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Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan Africa

High-risk human papillomavirus (HR-HPV) infection is the most common sexually transmitted infection. Penile and cervical cancer rates are highest in sub-Saharan Africa. However, little is known about the impact of HIV infection on HR-HPV acquisition and clearance among heterosexual men. HR-HPV incid... Full description

Journal Title: AIDS (London) 2012, Vol.26 (12), p.1555-1565
Main Author: TOBIAN, Aaron A. R
Other Authors: KIGOZI, Godfrey , GRAY, Ronald H , GRAVITT, Patti E , CHANGCHANG XIAO , SERWADDA, David , EATON, Kevin P , XIANGRONG KONG , WAWER, Maria J , NALUGODA, Fred , QUINN, Thomas C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
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title: Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan Africa
format: Article
creator:
  • TOBIAN, Aaron A. R
  • KIGOZI, Godfrey
  • GRAY, Ronald H
  • GRAVITT, Patti E
  • CHANGCHANG XIAO
  • SERWADDA, David
  • EATON, Kevin P
  • XIANGRONG KONG
  • WAWER, Maria J
  • NALUGODA, Fred
  • QUINN, Thomas C
subjects:
  • Adolescent
  • Adult
  • AIDS/HIV
  • Biological and medical sciences
  • Circumcision, Male
  • Herpesvirus 2, Human - isolation & purification
  • Heterosexuality
  • HIV Infections - epidemiology
  • Human papillomavirus
  • Human viral diseases
  • Humans
  • Immunodeficiencies
  • Immunodeficiencies. Immunoglobulinopathies
  • Immunopathology
  • Incidence
  • Infectious diseases
  • Male
  • Marital Status
  • Medical sciences
  • Middle Aged
  • Papillomaviridae - genetics
  • Papillomaviridae - isolation & purification
  • Papillomavirus Infections - epidemiology
  • Papillomavirus Infections - genetics
  • Penis - virology
  • Risk Factors
  • Sexual Behavior
  • Syphilis - epidemiology
  • Uganda - epidemiology
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Young Adult
ispartof: AIDS (London), 2012, Vol.26 (12), p.1555-1565
description: High-risk human papillomavirus (HR-HPV) infection is the most common sexually transmitted infection. Penile and cervical cancer rates are highest in sub-Saharan Africa. However, little is known about the impact of HIV infection on HR-HPV acquisition and clearance among heterosexual men. HR-HPV incidence and clearance were evaluated in 999 men (776 HIV-negative and 223 HIV-positive) aged 15-49 years who participated in male circumcision trials in Rakai, Uganda. Penile swabs were tested for HR-HPV by Roche HPV Linear Array. A Poisson multivariable model was used to estimate adjusted incidence rate ratios (adjIRRs) and clearance risk ratios (adjRRs). HR-HPV incidence was 66.5/100 person-years in HIV-positive men and 32.9/100 person-years among HIV-negative men [IRR=2.02, 95% confidence interval (CI) 1.67-2.44]. Incidence was higher in the unmarried men (adjIRR=1.73, 95% CI 1.19-2.52), and decreased with age (adjIRR for men >35 years=0.64, 95% CI 0.43-0.94) and male circumcision (adjIRR=0.70, 95% CI 0.55-0.89). HR-HPV clearance was 114.7/100 person-years for HIV-positive men and 170.2/100 person-years for HIV-negative men (risk ratio=0.67, 95% CI 0.59-0.77). HR-HPV clearance in HIV-negative men increased with circumcision (adjRR=1.48, 95% CI 1.26-1.74), HSV-2 infection (adjRR=1.20, 95% CI 1.01-1.44), and symptoms of urethral discharge (adjRR=1.35, 95% CI 1.06-1.73). Clearance of HR-HPV was significantly lower for unmarried men (adjRR 0.76, 95% CI 0.59-0.98). HR-HPV is common among heterosexual Ugandan men, particularly the HIV-infected. HIV infection increases HR-HPV acquisition and reduces HR-HPV clearance. Promotion of male circumcision and additional prevention measures, such as HPV vaccination, is critical in sub-Saharan Africa.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleHuman papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan Africa
creatorTOBIAN, Aaron A. R ; KIGOZI, Godfrey ; GRAY, Ronald H ; GRAVITT, Patti E ; CHANGCHANG XIAO ; SERWADDA, David ; EATON, Kevin P ; XIANGRONG KONG ; WAWER, Maria J ; NALUGODA, Fred ; QUINN, Thomas C
creatorcontribTOBIAN, Aaron A. R ; KIGOZI, Godfrey ; GRAY, Ronald H ; GRAVITT, Patti E ; CHANGCHANG XIAO ; SERWADDA, David ; EATON, Kevin P ; XIANGRONG KONG ; WAWER, Maria J ; NALUGODA, Fred ; QUINN, Thomas C
descriptionHigh-risk human papillomavirus (HR-HPV) infection is the most common sexually transmitted infection. Penile and cervical cancer rates are highest in sub-Saharan Africa. However, little is known about the impact of HIV infection on HR-HPV acquisition and clearance among heterosexual men. HR-HPV incidence and clearance were evaluated in 999 men (776 HIV-negative and 223 HIV-positive) aged 15-49 years who participated in male circumcision trials in Rakai, Uganda. Penile swabs were tested for HR-HPV by Roche HPV Linear Array. A Poisson multivariable model was used to estimate adjusted incidence rate ratios (adjIRRs) and clearance risk ratios (adjRRs). HR-HPV incidence was 66.5/100 person-years in HIV-positive men and 32.9/100 person-years among HIV-negative men [IRR=2.02, 95% confidence interval (CI) 1.67-2.44]. Incidence was higher in the unmarried men (adjIRR=1.73, 95% CI 1.19-2.52), and decreased with age (adjIRR for men >35 years=0.64, 95% CI 0.43-0.94) and male circumcision (adjIRR=0.70, 95% CI 0.55-0.89). HR-HPV clearance was 114.7/100 person-years for HIV-positive men and 170.2/100 person-years for HIV-negative men (risk ratio=0.67, 95% CI 0.59-0.77). HR-HPV clearance in HIV-negative men increased with circumcision (adjRR=1.48, 95% CI 1.26-1.74), HSV-2 infection (adjRR=1.20, 95% CI 1.01-1.44), and symptoms of urethral discharge (adjRR=1.35, 95% CI 1.06-1.73). Clearance of HR-HPV was significantly lower for unmarried men (adjRR 0.76, 95% CI 0.59-0.98). HR-HPV is common among heterosexual Ugandan men, particularly the HIV-infected. HIV infection increases HR-HPV acquisition and reduces HR-HPV clearance. Promotion of male circumcision and additional prevention measures, such as HPV vaccination, is critical in sub-Saharan Africa.
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subjectAdolescent ; Adult ; AIDS/HIV ; Biological and medical sciences ; Circumcision, Male ; Herpesvirus 2, Human - isolation & purification ; Heterosexuality ; HIV Infections - epidemiology ; Human papillomavirus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Incidence ; Infectious diseases ; Male ; Marital Status ; Medical sciences ; Middle Aged ; Papillomaviridae - genetics ; Papillomaviridae - isolation & purification ; Papillomavirus Infections - epidemiology ; Papillomavirus Infections - genetics ; Penis - virology ; Risk Factors ; Sexual Behavior ; Syphilis - epidemiology ; Uganda - epidemiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Young Adult
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0Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan Africa
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descriptionHigh-risk human papillomavirus (HR-HPV) infection is the most common sexually transmitted infection. Penile and cervical cancer rates are highest in sub-Saharan Africa. However, little is known about the impact of HIV infection on HR-HPV acquisition and clearance among heterosexual men. HR-HPV incidence and clearance were evaluated in 999 men (776 HIV-negative and 223 HIV-positive) aged 15-49 years who participated in male circumcision trials in Rakai, Uganda. Penile swabs were tested for HR-HPV by Roche HPV Linear Array. A Poisson multivariable model was used to estimate adjusted incidence rate ratios (adjIRRs) and clearance risk ratios (adjRRs). HR-HPV incidence was 66.5/100 person-years in HIV-positive men and 32.9/100 person-years among HIV-negative men [IRR=2.02, 95% confidence interval (CI) 1.67-2.44]. Incidence was higher in the unmarried men (adjIRR=1.73, 95% CI 1.19-2.52), and decreased with age (adjIRR for men >35 years=0.64, 95% CI 0.43-0.94) and male circumcision (adjIRR=0.70, 95% CI 0.55-0.89). HR-HPV clearance was 114.7/100 person-years for HIV-positive men and 170.2/100 person-years for HIV-negative men (risk ratio=0.67, 95% CI 0.59-0.77). HR-HPV clearance in HIV-negative men increased with circumcision (adjRR=1.48, 95% CI 1.26-1.74), HSV-2 infection (adjRR=1.20, 95% CI 1.01-1.44), and symptoms of urethral discharge (adjRR=1.35, 95% CI 1.06-1.73). Clearance of HR-HPV was significantly lower for unmarried men (adjRR 0.76, 95% CI 0.59-0.98). HR-HPV is common among heterosexual Ugandan men, particularly the HIV-infected. HIV infection increases HR-HPV acquisition and reduces HR-HPV clearance. Promotion of male circumcision and additional prevention measures, such as HPV vaccination, is critical in sub-Saharan Africa.
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5Herpesvirus 2, Human - isolation & purification
6Heterosexuality
7HIV Infections - epidemiology
8Human papillomavirus
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21Papillomaviridae - isolation & purification
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24Penis - virology
25Risk Factors
26Sexual Behavior
27Syphilis - epidemiology
28Uganda - epidemiology
29Viral diseases
30Viral diseases of the lymphoid tissue and the blood. Aids
31Young Adult
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titleHuman papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan Africa
authorTOBIAN, Aaron A. R ; KIGOZI, Godfrey ; GRAY, Ronald H ; GRAVITT, Patti E ; CHANGCHANG XIAO ; SERWADDA, David ; EATON, Kevin P ; XIANGRONG KONG ; WAWER, Maria J ; NALUGODA, Fred ; QUINN, Thomas C
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abstractHigh-risk human papillomavirus (HR-HPV) infection is the most common sexually transmitted infection. Penile and cervical cancer rates are highest in sub-Saharan Africa. However, little is known about the impact of HIV infection on HR-HPV acquisition and clearance among heterosexual men. HR-HPV incidence and clearance were evaluated in 999 men (776 HIV-negative and 223 HIV-positive) aged 15-49 years who participated in male circumcision trials in Rakai, Uganda. Penile swabs were tested for HR-HPV by Roche HPV Linear Array. A Poisson multivariable model was used to estimate adjusted incidence rate ratios (adjIRRs) and clearance risk ratios (adjRRs). HR-HPV incidence was 66.5/100 person-years in HIV-positive men and 32.9/100 person-years among HIV-negative men [IRR=2.02, 95% confidence interval (CI) 1.67-2.44]. Incidence was higher in the unmarried men (adjIRR=1.73, 95% CI 1.19-2.52), and decreased with age (adjIRR for men >35 years=0.64, 95% CI 0.43-0.94) and male circumcision (adjIRR=0.70, 95% CI 0.55-0.89). HR-HPV clearance was 114.7/100 person-years for HIV-positive men and 170.2/100 person-years for HIV-negative men (risk ratio=0.67, 95% CI 0.59-0.77). HR-HPV clearance in HIV-negative men increased with circumcision (adjRR=1.48, 95% CI 1.26-1.74), HSV-2 infection (adjRR=1.20, 95% CI 1.01-1.44), and symptoms of urethral discharge (adjRR=1.35, 95% CI 1.06-1.73). Clearance of HR-HPV was significantly lower for unmarried men (adjRR 0.76, 95% CI 0.59-0.98). HR-HPV is common among heterosexual Ugandan men, particularly the HIV-infected. HIV infection increases HR-HPV acquisition and reduces HR-HPV clearance. Promotion of male circumcision and additional prevention measures, such as HPV vaccination, is critical in sub-Saharan Africa.
copHagerstown, MD
pubLippincott Williams & Wilkins
pmid22441255
doi10.1097/QAD.0b013e328353b83c
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