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Association of physical activity as a distinctive feature of clustering of lifestyle behaviours with dementia risk: evidence from the English Longitudinal Study of Ageing

Whereas the association between individual lifestyle behaviours and dementia risk has been well researched, their combined influence is poorly understood. We examined dementia risk in relation to clusters of lifestyle behaviours in a representative sample of English older adults. Data from 3975 men... Full description

Journal Title: The Lancet (British edition) 2017-11, Vol.390, p.S29-S29
Main Author: Cadar, Dorina
Other Authors: Hackett, Ruth A , Mischie, Monica , Llewellyn, David J , Batty, G David , Steptoe, Andrew
Format: Electronic Article Electronic Article
Language: English
Subjects:
Aged
Aging
Clustering
Consortia
Coronary heart disease
Correlation analysis
Dementia
Dementia disorders
Exercise
Exercise for the aged
Fruit
Hypertension
Physical activity
Physical fitness
Physical fitness for the aged
Risk factors
Quelle: Alma/SFX Local Collection
Publisher: London: Elsevier Ltd
ID: ISSN: 0140-6736
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recordid: cdi_proquest_journals_1973126912
title: Association of physical activity as a distinctive feature of clustering of lifestyle behaviours with dementia risk: evidence from the English Longitudinal Study of Ageing
format: Article
creator:
  • Cadar, Dorina
  • Hackett, Ruth A
  • Mischie, Monica
  • Llewellyn, David J
  • Batty, G David
  • Steptoe, Andrew
subjects:
  • Aged
  • Aging
  • Clustering
  • Consortia
  • Coronary heart disease
  • Correlation analysis
  • Dementia
  • Dementia disorders
  • Exercise
  • Exercise for the aged
  • Fruit
  • Hypertension
  • Physical activity
  • Physical fitness
  • Physical fitness for the aged
  • Risk factors
ispartof: The Lancet (British edition), 2017-11, Vol.390, p.S29-S29
description: Whereas the association between individual lifestyle behaviours and dementia risk has been well researched, their combined influence is poorly understood. We examined dementia risk in relation to clusters of lifestyle behaviours in a representative sample of English older adults. Data from 3975 men and women (≥60 years) participating in the English Longitudinal Study of Ageing were analysed with latent class analysis. We assessed different clusters of lifestyle behaviours (physical activity levels, consumption of fruit and vegetables, alcohol consumption, smoking behaviour) at wave 3 (considered for these analyses as the baseline), in association with new dementia cases 8 years later (wave 7). Age, sex, marital status, education, memory ability, symptoms of depression, body-mass index, stroke, hypertension, and coronary heart disease, measured at baseline, were included as covariates. From the overall sample, 5% (n=178) developed dementia at wave 7. We identified two distinctive classes of lifestyle behaviours at baseline that were predictive of subsequent dementia, which mainly varied by physical activity levels. 1222 (60%) of 2037 individuals in class I were physically active, 1425 (70%) consumed at least five portions of fruit and vegetables, 672 (33%) drank alcohol daily, and 102 (
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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descriptionWhereas the association between individual lifestyle behaviours and dementia risk has been well researched, their combined influence is poorly understood. We examined dementia risk in relation to clusters of lifestyle behaviours in a representative sample of English older adults. Data from 3975 men and women (≥60 years) participating in the English Longitudinal Study of Ageing were analysed with latent class analysis. We assessed different clusters of lifestyle behaviours (physical activity levels, consumption of fruit and vegetables, alcohol consumption, smoking behaviour) at wave 3 (considered for these analyses as the baseline), in association with new dementia cases 8 years later (wave 7). Age, sex, marital status, education, memory ability, symptoms of depression, body-mass index, stroke, hypertension, and coronary heart disease, measured at baseline, were included as covariates. From the overall sample, 5% (n=178) developed dementia at wave 7. We identified two distinctive classes of lifestyle behaviours at baseline that were predictive of subsequent dementia, which mainly varied by physical activity levels. 1222 (60%) of 2037 individuals in class I were physically active, 1425 (70%) consumed at least five portions of fruit and vegetables, 672 (33%) drank alcohol daily, and 102 (<1%) were smokers. By contrast, individuals in class II (n=1938) were less likely to be physically active (<1 %, n=174), 52% (1007) had a high intake of fruit and vegetables, and only a minority smoked or drank daily (<20%, 310 and 233, respectively). One in 100 individuals from class I and one in ten individuals from class II developed subsequent dementia. Individuals clustered in class I had a lower risk of dementia 8 years later, than did those in class II (odds ratio 0·16, 95% CI 0·11–0·21). This observational study does not establish the causal status of lifestyle factors associated with dementia risk. It does, however, suggest that physical inactivity should be targeted in future dementia prevention trials targeting modifiable risk factors. National Institute on Aging (NIA) (grant 528122), NIA (grant RO1AG7644), and a consortium of UK government departments coordinated by the Economic and Social Research Council (ESRC).
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subjectAged ; Aging ; Clustering ; Consortia ; Coronary heart disease ; Correlation analysis ; Dementia ; Dementia disorders ; Exercise ; Exercise for the aged ; Fruit ; Hypertension ; Physical activity ; Physical fitness ; Physical fitness for the aged ; Risk factors
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descriptionWhereas the association between individual lifestyle behaviours and dementia risk has been well researched, their combined influence is poorly understood. We examined dementia risk in relation to clusters of lifestyle behaviours in a representative sample of English older adults. Data from 3975 men and women (≥60 years) participating in the English Longitudinal Study of Ageing were analysed with latent class analysis. We assessed different clusters of lifestyle behaviours (physical activity levels, consumption of fruit and vegetables, alcohol consumption, smoking behaviour) at wave 3 (considered for these analyses as the baseline), in association with new dementia cases 8 years later (wave 7). Age, sex, marital status, education, memory ability, symptoms of depression, body-mass index, stroke, hypertension, and coronary heart disease, measured at baseline, were included as covariates. From the overall sample, 5% (n=178) developed dementia at wave 7. We identified two distinctive classes of lifestyle behaviours at baseline that were predictive of subsequent dementia, which mainly varied by physical activity levels. 1222 (60%) of 2037 individuals in class I were physically active, 1425 (70%) consumed at least five portions of fruit and vegetables, 672 (33%) drank alcohol daily, and 102 (<1%) were smokers. By contrast, individuals in class II (n=1938) were less likely to be physically active (<1 %, n=174), 52% (1007) had a high intake of fruit and vegetables, and only a minority smoked or drank daily (<20%, 310 and 233, respectively). One in 100 individuals from class I and one in ten individuals from class II developed subsequent dementia. Individuals clustered in class I had a lower risk of dementia 8 years later, than did those in class II (odds ratio 0·16, 95% CI 0·11–0·21). This observational study does not establish the causal status of lifestyle factors associated with dementia risk. It does, however, suggest that physical inactivity should be targeted in future dementia prevention trials targeting modifiable risk factors. National Institute on Aging (NIA) (grant 528122), NIA (grant RO1AG7644), and a consortium of UK government departments coordinated by the Economic and Social Research Council (ESRC).
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atitleAssociation of physical activity as a distinctive feature of clustering of lifestyle behaviours with dementia risk: evidence from the English Longitudinal Study of Ageing
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issn0140-6736
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abstractWhereas the association between individual lifestyle behaviours and dementia risk has been well researched, their combined influence is poorly understood. We examined dementia risk in relation to clusters of lifestyle behaviours in a representative sample of English older adults. Data from 3975 men and women (≥60 years) participating in the English Longitudinal Study of Ageing were analysed with latent class analysis. We assessed different clusters of lifestyle behaviours (physical activity levels, consumption of fruit and vegetables, alcohol consumption, smoking behaviour) at wave 3 (considered for these analyses as the baseline), in association with new dementia cases 8 years later (wave 7). Age, sex, marital status, education, memory ability, symptoms of depression, body-mass index, stroke, hypertension, and coronary heart disease, measured at baseline, were included as covariates. From the overall sample, 5% (n=178) developed dementia at wave 7. We identified two distinctive classes of lifestyle behaviours at baseline that were predictive of subsequent dementia, which mainly varied by physical activity levels. 1222 (60%) of 2037 individuals in class I were physically active, 1425 (70%) consumed at least five portions of fruit and vegetables, 672 (33%) drank alcohol daily, and 102 (<1%) were smokers. By contrast, individuals in class II (n=1938) were less likely to be physically active (<1 %, n=174), 52% (1007) had a high intake of fruit and vegetables, and only a minority smoked or drank daily (<20%, 310 and 233, respectively). One in 100 individuals from class I and one in ten individuals from class II developed subsequent dementia. Individuals clustered in class I had a lower risk of dementia 8 years later, than did those in class II (odds ratio 0·16, 95% CI 0·11–0·21). This observational study does not establish the causal status of lifestyle factors associated with dementia risk. It does, however, suggest that physical inactivity should be targeted in future dementia prevention trials targeting modifiable risk factors. National Institute on Aging (NIA) (grant 528122), NIA (grant RO1AG7644), and a consortium of UK government departments coordinated by the Economic and Social Research Council (ESRC).
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doi10.1016/S0140-6736(17)32964-1