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[alpha]-Lipoic acid supplementation enhances heat shock protein production and decreases post exercise lactic acid concentrations in exercised standardbred trotters

Byline: S. Kinnunen (a), S. Hyyppa (b), N. Oksala (c), D.E. Laaksonen (a)(d), M.-L. Hannila (e), C.K. Sen (f), M. Atalay (a) Keywords: Lipoic acid; Stress proteins; Exercise; Oxidative capacity; Horse Heat shock protein (HSP) expression is an adaptive mechanism against the disruption of cell homeost... Full description

Journal Title: Research in veterinary science 2009, Vol.87 (3), p.462
Main Author: Kinnunen, S
Other Authors: Hyyppa, S , Oksala, N , Laaksonen, D.E , Hannila, M.-L , Sen, C.K , Atalay, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Oxford: Elsevier B.V
ID: ISSN: 0034-5288
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title: [alpha]-Lipoic acid supplementation enhances heat shock protein production and decreases post exercise lactic acid concentrations in exercised standardbred trotters
format: Article
creator:
  • Kinnunen, S
  • Hyyppa, S
  • Oksala, N
  • Laaksonen, D.E
  • Hannila, M.-L
  • Sen, C.K
  • Atalay, M
subjects:
  • Aspartate
  • Citrates
  • Creatine
  • Creatine kinase
  • Exercise
  • Fitness equipment
  • Glucose
  • Harness racehorses
  • Heat shock proteins
  • Horses
  • Lactic acid
  • Legislators
  • Muscular system
  • Musculoskeletal system
  • Oxidative stress
  • Production management
  • Protein folding
  • Proteins
ispartof: Research in veterinary science, 2009, Vol.87 (3), p.462
description: Byline: S. Kinnunen (a), S. Hyyppa (b), N. Oksala (c), D.E. Laaksonen (a)(d), M.-L. Hannila (e), C.K. Sen (f), M. Atalay (a) Keywords: Lipoic acid; Stress proteins; Exercise; Oxidative capacity; Horse Heat shock protein (HSP) expression is an adaptive mechanism against the disruption of cell homeostasis during exercise. Several antioxidant supplementation strategies have been used to enhance tissue protection. In this study, we examined the effects of a redox modulator, [alpha]-lipoic acid (LA) on HSP responses in six standardbred trotters following intense aerobic exercise. DL-LA supplementation (25mgkg.sup.-1 d.sup.-1) for five weeks increased the resting levels of HSP90 (1.02[+ or -]0.155 in control and 1.26[+ or -]0.090 after supplementation in arbitrary units) and the recovery levels of inducible HSP70 (0.89[+ or -]0.056 in control and 1.05[+ or -]0.089 after supplementation in arbitrary units) in skeletal muscle. Furthermore, LA increased skeletal muscle citrate synthase activity at rest and lowered the blood lactate concentration during exercise without any changes in the heart rate. LA had no effect on concentrations of HSP60, HSP25 or GRP75 in skeletal muscle. LA decreased the exercise-induced increases in plasma aspartate aminotransferase and creatine kinase concentrations during recovery. Our results suggest that LA supplementation may enhance tissue protection and increase oxidative capacity of the muscle in horse. Author Affiliation: (a) Institute of Biomedicine, Physiology, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland (b) Equine Research, MTT Agrifood Finland, 32100 Ypaja, Finland (c) Division of Vascular Surgery, Department of Surgery, Tampere University Hospital, 33521 Tampere, Finland (d) Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland (e) Information Technology Centre, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland (f) Laboratory of Molecular Medicine, Department of Surgery, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA Article History: Accepted 16 April 2009
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0034-5288
fulltext: fulltext
issn:
  • 0034-5288
  • 1532-2661
url: Link


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title[alpha]-Lipoic acid supplementation enhances heat shock protein production and decreases post exercise lactic acid concentrations in exercised standardbred trotters
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creatorKinnunen, S ; Hyyppa, S ; Oksala, N ; Laaksonen, D.E ; Hannila, M.-L ; Sen, C.K ; Atalay, M
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subjectAspartate ; Citrates ; Creatine ; Creatine kinase ; Exercise ; Fitness equipment ; Glucose ; Harness racehorses ; Heat shock proteins ; Horses ; Lactic acid ; Legislators ; Muscular system ; Musculoskeletal system ; Oxidative stress ; Production management ; Protein folding ; Proteins
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title[alpha]-Lipoic acid supplementation enhances heat shock protein production and decreases post exercise lactic acid concentrations in exercised standardbred trotters
authorKinnunen, S ; Hyyppa, S ; Oksala, N ; Laaksonen, D.E ; Hannila, M.-L ; Sen, C.K ; Atalay, M
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atitle[alpha]-Lipoic acid supplementation enhances heat shock protein production and decreases post exercise lactic acid concentrations in exercised standardbred trotters
jtitleResearch in veterinary science
date2009-12-01
risdate2009
volume87
issue3
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pages462-
issn0034-5288
eissn1532-2661
abstractByline: S. Kinnunen (a), S. Hyyppa (b), N. Oksala (c), D.E. Laaksonen (a)(d), M.-L. Hannila (e), C.K. Sen (f), M. Atalay (a) Keywords: Lipoic acid; Stress proteins; Exercise; Oxidative capacity; Horse Heat shock protein (HSP) expression is an adaptive mechanism against the disruption of cell homeostasis during exercise. Several antioxidant supplementation strategies have been used to enhance tissue protection. In this study, we examined the effects of a redox modulator, [alpha]-lipoic acid (LA) on HSP responses in six standardbred trotters following intense aerobic exercise. DL-LA supplementation (25mgkg.sup.-1 d.sup.-1) for five weeks increased the resting levels of HSP90 (1.02[+ or -]0.155 in control and 1.26[+ or -]0.090 after supplementation in arbitrary units) and the recovery levels of inducible HSP70 (0.89[+ or -]0.056 in control and 1.05[+ or -]0.089 after supplementation in arbitrary units) in skeletal muscle. Furthermore, LA increased skeletal muscle citrate synthase activity at rest and lowered the blood lactate concentration during exercise without any changes in the heart rate. LA had no effect on concentrations of HSP60, HSP25 or GRP75 in skeletal muscle. LA decreased the exercise-induced increases in plasma aspartate aminotransferase and creatine kinase concentrations during recovery. Our results suggest that LA supplementation may enhance tissue protection and increase oxidative capacity of the muscle in horse. Author Affiliation: (a) Institute of Biomedicine, Physiology, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland (b) Equine Research, MTT Agrifood Finland, 32100 Ypaja, Finland (c) Division of Vascular Surgery, Department of Surgery, Tampere University Hospital, 33521 Tampere, Finland (d) Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland (e) Information Technology Centre, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland (f) Laboratory of Molecular Medicine, Department of Surgery, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA Article History: Accepted 16 April 2009
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pubElsevier B.V
doi10.1016/j.rvsc.2009.04.009