schliessen

Filtern

 

Bibliotheken

Dietary genistein suppresses chemically induced prostate cancer in Lobund–Wistar rats

Epidemiological reports suggest that Asians consuming a diet high in soy have a low incidence of clinically manifested prostate cancer. We have tested the hypothesis that life-time exposure to genistein, the primary isoflavone component of soy, is responsible for this protective effect. Lobund–Wista... Full description

Journal Title: Cancer letters 2002, Vol.186 (1), p.11-18
Main Author: Wang, Jun
Other Authors: Eltoum, Isam-Eldin , Lamartiniere, Coral A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Rat
Quelle: Alma/SFX Local Collection
Publisher: Shannon: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_journals_1505362193
title: Dietary genistein suppresses chemically induced prostate cancer in Lobund–Wistar rats
format: Article
creator:
  • Wang, Jun
  • Eltoum, Isam-Eldin
  • Lamartiniere, Coral A
subjects:
  • Animals
  • Anticarcinogenic Agents - administration & dosage
  • Biological and medical sciences
  • Cancer
  • Chemoprevention
  • Diet
  • General pharmacology
  • Genistein
  • Genistein - administration & dosage
  • Genistein - pharmacokinetics
  • Male
  • Medical research
  • Medical sciences
  • Methylnitrosourea
  • Pharmacognosy. Homeopathy. Health food
  • Pharmacology. Drug treatments
  • Prostate
  • Prostate cancer
  • Prostatic Neoplasms - chemically induced
  • Prostatic Neoplasms - prevention & control
  • Rat
  • Rats
  • Rats, Wistar
  • Rodents
  • Soy products
ispartof: Cancer letters, 2002, Vol.186 (1), p.11-18
description: Epidemiological reports suggest that Asians consuming a diet high in soy have a low incidence of clinically manifested prostate cancer. We have tested the hypothesis that life-time exposure to genistein, the primary isoflavone component of soy, is responsible for this protective effect. Lobund–Wistar rats were exposed to 0, 25 and 250 mg genistein/kg AIN-76A diet, starting at conception and continued until necropsy at 11 months. Male offspring were injected s.c. with Flutamide on days 50-66 and with testosterone on days 67-69, injected with N-methylnitrosourea (NMU) into the dorsal prostate on day 70, and given testosterone implants, starting at day 77. Genistein in the diet inhibited the development of NMU-induced prostate invasive adenocarcinomas, in a dose-dependent manner. Genistein did not alter body, prostate and testes weights. Male rats fed 0, 25 and 250 mg genistein/kg diet had serum genistein concentrations of 9, 60 and 861 pmol/ml, and prostate genistein concentrations of 85, 230 and 775 pmol/g tissue. We conclude that lifetime dietary genistein protected against chemically induced prostate cancer development in rats.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.2555327
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_journals_1505362193
sourceformatXML
sourcesystemPC
sourcerecordid3241471331
originalsourceidFETCH-LOGICAL-c410t-3fdbcff69903bad880bee5acca73dae8c4fc1775d1b63d1d424325dbc922cda33
addsrcrecordideNqFkN1KHDEYhkNR6mp7CZUBEfRg7PdNkvmhByJqq7DgQVs8DJnkG43szmyTjOCZ9-AdeiVm3aWCJx4FwvO-efMw9g3hCAHL77-Bg8h5zeUB4CFAjZiLT2yCdVXkVVPDBpv8R7bYdgh3ACBFJT-zLSyw5lDBhF2fOYraP2Q31LsQyfVZGBcLTyFQyMwtzZ3Rs9lD5no7GrLZwg8h6kiZ0b0hn-6z6dCOvX1-fLpODdpnXsfwhW12ehbo6_rcYX9_nv85vcinV78uT0-muREIMeedbU3XlU0DvNW2rqElktoYXXGrqTaiM1hV0mJbcotWFIIXMmWaojBWc77D9la9ade_kUJUd8Po-_SkQgmSlwU2S0quKJPWB0-dWng3T99WCGqpU73qVEtXClC96lQi5XbX7WM7J_uWWvtLwP4a0CF56nyS4sIbJ0RTNFWZuB_vBhiXLLqhj1672YczjldpSibvHXkVjKOk3zpPJio7uA8aXgC76aaF
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1505362193
display
typearticle
titleDietary genistein suppresses chemically induced prostate cancer in Lobund–Wistar rats
sourceAlma/SFX Local Collection
creatorWang, Jun ; Eltoum, Isam-Eldin ; Lamartiniere, Coral A
creatorcontribWang, Jun ; Eltoum, Isam-Eldin ; Lamartiniere, Coral A
descriptionEpidemiological reports suggest that Asians consuming a diet high in soy have a low incidence of clinically manifested prostate cancer. We have tested the hypothesis that life-time exposure to genistein, the primary isoflavone component of soy, is responsible for this protective effect. Lobund–Wistar rats were exposed to 0, 25 and 250 mg genistein/kg AIN-76A diet, starting at conception and continued until necropsy at 11 months. Male offspring were injected s.c. with Flutamide on days 50-66 and with testosterone on days 67-69, injected with N-methylnitrosourea (NMU) into the dorsal prostate on day 70, and given testosterone implants, starting at day 77. Genistein in the diet inhibited the development of NMU-induced prostate invasive adenocarcinomas, in a dose-dependent manner. Genistein did not alter body, prostate and testes weights. Male rats fed 0, 25 and 250 mg genistein/kg diet had serum genistein concentrations of 9, 60 and 861 pmol/ml, and prostate genistein concentrations of 85, 230 and 775 pmol/g tissue. We conclude that lifetime dietary genistein protected against chemically induced prostate cancer development in rats.
identifier
0ISSN: 0304-3835
1EISSN: 1872-7980
2DOI: 10.1016/S0304-3835(01)00811-4
3PMID: 12183070
4CODEN: CALEDQ
languageeng
publisherShannon: Elsevier Ireland Ltd
subjectAnimals ; Anticarcinogenic Agents - administration & dosage ; Biological and medical sciences ; Cancer ; Chemoprevention ; Diet ; General pharmacology ; Genistein ; Genistein - administration & dosage ; Genistein - pharmacokinetics ; Male ; Medical research ; Medical sciences ; Methylnitrosourea ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Prostate ; Prostate cancer ; Prostatic Neoplasms - chemically induced ; Prostatic Neoplasms - prevention & control ; Rat ; Rats ; Rats, Wistar ; Rodents ; Soy products
ispartofCancer letters, 2002, Vol.186 (1), p.11-18
rights
02002 Elsevier Science Ireland Ltd
12003 INIST-CNRS
2Copyright Elsevier Limited Dec 1, 2002
lds50peer_reviewed
citedbyFETCH-LOGICAL-c410t-3fdbcff69903bad880bee5acca73dae8c4fc1775d1b63d1d424325dbc922cda33
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14492976$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12183070$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Wang, Jun
1Eltoum, Isam-Eldin
2Lamartiniere, Coral A
title
0Dietary genistein suppresses chemically induced prostate cancer in Lobund–Wistar rats
1Cancer letters
addtitleCancer Lett
descriptionEpidemiological reports suggest that Asians consuming a diet high in soy have a low incidence of clinically manifested prostate cancer. We have tested the hypothesis that life-time exposure to genistein, the primary isoflavone component of soy, is responsible for this protective effect. Lobund–Wistar rats were exposed to 0, 25 and 250 mg genistein/kg AIN-76A diet, starting at conception and continued until necropsy at 11 months. Male offspring were injected s.c. with Flutamide on days 50-66 and with testosterone on days 67-69, injected with N-methylnitrosourea (NMU) into the dorsal prostate on day 70, and given testosterone implants, starting at day 77. Genistein in the diet inhibited the development of NMU-induced prostate invasive adenocarcinomas, in a dose-dependent manner. Genistein did not alter body, prostate and testes weights. Male rats fed 0, 25 and 250 mg genistein/kg diet had serum genistein concentrations of 9, 60 and 861 pmol/ml, and prostate genistein concentrations of 85, 230 and 775 pmol/g tissue. We conclude that lifetime dietary genistein protected against chemically induced prostate cancer development in rats.
subject
0Animals
1Anticarcinogenic Agents - administration & dosage
2Biological and medical sciences
3Cancer
4Chemoprevention
5Diet
6General pharmacology
7Genistein
8Genistein - administration & dosage
9Genistein - pharmacokinetics
10Male
11Medical research
12Medical sciences
13Methylnitrosourea
14Pharmacognosy. Homeopathy. Health food
15Pharmacology. Drug treatments
16Prostate
17Prostate cancer
18Prostatic Neoplasms - chemically induced
19Prostatic Neoplasms - prevention & control
20Rat
21Rats
22Rats, Wistar
23Rodents
24Soy products
issn
00304-3835
11872-7980
fulltexttrue
rsrctypearticle
creationdate2002
recordtypearticle
recordideNqFkN1KHDEYhkNR6mp7CZUBEfRg7PdNkvmhByJqq7DgQVs8DJnkG43szmyTjOCZ9-AdeiVm3aWCJx4FwvO-efMw9g3hCAHL77-Bg8h5zeUB4CFAjZiLT2yCdVXkVVPDBpv8R7bYdgh3ACBFJT-zLSyw5lDBhF2fOYraP2Q31LsQyfVZGBcLTyFQyMwtzZ3Rs9lD5no7GrLZwg8h6kiZ0b0hn-6z6dCOvX1-fLpODdpnXsfwhW12ehbo6_rcYX9_nv85vcinV78uT0-muREIMeedbU3XlU0DvNW2rqElktoYXXGrqTaiM1hV0mJbcotWFIIXMmWaojBWc77D9la9ade_kUJUd8Po-_SkQgmSlwU2S0quKJPWB0-dWng3T99WCGqpU73qVEtXClC96lQi5XbX7WM7J_uWWvtLwP4a0CF56nyS4sIbJ0RTNFWZuB_vBhiXLLqhj1672YczjldpSibvHXkVjKOk3zpPJio7uA8aXgC76aaF
startdate2002
enddate2002
creator
0Wang, Jun
1Eltoum, Isam-Eldin
2Lamartiniere, Coral A
general
0Elsevier Ireland Ltd
1Elsevier
2Elsevier Limited
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
93V.
107RV
117TO
127U9
137X7
147XB
1588E
1688G
178AO
188C1
198FE
208FH
218FI
228FJ
238FK
248G5
25ABUWG
26AZQEC
27BBNVY
28BENPR
29BHPHI
30DWQXO
31FYUFA
32GHDGH
33GNUQQ
34GUQSH
35H94
36HCIFZ
37K9.
38KB0
39LK8
40M0S
41M1P
42M2M
43M2O
44M7P
45MBDVC
46NAPCQ
47PADUT
48PQEST
49PQQKQ
50PQUKI
51PRINS
52Q9U
sort
creationdate2002
titleDietary genistein suppresses chemically induced prostate cancer in Lobund–Wistar rats
authorWang, Jun ; Eltoum, Isam-Eldin ; Lamartiniere, Coral A
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c410t-3fdbcff69903bad880bee5acca73dae8c4fc1775d1b63d1d424325dbc922cda33
rsrctypearticles
prefilterarticles
languageeng
creationdate2002
topic
0Animals
1Anticarcinogenic Agents - administration & dosage
2Biological and medical sciences
3Cancer
4Chemoprevention
5Diet
6General pharmacology
7Genistein
8Genistein - administration & dosage
9Genistein - pharmacokinetics
10Male
11Medical research
12Medical sciences
13Methylnitrosourea
14Pharmacognosy. Homeopathy. Health food
15Pharmacology. Drug treatments
16Prostate
17Prostate cancer
18Prostatic Neoplasms - chemically induced
19Prostatic Neoplasms - prevention & control
20Rat
21Rats
22Rats, Wistar
23Rodents
24Soy products
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Wang, Jun
1Eltoum, Isam-Eldin
2Lamartiniere, Coral A
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8ProQuest Central (Corporate)
9Nursing & Allied Health Database
10Oncogenes and Growth Factors Abstracts
11Virology and AIDS Abstracts
12Health & Medical Collection
13ProQuest Central (purchase pre-March 2016)
14Medical Database (Alumni Edition)
15Psychology Database (Alumni)
16ProQuest Pharma Collection
17Public Health Database
18ProQuest SciTech Collection
19ProQuest Natural Science Collection
20Hospital Premium Collection
21Hospital Premium Collection (Alumni Edition)
22ProQuest Central (Alumni) (purchase pre-March 2016)
23Research Library (Alumni Edition)
24ProQuest Central (Alumni Edition)
25ProQuest Central Essentials
26Biological Science Collection
27ProQuest Central
28Natural Science Collection
29ProQuest Central Korea
30Health Research Premium Collection
31Health Research Premium Collection (Alumni)
32ProQuest Central Student
33Research Library Prep
34AIDS and Cancer Research Abstracts
35SciTech Premium Collection
36ProQuest Health & Medical Complete (Alumni)
37Nursing & Allied Health Database (Alumni Edition)
38ProQuest Biological Science Collection
39Health & Medical Collection (Alumni Edition)
40Medical Database
41Psychology Database
42Research Library
43Biological Science Database
44Research Library (Corporate)
45Nursing & Allied Health Premium
46Research Library China
47ProQuest One Academic Eastern Edition
48ProQuest One Academic
49ProQuest One Academic UKI Edition
50ProQuest Central China
51ProQuest Central Basic
jtitleCancer letters
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Wang, Jun
1Eltoum, Isam-Eldin
2Lamartiniere, Coral A
formatjournal
genrearticle
ristypeJOUR
atitleDietary genistein suppresses chemically induced prostate cancer in Lobund–Wistar rats
jtitleCancer letters
addtitleCancer Lett
date2002
risdate2002
volume186
issue1
spage11
epage18
pages11-18
issn0304-3835
eissn1872-7980
codenCALEDQ
abstractEpidemiological reports suggest that Asians consuming a diet high in soy have a low incidence of clinically manifested prostate cancer. We have tested the hypothesis that life-time exposure to genistein, the primary isoflavone component of soy, is responsible for this protective effect. Lobund–Wistar rats were exposed to 0, 25 and 250 mg genistein/kg AIN-76A diet, starting at conception and continued until necropsy at 11 months. Male offspring were injected s.c. with Flutamide on days 50-66 and with testosterone on days 67-69, injected with N-methylnitrosourea (NMU) into the dorsal prostate on day 70, and given testosterone implants, starting at day 77. Genistein in the diet inhibited the development of NMU-induced prostate invasive adenocarcinomas, in a dose-dependent manner. Genistein did not alter body, prostate and testes weights. Male rats fed 0, 25 and 250 mg genistein/kg diet had serum genistein concentrations of 9, 60 and 861 pmol/ml, and prostate genistein concentrations of 85, 230 and 775 pmol/g tissue. We conclude that lifetime dietary genistein protected against chemically induced prostate cancer development in rats.
copShannon
pubElsevier Ireland Ltd
pmid12183070
doi10.1016/S0304-3835(01)00811-4