schliessen

Filtern

 

Bibliotheken

What is the Dose-Response Relationship between Vitamin D and Cancer Risk?

An inverse association between serum 25-hydroxyvitamin D [25(OH)D], and risk of cancers of the colon, breast, and ovary has been reported in wellconducted observational studies.1 These studies have been supported by numerous natural experiments, specifically, studies that examine differences in inci... Full description

Journal Title: Nutrition reviews 2007-08, Vol.65 (Supplement 1), p.91-95
Main Author: Garland, Cedric F
Other Authors: Grant, William B , Mohr, Sharif B , Gorham, Edward D , Garland, Frank C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Lawrence, KS: International Life Sciences Institute
ID: ISSN: 0029-6643
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_journals_212340540
title: What is the Dose-Response Relationship between Vitamin D and Cancer Risk?
format: Article
creator:
  • Garland, Cedric F
  • Grant, William B
  • Mohr, Sharif B
  • Gorham, Edward D
  • Garland, Frank C
subjects:
  • Anticarcinogenic Agents - administration & dosage
  • Biological and medical sciences
  • Breast cancer
  • Colorectal cancer
  • Dose-Response Relationship, Drug
  • Epidemiology
  • Humans
  • Medical sciences
  • Neoplasms - epidemiology
  • Neoplasms - etiology
  • Nutrition
  • Risk Factors
  • Tumors
  • Vitamin D
  • Vitamin D - administration & dosage
ispartof: Nutrition reviews, 2007-08, Vol.65 (Supplement 1), p.91-95
description: An inverse association between serum 25-hydroxyvitamin D [25(OH)D], and risk of cancers of the colon, breast, and ovary has been reported in wellconducted observational studies.1 These studies have been supported by numerous natural experiments, specifically, studies that examine differences in incidence rates according to naturally occurring variations among populations in their ambient exposure to solar ultraviolet B irradiance, the main source of vitamin D.2-6 The presence of a dose-response gradient is one of the key criteria for determining whether an association is causal. Vitamin D is essential for the expression of proteins involved in expression of intercellular junctions such as E-cadherin.19,20 Tissue culture systems of normal epithelial cells have confirmed that tight junctions, desmosomes, and gap junctions are the most common junctions between epithelial cells.20 The proteins that constitute junctional systems decline when the concentration of vitamin D metabolites is low.19,20 In the absence of intact intercellular junctions, epithelial cells may separate, lose their normal cuboidal architecture, and acquire an increasingly amorphous architecture, with loss of function and apical-basal polarity.21 This phenomenon has been termed decoupling.\n Concern about such a slow-growing malignancy would be irrelevant.
language: eng
source:
identifier: ISSN: 0029-6643
fulltext: no_fulltext
issn:
  • 0029-6643
  • 1753-4887
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.054773
LOCALfalse
PrimoNMBib
record
control
sourceidpubtec_proqu
recordidTN_cdi_proquest_journals_212340540
sourceformatXML
sourcesystemPC
ingidilsi/nure/2007/00000065/A00108s1/art00007
sourcerecordidilsi/nure/2007/00000065/A00108s1/art00007
originalsourceidFETCH-LOGICAL-c2649-86a9b7c614a0dc57178d18905c4a27732aa0c783611d46738ebd913aef46af900
addsrcrecordideNqFkl1r2zAYhcXYWLNsv2AwxGC7c_rKkiXranTpPgqFQrqPS_FGlht1tpxKNmP_vvISKPSmAiEhzjnv4UGEvGWwYhzYaYirEkCtcLpZXWtWXOvqGVkwVfFC1LV6ThYApS6kFPyEvErpFgBYqflLcsJULRVXekEufu9wpD7Rcefo-ZBcsXFpP4Tk6MZ1OPp83fk93brxr3OB_vIj9j7Qc4qhoWsM1kW68enPp9fkRYtdcm-O55L8_Prlx_p7cXn17WJ9dlnYUgpd1BL1VlnJBEJjK5WrNKzWUFmBpVK8RASrai4Za0QuWbttoxlH1wqJrQZYko-H3H0c7iaXRtP7ZF3XYXDDlIysS8UAdBa-fyS8HaYYcjdTspILqMScxg8iG4eUomvNPvoe4z_DwMyYTYhmxmwyZpMx511l17tj9LTtXfPgOXLNgg9HASaLXRszKJ8edBq44Dl-SfSj8TYDnqmPEX33RInPB68PNy6MaFKPXZcbJeO75E2Yoju44P-SlTnLPwDqxAzGcX5ScA9Tx61R
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid212340540
display
typearticle
titleWhat is the Dose-Response Relationship between Vitamin D and Cancer Risk?
creatorGarland, Cedric F ; Grant, William B ; Mohr, Sharif B ; Gorham, Edward D ; Garland, Frank C
creatorcontribGarland, Cedric F ; Grant, William B ; Mohr, Sharif B ; Gorham, Edward D ; Garland, Frank C
descriptionAn inverse association between serum 25-hydroxyvitamin D [25(OH)D], and risk of cancers of the colon, breast, and ovary has been reported in wellconducted observational studies.1 These studies have been supported by numerous natural experiments, specifically, studies that examine differences in incidence rates according to naturally occurring variations among populations in their ambient exposure to solar ultraviolet B irradiance, the main source of vitamin D.2-6 The presence of a dose-response gradient is one of the key criteria for determining whether an association is causal. Vitamin D is essential for the expression of proteins involved in expression of intercellular junctions such as E-cadherin.19,20 Tissue culture systems of normal epithelial cells have confirmed that tight junctions, desmosomes, and gap junctions are the most common junctions between epithelial cells.20 The proteins that constitute junctional systems decline when the concentration of vitamin D metabolites is low.19,20 In the absence of intact intercellular junctions, epithelial cells may separate, lose their normal cuboidal architecture, and acquire an increasingly amorphous architecture, with loss of function and apical-basal polarity.21 This phenomenon has been termed decoupling.\n Concern about such a slow-growing malignancy would be irrelevant.
identifier
0ISSN: 0029-6643
1EISSN: 1753-4887
2DOI: 10.1301/nr.2007.aug.S91-S95
3PMID: 17867379
4CODEN: NUREA8
languageeng
publisherLawrence, KS: International Life Sciences Institute
subjectAnticarcinogenic Agents - administration & dosage ; Biological and medical sciences ; Breast cancer ; Colorectal cancer ; Dose-Response Relationship, Drug ; Epidemiology ; Humans ; Medical sciences ; Neoplasms - epidemiology ; Neoplasms - etiology ; Nutrition ; Risk Factors ; Tumors ; Vitamin D ; Vitamin D - administration & dosage
ispartofNutrition reviews, 2007-08, Vol.65 (Supplement 1), p.91-95
rights
02007 INIST-CNRS
1Copyright International Life Sciences Institute Aug 2007
lds50peer_reviewed
citedbyFETCH-LOGICAL-c2649-86a9b7c614a0dc57178d18905c4a27732aa0c783611d46738ebd913aef46af900
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19034313$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17867379$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Garland, Cedric F
1Grant, William B
2Mohr, Sharif B
3Gorham, Edward D
4Garland, Frank C
title
0What is the Dose-Response Relationship between Vitamin D and Cancer Risk?
1Nutrition reviews
addtitleNutr Rev
descriptionAn inverse association between serum 25-hydroxyvitamin D [25(OH)D], and risk of cancers of the colon, breast, and ovary has been reported in wellconducted observational studies.1 These studies have been supported by numerous natural experiments, specifically, studies that examine differences in incidence rates according to naturally occurring variations among populations in their ambient exposure to solar ultraviolet B irradiance, the main source of vitamin D.2-6 The presence of a dose-response gradient is one of the key criteria for determining whether an association is causal. Vitamin D is essential for the expression of proteins involved in expression of intercellular junctions such as E-cadherin.19,20 Tissue culture systems of normal epithelial cells have confirmed that tight junctions, desmosomes, and gap junctions are the most common junctions between epithelial cells.20 The proteins that constitute junctional systems decline when the concentration of vitamin D metabolites is low.19,20 In the absence of intact intercellular junctions, epithelial cells may separate, lose their normal cuboidal architecture, and acquire an increasingly amorphous architecture, with loss of function and apical-basal polarity.21 This phenomenon has been termed decoupling.\n Concern about such a slow-growing malignancy would be irrelevant.
subject
0Anticarcinogenic Agents - administration & dosage
1Biological and medical sciences
2Breast cancer
3Colorectal cancer
4Dose-Response Relationship, Drug
5Epidemiology
6Humans
7Medical sciences
8Neoplasms - epidemiology
9Neoplasms - etiology
10Nutrition
11Risk Factors
12Tumors
13Vitamin D
14Vitamin D - administration & dosage
issn
00029-6643
11753-4887
fulltextfalse
rsrctypearticle
creationdate2007
recordtypearticle
recordideNqFkl1r2zAYhcXYWLNsv2AwxGC7c_rKkiXranTpPgqFQrqPS_FGlht1tpxKNmP_vvISKPSmAiEhzjnv4UGEvGWwYhzYaYirEkCtcLpZXWtWXOvqGVkwVfFC1LV6ThYApS6kFPyEvErpFgBYqflLcsJULRVXekEufu9wpD7Rcefo-ZBcsXFpP4Tk6MZ1OPp83fk93brxr3OB_vIj9j7Qc4qhoWsM1kW68enPp9fkRYtdcm-O55L8_Prlx_p7cXn17WJ9dlnYUgpd1BL1VlnJBEJjK5WrNKzWUFmBpVK8RASrai4Za0QuWbttoxlH1wqJrQZYko-H3H0c7iaXRtP7ZF3XYXDDlIysS8UAdBa-fyS8HaYYcjdTspILqMScxg8iG4eUomvNPvoe4z_DwMyYTYhmxmwyZpMx511l17tj9LTtXfPgOXLNgg9HASaLXRszKJ8edBq44Dl-SfSj8TYDnqmPEX33RInPB68PNy6MaFKPXZcbJeO75E2Yoju44P-SlTnLPwDqxAzGcX5ScA9Tx61R
startdate200708
enddate200708
creator
0Garland, Cedric F
1Grant, William B
2Mohr, Sharif B
3Gorham, Edward D
4Garland, Frank C
general
0International Life Sciences Institute
1Oxford University Press
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
93V.
107RV
117X2
127X7
137XB
1488E
1588I
168AO
178C1
188FE
198FH
208FI
218FJ
228FK
238G5
24ABUWG
25ATCPS
26AZQEC
27BEC
28BENPR
29BHPHI
30DWQXO
31FYUFA
32GHDGH
33GNUQQ
34GUQSH
35HCIFZ
36K9-
37K9.
38KB0
39M0K
40M0R
41M0S
42M1P
43M2O
44M2P
45MBDVC
46NAPCQ
47PADUT
48PQEST
49PQQKQ
50PQUKI
51PRINS
52Q9U
53S0X
547X8
sort
creationdate200708
titleWhat is the Dose-Response Relationship between Vitamin D and Cancer Risk?
authorGarland, Cedric F ; Grant, William B ; Mohr, Sharif B ; Gorham, Edward D ; Garland, Frank C
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c2649-86a9b7c614a0dc57178d18905c4a27732aa0c783611d46738ebd913aef46af900
rsrctypearticles
prefilterarticles
languageeng
creationdate2007
topic
0Anticarcinogenic Agents - administration & dosage
1Biological and medical sciences
2Breast cancer
3Colorectal cancer
4Dose-Response Relationship, Drug
5Epidemiology
6Humans
7Medical sciences
8Neoplasms - epidemiology
9Neoplasms - etiology
10Nutrition
11Risk Factors
12Tumors
13Vitamin D
14Vitamin D - administration & dosage
toplevelpeer_reviewed
creatorcontrib
0Garland, Cedric F
1Grant, William B
2Mohr, Sharif B
3Gorham, Edward D
4Garland, Frank C
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8ProQuest Central (Corporate)
9Nursing & Allied Health Database
10Agricultural Science Collection
11Health & Medical Collection
12ProQuest Central (purchase pre-March 2016)
13Medical Database (Alumni Edition)
14Science Database (Alumni Edition)
15ProQuest Pharma Collection
16Public Health Database
17ProQuest SciTech Collection
18ProQuest Natural Science Collection
19Hospital Premium Collection
20Hospital Premium Collection (Alumni Edition)
21ProQuest Central (Alumni) (purchase pre-March 2016)
22Research Library (Alumni Edition)
23ProQuest Central (Alumni Edition)
24Agricultural & Environmental Science Collection
25ProQuest Central Essentials
26eLibrary
27ProQuest Central
28Natural Science Collection
29ProQuest Central Korea
30Health Research Premium Collection
31Health Research Premium Collection (Alumni)
32ProQuest Central Student
33Research Library Prep
34SciTech Premium Collection
35Consumer Health Database (Alumni Edition)
36ProQuest Health & Medical Complete (Alumni)
37Nursing & Allied Health Database (Alumni Edition)
38Agricultural Science Database
39Consumer Health Database
40Health & Medical Collection (Alumni Edition)
41Medical Database
42Research Library
43Science Database
44Research Library (Corporate)
45Nursing & Allied Health Premium
46Research Library China
47ProQuest One Academic Eastern Edition
48ProQuest One Academic
49ProQuest One Academic UKI Edition
50ProQuest Central China
51ProQuest Central Basic
52SIRS Editorial
53MEDLINE - Academic
jtitleNutrition reviews
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Garland, Cedric F
1Grant, William B
2Mohr, Sharif B
3Gorham, Edward D
4Garland, Frank C
formatjournal
genrearticle
ristypeJOUR
atitleWhat is the Dose-Response Relationship between Vitamin D and Cancer Risk?
jtitleNutrition reviews
addtitleNutr Rev
date2007-08
risdate2007
volume65
issueSupplement 1
spage91
epage95
pages91-95
issn0029-6643
eissn1753-4887
codenNUREA8
abstractAn inverse association between serum 25-hydroxyvitamin D [25(OH)D], and risk of cancers of the colon, breast, and ovary has been reported in wellconducted observational studies.1 These studies have been supported by numerous natural experiments, specifically, studies that examine differences in incidence rates according to naturally occurring variations among populations in their ambient exposure to solar ultraviolet B irradiance, the main source of vitamin D.2-6 The presence of a dose-response gradient is one of the key criteria for determining whether an association is causal. Vitamin D is essential for the expression of proteins involved in expression of intercellular junctions such as E-cadherin.19,20 Tissue culture systems of normal epithelial cells have confirmed that tight junctions, desmosomes, and gap junctions are the most common junctions between epithelial cells.20 The proteins that constitute junctional systems decline when the concentration of vitamin D metabolites is low.19,20 In the absence of intact intercellular junctions, epithelial cells may separate, lose their normal cuboidal architecture, and acquire an increasingly amorphous architecture, with loss of function and apical-basal polarity.21 This phenomenon has been termed decoupling.\n Concern about such a slow-growing malignancy would be irrelevant.
copLawrence, KS
pubInternational Life Sciences Institute
pmid17867379
doi10.1301/nr.2007.aug.S91-S95