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Emerging Concepts on the Role of Innate Immunity in the Prevention and Control of HIV Infection

While neutralizing antibodies can provide sterilizing protection from HIV infection via their variable domains, the antibody constant domain provides a functional link between innate and adaptive immunity and offers a means to harness the potent antiviral properties of a wide spectrum of innate immu... Full description

Journal Title: Annual review of medicine 2012-02-18, Vol.63 (1), p.113-130
Main Author: Ackerman, Margaret E
Other Authors: Dugast, Anne-Sophie , Alter, Galit
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
IgG
Quelle: Alma/SFX Local Collection
Publisher: United States: Annual Reviews
ID: ISSN: 0066-4219
Link: https://www.ncbi.nlm.nih.gov/pubmed/22077718
Zum Text:
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title: Emerging Concepts on the Role of Innate Immunity in the Prevention and Control of HIV Infection
format: Article
creator:
  • Ackerman, Margaret E
  • Dugast, Anne-Sophie
  • Alter, Galit
subjects:
  • AIDS Vaccines - immunology
  • Antibodies, Neutralizing - immunology
  • Antibodies, Neutralizing - therapeutic use
  • antibody-dependent cellular cytotoxicity
  • antibody-dependent cellular viral inhibition
  • Control
  • Disease prevention
  • Disease transmission
  • effector function
  • FcγR
  • Health aspects
  • HIV
  • HIV infection
  • HIV Infections - immunology
  • HIV Infections - prevention & control
  • Human immunodeficiency virus
  • Humans
  • IgG
  • IgG Fc
  • Immune system
  • Immunity, Innate - immunology
  • Immunotherapy
  • Physiological aspects
  • Prevention
  • Viral infections
ispartof: Annual review of medicine, 2012-02-18, Vol.63 (1), p.113-130
description: While neutralizing antibodies can provide sterilizing protection from HIV infection via their variable domains, the antibody constant domain provides a functional link between innate and adaptive immunity and offers a means to harness the potent antiviral properties of a wide spectrum of innate immune effector cells. There has been a growing appreciation of the role of these effector mechanisms across fields from cancer immunotherapy to autoimmunity and infectious disease, as well as speculation that this mechanism may be responsible for the protection observed in the RV144 HIV vaccine trial. This review summarizes these extraneutralizing humoral immune activities, progress in defining the importance of these effector mechanisms during progression in HIV infection, and the potential impact that such vaccine-induced immune responses may have on protection from infection.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0066-4219
fulltext: fulltext
issn:
  • 0066-4219
  • 1545-326X
url: Link


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descriptionWhile neutralizing antibodies can provide sterilizing protection from HIV infection via their variable domains, the antibody constant domain provides a functional link between innate and adaptive immunity and offers a means to harness the potent antiviral properties of a wide spectrum of innate immune effector cells. There has been a growing appreciation of the role of these effector mechanisms across fields from cancer immunotherapy to autoimmunity and infectious disease, as well as speculation that this mechanism may be responsible for the protection observed in the RV144 HIV vaccine trial. This review summarizes these extraneutralizing humoral immune activities, progress in defining the importance of these effector mechanisms during progression in HIV infection, and the potential impact that such vaccine-induced immune responses may have on protection from infection.
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subjectAIDS Vaccines - immunology ; Antibodies, Neutralizing - immunology ; Antibodies, Neutralizing - therapeutic use ; antibody-dependent cellular cytotoxicity ; antibody-dependent cellular viral inhibition ; Control ; Disease prevention ; Disease transmission ; effector function ; FcγR ; Health aspects ; HIV ; HIV infection ; HIV Infections - immunology ; HIV Infections - prevention & control ; Human immunodeficiency virus ; Humans ; IgG ; IgG Fc ; Immune system ; Immunity, Innate - immunology ; Immunotherapy ; Physiological aspects ; Prevention ; Viral infections
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descriptionWhile neutralizing antibodies can provide sterilizing protection from HIV infection via their variable domains, the antibody constant domain provides a functional link between innate and adaptive immunity and offers a means to harness the potent antiviral properties of a wide spectrum of innate immune effector cells. There has been a growing appreciation of the role of these effector mechanisms across fields from cancer immunotherapy to autoimmunity and infectious disease, as well as speculation that this mechanism may be responsible for the protection observed in the RV144 HIV vaccine trial. This review summarizes these extraneutralizing humoral immune activities, progress in defining the importance of these effector mechanisms during progression in HIV infection, and the potential impact that such vaccine-induced immune responses may have on protection from infection.
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abstractWhile neutralizing antibodies can provide sterilizing protection from HIV infection via their variable domains, the antibody constant domain provides a functional link between innate and adaptive immunity and offers a means to harness the potent antiviral properties of a wide spectrum of innate immune effector cells. There has been a growing appreciation of the role of these effector mechanisms across fields from cancer immunotherapy to autoimmunity and infectious disease, as well as speculation that this mechanism may be responsible for the protection observed in the RV144 HIV vaccine trial. This review summarizes these extraneutralizing humoral immune activities, progress in defining the importance of these effector mechanisms during progression in HIV infection, and the potential impact that such vaccine-induced immune responses may have on protection from infection.
copUnited States
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pmid22077718
doi10.1146/annurev-med-050310-085221