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Referral patterns and social deprivation in paracetamol-induced liver injury in Scotland

Paracetamol overdose is the commonest cause of acute liver failure in the UK, which has led to measures to restrict its sale. We aimed to establish whether changes in the referral of patients with paracetamol-induced acute liver failure have occurred since the introduction of legislation. We compare... Full description

Journal Title: The Lancet (British edition) 2001, Vol.358 (9293), p.1612-1613
Main Author: Newsome, Phillp N
Other Authors: Bathgate, Andrew J , Henderson, Neil C , MacGilchrist, Alastair J , Plevris, John N , Masterton, George , Garden, O James , Lee, Alistair , Hayes, Peter C , Simpson, Kenneth J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 0140-6736
Link: https://www.ncbi.nlm.nih.gov/pubmed/11716892
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recordid: cdi_proquest_journals_2067774710
title: Referral patterns and social deprivation in paracetamol-induced liver injury in Scotland
format: Article
creator:
  • Newsome, Phillp N
  • Bathgate, Andrew J
  • Henderson, Neil C
  • MacGilchrist, Alastair J
  • Plevris, John N
  • Masterton, George
  • Garden, O James
  • Lee, Alistair
  • Hayes, Peter C
  • Simpson, Kenneth J
subjects:
  • Acetaminophen
  • Acetaminophen - poisoning
  • Adult
  • Allografts
  • Analgesics
  • Analgesics, Non-Narcotic - poisoning
  • Deprivation
  • Dosage and administration
  • Drug Overdose
  • Drugs
  • Female
  • Humans
  • Legislation
  • Legislation, Drug
  • Liver
  • Liver diseases
  • Liver failure
  • Liver Failure, Acute - chemically induced
  • Liver Failure, Acute - classification
  • Liver Failure, Acute - epidemiology
  • Liver transplantation
  • Male
  • Overdose
  • Paracetamol
  • Patients
  • Poisoning
  • Population
  • Prejudice
  • Referral and Consultation
  • Referrals
  • Risk Factors
  • Scotland - epidemiology
  • Severity of Illness Index
  • Syngeneic grafts
  • Transplantation
  • Transplantation of organs, tissues, etc
  • Transplants & implants
ispartof: The Lancet (British edition), 2001, Vol.358 (9293), p.1612-1613
description: Paracetamol overdose is the commonest cause of acute liver failure in the UK, which has led to measures to restrict its sale. We aimed to establish whether changes in the referral of patients with paracetamol-induced acute liver failure have occurred since the introduction of legislation. We compared data from patients admitted to the Scottish Liver Transplantation Unit in 1992–98 with those admitted in 1998–2001. The incidence of paracetamol-induced liver failure, severity of patients' illness, and outcome did not differ between the groups. Patients with paracetamol-induced acute liver failure had higher Carstairs scores (1·99 [95% CI 1·33−2·65]; n=190) than patients with non-paracetamol acute liver failure (0·02 [−0·79 to 0·84]; n = 68). We have shown an association between paracetamol-induced acute liver failure and social deprivation.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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titleReferral patterns and social deprivation in paracetamol-induced liver injury in Scotland
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creatorNewsome, Phillp N ; Bathgate, Andrew J ; Henderson, Neil C ; MacGilchrist, Alastair J ; Plevris, John N ; Masterton, George ; Garden, O James ; Lee, Alistair ; Hayes, Peter C ; Simpson, Kenneth J
creatorcontribNewsome, Phillp N ; Bathgate, Andrew J ; Henderson, Neil C ; MacGilchrist, Alastair J ; Plevris, John N ; Masterton, George ; Garden, O James ; Lee, Alistair ; Hayes, Peter C ; Simpson, Kenneth J
descriptionParacetamol overdose is the commonest cause of acute liver failure in the UK, which has led to measures to restrict its sale. We aimed to establish whether changes in the referral of patients with paracetamol-induced acute liver failure have occurred since the introduction of legislation. We compared data from patients admitted to the Scottish Liver Transplantation Unit in 1992–98 with those admitted in 1998–2001. The incidence of paracetamol-induced liver failure, severity of patients' illness, and outcome did not differ between the groups. Patients with paracetamol-induced acute liver failure had higher Carstairs scores (1·99 [95% CI 1·33−2·65]; n=190) than patients with non-paracetamol acute liver failure (0·02 [−0·79 to 0·84]; n = 68). We have shown an association between paracetamol-induced acute liver failure and social deprivation.
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languageeng
publisherEngland: Elsevier Ltd
subjectAcetaminophen ; Acetaminophen - poisoning ; Adult ; Allografts ; Analgesics ; Analgesics, Non-Narcotic - poisoning ; Deprivation ; Dosage and administration ; Drug Overdose ; Drugs ; Female ; Humans ; Legislation ; Legislation, Drug ; Liver ; Liver diseases ; Liver failure ; Liver Failure, Acute - chemically induced ; Liver Failure, Acute - classification ; Liver Failure, Acute - epidemiology ; Liver transplantation ; Male ; Overdose ; Paracetamol ; Patients ; Poisoning ; Population ; Prejudice ; Referral and Consultation ; Referrals ; Risk Factors ; Scotland - epidemiology ; Severity of Illness Index ; Syngeneic grafts ; Transplantation ; Transplantation of organs, tissues, etc ; Transplants & implants
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descriptionParacetamol overdose is the commonest cause of acute liver failure in the UK, which has led to measures to restrict its sale. We aimed to establish whether changes in the referral of patients with paracetamol-induced acute liver failure have occurred since the introduction of legislation. We compared data from patients admitted to the Scottish Liver Transplantation Unit in 1992–98 with those admitted in 1998–2001. The incidence of paracetamol-induced liver failure, severity of patients' illness, and outcome did not differ between the groups. Patients with paracetamol-induced acute liver failure had higher Carstairs scores (1·99 [95% CI 1·33−2·65]; n=190) than patients with non-paracetamol acute liver failure (0·02 [−0·79 to 0·84]; n = 68). We have shown an association between paracetamol-induced acute liver failure and social deprivation.
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2Adult
3Allografts
4Analgesics
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8Drug Overdose
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11Humans
12Legislation
13Legislation, Drug
14Liver
15Liver diseases
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17Liver Failure, Acute - chemically induced
18Liver Failure, Acute - classification
19Liver Failure, Acute - epidemiology
20Liver transplantation
21Male
22Overdose
23Paracetamol
24Patients
25Poisoning
26Population
27Prejudice
28Referral and Consultation
29Referrals
30Risk Factors
31Scotland - epidemiology
32Severity of Illness Index
33Syngeneic grafts
34Transplantation
35Transplantation of organs, tissues, etc
36Transplants & implants
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titleReferral patterns and social deprivation in paracetamol-induced liver injury in Scotland
authorNewsome, Phillp N ; Bathgate, Andrew J ; Henderson, Neil C ; MacGilchrist, Alastair J ; Plevris, John N ; Masterton, George ; Garden, O James ; Lee, Alistair ; Hayes, Peter C ; Simpson, Kenneth J
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4Analgesics
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8Drug Overdose
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19Liver Failure, Acute - epidemiology
20Liver transplantation
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22Overdose
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26Population
27Prejudice
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34Transplantation
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1Bathgate, Andrew J
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8Hayes, Peter C
9Simpson, Kenneth J
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atitleReferral patterns and social deprivation in paracetamol-induced liver injury in Scotland
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date2001-11-10
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volume358
issue9293
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abstractParacetamol overdose is the commonest cause of acute liver failure in the UK, which has led to measures to restrict its sale. We aimed to establish whether changes in the referral of patients with paracetamol-induced acute liver failure have occurred since the introduction of legislation. We compared data from patients admitted to the Scottish Liver Transplantation Unit in 1992–98 with those admitted in 1998–2001. The incidence of paracetamol-induced liver failure, severity of patients' illness, and outcome did not differ between the groups. Patients with paracetamol-induced acute liver failure had higher Carstairs scores (1·99 [95% CI 1·33−2·65]; n=190) than patients with non-paracetamol acute liver failure (0·02 [−0·79 to 0·84]; n = 68). We have shown an association between paracetamol-induced acute liver failure and social deprivation.
copEngland
pubElsevier Ltd
pmid11716892
doi10.1016/S0140-6736(01)06663-6