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Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation

Background Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well characterised and clinically relevant outcome measures. Aim To evaluate a range of conventional and novel biomarkers of CF lung disease in a multicentre setting as a contributing study in selecting outcome a... Full description

Journal Title: Thorax 2013, Vol.68 (6), p.532-539
Main Author: Horsley, Alex R
Other Authors: Davies, Jane C , Gray, Robert D , Macleod, Kenneth A , Donovan, Jackie , Aziz, Zelena A , Bell, Nicholas J , Rainer, Margaret , Mt-Isa, Shahrul , Voase, Nia , Dewar, Maria H , Saunders, Clare , Gibson, James S , Parra-Leiton, Javier , Larsen, Mia D , Jeswiet, Sarah , Soussi, Samia , Bakar, Yusura , Meister, Mark G , Tyler, Philippa , Doherty, Ann , Hansell, David M , Ashby, Deborah , Hyde, Stephen C , Gill, Deborah R , Greening, Andrew P , Porteous, David J , Innes, J Alastair , Boyd, A Christopher , Griesenbach, Uta , Cunningham, Steve , Alton, Eric WFW
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: BMJ Publishing Group Ltd and British Thoracic Society
ID: ISSN: 0040-6376
Link: https://www.ncbi.nlm.nih.gov/pubmed/23396354
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title: Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation
format: Article
creator:
  • Horsley, Alex R
  • Davies, Jane C
  • Gray, Robert D
  • Macleod, Kenneth A
  • Donovan, Jackie
  • Aziz, Zelena A
  • Bell, Nicholas J
  • Rainer, Margaret
  • Mt-Isa, Shahrul
  • Voase, Nia
  • Dewar, Maria H
  • Saunders, Clare
  • Gibson, James S
  • Parra-Leiton, Javier
  • Larsen, Mia D
  • Jeswiet, Sarah
  • Soussi, Samia
  • Bakar, Yusura
  • Meister, Mark G
  • Tyler, Philippa
  • Doherty, Ann
  • Hansell, David M
  • Ashby, Deborah
  • Hyde, Stephen C
  • Gill, Deborah R
  • Greening, Andrew P
  • Porteous, David J
  • Innes, J Alastair
  • Boyd, A Christopher
  • Griesenbach, Uta
  • Cunningham, Steve
  • Alton, Eric WFW
subjects:
  • Adolescent
  • Adult
  • Anti-Bacterial Agents - administration & dosage
  • Anti-Bacterial Agents - therapeutic use
  • Biological markers
  • Biomarkers - blood
  • C-Reactive Protein - metabolism
  • Care and treatment
  • Child
  • Cystic Fibrosis
  • Cystic Fibrosis - diagnosis
  • Cystic Fibrosis - drug therapy
  • Cystic Fibrosis - physiopathology
  • Female
  • Forced Expiratory Volume - physiology
  • Gene therapy
  • Humans
  • Imaging/CT MRI etc
  • Injections, Intravenous
  • Interleukin-6 - blood
  • Leukocyte L1 Antigen Complex - blood
  • Lung - diagnostic imaging
  • Lung - physiopathology
  • Lung Diseases - diagnosis
  • Lung Diseases - drug therapy
  • Lung Diseases - physiopathology
  • Lung Physiology
  • Male
  • Physiological aspects
  • Recurrence
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Young Adult
ispartof: Thorax, 2013, Vol.68 (6), p.532-539
description: Background Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well characterised and clinically relevant outcome measures. Aim To evaluate a range of conventional and novel biomarkers of CF lung disease in a multicentre setting as a contributing study in selecting outcome assays for a clinical trial of CFTR gene therapy. Methods A multicentre observational study of adult and paediatric patients with CF (>10 years) treated for a physician-defined exacerbation of CF pulmonary symptoms. Measurements were performed at commencement and immediately after a course of intravenous antibiotics. Disease activity was assessed using 46 assays across five key domains: symptoms, lung physiology, structural changes on CT, pulmonary and systemic inflammatory markers. Results Statistically significant improvements were seen in forced expiratory volume in 1 s (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0040-6376
fulltext: fulltext
issn:
  • 0040-6376
  • 1468-3296
url: Link


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subjectAdolescent ; Adult ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Biological markers ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Care and treatment ; Child ; Cystic Fibrosis ; Cystic Fibrosis - diagnosis ; Cystic Fibrosis - drug therapy ; Cystic Fibrosis - physiopathology ; Female ; Forced Expiratory Volume - physiology ; Gene therapy ; Humans ; Imaging/CT MRI etc ; Injections, Intravenous ; Interleukin-6 - blood ; Leukocyte L1 Antigen Complex - blood ; Lung - diagnostic imaging ; Lung - physiopathology ; Lung Diseases - diagnosis ; Lung Diseases - drug therapy ; Lung Diseases - physiopathology ; Lung Physiology ; Male ; Physiological aspects ; Recurrence ; Tomography, X-Ray Computed ; Treatment Outcome ; Young Adult
ispartofThorax, 2013, Vol.68 (6), p.532-539
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titleChanges in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation
authorHorsley, Alex R ; Davies, Jane C ; Gray, Robert D ; Macleod, Kenneth A ; Donovan, Jackie ; Aziz, Zelena A ; Bell, Nicholas J ; Rainer, Margaret ; Mt-Isa, Shahrul ; Voase, Nia ; Dewar, Maria H ; Saunders, Clare ; Gibson, James S ; Parra-Leiton, Javier ; Larsen, Mia D ; Jeswiet, Sarah ; Soussi, Samia ; Bakar, Yusura ; Meister, Mark G ; Tyler, Philippa ; Doherty, Ann ; Hansell, David M ; Ashby, Deborah ; Hyde, Stephen C ; Gill, Deborah R ; Greening, Andrew P ; Porteous, David J ; Innes, J Alastair ; Boyd, A Christopher ; Griesenbach, Uta ; Cunningham, Steve ; Alton, Eric WFW
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8Mt-Isa, Shahrul
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23Hyde, Stephen C
24Gill, Deborah R
25Greening, Andrew P
26Porteous, David J
27Innes, J Alastair
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29Griesenbach, Uta
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atitleChanges in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation
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pmid23396354
doi10.1136/thoraxjnl-2012-202538
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