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Intrinsic Epigenetic Factors Cooperate with the Steroid Hormone Ecdysone to Govern Dendrite Pruning inDrosophila

Pruning that selectively removes unnecessary axons/dendrites is crucial for sculpting neural circuits during development. DuringDrosophilametamorphosis, dendritic arborization sensory neurons, ddaCs, selectively prune their larval dendrites in response to the steroid hormone ecdysone. However, it is... Full description

Journal Title: Neuron (Cambridge Mass.), 2011, Vol.72 (1), p.86
Main Author: Daniel Kirilly
Other Authors: Jack Jing Lin Wong , Edwin Kok Hao Lim , Yan Wang , Heng Zhang , Cheng Wang , Qiuming Liao , Haifeng Wang , Yih-Cherng Liou , Hongyan Wang , Fengwei Yu
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Cambridge: Elsevier Limited
ID: ISSN: 0896-6273
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recordid: cdi_proquest_journals_1547872299
title: Intrinsic Epigenetic Factors Cooperate with the Steroid Hormone Ecdysone to Govern Dendrite Pruning inDrosophila
format: Article
creator:
  • Daniel Kirilly
  • Jack Jing Lin Wong
  • Edwin Kok Hao Lim
  • Yan Wang
  • Heng Zhang
  • Cheng Wang
  • Qiuming Liao
  • Haifeng Wang
  • Yih-Cherng Liou
  • Hongyan Wang
  • Fengwei Yu
subjects:
  • Epigenetics
  • Gene expression
  • Insects
  • Nervous system
  • Neurons
  • Transcription factors
ispartof: Neuron (Cambridge, Mass.), 2011, Vol.72 (1), p.86
description: Pruning that selectively removes unnecessary axons/dendrites is crucial for sculpting neural circuits during development. DuringDrosophilametamorphosis, dendritic arborization sensory neurons, ddaCs, selectively prune their larval dendrites in response to the steroid hormone ecdysone. However, it is unknown whether epigenetic factors are involved in dendrite pruning. Here, we analyzed 81 epigenetic factors, from which a Brahma (Brm)-containing chromatin remodeler and a histone acetyltransferase CREB-binding protein (CBP) were identified for their critical roles in initiating dendrite pruning. Brm and CBP specifically activate a key ecdysone response gene,sox14, but notEcR-B1. Furthermore, the HAT activity of CBP is important forsox14expression and dendrite pruning. EcR-B1 associates with CBP in the presence of ecdysone, which is facilitated by Brm, resulting in local enrichment of an active chromatin mark H3K27Ac at thesox14locus. Thus, specific intrinsic epigenetic factors cooperate with steroid hormones to activate selective transcriptional programs, thereby initiating neuronal remodeling.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0896-6273
fulltext: fulltext
issn:
  • 0896-6273
  • 1097-4199
url: Link


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titleIntrinsic Epigenetic Factors Cooperate with the Steroid Hormone Ecdysone to Govern Dendrite Pruning inDrosophila
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creatorDaniel Kirilly ; Jack Jing Lin Wong ; Edwin Kok Hao Lim ; Yan Wang ; Heng Zhang ; Cheng Wang ; Qiuming Liao ; Haifeng Wang ; Yih-Cherng Liou ; Hongyan Wang ; Fengwei Yu
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descriptionPruning that selectively removes unnecessary axons/dendrites is crucial for sculpting neural circuits during development. DuringDrosophilametamorphosis, dendritic arborization sensory neurons, ddaCs, selectively prune their larval dendrites in response to the steroid hormone ecdysone. However, it is unknown whether epigenetic factors are involved in dendrite pruning. Here, we analyzed 81 epigenetic factors, from which a Brahma (Brm)-containing chromatin remodeler and a histone acetyltransferase CREB-binding protein (CBP) were identified for their critical roles in initiating dendrite pruning. Brm and CBP specifically activate a key ecdysone response gene,sox14, but notEcR-B1. Furthermore, the HAT activity of CBP is important forsox14expression and dendrite pruning. EcR-B1 associates with CBP in the presence of ecdysone, which is facilitated by Brm, resulting in local enrichment of an active chromatin mark H3K27Ac at thesox14locus. Thus, specific intrinsic epigenetic factors cooperate with steroid hormones to activate selective transcriptional programs, thereby initiating neuronal remodeling.
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abstractPruning that selectively removes unnecessary axons/dendrites is crucial for sculpting neural circuits during development. DuringDrosophilametamorphosis, dendritic arborization sensory neurons, ddaCs, selectively prune their larval dendrites in response to the steroid hormone ecdysone. However, it is unknown whether epigenetic factors are involved in dendrite pruning. Here, we analyzed 81 epigenetic factors, from which a Brahma (Brm)-containing chromatin remodeler and a histone acetyltransferase CREB-binding protein (CBP) were identified for their critical roles in initiating dendrite pruning. Brm and CBP specifically activate a key ecdysone response gene,sox14, but notEcR-B1. Furthermore, the HAT activity of CBP is important forsox14expression and dendrite pruning. EcR-B1 associates with CBP in the presence of ecdysone, which is facilitated by Brm, resulting in local enrichment of an active chromatin mark H3K27Ac at thesox14locus. Thus, specific intrinsic epigenetic factors cooperate with steroid hormones to activate selective transcriptional programs, thereby initiating neuronal remodeling.
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doi10.1016/j.neuron.2011.08.003