterol sterols after an acute dose of plant stanol ester on its long-term consumption
format: Article
creator:
  • Gylling, H
  • Hallikainen, M
  • Simonen, P
  • Miettinen, H. E
  • Nissinen, M. J
  • Miettinen, T. A
subjects:
  • Adolescent
  • Adult
  • Aged
  • Anticholesteremic Agents - administration & dosage
  • Anticholesteremic Agents - blood
  • Biological and medical sciences
  • Chemistry
  • Chemistry and Materials Science
  • Cholesterol - blood
  • Cholesterol, VLDL - blood
  • Chylomicrons - blood
  • Diet
  • Double-Blind Method
  • Feeding. Feeding behavior
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Humans
  • Lipoproteins - blood
  • Male
  • Middle Aged
  • Nutrition
  • Original Contribution
  • Postprandial Period - drug effects
  • Serum - drug effects
  • Sitosterols - administration & dosage
  • Sitosterols - blood
  • Sterols - blood
  • Toxicity Tests, Acute - methods
  • Triglycerides - blood
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Young Adult
ispartof: European journal of nutrition, 2011-09-23, Vol.51 (5), p.615-622
description: Purpose Chronic inhibition of cholesterol absorption with large doses of plant stanol esters (staest) alters profoundly cholesterol metabolism, but it is unknown how an acute inhibition with a large staest dose alters the postprandial serum and lipoprotein cholesterol precursor, plant sterol, and sitostanol contents. Methods Hypercholesterolemic subjects, randomly and double-blind divided into control ( n  = 18) and intervention groups ( n  = 20), consumed experimental diet without and with staest (plant stanols 8.8 g/day) for 10 weeks. Next morning after a fasting blood sample (0 h), the subjects had a breakfast without or with staest (4.5 g of plant stanols). Blood sampling was repeated 4 h later. Lipoproteins were separated with ultracentrifugation, and sterols were measured with gas–liquid chromatography. Results In 0-h chylomicrons and VLDL, plant sterols were lower in staest than in controls. Postprandially, cholestenol (cholesterol synthesis marker) was reduced in chylomicrons in staest compared with controls (−0.13 ± 0.04 μg/dL vs. 0.01 ± 0.08 μg/dL, P  
language: eng
source:
identifier: ISSN: 1436-6207
fulltext: no_fulltext
issn:
  • 1436-6207
  • 1436-6215
url: Link


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titleSerum and lipoprotein sitostanol and non-cholesterol sterols after an acute dose of plant stanol ester on its long-term consumption
creatorGylling, H ; Hallikainen, M ; Simonen, P ; Miettinen, H. E ; Nissinen, M. J ; Miettinen, T. A
creatorcontribGylling, H ; Hallikainen, M ; Simonen, P ; Miettinen, H. E ; Nissinen, M. J ; Miettinen, T. A
descriptionPurpose Chronic inhibition of cholesterol absorption with large doses of plant stanol esters (staest) alters profoundly cholesterol metabolism, but it is unknown how an acute inhibition with a large staest dose alters the postprandial serum and lipoprotein cholesterol precursor, plant sterol, and sitostanol contents. Methods Hypercholesterolemic subjects, randomly and double-blind divided into control ( n  = 18) and intervention groups ( n  = 20), consumed experimental diet without and with staest (plant stanols 8.8 g/day) for 10 weeks. Next morning after a fasting blood sample (0 h), the subjects had a breakfast without or with staest (4.5 g of plant stanols). Blood sampling was repeated 4 h later. Lipoproteins were separated with ultracentrifugation, and sterols were measured with gas–liquid chromatography. Results In 0-h chylomicrons and VLDL, plant sterols were lower in staest than in controls. Postprandially, cholestenol (cholesterol synthesis marker) was reduced in chylomicrons in staest compared with controls (−0.13 ± 0.04 μg/dL vs. 0.01 ± 0.08 μg/dL, P  < 0.05). Staest decreased postprandially avenasterol in chylomicrons ( P  < 0.05 from 0 h). Sitostanol was high at 0 h by chronic staest in serum and VLDL but not in chylomicrons. Postprandial sitostanol was increased by staest in VLDL only. Conclusions Chronic cholesterol absorption inhibition with large amount of plant stanol esters decreases plant sterols in triglyceride-rich lipoproteins. Acute plant stanol ester consumption increases sitostanol content in triglyceride-rich lipoproteins but suggests to decrease the risk of plant sterol and plant stanol accumulation into vascular wall by chylomicrons.
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subjectAdolescent ; Adult ; Aged ; Anticholesteremic Agents - administration & dosage ; Anticholesteremic Agents - blood ; Biological and medical sciences ; Chemistry ; Chemistry and Materials Science ; Cholesterol - blood ; Cholesterol, VLDL - blood ; Chylomicrons - blood ; Diet ; Double-Blind Method ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Lipoproteins - blood ; Male ; Middle Aged ; Nutrition ; Original Contribution ; Postprandial Period - drug effects ; Serum - drug effects ; Sitosterols - administration & dosage ; Sitosterols - blood ; Sterols - blood ; Toxicity Tests, Acute - methods ; Triglycerides - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Young Adult
ispartofEuropean journal of nutrition, 2011-09-23, Vol.51 (5), p.615-622
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descriptionPurpose Chronic inhibition of cholesterol absorption with large doses of plant stanol esters (staest) alters profoundly cholesterol metabolism, but it is unknown how an acute inhibition with a large staest dose alters the postprandial serum and lipoprotein cholesterol precursor, plant sterol, and sitostanol contents. Methods Hypercholesterolemic subjects, randomly and double-blind divided into control ( n  = 18) and intervention groups ( n  = 20), consumed experimental diet without and with staest (plant stanols 8.8 g/day) for 10 weeks. Next morning after a fasting blood sample (0 h), the subjects had a breakfast without or with staest (4.5 g of plant stanols). Blood sampling was repeated 4 h later. Lipoproteins were separated with ultracentrifugation, and sterols were measured with gas–liquid chromatography. Results In 0-h chylomicrons and VLDL, plant sterols were lower in staest than in controls. Postprandially, cholestenol (cholesterol synthesis marker) was reduced in chylomicrons in staest compared with controls (−0.13 ± 0.04 μg/dL vs. 0.01 ± 0.08 μg/dL, P  < 0.05). Staest decreased postprandially avenasterol in chylomicrons ( P  < 0.05 from 0 h). Sitostanol was high at 0 h by chronic staest in serum and VLDL but not in chylomicrons. Postprandial sitostanol was increased by staest in VLDL only. Conclusions Chronic cholesterol absorption inhibition with large amount of plant stanol esters decreases plant sterols in triglyceride-rich lipoproteins. Acute plant stanol ester consumption increases sitostanol content in triglyceride-rich lipoproteins but suggests to decrease the risk of plant sterol and plant stanol accumulation into vascular wall by chylomicrons.
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24Sitosterols - administration & dosage
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26Sterols - blood
27Toxicity Tests, Acute - methods
28Triglycerides - blood
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titleSerum and lipoprotein sitostanol and non-cholesterol sterols after an acute dose of plant stanol ester on its long-term consumption
authorGylling, H ; Hallikainen, M ; Simonen, P ; Miettinen, H. E ; Nissinen, M. J ; Miettinen, T. A
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jtitleEuropean journal of nutrition
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2Simonen, P
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atitleSerum and lipoprotein sitostanol and non-cholesterol sterols after an acute dose of plant stanol ester on its long-term consumption
jtitleEuropean journal of nutrition
stitleEur J Nutr
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date2011-09-23
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volume51
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pages615-622
issn1436-6207
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abstractPurpose Chronic inhibition of cholesterol absorption with large doses of plant stanol esters (staest) alters profoundly cholesterol metabolism, but it is unknown how an acute inhibition with a large staest dose alters the postprandial serum and lipoprotein cholesterol precursor, plant sterol, and sitostanol contents. Methods Hypercholesterolemic subjects, randomly and double-blind divided into control ( n  = 18) and intervention groups ( n  = 20), consumed experimental diet without and with staest (plant stanols 8.8 g/day) for 10 weeks. Next morning after a fasting blood sample (0 h), the subjects had a breakfast without or with staest (4.5 g of plant stanols). Blood sampling was repeated 4 h later. Lipoproteins were separated with ultracentrifugation, and sterols were measured with gas–liquid chromatography. Results In 0-h chylomicrons and VLDL, plant sterols were lower in staest than in controls. Postprandially, cholestenol (cholesterol synthesis marker) was reduced in chylomicrons in staest compared with controls (−0.13 ± 0.04 μg/dL vs. 0.01 ± 0.08 μg/dL, P  < 0.05). Staest decreased postprandially avenasterol in chylomicrons ( P  < 0.05 from 0 h). Sitostanol was high at 0 h by chronic staest in serum and VLDL but not in chylomicrons. Postprandial sitostanol was increased by staest in VLDL only. Conclusions Chronic cholesterol absorption inhibition with large amount of plant stanol esters decreases plant sterols in triglyceride-rich lipoproteins. Acute plant stanol ester consumption increases sitostanol content in triglyceride-rich lipoproteins but suggests to decrease the risk of plant sterol and plant stanol accumulation into vascular wall by chylomicrons.
copBerlin/Heidelberg
pubSpringer-Verlag
pmid21947207
doi10.1007/s00394-011-0249-5