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Dysregulation of miR-338-3p among various malignancies and the histone modification site of epigenetic regulation

Objective: To evaluate the expression of miR-338-3p among various types of cancers and investigate the histone modification sites of epigenetics. Methods: The data of miR-338-3p expression profile among 15 cancer types were obtained from TCGA Pan-Cancer database (The Cancer Genome Atlas). The expres... Full description

Journal Title: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban 2019-01-01 (5), p.706
Main Author: WANG Wen-jing
Other Authors: WANG Xiao-fei , LIU Li-ying , TONG Dong-dong , LI Qian , NI Lei , GUO Bo
Format: Electronic Article Electronic Article
Language: chi
Subjects:
Publisher: Xi'an: Xi'an Jiaotong University
ID: ISSN: 1671-8259
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title: Dysregulation of miR-338-3p among various malignancies and the histone modification site of epigenetic regulation
format: Article
creator:
  • WANG Wen-jing
  • WANG Xiao-fei
  • LIU Li-ying
  • TONG Dong-dong
  • LI Qian
  • NI Lei
  • GUO Bo
subjects:
  • Epigenetics
  • Genomes
  • Stomach cancer
ispartof: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban, 2019-01-01 (5), p.706
description: Objective: To evaluate the expression of miR-338-3p among various types of cancers and investigate the histone modification sites of epigenetics. Methods: The data of miR-338-3p expression profile among 15 cancer types were obtained from TCGA Pan-Cancer database (The Cancer Genome Atlas). The expression of miR-338-3p in 45 normal tissues and 366 malignancy tissues of gastric cancer was analyzed. The potential histone modification site in miR-338-3p promoter region was predicated with CRCH37 (Genome Reference Consortium). Chromatin immune coprecipitation (ChIP) and PCR were adopted to detect the modification sites of histone. Results: Compared with its counterpart, the miR-338-3p in colon adenocarcinoma, kidney renal clear cell carcinoma and liver hepatocellular carcinoma showed a significantly higher expression (P
language: chi
source:
identifier: ISSN: 1671-8259
fulltext: no_fulltext
issn:
  • 1671-8259
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titleDysregulation of miR-338-3p among various malignancies and the histone modification site of epigenetic regulation
creatorWANG Wen-jing ; WANG Xiao-fei ; LIU Li-ying ; TONG Dong-dong ; LI Qian ; NI Lei ; GUO Bo
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descriptionObjective: To evaluate the expression of miR-338-3p among various types of cancers and investigate the histone modification sites of epigenetics. Methods: The data of miR-338-3p expression profile among 15 cancer types were obtained from TCGA Pan-Cancer database (The Cancer Genome Atlas). The expression of miR-338-3p in 45 normal tissues and 366 malignancy tissues of gastric cancer was analyzed. The potential histone modification site in miR-338-3p promoter region was predicated with CRCH37 (Genome Reference Consortium). Chromatin immune coprecipitation (ChIP) and PCR were adopted to detect the modification sites of histone. Results: Compared with its counterpart, the miR-338-3p in colon adenocarcinoma, kidney renal clear cell carcinoma and liver hepatocellular carcinoma showed a significantly higher expression (P<0.05), but a significantly lower one in esophageal carcinoma, head and neck squamous cell carcinoma, kidney chromophobe, kidney renal papillary cell carcinoma, lung squamous cell carcinoma and thyroid carcinoma cancer (P<0.05). miR-338-3p expression was decreased in 45 normal gastric tissues compared with in 366 gastric cancer tissues. H3K9m2 and H3K4m3 were considered as two potential sites of histone modification of epigenetics which might induce the down-regulation of miR-338-3p in gastric cancer. Conclusion: miR-338-3p expression was decreased in gastric cancer and closely associated with two potential sites of histone modification of H3K9m2 and H3K4m3.
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descriptionObjective: To evaluate the expression of miR-338-3p among various types of cancers and investigate the histone modification sites of epigenetics. Methods: The data of miR-338-3p expression profile among 15 cancer types were obtained from TCGA Pan-Cancer database (The Cancer Genome Atlas). The expression of miR-338-3p in 45 normal tissues and 366 malignancy tissues of gastric cancer was analyzed. The potential histone modification site in miR-338-3p promoter region was predicated with CRCH37 (Genome Reference Consortium). Chromatin immune coprecipitation (ChIP) and PCR were adopted to detect the modification sites of histone. Results: Compared with its counterpart, the miR-338-3p in colon adenocarcinoma, kidney renal clear cell carcinoma and liver hepatocellular carcinoma showed a significantly higher expression (P<0.05), but a significantly lower one in esophageal carcinoma, head and neck squamous cell carcinoma, kidney chromophobe, kidney renal papillary cell carcinoma, lung squamous cell carcinoma and thyroid carcinoma cancer (P<0.05). miR-338-3p expression was decreased in 45 normal gastric tissues compared with in 366 gastric cancer tissues. H3K9m2 and H3K4m3 were considered as two potential sites of histone modification of epigenetics which might induce the down-regulation of miR-338-3p in gastric cancer. Conclusion: miR-338-3p expression was decreased in gastric cancer and closely associated with two potential sites of histone modification of H3K9m2 and H3K4m3.
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abstractObjective: To evaluate the expression of miR-338-3p among various types of cancers and investigate the histone modification sites of epigenetics. Methods: The data of miR-338-3p expression profile among 15 cancer types were obtained from TCGA Pan-Cancer database (The Cancer Genome Atlas). The expression of miR-338-3p in 45 normal tissues and 366 malignancy tissues of gastric cancer was analyzed. The potential histone modification site in miR-338-3p promoter region was predicated with CRCH37 (Genome Reference Consortium). Chromatin immune coprecipitation (ChIP) and PCR were adopted to detect the modification sites of histone. Results: Compared with its counterpart, the miR-338-3p in colon adenocarcinoma, kidney renal clear cell carcinoma and liver hepatocellular carcinoma showed a significantly higher expression (P<0.05), but a significantly lower one in esophageal carcinoma, head and neck squamous cell carcinoma, kidney chromophobe, kidney renal papillary cell carcinoma, lung squamous cell carcinoma and thyroid carcinoma cancer (P<0.05). miR-338-3p expression was decreased in 45 normal gastric tissues compared with in 366 gastric cancer tissues. H3K9m2 and H3K4m3 were considered as two potential sites of histone modification of epigenetics which might induce the down-regulation of miR-338-3p in gastric cancer. Conclusion: miR-338-3p expression was decreased in gastric cancer and closely associated with two potential sites of histone modification of H3K9m2 and H3K4m3.
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doi10.7652/jdyxb201905008