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Diabetic retinopathy at diagnosis of type 2 diabetes in the UK: a database analysis

Aims/hypothesis The aim of this study was to estimate the prevalence of and risk factors for diabetic retinopathy in newly diagnosed type 2 diabetes in general practices in the UK. Methods The Disease Analyzer Database (UK) assembles longitudinal data on diagnoses, prescriptions and laboratory value... Full description

Journal Title: Diabetologia 2012-10-06, Vol.56 (1), p.109-111
Main Author: Kostev, K
Other Authors: Rathmann, W
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0012-186X
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title: Diabetic retinopathy at diagnosis of type 2 diabetes in the UK: a database analysis
format: Article
creator:
  • Kostev, K
  • Rathmann, W
subjects:
  • Age Factors
  • Aged
  • Analysis
  • Antihypertensive Agents - adverse effects
  • Antihypertensive Agents - therapeutic use
  • Biological and medical sciences
  • Databases
  • Databases, Factual
  • Diabetes Mellitus, Type 2 - blood
  • Diabetes Mellitus, Type 2 - complications
  • Diabetes Mellitus, Type 2 - diagnosis
  • Diabetes. Impaired glucose tolerance
  • Diabetic retinopathy
  • Diabetic Retinopathy - chemically induced
  • Diabetic Retinopathy - diagnosis
  • Diabetic Retinopathy - epidemiology
  • Diabetic Retinopathy - etiology
  • Early Diagnosis
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Family medicine
  • Female
  • General Practice
  • Glycated Hemoglobin A - analysis
  • Human Physiology
  • Humans
  • Hyperglycemia
  • Hyperglycemia - etiology
  • Hyperglycemia - physiopathology
  • Hypertension
  • Hypertension - complications
  • Hypertension - drug therapy
  • Hypertension - physiopathology
  • Internal Medicine
  • Longitudinal Studies
  • Male
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Middle Aged
  • Ophthalmology
  • Physicians (General practice)
  • Prevalence
  • Retinopathies
  • Retrospective Studies
  • Risk Factors
  • Sex Characteristics
  • Short Communication
  • Type 2 diabetes
  • United Kingdom - epidemiology
ispartof: Diabetologia, 2012-10-06, Vol.56 (1), p.109-111
description: Aims/hypothesis The aim of this study was to estimate the prevalence of and risk factors for diabetic retinopathy in newly diagnosed type 2 diabetes in general practices in the UK. Methods The Disease Analyzer Database (UK) assembles longitudinal data on diagnoses, prescriptions and laboratory values reported from 674 office-based physicians (97 general practices). Patients with newly diagnosed type 2 diabetes (between 2005 and 2009) were identified and the presence of retinopathy was defined based on the International Classification of Diseases code (E11.3) or on the original diagnosis text. The time period between first diabetes diagnosis and first retinopathy diagnosis was calculated. Logistic regression was used to examine associations of potential risk factors with prevalent diabetic retinopathy. Results There were 12,524 patients with newly diagnosed type 2 diabetes mellitus in the general practices. The mean age was 65 years with slightly more male patients (56%). The prevalence of diagnosed retinopathy was 19.0% (95% CI 18.3%, 19.7%). The median time to first retinopathy diagnosis was 309 (interquartile range 50–693) days. Factors independently associated with retinopathy in multivariate logistic regression were age (OR 1.02 [95% CI 1.01, 1.03] per year of age), male sex (OR 1.11 [95% CI 1.01, 1.22]), HbA 1c (OR 1.12 [95% CI 1.02, 1.22] per 1% [11 mmol/mol] increase), systolic blood pressure (OR 1.03 [95% CI 1.01, 1.05] per 10 units) and antihypertensive drugs. No significant relationships were observed for obesity and diastolic blood pressure. Conclusions/interpretation Diabetic retinopathy was diagnosed in about one out of five patients with type 2 diabetes during the first year after diabetes diagnosis in UK general practices. Age, male sex, hyperglycaemia and hypertension were identified as risk factors of early retinopathy in type 2 diabetes.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleDiabetic retinopathy at diagnosis of type 2 diabetes in the UK: a database analysis
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descriptionAims/hypothesis The aim of this study was to estimate the prevalence of and risk factors for diabetic retinopathy in newly diagnosed type 2 diabetes in general practices in the UK. Methods The Disease Analyzer Database (UK) assembles longitudinal data on diagnoses, prescriptions and laboratory values reported from 674 office-based physicians (97 general practices). Patients with newly diagnosed type 2 diabetes (between 2005 and 2009) were identified and the presence of retinopathy was defined based on the International Classification of Diseases code (E11.3) or on the original diagnosis text. The time period between first diabetes diagnosis and first retinopathy diagnosis was calculated. Logistic regression was used to examine associations of potential risk factors with prevalent diabetic retinopathy. Results There were 12,524 patients with newly diagnosed type 2 diabetes mellitus in the general practices. The mean age was 65 years with slightly more male patients (56%). The prevalence of diagnosed retinopathy was 19.0% (95% CI 18.3%, 19.7%). The median time to first retinopathy diagnosis was 309 (interquartile range 50–693) days. Factors independently associated with retinopathy in multivariate logistic regression were age (OR 1.02 [95% CI 1.01, 1.03] per year of age), male sex (OR 1.11 [95% CI 1.01, 1.22]), HbA 1c (OR 1.12 [95% CI 1.02, 1.22] per 1% [11 mmol/mol] increase), systolic blood pressure (OR 1.03 [95% CI 1.01, 1.05] per 10 units) and antihypertensive drugs. No significant relationships were observed for obesity and diastolic blood pressure. Conclusions/interpretation Diabetic retinopathy was diagnosed in about one out of five patients with type 2 diabetes during the first year after diabetes diagnosis in UK general practices. Age, male sex, hyperglycaemia and hypertension were identified as risk factors of early retinopathy in type 2 diabetes.
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subjectAge Factors ; Aged ; Analysis ; Antihypertensive Agents - adverse effects ; Antihypertensive Agents - therapeutic use ; Biological and medical sciences ; Databases ; Databases, Factual ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes. Impaired glucose tolerance ; Diabetic retinopathy ; Diabetic Retinopathy - chemically induced ; Diabetic Retinopathy - diagnosis ; Diabetic Retinopathy - epidemiology ; Diabetic Retinopathy - etiology ; Early Diagnosis ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Family medicine ; Female ; General Practice ; Glycated Hemoglobin A - analysis ; Human Physiology ; Humans ; Hyperglycemia ; Hyperglycemia - etiology ; Hyperglycemia - physiopathology ; Hypertension ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - physiopathology ; Internal Medicine ; Longitudinal Studies ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Ophthalmology ; Physicians (General practice) ; Prevalence ; Retinopathies ; Retrospective Studies ; Risk Factors ; Sex Characteristics ; Short Communication ; Type 2 diabetes ; United Kingdom - epidemiology
ispartofDiabetologia, 2012-10-06, Vol.56 (1), p.109-111
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descriptionAims/hypothesis The aim of this study was to estimate the prevalence of and risk factors for diabetic retinopathy in newly diagnosed type 2 diabetes in general practices in the UK. Methods The Disease Analyzer Database (UK) assembles longitudinal data on diagnoses, prescriptions and laboratory values reported from 674 office-based physicians (97 general practices). Patients with newly diagnosed type 2 diabetes (between 2005 and 2009) were identified and the presence of retinopathy was defined based on the International Classification of Diseases code (E11.3) or on the original diagnosis text. The time period between first diabetes diagnosis and first retinopathy diagnosis was calculated. Logistic regression was used to examine associations of potential risk factors with prevalent diabetic retinopathy. Results There were 12,524 patients with newly diagnosed type 2 diabetes mellitus in the general practices. The mean age was 65 years with slightly more male patients (56%). The prevalence of diagnosed retinopathy was 19.0% (95% CI 18.3%, 19.7%). The median time to first retinopathy diagnosis was 309 (interquartile range 50–693) days. Factors independently associated with retinopathy in multivariate logistic regression were age (OR 1.02 [95% CI 1.01, 1.03] per year of age), male sex (OR 1.11 [95% CI 1.01, 1.22]), HbA 1c (OR 1.12 [95% CI 1.02, 1.22] per 1% [11 mmol/mol] increase), systolic blood pressure (OR 1.03 [95% CI 1.01, 1.05] per 10 units) and antihypertensive drugs. No significant relationships were observed for obesity and diastolic blood pressure. Conclusions/interpretation Diabetic retinopathy was diagnosed in about one out of five patients with type 2 diabetes during the first year after diabetes diagnosis in UK general practices. Age, male sex, hyperglycaemia and hypertension were identified as risk factors of early retinopathy in type 2 diabetes.
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5Biological and medical sciences
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8Diabetes Mellitus, Type 2 - blood
9Diabetes Mellitus, Type 2 - complications
10Diabetes Mellitus, Type 2 - diagnosis
11Diabetes. Impaired glucose tolerance
12Diabetic retinopathy
13Diabetic Retinopathy - chemically induced
14Diabetic Retinopathy - diagnosis
15Diabetic Retinopathy - epidemiology
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18Endocrine pancreas. Apud cells (diseases)
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20Etiopathogenesis. Screening. Investigations. Target tissue resistance
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22Female
23General Practice
24Glycated Hemoglobin A - analysis
25Human Physiology
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27Hyperglycemia
28Hyperglycemia - etiology
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31Hypertension - complications
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33Hypertension - physiopathology
34Internal Medicine
35Longitudinal Studies
36Male
37Medical sciences
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39Medicine & Public Health
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42Ophthalmology
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45Retinopathies
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abstractAims/hypothesis The aim of this study was to estimate the prevalence of and risk factors for diabetic retinopathy in newly diagnosed type 2 diabetes in general practices in the UK. Methods The Disease Analyzer Database (UK) assembles longitudinal data on diagnoses, prescriptions and laboratory values reported from 674 office-based physicians (97 general practices). Patients with newly diagnosed type 2 diabetes (between 2005 and 2009) were identified and the presence of retinopathy was defined based on the International Classification of Diseases code (E11.3) or on the original diagnosis text. The time period between first diabetes diagnosis and first retinopathy diagnosis was calculated. Logistic regression was used to examine associations of potential risk factors with prevalent diabetic retinopathy. Results There were 12,524 patients with newly diagnosed type 2 diabetes mellitus in the general practices. The mean age was 65 years with slightly more male patients (56%). The prevalence of diagnosed retinopathy was 19.0% (95% CI 18.3%, 19.7%). The median time to first retinopathy diagnosis was 309 (interquartile range 50–693) days. Factors independently associated with retinopathy in multivariate logistic regression were age (OR 1.02 [95% CI 1.01, 1.03] per year of age), male sex (OR 1.11 [95% CI 1.01, 1.22]), HbA 1c (OR 1.12 [95% CI 1.02, 1.22] per 1% [11 mmol/mol] increase), systolic blood pressure (OR 1.03 [95% CI 1.01, 1.05] per 10 units) and antihypertensive drugs. No significant relationships were observed for obesity and diastolic blood pressure. Conclusions/interpretation Diabetic retinopathy was diagnosed in about one out of five patients with type 2 diabetes during the first year after diabetes diagnosis in UK general practices. Age, male sex, hyperglycaemia and hypertension were identified as risk factors of early retinopathy in type 2 diabetes.
copBerlin/Heidelberg
pubSpringer-Verlag
pmid23052061
doi10.1007/s00125-012-2742-7