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Molecular targeting of malignant glioma cells with an EphA2-specific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells

Highlights ► hMSCs can be genetically modified to release the EphrinA1-PE38 immunotoxin. ► EphrinA1-P38 shows potent killing effect on EphA2-overexpressing glioma cells. ► hMSCs expressing EphrinA1-P38 inhibit tumor growth in a malignant glioma model. ► hMSCs expressing EphrinA1-PE38 represent a nov... Full description

Journal Title: Cancer letters 2011, Vol.312 (2), p.168-177
Main Author: Sun, Xin-lin
Other Authors: Xu, Zhi-min , Ke, Yi-quan , Hu, Chang-chen , Wang, Shi-yong , Ling, Geng-qiang , Yan, Zhong-jie , Liu, Yi-jing , Song, Zhen-hua , Jiang, Xiao-dan , Xu, Ru-xiang
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/21924825
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title: Molecular targeting of malignant glioma cells with an EphA2-specific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells
format: Article
creator:
  • Sun, Xin-lin
  • Xu, Zhi-min
  • Ke, Yi-quan
  • Hu, Chang-chen
  • Wang, Shi-yong
  • Ling, Geng-qiang
  • Yan, Zhong-jie
  • Liu, Yi-jing
  • Song, Zhen-hua
  • Jiang, Xiao-dan
  • Xu, Ru-xiang
subjects:
  • Adenovirus
  • Adenoviruses
  • Analysis
  • Animals
  • Antitumor agents
  • Base Sequence
  • Blotting, Western
  • Bone marrow
  • Bone Marrow Cells - pathology
  • Brain
  • Brain Neoplasms - drug therapy
  • Brain Neoplasms - pathology
  • Brain tumors
  • Cell culture
  • Cell Line, Tumor
  • Cloning
  • Cytotoxicity
  • DNA Primers
  • EphA2
  • EphA2 protein
  • Experiments
  • Female
  • Gene therapy
  • Genes
  • Genetic engineering
  • Genetically modified organisms
  • Glioma
  • Glioma - drug therapy
  • Glioma - pathology
  • Glioma cells
  • Gliomas
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • Immunotoxin
  • Immunotoxins
  • Immunotoxins - therapeutic use
  • Kinases
  • Ligands
  • Malignant glioma
  • Medical prognosis
  • Mesenchymal stem cells
  • Mesenchymal Stromal Cells - pathology
  • Mesenchyme
  • Mice
  • Mice, Inbred BALB C
  • Plasmids
  • Polymerase Chain Reaction
  • Proteins
  • Receptor, EphA2 - immunology
  • Science
  • Stem cells
  • Studies
  • Tropism
  • Tumors
ispartof: Cancer letters, 2011, Vol.312 (2), p.168-177
description: Highlights ► hMSCs can be genetically modified to release the EphrinA1-PE38 immunotoxin. ► EphrinA1-P38 shows potent killing effect on EphA2-overexpressing glioma cells. ► hMSCs expressing EphrinA1-P38 inhibit tumor growth in a malignant glioma model. ► hMSCs expressing EphrinA1-PE38 represent a novel approach for human giloma therapy.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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titleMolecular targeting of malignant glioma cells with an EphA2-specific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells
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creatorSun, Xin-lin ; Xu, Zhi-min ; Ke, Yi-quan ; Hu, Chang-chen ; Wang, Shi-yong ; Ling, Geng-qiang ; Yan, Zhong-jie ; Liu, Yi-jing ; Song, Zhen-hua ; Jiang, Xiao-dan ; Xu, Ru-xiang
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descriptionHighlights ► hMSCs can be genetically modified to release the EphrinA1-PE38 immunotoxin. ► EphrinA1-P38 shows potent killing effect on EphA2-overexpressing glioma cells. ► hMSCs expressing EphrinA1-P38 inhibit tumor growth in a malignant glioma model. ► hMSCs expressing EphrinA1-PE38 represent a novel approach for human giloma therapy.
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1EISSN: 1872-7980
2DOI: 10.1016/j.canlet.2011.07.035
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languageeng
publisherIreland: Elsevier Ireland Ltd
subjectAdenovirus ; Adenoviruses ; Analysis ; Animals ; Antitumor agents ; Base Sequence ; Blotting, Western ; Bone marrow ; Bone Marrow Cells - pathology ; Brain ; Brain Neoplasms - drug therapy ; Brain Neoplasms - pathology ; Brain tumors ; Cell culture ; Cell Line, Tumor ; Cloning ; Cytotoxicity ; DNA Primers ; EphA2 ; EphA2 protein ; Experiments ; Female ; Gene therapy ; Genes ; Genetic engineering ; Genetically modified organisms ; Glioma ; Glioma - drug therapy ; Glioma - pathology ; Glioma cells ; Gliomas ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunotoxin ; Immunotoxins ; Immunotoxins - therapeutic use ; Kinases ; Ligands ; Malignant glioma ; Medical prognosis ; Mesenchymal stem cells ; Mesenchymal Stromal Cells - pathology ; Mesenchyme ; Mice ; Mice, Inbred BALB C ; Plasmids ; Polymerase Chain Reaction ; Proteins ; Receptor, EphA2 - immunology ; Science ; Stem cells ; Studies ; Tropism ; Tumors
ispartofCancer letters, 2011, Vol.312 (2), p.168-177
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descriptionHighlights ► hMSCs can be genetically modified to release the EphrinA1-PE38 immunotoxin. ► EphrinA1-P38 shows potent killing effect on EphA2-overexpressing glioma cells. ► hMSCs expressing EphrinA1-P38 inhibit tumor growth in a malignant glioma model. ► hMSCs expressing EphrinA1-PE38 represent a novel approach for human giloma therapy.
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39Medical prognosis
40Mesenchymal stem cells
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45Plasmids
46Polymerase Chain Reaction
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titleMolecular targeting of malignant glioma cells with an EphA2-specific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells
authorSun, Xin-lin ; Xu, Zhi-min ; Ke, Yi-quan ; Hu, Chang-chen ; Wang, Shi-yong ; Ling, Geng-qiang ; Yan, Zhong-jie ; Liu, Yi-jing ; Song, Zhen-hua ; Jiang, Xiao-dan ; Xu, Ru-xiang
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2Analysis
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4Antitumor agents
5Base Sequence
6Blotting, Western
7Bone marrow
8Bone Marrow Cells - pathology
9Brain
10Brain Neoplasms - drug therapy
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12Brain tumors
13Cell culture
14Cell Line, Tumor
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19EphA2 protein
20Experiments
21Female
22Gene therapy
23Genes
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25Genetically modified organisms
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atitleMolecular targeting of malignant glioma cells with an EphA2-specific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells
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date2011
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pages168-177
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abstractHighlights ► hMSCs can be genetically modified to release the EphrinA1-PE38 immunotoxin. ► EphrinA1-P38 shows potent killing effect on EphA2-overexpressing glioma cells. ► hMSCs expressing EphrinA1-P38 inhibit tumor growth in a malignant glioma model. ► hMSCs expressing EphrinA1-PE38 represent a novel approach for human giloma therapy.
copIreland
pubElsevier Ireland Ltd
pmid21924825
doi10.1016/j.canlet.2011.07.035