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The ACE Gene I/D Polymorphism Is Not Associated With the Blood Pressure and Cardiovascular Benefits of ACE Inhibition

The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene might have consequences for the risks of vascular diseases. We examined the ACE genotype and the effects of a perindopril-based blood pressure-lowering regimen on macrovascular events, dementia, and cognitive d... Full description

Journal Title: Hypertension 2003, Vol.42 (3), p.297-303
Main Author: Harrap, Stephen B
Other Authors: Tzourio, Christophe , Cambien, Francois , Poirier, Odette , Raoux, Segolene , Chalmers, John , Chapman, Neil , Colman, Samuel , Leguennec, Solenn , MacMahon, Stephen , Neal, Bruce , Ohkubo, Takayoshi , Woodward, Mark
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Philadelphia, PA: Am Heart Assoc
ID: ISSN: 0194-911X
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recordid: cdi_proquest_journals_205279863
title: The ACE Gene I/D Polymorphism Is Not Associated With the Blood Pressure and Cardiovascular Benefits of ACE Inhibition
format: Article
creator:
  • Harrap, Stephen B
  • Tzourio, Christophe
  • Cambien, Francois
  • Poirier, Odette
  • Raoux, Segolene
  • Chalmers, John
  • Chapman, Neil
  • Colman, Samuel
  • Leguennec, Solenn
  • MacMahon, Stephen
  • Neal, Bruce
  • Ohkubo, Takayoshi
  • Woodward, Mark
subjects:
  • Adult
  • Angiotensin-Converting Enzyme Inhibitors - therapeutic use
  • Antihypertensive agents
  • Biological and medical sciences
  • Blood Pressure - drug effects
  • Cardiovascular system
  • Cognition Disorders - complications
  • Dementia - complications
  • Female
  • Genotype
  • Humans
  • Hypertension - complications
  • Hypertension - drug therapy
  • Hypertension - physiopathology
  • Male
  • Medical sciences
  • Middle Aged
  • Mutagenesis, Insertional
  • Peptidyl-Dipeptidase A - genetics
  • Perindopril - therapeutic use
  • Pharmacology. Drug treatments
  • Polymorphism, Genetic
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • Sequence Deletion
  • Statistics as Topic
  • Stroke - complications
  • Survival Analysis
  • Time Factors
  • Treatment Outcome
  • Vascular Diseases - complications
ispartof: Hypertension, 2003, Vol.42 (3), p.297-303
description: The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene might have consequences for the risks of vascular diseases. We examined the ACE genotype and the effects of a perindopril-based blood pressure-lowering regimen on macrovascular events, dementia, and cognitive decline among hypertensive and nonhypertensive patients with a history of cerebrovascular disease. ACE I/D genotypes were measured in 5688 of 6105 individuals with previous stroke or transient ischemic attack who participated in the PROGRESS trial. The DD genotype was significantly (P
language: eng
source:
identifier: ISSN: 0194-911X
fulltext: no_fulltext
issn:
  • 0194-911X
  • 1524-4563
url: Link


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titleThe ACE Gene I/D Polymorphism Is Not Associated With the Blood Pressure and Cardiovascular Benefits of ACE Inhibition
creatorHarrap, Stephen B ; Tzourio, Christophe ; Cambien, Francois ; Poirier, Odette ; Raoux, Segolene ; Chalmers, John ; Chapman, Neil ; Colman, Samuel ; Leguennec, Solenn ; MacMahon, Stephen ; Neal, Bruce ; Ohkubo, Takayoshi ; Woodward, Mark
creatorcontribHarrap, Stephen B ; Tzourio, Christophe ; Cambien, Francois ; Poirier, Odette ; Raoux, Segolene ; Chalmers, John ; Chapman, Neil ; Colman, Samuel ; Leguennec, Solenn ; MacMahon, Stephen ; Neal, Bruce ; Ohkubo, Takayoshi ; Woodward, Mark ; PROGRESS Collaborative Group
descriptionThe insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene might have consequences for the risks of vascular diseases. We examined the ACE genotype and the effects of a perindopril-based blood pressure-lowering regimen on macrovascular events, dementia, and cognitive decline among hypertensive and nonhypertensive patients with a history of cerebrovascular disease. ACE I/D genotypes were measured in 5688 of 6105 individuals with previous stroke or transient ischemic attack who participated in the PROGRESS trial. The DD genotype was significantly (P<0.0001) less frequent in Asian subjects (Chinese and Japanese, 14.7%) than in non-Asian subjects (32.0%). Controlling for racial background, there were no associations between ACE genotypes and cerebrovascular disease history or cardiovascular risk factors, including baseline blood pressure. The ACE genotype was not associated with the long-term risks of stroke, cardiac events, mortality, dementia, or cognitive decline; neither did the ACE genotype predict the blood pressure reduction associated with the use of the ACE inhibitor perindopril. Similarly, there was no evidence that the ACE genotype modified the relative benefits of ACE inhibitor-based therapy over placebo. This study provides no evidence that in patients with cerebrovascular disease, knowledge of ACE genotype is useful for predicting either the risk of disease or the benefits of perindopril-based blood pressure-lowering treatment.
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subjectAdult ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Antihypertensive agents ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Cognition Disorders - complications ; Dementia - complications ; Female ; Genotype ; Humans ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - physiopathology ; Male ; Medical sciences ; Middle Aged ; Mutagenesis, Insertional ; Peptidyl-Dipeptidase A - genetics ; Perindopril - therapeutic use ; Pharmacology. Drug treatments ; Polymorphism, Genetic ; Randomized Controlled Trials as Topic ; Risk Factors ; Sequence Deletion ; Statistics as Topic ; Stroke - complications ; Survival Analysis ; Time Factors ; Treatment Outcome ; Vascular Diseases - complications
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descriptionThe insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene might have consequences for the risks of vascular diseases. We examined the ACE genotype and the effects of a perindopril-based blood pressure-lowering regimen on macrovascular events, dementia, and cognitive decline among hypertensive and nonhypertensive patients with a history of cerebrovascular disease. ACE I/D genotypes were measured in 5688 of 6105 individuals with previous stroke or transient ischemic attack who participated in the PROGRESS trial. The DD genotype was significantly (P<0.0001) less frequent in Asian subjects (Chinese and Japanese, 14.7%) than in non-Asian subjects (32.0%). Controlling for racial background, there were no associations between ACE genotypes and cerebrovascular disease history or cardiovascular risk factors, including baseline blood pressure. The ACE genotype was not associated with the long-term risks of stroke, cardiac events, mortality, dementia, or cognitive decline; neither did the ACE genotype predict the blood pressure reduction associated with the use of the ACE inhibitor perindopril. Similarly, there was no evidence that the ACE genotype modified the relative benefits of ACE inhibitor-based therapy over placebo. This study provides no evidence that in patients with cerebrovascular disease, knowledge of ACE genotype is useful for predicting either the risk of disease or the benefits of perindopril-based blood pressure-lowering treatment.
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7Dementia - complications
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24Sequence Deletion
25Statistics as Topic
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29Treatment Outcome
30Vascular Diseases - complications
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titleThe ACE Gene I/D Polymorphism Is Not Associated With the Blood Pressure and Cardiovascular Benefits of ACE Inhibition
authorHarrap, Stephen B ; Tzourio, Christophe ; Cambien, Francois ; Poirier, Odette ; Raoux, Segolene ; Chalmers, John ; Chapman, Neil ; Colman, Samuel ; Leguennec, Solenn ; MacMahon, Stephen ; Neal, Bruce ; Ohkubo, Takayoshi ; Woodward, Mark
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8Leguennec, Solenn
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abstractThe insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene might have consequences for the risks of vascular diseases. We examined the ACE genotype and the effects of a perindopril-based blood pressure-lowering regimen on macrovascular events, dementia, and cognitive decline among hypertensive and nonhypertensive patients with a history of cerebrovascular disease. ACE I/D genotypes were measured in 5688 of 6105 individuals with previous stroke or transient ischemic attack who participated in the PROGRESS trial. The DD genotype was significantly (P<0.0001) less frequent in Asian subjects (Chinese and Japanese, 14.7%) than in non-Asian subjects (32.0%). Controlling for racial background, there were no associations between ACE genotypes and cerebrovascular disease history or cardiovascular risk factors, including baseline blood pressure. The ACE genotype was not associated with the long-term risks of stroke, cardiac events, mortality, dementia, or cognitive decline; neither did the ACE genotype predict the blood pressure reduction associated with the use of the ACE inhibitor perindopril. Similarly, there was no evidence that the ACE genotype modified the relative benefits of ACE inhibitor-based therapy over placebo. This study provides no evidence that in patients with cerebrovascular disease, knowledge of ACE genotype is useful for predicting either the risk of disease or the benefits of perindopril-based blood pressure-lowering treatment.
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