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Longitudinal imaging of Alzheimer pathology using [C-11]PIB, [F-18]FDDNP and [F-18]FDG PET

Purpose [ 11 C]PIB and [ 18 F]FDDNP are PET tracers for in vivo detection of the neuropathology underlying Alzheimer’s disease (AD). [ 18 F]FDG is a glucose analogue and its uptake reflects metabolic activity. The purpose of this study was to examine longitudinal changes in these tracers in patients... Full description

Journal Title: European journal of nuclear medicine and molecular imaging 2012, Vol.39 (6), p.990-1000
Main Author: Ossenkoppele, R
Other Authors: Tolboom, N , Foster-Dingley, J.C , Aiaanse, S.F , Boellaard, R , Yaqub, M.M , Windhorst, A.D , Barkhof, F , Lammertsma, A.A , Scheltens, P , van der Flier, W.M , van Berckel, B.N.M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 1619-7070
Link: https://www.ncbi.nlm.nih.gov/pubmed/22441582
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title: Longitudinal imaging of Alzheimer pathology using [C-11]PIB, [F-18]FDDNP and [F-18]FDG PET
format: Article
creator:
  • Ossenkoppele, R
  • Tolboom, N
  • Foster-Dingley, J.C
  • Aiaanse, S.F
  • Boellaard, R
  • Yaqub, M.M
  • Windhorst, A.D
  • Barkhof, F
  • Lammertsma, A.A
  • Scheltens, P
  • van der Flier, W.M
  • van Berckel, B.N.M
subjects:
  • Aged
  • Alzheimer Disease - diagnostic imaging
  • Alzheimer Disease - pathology
  • Alzheimer's disease
  • Alzheimers disease
  • Amyloid
  • Aniline Compounds
  • Benzothiazoles
  • Cardiology
  • Case-Control Studies
  • Cognitive ability
  • Cognitive Dysfunction - diagnostic imaging
  • Female
  • Glucose
  • Humans
  • Imaging
  • Longitudinal Studies
  • Male
  • Medicine
  • Medicine & Public Health
  • Metabolic disorders
  • Middle Aged
  • Neurodegenerative diseases
  • Neuropathology
  • Nitriles
  • Nuclear Medicine
  • Oncology
  • Original Article
  • Orthopedics
  • Pathology
  • Positron emission tomography
  • Positron-Emission Tomography - methods
  • Radiology
  • Stilbenes
  • Temporal lobe
  • Time Factors
  • Tomography
  • Tracers
ispartof: European journal of nuclear medicine and molecular imaging, 2012, Vol.39 (6), p.990-1000
description: Purpose [ 11 C]PIB and [ 18 F]FDDNP are PET tracers for in vivo detection of the neuropathology underlying Alzheimer’s disease (AD). [ 18 F]FDG is a glucose analogue and its uptake reflects metabolic activity. The purpose of this study was to examine longitudinal changes in these tracers in patients with AD or mild cognitive impairment (MCI) and in healthy controls. Methods Longitudinal, paired, dynamic [ 11 C]PIB and [ 18 F]FDDNP (90 min each) and static [ 18 F]FDG (15 min) PET scans were obtained in 11 controls, 12 MCI patients and 8 AD patients. The mean interval between baseline and follow-up was 2.5 years (range 2.0–4.0 years). Parametric [ 11 C]PIB and [ 18 F]FDDNP images of binding potential (BP ND ) and [ 18 F]FDG standardized uptake value ratio (SUVr) images were generated. Results A significant increase in global cortical [ 11 C]PIB BP ND was found in MCI patients, but no changes were observed in AD patients or controls. Subsequent regional analysis revealed that this increase in [ 11 C]PIB BP ND in MCI patients was most prominent in the lateral temporal lobe ( p  
language: eng
source:
identifier: ISSN: 1619-7070
fulltext: no_fulltext
issn:
  • 1619-7070
  • 1619-7089
url: Link


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titleLongitudinal imaging of Alzheimer pathology using [C-11]PIB, [F-18]FDDNP and [F-18]FDG PET
creatorOssenkoppele, R ; Tolboom, N ; Foster-Dingley, J.C ; Aiaanse, S.F ; Boellaard, R ; Yaqub, M.M ; Windhorst, A.D ; Barkhof, F ; Lammertsma, A.A ; Scheltens, P ; van der Flier, W.M ; van Berckel, B.N.M
creatorcontribOssenkoppele, R ; Tolboom, N ; Foster-Dingley, J.C ; Aiaanse, S.F ; Boellaard, R ; Yaqub, M.M ; Windhorst, A.D ; Barkhof, F ; Lammertsma, A.A ; Scheltens, P ; van der Flier, W.M ; van Berckel, B.N.M
descriptionPurpose [ 11 C]PIB and [ 18 F]FDDNP are PET tracers for in vivo detection of the neuropathology underlying Alzheimer’s disease (AD). [ 18 F]FDG is a glucose analogue and its uptake reflects metabolic activity. The purpose of this study was to examine longitudinal changes in these tracers in patients with AD or mild cognitive impairment (MCI) and in healthy controls. Methods Longitudinal, paired, dynamic [ 11 C]PIB and [ 18 F]FDDNP (90 min each) and static [ 18 F]FDG (15 min) PET scans were obtained in 11 controls, 12 MCI patients and 8 AD patients. The mean interval between baseline and follow-up was 2.5 years (range 2.0–4.0 years). Parametric [ 11 C]PIB and [ 18 F]FDDNP images of binding potential (BP ND ) and [ 18 F]FDG standardized uptake value ratio (SUVr) images were generated. Results A significant increase in global cortical [ 11 C]PIB BP ND was found in MCI patients, but no changes were observed in AD patients or controls. Subsequent regional analysis revealed that this increase in [ 11 C]PIB BP ND in MCI patients was most prominent in the lateral temporal lobe ( p  < 0.05). For [ 18 F]FDDNP, no changes in global BP ND were found. [ 18 F]FDG uptake was reduced at follow-up in the AD group only, especially in frontal, parietal and lateral temporal lobes (all p  < 0.01). Changes in global [ 11 C]PIB binding (ρ = −0.42, p  < 0.05) and posterior cingulate [ 18 F]FDG uptake (ρ = 0.54, p  < 0.01) were correlated with changes in Mini-Mental-State Examination score over time across groups, whilst changes in [ 18 F]FDDNP binding (ρ = −0.18, p  = 0.35) were not. Conclusion [ 11 C]PIB and [ 18 F]FDG track molecular changes in different stages of AD. We found increased amyloid load in MCI patients and progressive metabolic impairment in AD patients. [ 18 F]FDDNP seems to be less useful for examining disease progression.
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subjectAged ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - pathology ; Alzheimer's disease ; Alzheimers disease ; Amyloid ; Aniline Compounds ; Benzothiazoles ; Cardiology ; Case-Control Studies ; Cognitive ability ; Cognitive Dysfunction - diagnostic imaging ; Female ; Glucose ; Humans ; Imaging ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Metabolic disorders ; Middle Aged ; Neurodegenerative diseases ; Neuropathology ; Nitriles ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; Pathology ; Positron emission tomography ; Positron-Emission Tomography - methods ; Radiology ; Stilbenes ; Temporal lobe ; Time Factors ; Tomography ; Tracers
ispartofEuropean journal of nuclear medicine and molecular imaging, 2012, Vol.39 (6), p.990-1000
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1Tolboom, N
2Foster-Dingley, J.C
3Aiaanse, S.F
4Boellaard, R
5Yaqub, M.M
6Windhorst, A.D
7Barkhof, F
8Lammertsma, A.A
9Scheltens, P
10van der Flier, W.M
11van Berckel, B.N.M
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0Longitudinal imaging of Alzheimer pathology using [C-11]PIB, [F-18]FDDNP and [F-18]FDG PET
1European journal of nuclear medicine and molecular imaging
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descriptionPurpose [ 11 C]PIB and [ 18 F]FDDNP are PET tracers for in vivo detection of the neuropathology underlying Alzheimer’s disease (AD). [ 18 F]FDG is a glucose analogue and its uptake reflects metabolic activity. The purpose of this study was to examine longitudinal changes in these tracers in patients with AD or mild cognitive impairment (MCI) and in healthy controls. Methods Longitudinal, paired, dynamic [ 11 C]PIB and [ 18 F]FDDNP (90 min each) and static [ 18 F]FDG (15 min) PET scans were obtained in 11 controls, 12 MCI patients and 8 AD patients. The mean interval between baseline and follow-up was 2.5 years (range 2.0–4.0 years). Parametric [ 11 C]PIB and [ 18 F]FDDNP images of binding potential (BP ND ) and [ 18 F]FDG standardized uptake value ratio (SUVr) images were generated. Results A significant increase in global cortical [ 11 C]PIB BP ND was found in MCI patients, but no changes were observed in AD patients or controls. Subsequent regional analysis revealed that this increase in [ 11 C]PIB BP ND in MCI patients was most prominent in the lateral temporal lobe ( p  < 0.05). For [ 18 F]FDDNP, no changes in global BP ND were found. [ 18 F]FDG uptake was reduced at follow-up in the AD group only, especially in frontal, parietal and lateral temporal lobes (all p  < 0.01). Changes in global [ 11 C]PIB binding (ρ = −0.42, p  < 0.05) and posterior cingulate [ 18 F]FDG uptake (ρ = 0.54, p  < 0.01) were correlated with changes in Mini-Mental-State Examination score over time across groups, whilst changes in [ 18 F]FDDNP binding (ρ = −0.18, p  = 0.35) were not. Conclusion [ 11 C]PIB and [ 18 F]FDG track molecular changes in different stages of AD. We found increased amyloid load in MCI patients and progressive metabolic impairment in AD patients. [ 18 F]FDDNP seems to be less useful for examining disease progression.
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4Alzheimers disease
5Amyloid
6Aniline Compounds
7Benzothiazoles
8Cardiology
9Case-Control Studies
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15Imaging
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17Male
18Medicine
19Medicine & Public Health
20Metabolic disorders
21Middle Aged
22Neurodegenerative diseases
23Neuropathology
24Nitriles
25Nuclear Medicine
26Oncology
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28Orthopedics
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30Positron emission tomography
31Positron-Emission Tomography - methods
32Radiology
33Stilbenes
34Temporal lobe
35Time Factors
36Tomography
37Tracers
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titleLongitudinal imaging of Alzheimer pathology using [C-11]PIB, [F-18]FDDNP and [F-18]FDG PET
authorOssenkoppele, R ; Tolboom, N ; Foster-Dingley, J.C ; Aiaanse, S.F ; Boellaard, R ; Yaqub, M.M ; Windhorst, A.D ; Barkhof, F ; Lammertsma, A.A ; Scheltens, P ; van der Flier, W.M ; van Berckel, B.N.M
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1Alzheimer Disease - diagnostic imaging
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6Aniline Compounds
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35Time Factors
36Tomography
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abstractPurpose [ 11 C]PIB and [ 18 F]FDDNP are PET tracers for in vivo detection of the neuropathology underlying Alzheimer’s disease (AD). [ 18 F]FDG is a glucose analogue and its uptake reflects metabolic activity. The purpose of this study was to examine longitudinal changes in these tracers in patients with AD or mild cognitive impairment (MCI) and in healthy controls. Methods Longitudinal, paired, dynamic [ 11 C]PIB and [ 18 F]FDDNP (90 min each) and static [ 18 F]FDG (15 min) PET scans were obtained in 11 controls, 12 MCI patients and 8 AD patients. The mean interval between baseline and follow-up was 2.5 years (range 2.0–4.0 years). Parametric [ 11 C]PIB and [ 18 F]FDDNP images of binding potential (BP ND ) and [ 18 F]FDG standardized uptake value ratio (SUVr) images were generated. Results A significant increase in global cortical [ 11 C]PIB BP ND was found in MCI patients, but no changes were observed in AD patients or controls. Subsequent regional analysis revealed that this increase in [ 11 C]PIB BP ND in MCI patients was most prominent in the lateral temporal lobe ( p  < 0.05). For [ 18 F]FDDNP, no changes in global BP ND were found. [ 18 F]FDG uptake was reduced at follow-up in the AD group only, especially in frontal, parietal and lateral temporal lobes (all p  < 0.01). Changes in global [ 11 C]PIB binding (ρ = −0.42, p  < 0.05) and posterior cingulate [ 18 F]FDG uptake (ρ = 0.54, p  < 0.01) were correlated with changes in Mini-Mental-State Examination score over time across groups, whilst changes in [ 18 F]FDDNP binding (ρ = −0.18, p  = 0.35) were not. Conclusion [ 11 C]PIB and [ 18 F]FDG track molecular changes in different stages of AD. We found increased amyloid load in MCI patients and progressive metabolic impairment in AD patients. [ 18 F]FDDNP seems to be less useful for examining disease progression.
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