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Inflammation, coagulation and risk of locomotor disability in elderly women: findings from the British Women's Heart and Health Study

This study investigated associations between chronic inflammation and coagulation and incident locomotor disability using prospective data from the British Women's Heart and Health Study. Locomotor disability was assessed using self-reported questionnaires in 1999/2000, and 3 and 7 years later. Scor... Full description

Journal Title: EUROPEAN JOURNAL OF EPIDEMIOLOGY 2012, Vol.27 (8), p.633-645
Main Author: NÜESCH, Eveline
Other Authors: DALE, Caroline E , AMUZU, Antoinette , KUPER, Hannah , BOWLING, Ann , PLOUBIDIS, George B , LOWE, Gordon , RUMLEY, Ann , EBRAHIM, Shah , CASAS, Juan P
Format: Electronic Article Electronic Article
Language: English
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Publisher: Dordrecht: Springer
ID: ISSN: 0393-2990
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title: Inflammation, coagulation and risk of locomotor disability in elderly women: findings from the British Women's Heart and Health Study
format: Article
creator:
  • NÜESCH, Eveline
  • DALE, Caroline E
  • AMUZU, Antoinette
  • KUPER, Hannah
  • BOWLING, Ann
  • PLOUBIDIS, George B
  • LOWE, Gordon
  • RUMLEY, Ann
  • EBRAHIM, Shah
  • CASAS, Juan P
subjects:
  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Bioindicators
  • Biological and medical sciences
  • Biological markers
  • Biomarkers - blood
  • Blood
  • Blood Coagulation
  • Cardiology
  • Chronic Disease
  • Chronic diseases
  • Coagulation
  • Demography
  • Disabilities
  • Disability
  • Disabled Persons - statistics & numerical data
  • Elderly
  • Epidemiology
  • European Continental Ancestry Group - statistics & numerical data
  • Female
  • Females
  • Follow-Up Studies
  • General aspects
  • Humans
  • Incidence
  • Infectious Diseases
  • Inflammation
  • Inflammation - blood
  • Inflammatory diseases
  • Life Style
  • Lifestyle
  • Locomotion - physiology
  • LOCOMOTOR DISEASES
  • Male
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Miscellaneous
  • Motor ability
  • Motor Activity - physiology
  • Older adults
  • Older people
  • Oncology
  • P values
  • Prospective Studies
  • Public Health
  • Public health. Hygiene
  • Public health. Hygiene-occupational medicine
  • Risk Factors
  • Self Report
  • Socioeconomic Factors
  • Socioeconomics
  • Surveys and Questionnaires
  • United Kingdom - epidemiology
  • Women
  • Womens health
ispartof: EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2012, Vol.27 (8), p.633-645
description: This study investigated associations between chronic inflammation and coagulation and incident locomotor disability using prospective data from the British Women's Heart and Health Study. Locomotor disability was assessed using self-reported questionnaires in 1999/2000, and 3 and 7 years later. Scores for inflammation and coagulation were obtained from summation of quartile categories of all available biomarkers from blood samples taken at baseline. 534 women developed locomotor disability after 3 years, 260 women after 7 years, while 871 women remained free of locomotor disability over the whole study period. After adjustment for demographic characteristics, lifestyle factors and health conditions, we found associations between inflammation and incident locomotor disability after three (OR per unit increase in score = 1.08, 95 % confidence interval (CI): 1.03, 1.13) and 7 years (OR = 1.10, 95 % CI: 1.03, 1.18) and between coagulation and incident locomotor disability after 3 (OR = 1.06, 95 % CI: 0.98, 1.14) and 7 years (OR = 1.09, 95 % CI: 1.00, 1.18). This corresponds to ORs between 1.8 and 2.4 comparing women with highest to lowest inflammation or coagulation scores. These results support the role of inflammation and coagulation in the development of locomotor disability in elderly women irrespective of their lifestyle factors and underlying age-related chronic diseases.
language: eng
source:
identifier: ISSN: 0393-2990
fulltext: no_fulltext
issn:
  • 0393-2990
  • 1573-7284
url: Link


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titleInflammation, coagulation and risk of locomotor disability in elderly women: findings from the British Women's Heart and Health Study
creatorNÜESCH, Eveline ; DALE, Caroline E ; AMUZU, Antoinette ; KUPER, Hannah ; BOWLING, Ann ; PLOUBIDIS, George B ; LOWE, Gordon ; RUMLEY, Ann ; EBRAHIM, Shah ; CASAS, Juan P
creatorcontribNÜESCH, Eveline ; DALE, Caroline E ; AMUZU, Antoinette ; KUPER, Hannah ; BOWLING, Ann ; PLOUBIDIS, George B ; LOWE, Gordon ; RUMLEY, Ann ; EBRAHIM, Shah ; CASAS, Juan P
descriptionThis study investigated associations between chronic inflammation and coagulation and incident locomotor disability using prospective data from the British Women's Heart and Health Study. Locomotor disability was assessed using self-reported questionnaires in 1999/2000, and 3 and 7 years later. Scores for inflammation and coagulation were obtained from summation of quartile categories of all available biomarkers from blood samples taken at baseline. 534 women developed locomotor disability after 3 years, 260 women after 7 years, while 871 women remained free of locomotor disability over the whole study period. After adjustment for demographic characteristics, lifestyle factors and health conditions, we found associations between inflammation and incident locomotor disability after three (OR per unit increase in score = 1.08, 95 % confidence interval (CI): 1.03, 1.13) and 7 years (OR = 1.10, 95 % CI: 1.03, 1.18) and between coagulation and incident locomotor disability after 3 (OR = 1.06, 95 % CI: 0.98, 1.14) and 7 years (OR = 1.09, 95 % CI: 1.00, 1.18). This corresponds to ORs between 1.8 and 2.4 comparing women with highest to lowest inflammation or coagulation scores. These results support the role of inflammation and coagulation in the development of locomotor disability in elderly women irrespective of their lifestyle factors and underlying age-related chronic diseases.
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subjectActivities of Daily Living ; Aged ; Aged, 80 and over ; Bioindicators ; Biological and medical sciences ; Biological markers ; Biomarkers - blood ; Blood ; Blood Coagulation ; Cardiology ; Chronic Disease ; Chronic diseases ; Coagulation ; Demography ; Disabilities ; Disability ; Disabled Persons - statistics & numerical data ; Elderly ; Epidemiology ; European Continental Ancestry Group - statistics & numerical data ; Female ; Females ; Follow-Up Studies ; General aspects ; Humans ; Incidence ; Infectious Diseases ; Inflammation ; Inflammation - blood ; Inflammatory diseases ; Life Style ; Lifestyle ; Locomotion - physiology ; LOCOMOTOR DISEASES ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Miscellaneous ; Motor ability ; Motor Activity - physiology ; Older adults ; Older people ; Oncology ; P values ; Prospective Studies ; Public Health ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Self Report ; Socioeconomic Factors ; Socioeconomics ; Surveys and Questionnaires ; United Kingdom - epidemiology ; Women ; Womens health
ispartofEUROPEAN JOURNAL OF EPIDEMIOLOGY, 2012, Vol.27 (8), p.633-645
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0NÜESCH, Eveline
1DALE, Caroline E
2AMUZU, Antoinette
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4BOWLING, Ann
5PLOUBIDIS, George B
6LOWE, Gordon
7RUMLEY, Ann
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descriptionThis study investigated associations between chronic inflammation and coagulation and incident locomotor disability using prospective data from the British Women's Heart and Health Study. Locomotor disability was assessed using self-reported questionnaires in 1999/2000, and 3 and 7 years later. Scores for inflammation and coagulation were obtained from summation of quartile categories of all available biomarkers from blood samples taken at baseline. 534 women developed locomotor disability after 3 years, 260 women after 7 years, while 871 women remained free of locomotor disability over the whole study period. After adjustment for demographic characteristics, lifestyle factors and health conditions, we found associations between inflammation and incident locomotor disability after three (OR per unit increase in score = 1.08, 95 % confidence interval (CI): 1.03, 1.13) and 7 years (OR = 1.10, 95 % CI: 1.03, 1.18) and between coagulation and incident locomotor disability after 3 (OR = 1.06, 95 % CI: 0.98, 1.14) and 7 years (OR = 1.09, 95 % CI: 1.00, 1.18). This corresponds to ORs between 1.8 and 2.4 comparing women with highest to lowest inflammation or coagulation scores. These results support the role of inflammation and coagulation in the development of locomotor disability in elderly women irrespective of their lifestyle factors and underlying age-related chronic diseases.
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30Life Style
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37Medicine & Public Health
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42Older people
43Oncology
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49Risk Factors
50Self Report
51Socioeconomic Factors
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titleInflammation, coagulation and risk of locomotor disability in elderly women: findings from the British Women's Heart and Health Study
authorNÜESCH, Eveline ; DALE, Caroline E ; AMUZU, Antoinette ; KUPER, Hannah ; BOWLING, Ann ; PLOUBIDIS, George B ; LOWE, Gordon ; RUMLEY, Ann ; EBRAHIM, Shah ; CASAS, Juan P
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2Aged, 80 and over
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5Biological markers
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8Blood Coagulation
9Cardiology
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13Demography
14Disabilities
15Disability
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abstractThis study investigated associations between chronic inflammation and coagulation and incident locomotor disability using prospective data from the British Women's Heart and Health Study. Locomotor disability was assessed using self-reported questionnaires in 1999/2000, and 3 and 7 years later. Scores for inflammation and coagulation were obtained from summation of quartile categories of all available biomarkers from blood samples taken at baseline. 534 women developed locomotor disability after 3 years, 260 women after 7 years, while 871 women remained free of locomotor disability over the whole study period. After adjustment for demographic characteristics, lifestyle factors and health conditions, we found associations between inflammation and incident locomotor disability after three (OR per unit increase in score = 1.08, 95 % confidence interval (CI): 1.03, 1.13) and 7 years (OR = 1.10, 95 % CI: 1.03, 1.18) and between coagulation and incident locomotor disability after 3 (OR = 1.06, 95 % CI: 0.98, 1.14) and 7 years (OR = 1.09, 95 % CI: 1.00, 1.18). This corresponds to ORs between 1.8 and 2.4 comparing women with highest to lowest inflammation or coagulation scores. These results support the role of inflammation and coagulation in the development of locomotor disability in elderly women irrespective of their lifestyle factors and underlying age-related chronic diseases.
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