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Does somatic illness explain the association between common mental disorder and elevated mortality? Findings from extended follow-up of study members in the UK Health and Lifestyle Survey

BackgroundCommon mental disorder (psychological distress) is associated with an increased risk of disease-specific mortality. Given that physical illness is related to both exposure and outcome, it may explain this relation through confounding or mediation.MethodsThe authors used a 20-year follow-up... Full description

Journal Title: Journal of epidemiology and community health (1979) 2012, Vol.66 (7), p.647-649
Main Author: Batty, G David
Other Authors: Hamer, Mark , Der, Geoff
Format: Electronic Article Electronic Article
Language: English
Subjects:
Men
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd
ID: ISSN: 0143-005X
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recordid: cdi_proquest_miscellaneous_1019095935
title: Does somatic illness explain the association between common mental disorder and elevated mortality? Findings from extended follow-up of study members in the UK Health and Lifestyle Survey
format: Article
creator:
  • Batty, G David
  • Hamer, Mark
  • Der, Geoff
subjects:
  • Adult
  • Biological and medical sciences
  • cancer
  • Cardiovascular disease
  • Care and treatment
  • CHD/coronary heart
  • Cigarette smoking
  • Common mental disorder
  • Coronary heart disease
  • Diagnosis
  • Disease risk
  • Diseases
  • Epidemiology
  • Female
  • Follow-Up Studies
  • General aspects
  • Health aspects
  • Health risk assessment
  • Health Surveys
  • Heart diseases
  • Humans
  • Lifestyle
  • Male
  • Medical sciences
  • Men
  • Mental disorders
  • Mental Disorders - mortality
  • Mental illness
  • Middle Aged
  • Miscellaneous
  • Mortality
  • Mortality - trends
  • physical illness
  • Psychology. Psychoanalysis. Psychiatry
  • Psychopathology. Psychiatry
  • Public health. Hygiene
  • Public health. Hygiene-occupational medicine
  • Short reports
  • Somatoform Disorders
  • State Medicine
  • United Kingdom - epidemiology
  • Women
ispartof: Journal of epidemiology and community health (1979), 2012, Vol.66 (7), p.647-649
description: BackgroundCommon mental disorder (psychological distress) is associated with an increased risk of disease-specific mortality. Given that physical illness is related to both exposure and outcome, it may explain this relation through confounding or mediation.MethodsThe authors used a 20-year follow-up of the UK Health and Lifestyle Survey (6127 men and women) in which common mental disorder was ascertained at baseline using the 30 item General Health Questionnaire and physical illness using a range of enquiries. Study members were an average of 45.2 years (SD 17.0) at study induction.ResultsIn age-adjusted analyses, a 1 SD increase in common mental disorder score was associated with an elevated risk of mortality outcomes coronary heart disease (CHD) in men (HR 1.11, 95% CI 0.96 to 1.27), CHD in women (1.33, 1.16 to 1.51); plus, in men and women combined, stroke (1.13, 0.96 to 1.30), respiratory disease (1.31, 1.15 to 1.48), lung cancer (1.11, 0.92 to 1.33), ‘other’ cancer (1.14, 1.03 to 1.26) and all causes (1.18, 1.12 to 1.23). Controlling for prior physical illness effectively eliminated the common mental disorder–mortality relation in all analyses with the exception of CHD in women.ConclusionThat physical illness largely explains the link between common mental disorder and mortality in the present cohort is compatible with either a confounding or mediation explanation.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0143-005X
fulltext: fulltext
issn:
  • 0143-005X
  • 1470-2738
url: Link


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titleDoes somatic illness explain the association between common mental disorder and elevated mortality? Findings from extended follow-up of study members in the UK Health and Lifestyle Survey
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creatorBatty, G David ; Hamer, Mark ; Der, Geoff
creatorcontribBatty, G David ; Hamer, Mark ; Der, Geoff
descriptionBackgroundCommon mental disorder (psychological distress) is associated with an increased risk of disease-specific mortality. Given that physical illness is related to both exposure and outcome, it may explain this relation through confounding or mediation.MethodsThe authors used a 20-year follow-up of the UK Health and Lifestyle Survey (6127 men and women) in which common mental disorder was ascertained at baseline using the 30 item General Health Questionnaire and physical illness using a range of enquiries. Study members were an average of 45.2 years (SD 17.0) at study induction.ResultsIn age-adjusted analyses, a 1 SD increase in common mental disorder score was associated with an elevated risk of mortality outcomes coronary heart disease (CHD) in men (HR 1.11, 95% CI 0.96 to 1.27), CHD in women (1.33, 1.16 to 1.51); plus, in men and women combined, stroke (1.13, 0.96 to 1.30), respiratory disease (1.31, 1.15 to 1.48), lung cancer (1.11, 0.92 to 1.33), ‘other’ cancer (1.14, 1.03 to 1.26) and all causes (1.18, 1.12 to 1.23). Controlling for prior physical illness effectively eliminated the common mental disorder–mortality relation in all analyses with the exception of CHD in women.ConclusionThat physical illness largely explains the link between common mental disorder and mortality in the present cohort is compatible with either a confounding or mediation explanation.
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subjectAdult ; Biological and medical sciences ; cancer ; Cardiovascular disease ; Care and treatment ; CHD/coronary heart ; Cigarette smoking ; Common mental disorder ; Coronary heart disease ; Diagnosis ; Disease risk ; Diseases ; Epidemiology ; Female ; Follow-Up Studies ; General aspects ; Health aspects ; Health risk assessment ; Health Surveys ; Heart diseases ; Humans ; Lifestyle ; Male ; Medical sciences ; Men ; Mental disorders ; Mental Disorders - mortality ; Mental illness ; Middle Aged ; Miscellaneous ; Mortality ; Mortality - trends ; physical illness ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Short reports ; Somatoform Disorders ; State Medicine ; United Kingdom - epidemiology ; Women
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descriptionBackgroundCommon mental disorder (psychological distress) is associated with an increased risk of disease-specific mortality. Given that physical illness is related to both exposure and outcome, it may explain this relation through confounding or mediation.MethodsThe authors used a 20-year follow-up of the UK Health and Lifestyle Survey (6127 men and women) in which common mental disorder was ascertained at baseline using the 30 item General Health Questionnaire and physical illness using a range of enquiries. Study members were an average of 45.2 years (SD 17.0) at study induction.ResultsIn age-adjusted analyses, a 1 SD increase in common mental disorder score was associated with an elevated risk of mortality outcomes coronary heart disease (CHD) in men (HR 1.11, 95% CI 0.96 to 1.27), CHD in women (1.33, 1.16 to 1.51); plus, in men and women combined, stroke (1.13, 0.96 to 1.30), respiratory disease (1.31, 1.15 to 1.48), lung cancer (1.11, 0.92 to 1.33), ‘other’ cancer (1.14, 1.03 to 1.26) and all causes (1.18, 1.12 to 1.23). Controlling for prior physical illness effectively eliminated the common mental disorder–mortality relation in all analyses with the exception of CHD in women.ConclusionThat physical illness largely explains the link between common mental disorder and mortality in the present cohort is compatible with either a confounding or mediation explanation.
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41Women
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abstractBackgroundCommon mental disorder (psychological distress) is associated with an increased risk of disease-specific mortality. Given that physical illness is related to both exposure and outcome, it may explain this relation through confounding or mediation.MethodsThe authors used a 20-year follow-up of the UK Health and Lifestyle Survey (6127 men and women) in which common mental disorder was ascertained at baseline using the 30 item General Health Questionnaire and physical illness using a range of enquiries. Study members were an average of 45.2 years (SD 17.0) at study induction.ResultsIn age-adjusted analyses, a 1 SD increase in common mental disorder score was associated with an elevated risk of mortality outcomes coronary heart disease (CHD) in men (HR 1.11, 95% CI 0.96 to 1.27), CHD in women (1.33, 1.16 to 1.51); plus, in men and women combined, stroke (1.13, 0.96 to 1.30), respiratory disease (1.31, 1.15 to 1.48), lung cancer (1.11, 0.92 to 1.33), ‘other’ cancer (1.14, 1.03 to 1.26) and all causes (1.18, 1.12 to 1.23). Controlling for prior physical illness effectively eliminated the common mental disorder–mortality relation in all analyses with the exception of CHD in women.ConclusionThat physical illness largely explains the link between common mental disorder and mortality in the present cohort is compatible with either a confounding or mediation explanation.
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