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Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer

Abstract Background : Green tea polyphenol (GTP) suppresses malignancy in bladder cancer cell lines. However, the detail of its anti-carcinogenic effect in vivo is not fully understood. This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given N-butyl-(-4-hydroxy... Full description

Journal Title: Cancer epidemiology 2010, Vol.34 (3), p.350-354
Main Author: Sagara, Yuji
Other Authors: Miyata, Yasuyoshi , Nomata, Koichiro , Hayashi, Tomayoshi , Kanetake, Hiroshi
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Netherlands: Elsevier Ltd
ID: ISSN: 1877-7821
Link: https://www.ncbi.nlm.nih.gov/pubmed/20362526
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recordid: cdi_proquest_journals_1032598278
title: Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer
format: Article
creator:
  • Sagara, Yuji
  • Miyata, Yasuyoshi
  • Nomata, Koichiro
  • Hayashi, Tomayoshi
  • Kanetake, Hiroshi
subjects:
  • Angiogenesis
  • Angiogenesis Inhibitors - therapeutic use
  • Animals
  • Antineoplastic Agents, Phytogenic - therapeutic use
  • Bladder cancer
  • Butylhydroxybutylnitrosamine
  • Camellia sinensis
  • Cancer
  • Cancer prevention
  • Chemical-induced model
  • Drinking water
  • Female
  • Flavonoids - therapeutic use
  • Green tea polyphenol
  • Hematology, Oncology and Palliative Medicine
  • Internal Medicine
  • Mice
  • Mortality
  • Neoplasm Invasiveness
  • Phenols - therapeutic use
  • Plant Extracts - therapeutic use
  • Polyphenols
  • Rodents
  • Studies
  • Urinary Bladder Neoplasms - chemically induced
  • Urinary Bladder Neoplasms - drug therapy
  • Urinary Bladder Neoplasms - pathology
ispartof: Cancer epidemiology, 2010, Vol.34 (3), p.350-354
description: Abstract Background : Green tea polyphenol (GTP) suppresses malignancy in bladder cancer cell lines. However, the detail of its anti-carcinogenic effect in vivo is not fully understood. This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN), with and without GTP. Methods : Eight-week-old female C3H/He mice were treated with and without 0.05% BBN solution for 14 or 24 weeks. In addition, they were also treated with and without 0.5% GTP solution for the same periods. Histopathological diagnosis was established using hematoxylin and eosin staining, and microvessel density (MVD) was estimated by counting CD34- and von Willebrand factor-positive vessels in the tumor area. Results : At 14 weeks, cancer cells were detected in BBN and BBN + GTP mice [5/14 (35.7%) and 3/14 (21.4%), respectively, p = 0.678]. At 24 weeks, the incidence of cancer cells was also similar between the groups (BBN + GTP: 61.9% vs. BBN: 82.6%; p = 0.179). However, the frequency of invasive tumors in BBN + GTP mice was significantly lower (23.8%; p = 0.030) than in those given BBN alone (65.2%). Tumor volume and MVD of intratumoral and stromal region in the BBN + GTP group were also significantly lower than in BBN mice. Conclusion : The results showed that GTP had no anti-carcinogenic effect, but inhibited tumor growth and invasion in mice with established bladder cancer, at least in part through the regulation of angiogenesis. Our data suggest that GTP seems to suppress tumor development in bladder cancer.
language: eng
source:
identifier: ISSN: 1877-7821
fulltext: no_fulltext
issn:
  • 1877-7821
  • 1877-783X
url: Link


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titleGreen tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer
creatorSagara, Yuji ; Miyata, Yasuyoshi ; Nomata, Koichiro ; Hayashi, Tomayoshi ; Kanetake, Hiroshi
creatorcontribSagara, Yuji ; Miyata, Yasuyoshi ; Nomata, Koichiro ; Hayashi, Tomayoshi ; Kanetake, Hiroshi
descriptionAbstract Background : Green tea polyphenol (GTP) suppresses malignancy in bladder cancer cell lines. However, the detail of its anti-carcinogenic effect in vivo is not fully understood. This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN), with and without GTP. Methods : Eight-week-old female C3H/He mice were treated with and without 0.05% BBN solution for 14 or 24 weeks. In addition, they were also treated with and without 0.5% GTP solution for the same periods. Histopathological diagnosis was established using hematoxylin and eosin staining, and microvessel density (MVD) was estimated by counting CD34- and von Willebrand factor-positive vessels in the tumor area. Results : At 14 weeks, cancer cells were detected in BBN and BBN + GTP mice [5/14 (35.7%) and 3/14 (21.4%), respectively, p = 0.678]. At 24 weeks, the incidence of cancer cells was also similar between the groups (BBN + GTP: 61.9% vs. BBN: 82.6%; p = 0.179). However, the frequency of invasive tumors in BBN + GTP mice was significantly lower (23.8%; p = 0.030) than in those given BBN alone (65.2%). Tumor volume and MVD of intratumoral and stromal region in the BBN + GTP group were also significantly lower than in BBN mice. Conclusion : The results showed that GTP had no anti-carcinogenic effect, but inhibited tumor growth and invasion in mice with established bladder cancer, at least in part through the regulation of angiogenesis. Our data suggest that GTP seems to suppress tumor development in bladder cancer.
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subjectAngiogenesis ; Angiogenesis Inhibitors - therapeutic use ; Animals ; Antineoplastic Agents, Phytogenic - therapeutic use ; Bladder cancer ; Butylhydroxybutylnitrosamine ; Camellia sinensis ; Cancer ; Cancer prevention ; Chemical-induced model ; Drinking water ; Female ; Flavonoids - therapeutic use ; Green tea polyphenol ; Hematology, Oncology and Palliative Medicine ; Internal Medicine ; Mice ; Mortality ; Neoplasm Invasiveness ; Phenols - therapeutic use ; Plant Extracts - therapeutic use ; Polyphenols ; Rodents ; Studies ; Urinary Bladder Neoplasms - chemically induced ; Urinary Bladder Neoplasms - drug therapy ; Urinary Bladder Neoplasms - pathology
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descriptionAbstract Background : Green tea polyphenol (GTP) suppresses malignancy in bladder cancer cell lines. However, the detail of its anti-carcinogenic effect in vivo is not fully understood. This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN), with and without GTP. Methods : Eight-week-old female C3H/He mice were treated with and without 0.05% BBN solution for 14 or 24 weeks. In addition, they were also treated with and without 0.5% GTP solution for the same periods. Histopathological diagnosis was established using hematoxylin and eosin staining, and microvessel density (MVD) was estimated by counting CD34- and von Willebrand factor-positive vessels in the tumor area. Results : At 14 weeks, cancer cells were detected in BBN and BBN + GTP mice [5/14 (35.7%) and 3/14 (21.4%), respectively, p = 0.678]. At 24 weeks, the incidence of cancer cells was also similar between the groups (BBN + GTP: 61.9% vs. BBN: 82.6%; p = 0.179). However, the frequency of invasive tumors in BBN + GTP mice was significantly lower (23.8%; p = 0.030) than in those given BBN alone (65.2%). Tumor volume and MVD of intratumoral and stromal region in the BBN + GTP group were also significantly lower than in BBN mice. Conclusion : The results showed that GTP had no anti-carcinogenic effect, but inhibited tumor growth and invasion in mice with established bladder cancer, at least in part through the regulation of angiogenesis. Our data suggest that GTP seems to suppress tumor development in bladder cancer.
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2Animals
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4Bladder cancer
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19Phenols - therapeutic use
20Plant Extracts - therapeutic use
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22Rodents
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26Urinary Bladder Neoplasms - pathology
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titleGreen tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer
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abstractAbstract Background : Green tea polyphenol (GTP) suppresses malignancy in bladder cancer cell lines. However, the detail of its anti-carcinogenic effect in vivo is not fully understood. This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN), with and without GTP. Methods : Eight-week-old female C3H/He mice were treated with and without 0.05% BBN solution for 14 or 24 weeks. In addition, they were also treated with and without 0.5% GTP solution for the same periods. Histopathological diagnosis was established using hematoxylin and eosin staining, and microvessel density (MVD) was estimated by counting CD34- and von Willebrand factor-positive vessels in the tumor area. Results : At 14 weeks, cancer cells were detected in BBN and BBN + GTP mice [5/14 (35.7%) and 3/14 (21.4%), respectively, p = 0.678]. At 24 weeks, the incidence of cancer cells was also similar between the groups (BBN + GTP: 61.9% vs. BBN: 82.6%; p = 0.179). However, the frequency of invasive tumors in BBN + GTP mice was significantly lower (23.8%; p = 0.030) than in those given BBN alone (65.2%). Tumor volume and MVD of intratumoral and stromal region in the BBN + GTP group were also significantly lower than in BBN mice. Conclusion : The results showed that GTP had no anti-carcinogenic effect, but inhibited tumor growth and invasion in mice with established bladder cancer, at least in part through the regulation of angiogenesis. Our data suggest that GTP seems to suppress tumor development in bladder cancer.
copNetherlands
pubElsevier Ltd
pmid20362526
doi10.1016/j.canep.2010.03.001