Swimming Training Prevents Alterations in Acetylcholinesterase and Butyrylcholinesterase Activities in Hypertensive Rats
Journal Title: | American journal of hypertension 2014-04, Vol.27 (4), p.522-529 |
Main Author: | Cardoso, Andréia Machado |
Other Authors: | Abdalla, Fátima Husein , Bagatini, Margarete Dulce , Martins, Caroline Curry , da Silva Fiorin, Fernando , Baldissarelli, Jucimara , Costa, Pauline , de Mello, Fábio Fernandes , Fiorenza, Amanda Maino , da Silva Serres, Jonas Daci , Gonçalves, Jamile Fabbrin , Chaves, Heloísa , Royes, Luiz Fernando Freire , Belló-Klein, Adriane , Morsch, Vera Maria , Schetinger, Maria Rosa Chitolina |
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English |
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Quelle: | Alma/SFX Local Collection |
Publisher: | US: Oxford University Press |
ID: | ISSN: 0895-7061 |
Link: | https://www.ncbi.nlm.nih.gov/pubmed/23479073 |
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recordid: | cdi_proquest_journals_1611607893 |
title: | Swimming Training Prevents Alterations in Acetylcholinesterase and Butyrylcholinesterase Activities in Hypertensive Rats |
format: | Article |
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ispartof: | American journal of hypertension, 2014-04, Vol.27 (4), p.522-529 |
description: | BACKGROUND Cholinergic enzyme activities are altered in hypertension, reflecting a low-grade inflammation. Regular physical exercise exerts anti-inflammatory effects and has been described as a coadjutant in the treatment of hypertension. In this study, we investigated the effect of 6 weeks of swimming training on cholinergic enzyme activities (acetylcholinesterase and butyrylcholinesterase) in Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. METHODS The rats were divided into 4 groups: control (n = 10), exercise (n = 10), L-NAME (n = 10), and exercise L-NAME (n = 10). The animals were trained 5 times per week in an adapted swimming system for 60 minutes with a gradual increase of the workload up to 5% of animal's body weight. Enzyme activities were measured spectrophotometrically in lymphocytes, whole blood, and serum. RESULTS A significant rise in acetylcholinesterase activity was observed in lymphocytes and whole blood as well as in serum butyrylcholinesterase activity in the L-NAME group when compared with the other groups (P < 0.05), and the increase in cholinesterase activities was positively correlated with the rise in blood pressure (r = 0.5721, r = 0.6121, and r = 0.5811, respectively). Swimming training was efficient in preventing these alterations in the exercise L-NAME group, which displayed values similar to those of the control group. Exercise training demonstrated a significant hypotensive effect in hypertensive rats. CONCLUSIONS Exercise training was shown to prevent increased cholinesterase related to inflammatory processes in hypertensive rats, providing a new insight about protective exercise mechanisms to avoid hypertension-related inflammation. |
language: | eng |
source: | Alma/SFX Local Collection |
identifier: | ISSN: 0895-7061 |
fulltext: | fulltext |
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