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Adiponectin: mechanistic insights and clinical implications

Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over the past 15 years. A multitude of different functions have been attributed to this adipokine. It has been characterised in vitro at the level of tissue culture systems and in vivo through genetic manipulatio... Full description

Journal Title: Diabetologia 2012, Vol.55 (9), p.2319-2326
Main Author: Turer, A. T
Other Authors: Scherer, P. E
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0012-186X
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title: Adiponectin: mechanistic insights and clinical implications
format: Article
creator:
  • Turer, A. T
  • Scherer, P. E
subjects:
  • Adiponectin - genetics
  • Adiponectin - metabolism
  • Adiponectin - secretion
  • Adipose Tissue - metabolism
  • Animals
  • Biological and medical sciences
  • Biomarkers - metabolism
  • Cardiovascular Diseases - genetics
  • Cardiovascular Diseases - metabolism
  • Cells
  • Ceramides
  • Diabetes
  • Diabetes. Impaired glucose tolerance
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Gene Expression Regulation - genetics
  • Genetic engineering
  • Human Physiology
  • Humans
  • Inflammation - genetics
  • Inflammation - metabolism
  • Insulin Resistance - genetics
  • Internal Medicine
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Obesity
  • Plant lipids
  • Receptors, Adiponectin - genetics
  • Receptors, Adiponectin - metabolism
  • Review
ispartof: Diabetologia, 2012, Vol.55 (9), p.2319-2326
description: Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over the past 15 years. A multitude of different functions have been attributed to this adipokine. It has been characterised in vitro at the level of tissue culture systems and in vivo through genetic manipulation of rodent models. It is also widely accepted as a biomarker in clinical studies. Originating in adipose tissue, generally positive metabolic effects have been attributed to adiponectin. In this review, we briefly discuss the key characteristics of this interesting but very complex molecule, highlight recent results in the context of its mechanism of action and summarise some of the key epidemiological data that helped establish adiponectin as a robust biomarker for insulin sensitivity, cardiovascular disease and many additional disease phenomena.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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descriptionAdiponectin is an adipocyte-derived secretory protein that has been very widely studied over the past 15 years. A multitude of different functions have been attributed to this adipokine. It has been characterised in vitro at the level of tissue culture systems and in vivo through genetic manipulation of rodent models. It is also widely accepted as a biomarker in clinical studies. Originating in adipose tissue, generally positive metabolic effects have been attributed to adiponectin. In this review, we briefly discuss the key characteristics of this interesting but very complex molecule, highlight recent results in the context of its mechanism of action and summarise some of the key epidemiological data that helped establish adiponectin as a robust biomarker for insulin sensitivity, cardiovascular disease and many additional disease phenomena.
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subjectAdiponectin - genetics ; Adiponectin - metabolism ; Adiponectin - secretion ; Adipose Tissue - metabolism ; Animals ; Biological and medical sciences ; Biomarkers - metabolism ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - metabolism ; Cells ; Ceramides ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Gene Expression Regulation - genetics ; Genetic engineering ; Human Physiology ; Humans ; Inflammation - genetics ; Inflammation - metabolism ; Insulin Resistance - genetics ; Internal Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Obesity ; Plant lipids ; Receptors, Adiponectin - genetics ; Receptors, Adiponectin - metabolism ; Review
ispartofDiabetologia, 2012, Vol.55 (9), p.2319-2326
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abstractAdiponectin is an adipocyte-derived secretory protein that has been very widely studied over the past 15 years. A multitude of different functions have been attributed to this adipokine. It has been characterised in vitro at the level of tissue culture systems and in vivo through genetic manipulation of rodent models. It is also widely accepted as a biomarker in clinical studies. Originating in adipose tissue, generally positive metabolic effects have been attributed to adiponectin. In this review, we briefly discuss the key characteristics of this interesting but very complex molecule, highlight recent results in the context of its mechanism of action and summarise some of the key epidemiological data that helped establish adiponectin as a robust biomarker for insulin sensitivity, cardiovascular disease and many additional disease phenomena.
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