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Associations of Inflammatory and Haemostatic Biomarkers with Poor Outcome in Acute Ischaemic Stroke

Background: Many inflammatory and haemostatic biomarkers show associations with acute ischaemic stroke outcome, but few studies compare a large range of markers. Methods: We assessed clinical status and 16 biomarkers within 24 h of onset in 180 consecutive acute ischaemic stroke patients. Results: A... Full description

Journal Title: Cerebrovascular diseases (Basel Switzerland), 2009-03, Vol.27 (3), p.247-253
Main Author: Welsh, Paul
Other Authors: Barber, Mark , Langhorne, Peter , Rumley, Ann , Lowe, Gordon D.O , Stott, David J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: S. Karger AG
ID: ISSN: 1015-9770
Link: https://www.ncbi.nlm.nih.gov/pubmed/19176958
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recordid: cdi_proquest_journals_221223365
title: Associations of Inflammatory and Haemostatic Biomarkers with Poor Outcome in Acute Ischaemic Stroke
format: Article
creator:
  • Welsh, Paul
  • Barber, Mark
  • Langhorne, Peter
  • Rumley, Ann
  • Lowe, Gordon D.O
  • Stott, David J
subjects:
  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Biomarkers - blood
  • Brain Ischemia - blood
  • Brain Ischemia - complications
  • Brain Ischemia - immunology
  • Brain Ischemia - mortality
  • C-Reactive Protein - analysis
  • Female
  • Fibrin Fibrinogen Degradation Products - analysis
  • Hemostasis
  • Humans
  • Inflammation Mediators - blood
  • Interleukin-6 - blood
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Original Paper
  • Prognosis
  • Prospective Studies
  • Risk Assessment
  • Risk Factors
  • Severity of Illness Index
  • Stroke - blood
  • Stroke - etiology
  • Stroke - immunology
  • Stroke - mortality
  • Time Factors
ispartof: Cerebrovascular diseases (Basel, Switzerland), 2009-03, Vol.27 (3), p.247-253
description: Background: Many inflammatory and haemostatic biomarkers show associations with acute ischaemic stroke outcome, but few studies compare a large range of markers. Methods: We assessed clinical status and 16 biomarkers within 24 h of onset in 180 consecutive acute ischaemic stroke patients. Results: A total of 94 patients had a poor outcome (dead or dependent at 30 days). C-reactive protein (CRP), IL-6, and fibrin D-dimer showed the strongest univariate associations with poor outcome (>2-fold increase; p < 0.01). When all biomarkers were included with clinical variables in a multivariable model, only D-dimer (OR 1.54; 95% CI 1.09–2.17), CRP (OR 1.31; 95% CI 1.03–1.68) and Scandinavian Stroke Scale (OR 0.91; 95% CI 0.88–0.95) were associated with poor outcome. Conclusions:D-dimer and CRP are independently associated with poor outcome in acute ischaemic stroke. More data is required to expand our understanding of these potential relationships with outcome.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1015-9770
fulltext: fulltext
issn:
  • 1015-9770
  • 1421-9786
url: Link


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descriptionBackground: Many inflammatory and haemostatic biomarkers show associations with acute ischaemic stroke outcome, but few studies compare a large range of markers. Methods: We assessed clinical status and 16 biomarkers within 24 h of onset in 180 consecutive acute ischaemic stroke patients. Results: A total of 94 patients had a poor outcome (dead or dependent at 30 days). C-reactive protein (CRP), IL-6, and fibrin D-dimer showed the strongest univariate associations with poor outcome (>2-fold increase; p < 0.01). When all biomarkers were included with clinical variables in a multivariable model, only D-dimer (OR 1.54; 95% CI 1.09–2.17), CRP (OR 1.31; 95% CI 1.03–1.68) and Scandinavian Stroke Scale (OR 0.91; 95% CI 0.88–0.95) were associated with poor outcome. Conclusions:D-dimer and CRP are independently associated with poor outcome in acute ischaemic stroke. More data is required to expand our understanding of these potential relationships with outcome.
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subjectAcute Disease ; Aged ; Aged, 80 and over ; Biomarkers - blood ; Brain Ischemia - blood ; Brain Ischemia - complications ; Brain Ischemia - immunology ; Brain Ischemia - mortality ; C-Reactive Protein - analysis ; Female ; Fibrin Fibrinogen Degradation Products - analysis ; Hemostasis ; Humans ; Inflammation Mediators - blood ; Interleukin-6 - blood ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Original Paper ; Prognosis ; Prospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Stroke - blood ; Stroke - etiology ; Stroke - immunology ; Stroke - mortality ; Time Factors
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abstractBackground: Many inflammatory and haemostatic biomarkers show associations with acute ischaemic stroke outcome, but few studies compare a large range of markers. Methods: We assessed clinical status and 16 biomarkers within 24 h of onset in 180 consecutive acute ischaemic stroke patients. Results: A total of 94 patients had a poor outcome (dead or dependent at 30 days). C-reactive protein (CRP), IL-6, and fibrin D-dimer showed the strongest univariate associations with poor outcome (>2-fold increase; p < 0.01). When all biomarkers were included with clinical variables in a multivariable model, only D-dimer (OR 1.54; 95% CI 1.09–2.17), CRP (OR 1.31; 95% CI 1.03–1.68) and Scandinavian Stroke Scale (OR 0.91; 95% CI 0.88–0.95) were associated with poor outcome. Conclusions:D-dimer and CRP are independently associated with poor outcome in acute ischaemic stroke. More data is required to expand our understanding of these potential relationships with outcome.
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