schliessen

Filtern

 

Bibliotheken

Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions

ObjectiveHelicobacter pylori infection and overexpression of cyclo-oxygenase-2 (COX-2) are associated with gastric cancer and its precursors. To evaluate the effect of a selective COX-2 inhibitor alone and combined with H pylori eradication on the evolution of precancerous gastric lesions, a randomi... Full description

Journal Title: Gut 2012-06, Vol.61 (6), p.812-818
Main Author: Wong, Benjamin C Y
Other Authors: Zhang, Lian , Ma, Jun-ling , Pan, Kai-feng , Li, Ji-you , Shen, Lin , Liu, Wei-dong , Feng, Guo-shuang , Zhang, Xiao-dong , Li, Jie , Lu, Ai-ping , Xia, Harry H X , Lam, Shiukum , You, Wei-cheng
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: London: BMJ Publishing Group Ltd and British Society of Gastroenterology
ID: ISSN: 0017-5749
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_journals_1779386136
title: Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions
format: Article
creator:
  • Wong, Benjamin C Y
  • Zhang, Lian
  • Ma, Jun-ling
  • Pan, Kai-feng
  • Li, Ji-you
  • Shen, Lin
  • Liu, Wei-dong
  • Feng, Guo-shuang
  • Zhang, Xiao-dong
  • Li, Jie
  • Lu, Ai-ping
  • Xia, Harry H X
  • Lam, Shiukum
  • You, Wei-cheng
subjects:
  • Adult
  • Amoxicillin - administration & dosage
  • Amoxicillin - therapeutic use
  • Anti-Bacterial Agents - administration & dosage
  • Anti-Bacterial Agents - therapeutic use
  • Antibiotics
  • Bacterial diseases
  • Bacterial diseases of the digestive system and abdomen
  • Biological and medical sciences
  • Biopsy
  • Bones, joints and connective tissue. Antiinflammatory agents
  • Celecoxib
  • cell proliferation
  • Clarithromycin - administration & dosage
  • Clarithromycin - therapeutic use
  • clinical trials
  • COX-2 inhibitor
  • COX-2 inhibitors
  • Cyclooxygenase 2 Inhibitors - therapeutic use
  • Dosage and administration
  • Double-Blind Method
  • Drug therapy
  • Drug Therapy, Combination
  • Endoscopy
  • epidemiology
  • Female
  • functional dyspepsia
  • Gastric cancer
  • Gastroenterology. Liver. Pancreas. Abdomen
  • Helicobacter infections
  • Helicobacter Infections - complications
  • Helicobacter Infections - drug therapy
  • Helicobacter pylori
  • Human bacterial diseases
  • Humans
  • Infectious diseases
  • intervention trial
  • Male
  • Medical sciences
  • Middle Aged
  • Omeprazole - administration & dosage
  • Omeprazole - therapeutic use
  • Pathology
  • Pharmacology. Drug treatments
  • Population
  • Precancerous conditions
  • Precancerous Conditions - etiology
  • Precancerous Conditions - pathology
  • Precancerous Conditions - prevention & control
  • precancerous lesions
  • Pyrazoles - therapeutic use
  • Quality
  • Stomach - pathology
  • Stomach cancer
  • Stomach Neoplasms - etiology
  • Stomach Neoplasms - pathology
  • Stomach Neoplasms - prevention & control
  • Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
  • Studies
  • Sulfonamides - therapeutic use
  • Tumors
ispartof: Gut, 2012-06, Vol.61 (6), p.812-818
description: ObjectiveHelicobacter pylori infection and overexpression of cyclo-oxygenase-2 (COX-2) are associated with gastric cancer and its precursors. To evaluate the effect of a selective COX-2 inhibitor alone and combined with H pylori eradication on the evolution of precancerous gastric lesions, a randomised, placebo-controlled trial was conducted in Linqu County, Shandong Province, China.MethodsA total of 1024 participants aged 35–64 years with H pylori infection and advanced gastric lesions were randomly assigned in a factorial design to two interventions or placebo: anti-H pylori treatment for 7 days, and a COX-2 inhibitor (celecoxib) for 24 months. The effects of the interventions were evaluated by the regression or progression of advanced gastric lesions.ResultsOf the 1024 participants who received anti-H pylori treatment or placebo, 919 completed a subsequent 24-month treatment with celecoxib or placebo. The H pylori eradication rate by per-protocol analysis was 78.2%. Compared with placebo, the proportions of regression of gastric lesions significantly increased in the celecoxib treatment (52.8% vs 41.2%) and anti-H pylori treatment (59.3% vs 41.2%) group, and OR by per-protocol analysis was 1.72 (95% CI 1.07 to 2.76) for celecoxib and 2.19 (95% CI 1.32 to 3.64) for H pylori eradication. No statistically significant effect was found for H pylori eradication followed by celecoxib on the regression of advanced gastric lesions (OR 1.48, 95% CI 0.91 to 2.40).ConclusionThis population-based intervention trial revealed that celecoxib treatment or H pylori eradication alone had beneficial effects on the regression of advanced gastric lesions. No favourable effects were seen for H pylori eradication followed by celecoxib treatment.Trial registrationHARECCTR0500053 in accordance with WHO ICTRP requirements.
language: eng
source:
identifier: ISSN: 0017-5749
fulltext: no_fulltext
issn:
  • 0017-5749
  • 1468-3288
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.634074
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_journals_1779386136
sourceformatXML
sourcesystemPC
galeidA296512932
sourcerecordidA296512932
originalsourceidFETCH-LOGICAL-1525t-1b6f8bf1be2faccfcb22cb1a34de4df1c76ba16b48ca03c8aea5b25e1e36eb1b0
addsrcrecordideNqFkl1rFDEUhgdR7Fr9A15IQARvpuZkJh9zWZdqhWKhVCnehCRzss06H9tkRuy_N8uuXRRBEkg45zlvPs5bFC-BngBU4t1qntZDVzIKUFaUAq8fFQuohSorptTjYpFjsuSybo6KZymtKaVKNfC0OGLQgBR1syhuz7xHNyUyepKwy9vwA8ny8qZkJAy3wYZpjMQMLTnHLrjRGjdhJJv7boyBYDRtcGYK40Dy3ER0ZnAYxzmRlUlTDI50mHI6PS-eeNMlfLFfj4svH86ul-flxeXHT8vTixI441MJVnhlPVhk3jjnnWXMWTBV3WLdenBSWAPC1soZWjll0HDLOAJWAi1Yely83elu4ng3Y5p0H5LDrjMD5mtp4BxEzYWo_49SRhWnTc0y-vovdD3OccgP0SBlUymRG3KgVqZDHQY_TtG4rag-ZY3gwJpqq3XyDyqPFvv8wwP6kON_FLzaHz7bHlu9iaE38V7_7mIG3uwBk5zpfMxNCOnAcSUlNCpz5Y4LacKfD3kTv2shK8n1569LfXP1_urbNeeaHXjbrx9ooHrrPr1zn966T-_cR38BBIXJyQ
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1779386136
display
typearticle
titleEffects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions
creatorWong, Benjamin C Y ; Zhang, Lian ; Ma, Jun-ling ; Pan, Kai-feng ; Li, Ji-you ; Shen, Lin ; Liu, Wei-dong ; Feng, Guo-shuang ; Zhang, Xiao-dong ; Li, Jie ; Lu, Ai-ping ; Xia, Harry H X ; Lam, Shiukum ; You, Wei-cheng
creatorcontribWong, Benjamin C Y ; Zhang, Lian ; Ma, Jun-ling ; Pan, Kai-feng ; Li, Ji-you ; Shen, Lin ; Liu, Wei-dong ; Feng, Guo-shuang ; Zhang, Xiao-dong ; Li, Jie ; Lu, Ai-ping ; Xia, Harry H X ; Lam, Shiukum ; You, Wei-cheng
descriptionObjectiveHelicobacter pylori infection and overexpression of cyclo-oxygenase-2 (COX-2) are associated with gastric cancer and its precursors. To evaluate the effect of a selective COX-2 inhibitor alone and combined with H pylori eradication on the evolution of precancerous gastric lesions, a randomised, placebo-controlled trial was conducted in Linqu County, Shandong Province, China.MethodsA total of 1024 participants aged 35–64 years with H pylori infection and advanced gastric lesions were randomly assigned in a factorial design to two interventions or placebo: anti-H pylori treatment for 7 days, and a COX-2 inhibitor (celecoxib) for 24 months. The effects of the interventions were evaluated by the regression or progression of advanced gastric lesions.ResultsOf the 1024 participants who received anti-H pylori treatment or placebo, 919 completed a subsequent 24-month treatment with celecoxib or placebo. The H pylori eradication rate by per-protocol analysis was 78.2%. Compared with placebo, the proportions of regression of gastric lesions significantly increased in the celecoxib treatment (52.8% vs 41.2%) and anti-H pylori treatment (59.3% vs 41.2%) group, and OR by per-protocol analysis was 1.72 (95% CI 1.07 to 2.76) for celecoxib and 2.19 (95% CI 1.32 to 3.64) for H pylori eradication. No statistically significant effect was found for H pylori eradication followed by celecoxib on the regression of advanced gastric lesions (OR 1.48, 95% CI 0.91 to 2.40).ConclusionThis population-based intervention trial revealed that celecoxib treatment or H pylori eradication alone had beneficial effects on the regression of advanced gastric lesions. No favourable effects were seen for H pylori eradication followed by celecoxib treatment.Trial registrationHARECCTR0500053 in accordance with WHO ICTRP requirements.
identifier
0ISSN: 0017-5749
1EISSN: 1468-3288
2DOI: 10.1136/gutjnl-2011-300154
3PMID: 21917649
4CODEN: GUTTAK
languageeng
publisherLondon: BMJ Publishing Group Ltd and British Society of Gastroenterology
subject
ispartofGut, 2012-06, Vol.61 (6), p.812-818
rights
02012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
12015 INIST-CNRS
2Copyright: 2012 (c) 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
lds50peer_reviewed
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25877198$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21917649$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Wong, Benjamin C Y
1Zhang, Lian
2Ma, Jun-ling
3Pan, Kai-feng
4Li, Ji-you
5Shen, Lin
6Liu, Wei-dong
7Feng, Guo-shuang
8Zhang, Xiao-dong
9Li, Jie
10Lu, Ai-ping
11Xia, Harry H X
12Lam, Shiukum
13You, Wei-cheng
title
0Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions
1Gut
addtitleGut
descriptionObjectiveHelicobacter pylori infection and overexpression of cyclo-oxygenase-2 (COX-2) are associated with gastric cancer and its precursors. To evaluate the effect of a selective COX-2 inhibitor alone and combined with H pylori eradication on the evolution of precancerous gastric lesions, a randomised, placebo-controlled trial was conducted in Linqu County, Shandong Province, China.MethodsA total of 1024 participants aged 35–64 years with H pylori infection and advanced gastric lesions were randomly assigned in a factorial design to two interventions or placebo: anti-H pylori treatment for 7 days, and a COX-2 inhibitor (celecoxib) for 24 months. The effects of the interventions were evaluated by the regression or progression of advanced gastric lesions.ResultsOf the 1024 participants who received anti-H pylori treatment or placebo, 919 completed a subsequent 24-month treatment with celecoxib or placebo. The H pylori eradication rate by per-protocol analysis was 78.2%. Compared with placebo, the proportions of regression of gastric lesions significantly increased in the celecoxib treatment (52.8% vs 41.2%) and anti-H pylori treatment (59.3% vs 41.2%) group, and OR by per-protocol analysis was 1.72 (95% CI 1.07 to 2.76) for celecoxib and 2.19 (95% CI 1.32 to 3.64) for H pylori eradication. No statistically significant effect was found for H pylori eradication followed by celecoxib on the regression of advanced gastric lesions (OR 1.48, 95% CI 0.91 to 2.40).ConclusionThis population-based intervention trial revealed that celecoxib treatment or H pylori eradication alone had beneficial effects on the regression of advanced gastric lesions. No favourable effects were seen for H pylori eradication followed by celecoxib treatment.Trial registrationHARECCTR0500053 in accordance with WHO ICTRP requirements.
subject
0Adult
1Amoxicillin - administration & dosage
2Amoxicillin - therapeutic use
3Anti-Bacterial Agents - administration & dosage
4Anti-Bacterial Agents - therapeutic use
5Antibiotics
6Bacterial diseases
7Bacterial diseases of the digestive system and abdomen
8Biological and medical sciences
9Biopsy
10Bones, joints and connective tissue. Antiinflammatory agents
11Celecoxib
12cell proliferation
13Clarithromycin - administration & dosage
14Clarithromycin - therapeutic use
15clinical trials
16COX-2 inhibitor
17COX-2 inhibitors
18Cyclooxygenase 2 Inhibitors - therapeutic use
19Dosage and administration
20Double-Blind Method
21Drug therapy
22Drug Therapy, Combination
23Endoscopy
24epidemiology
25Female
26functional dyspepsia
27Gastric cancer
28Gastroenterology. Liver. Pancreas. Abdomen
29Helicobacter infections
30Helicobacter Infections - complications
31Helicobacter Infections - drug therapy
32Helicobacter pylori
33Human bacterial diseases
34Humans
35Infectious diseases
36intervention trial
37Male
38Medical sciences
39Middle Aged
40Omeprazole - administration & dosage
41Omeprazole - therapeutic use
42Pathology
43Pharmacology. Drug treatments
44Population
45Precancerous conditions
46Precancerous Conditions - etiology
47Precancerous Conditions - pathology
48Precancerous Conditions - prevention & control
49precancerous lesions
50Pyrazoles - therapeutic use
51Quality
52Stomach - pathology
53Stomach cancer
54Stomach Neoplasms - etiology
55Stomach Neoplasms - pathology
56Stomach Neoplasms - prevention & control
57Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
58Studies
59Sulfonamides - therapeutic use
60Tumors
issn
00017-5749
11468-3288
fulltextfalse
rsrctypearticle
creationdate2012
recordtypearticle
recordideNqFkl1rFDEUhgdR7Fr9A15IQARvpuZkJh9zWZdqhWKhVCnehCRzss06H9tkRuy_N8uuXRRBEkg45zlvPs5bFC-BngBU4t1qntZDVzIKUFaUAq8fFQuohSorptTjYpFjsuSybo6KZymtKaVKNfC0OGLQgBR1syhuz7xHNyUyepKwy9vwA8ny8qZkJAy3wYZpjMQMLTnHLrjRGjdhJJv7boyBYDRtcGYK40Dy3ER0ZnAYxzmRlUlTDI50mHI6PS-eeNMlfLFfj4svH86ul-flxeXHT8vTixI441MJVnhlPVhk3jjnnWXMWTBV3WLdenBSWAPC1soZWjll0HDLOAJWAi1Yely83elu4ng3Y5p0H5LDrjMD5mtp4BxEzYWo_49SRhWnTc0y-vovdD3OccgP0SBlUymRG3KgVqZDHQY_TtG4rag-ZY3gwJpqq3XyDyqPFvv8wwP6kON_FLzaHz7bHlu9iaE38V7_7mIG3uwBk5zpfMxNCOnAcSUlNCpz5Y4LacKfD3kTv2shK8n1569LfXP1_urbNeeaHXjbrx9ooHrrPr1zn966T-_cR38BBIXJyQ
startdate201206
enddate201206
creator
0Wong, Benjamin C Y
1Zhang, Lian
2Ma, Jun-ling
3Pan, Kai-feng
4Li, Ji-you
5Shen, Lin
6Liu, Wei-dong
7Feng, Guo-shuang
8Zhang, Xiao-dong
9Li, Jie
10Lu, Ai-ping
11Xia, Harry H X
12Lam, Shiukum
13You, Wei-cheng
general
0BMJ Publishing Group Ltd and British Society of Gastroenterology
1BMJ Publishing Group
2BMJ Publishing Group Ltd
3BMJ Publishing Group LTD
scope
0BSCLL
1IQODW
2CGR
3CUY
4CVF
5ECM
6EIF
7NPM
8BSHEE
93V.
107X7
117XB
1288E
1388I
148AF
158FE
168FH
178FI
188FJ
198FK
20ABUWG
21AZQEC
22BBNVY
23BENPR
24BHPHI
25BTHHO
26DWQXO
27FYUFA
28GHDGH
29GNUQQ
30HCIFZ
31K9.
32LK8
33M0S
34M1P
35M2P
36M7P
37PQEST
38PQQKQ
39PQUKI
40PRINS
41Q9U
427QL
437T5
44C1K
45H94
sort
creationdate201206
titleEffects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions
authorWong, Benjamin C Y ; Zhang, Lian ; Ma, Jun-ling ; Pan, Kai-feng ; Li, Ji-you ; Shen, Lin ; Liu, Wei-dong ; Feng, Guo-shuang ; Zhang, Xiao-dong ; Li, Jie ; Lu, Ai-ping ; Xia, Harry H X ; Lam, Shiukum ; You, Wei-cheng
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1525t-1b6f8bf1be2faccfcb22cb1a34de4df1c76ba16b48ca03c8aea5b25e1e36eb1b0
rsrctypearticles
prefilterarticles
languageeng
creationdate2012
topic
0Adult
1Amoxicillin - administration & dosage
2Amoxicillin - therapeutic use
3Anti-Bacterial Agents - administration & dosage
4Anti-Bacterial Agents - therapeutic use
5Antibiotics
6Bacterial diseases
7Bacterial diseases of the digestive system and abdomen
8Biological and medical sciences
9Biopsy
10Bones, joints and connective tissue. Antiinflammatory agents
11Celecoxib
12cell proliferation
13Clarithromycin - administration & dosage
14Clarithromycin - therapeutic use
15clinical trials
16COX-2 inhibitor
17COX-2 inhibitors
18Cyclooxygenase 2 Inhibitors - therapeutic use
19Dosage and administration
20Double-Blind Method
21Drug therapy
22Drug Therapy, Combination
23Endoscopy
24epidemiology
25Female
26functional dyspepsia
27Gastric cancer
28Gastroenterology. Liver. Pancreas. Abdomen
29Helicobacter infections
30Helicobacter Infections - complications
31Helicobacter Infections - drug therapy
32Helicobacter pylori
33Human bacterial diseases
34Humans
35Infectious diseases
36intervention trial
37Male
38Medical sciences
39Middle Aged
40Omeprazole - administration & dosage
41Omeprazole - therapeutic use
42Pathology
43Pharmacology. Drug treatments
44Population
45Precancerous conditions
46Precancerous Conditions - etiology
47Precancerous Conditions - pathology
48Precancerous Conditions - prevention & control
49precancerous lesions
50Pyrazoles - therapeutic use
51Quality
52Stomach - pathology
53Stomach cancer
54Stomach Neoplasms - etiology
55Stomach Neoplasms - pathology
56Stomach Neoplasms - prevention & control
57Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
58Studies
59Sulfonamides - therapeutic use
60Tumors
toplevelpeer_reviewed
creatorcontrib
0Wong, Benjamin C Y
1Zhang, Lian
2Ma, Jun-ling
3Pan, Kai-feng
4Li, Ji-you
5Shen, Lin
6Liu, Wei-dong
7Feng, Guo-shuang
8Zhang, Xiao-dong
9Li, Jie
10Lu, Ai-ping
11Xia, Harry H X
12Lam, Shiukum
13You, Wei-cheng
collection
0Istex
1Pascal-Francis
2Medline
3MEDLINE
4MEDLINE (Ovid)
5MEDLINE
6MEDLINE
7PubMed
8Academic OneFile (A&I only)
9ProQuest Central (Corporate)
10Health & Medical Collection
11ProQuest Central (purchase pre-March 2016)
12Medical Database (Alumni Edition)
13Science Database (Alumni Edition)
14STEM Database
15ProQuest SciTech Collection
16ProQuest Natural Science Collection
17Hospital Premium Collection
18Hospital Premium Collection (Alumni Edition)
19ProQuest Central (Alumni) (purchase pre-March 2016)
20ProQuest Central (Alumni Edition)
21ProQuest Central Essentials
22Biological Science Collection
23ProQuest Central
24Natural Science Collection
25BMJ Journals
26ProQuest Central Korea
27Health Research Premium Collection
28Health Research Premium Collection (Alumni)
29ProQuest Central Student
30SciTech Premium Collection
31ProQuest Health & Medical Complete (Alumni)
32ProQuest Biological Science Collection
33Health & Medical Collection (Alumni Edition)
34Medical Database
35Science Database
36Biological Science Database
37ProQuest One Academic Eastern Edition
38ProQuest One Academic
39ProQuest One Academic UKI Edition
40ProQuest Central China
41ProQuest Central Basic
42Bacteriology Abstracts (Microbiology B)
43Immunology Abstracts
44Environmental Sciences and Pollution Management
45AIDS and Cancer Research Abstracts
jtitleGut
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Wong, Benjamin C Y
1Zhang, Lian
2Ma, Jun-ling
3Pan, Kai-feng
4Li, Ji-you
5Shen, Lin
6Liu, Wei-dong
7Feng, Guo-shuang
8Zhang, Xiao-dong
9Li, Jie
10Lu, Ai-ping
11Xia, Harry H X
12Lam, Shiukum
13You, Wei-cheng
formatjournal
genrearticle
ristypeJOUR
atitleEffects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions
jtitleGut
addtitleGut
date2012-06
risdate2012
volume61
issue6
spage812
epage818
pages812-818
issn0017-5749
eissn1468-3288
codenGUTTAK
notesBCYW and LZ contributed equally to this article.
abstractObjectiveHelicobacter pylori infection and overexpression of cyclo-oxygenase-2 (COX-2) are associated with gastric cancer and its precursors. To evaluate the effect of a selective COX-2 inhibitor alone and combined with H pylori eradication on the evolution of precancerous gastric lesions, a randomised, placebo-controlled trial was conducted in Linqu County, Shandong Province, China.MethodsA total of 1024 participants aged 35–64 years with H pylori infection and advanced gastric lesions were randomly assigned in a factorial design to two interventions or placebo: anti-H pylori treatment for 7 days, and a COX-2 inhibitor (celecoxib) for 24 months. The effects of the interventions were evaluated by the regression or progression of advanced gastric lesions.ResultsOf the 1024 participants who received anti-H pylori treatment or placebo, 919 completed a subsequent 24-month treatment with celecoxib or placebo. The H pylori eradication rate by per-protocol analysis was 78.2%. Compared with placebo, the proportions of regression of gastric lesions significantly increased in the celecoxib treatment (52.8% vs 41.2%) and anti-H pylori treatment (59.3% vs 41.2%) group, and OR by per-protocol analysis was 1.72 (95% CI 1.07 to 2.76) for celecoxib and 2.19 (95% CI 1.32 to 3.64) for H pylori eradication. No statistically significant effect was found for H pylori eradication followed by celecoxib on the regression of advanced gastric lesions (OR 1.48, 95% CI 0.91 to 2.40).ConclusionThis population-based intervention trial revealed that celecoxib treatment or H pylori eradication alone had beneficial effects on the regression of advanced gastric lesions. No favourable effects were seen for H pylori eradication followed by celecoxib treatment.Trial registrationHARECCTR0500053 in accordance with WHO ICTRP requirements.
copLondon
pubBMJ Publishing Group Ltd and British Society of Gastroenterology
pmid21917649
doi10.1136/gutjnl-2011-300154