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MicroRNAs Are Involved in End-Organ Damage During Hypertension

Even in the new millennium, arterial hypertension remains a serious condition, with considerable morbidity and mortality worldwide. Crucial in managing the disease is not only lowering arterial blood pressure but also preventing or treating the typical end-organ damage caused by long-lasting and ina... Full description

Journal Title: Hypertension (Dallas Tex. 1979), 2012-11, Vol.60 (5), p.1088-1093
Main Author: Heggermont, Ward A
Other Authors: Heymans, Stephane
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: American Heart Association, Inc
ID: ISSN: 0194-911X
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recordid: cdi_proquest_miscellaneous_1113981319
title: MicroRNAs Are Involved in End-Organ Damage During Hypertension
format: Article
creator:
  • Heggermont, Ward A
  • Heymans, Stephane
subjects:
  • Arterial hypertension. Arterial hypotension
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Cardiology. Vascular system
  • Cardiovascular Diseases - etiology
  • Cardiovascular Diseases - genetics
  • Clinical manifestations. Epidemiology. Investigative techniques. Etiology
  • general categories: basic science
  • genetics/genomics: gene expression/regulation
  • heart/cardiac: failure
  • Humans
  • Hypertension - complications
  • Hypertension - genetics
  • Hypertensive Retinopathy - etiology
  • Hypertensive Retinopathy - genetics
  • Kidney Diseases - etiology
  • Kidney Diseases - genetics
  • kidney: chronic failure
  • Medical sciences
  • microRNA
  • MicroRNAs - genetics
  • Models, Genetic
  • Risk Factors
  • vascular biology: hypertrophy/remodeling
ispartof: Hypertension (Dallas, Tex. 1979), 2012-11, Vol.60 (5), p.1088-1093
description: Even in the new millennium, arterial hypertension remains a serious condition, with considerable morbidity and mortality worldwide. Crucial in managing the disease is not only lowering arterial blood pressure but also preventing or treating the typical end-organ damage caused by long-lasting and inadequately treated hypertension. In the past decade, it has been shown that microRNAs (miRs) are involved in several hypertension-related pathologies, such as cardiac hypertrophy and fibrosis, hypertensive heart failure, renal fibrosis, kidney failure, and, to a lesser extent, eye disease and hemorrhagic stroke. Whereas others extensively reviewed the role of miRs in atherosclerosis and vascular disease, this review focuses on their role in target organ damage during arterial hypertension. We emphasize the involvement of miRs in pathological end-organ remodeling processes and try to demonstrate some common miR signatures in distinct end organs. Hence, we aimed to provide proof of arterial hypertension being a systemic disease, similar to diabetes mellitus or metabolic syndrome. Furthermore, miRs that act on one particular process in different end organs are interesting therapeutic targets. Some future perspectives in miR research are highlighted with respect to novel therapeutic strategies in the cardiovascular field.
language: eng
source:
identifier: ISSN: 0194-911X
fulltext: no_fulltext
issn:
  • 0194-911X
  • 1524-4563
url: Link


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descriptionEven in the new millennium, arterial hypertension remains a serious condition, with considerable morbidity and mortality worldwide. Crucial in managing the disease is not only lowering arterial blood pressure but also preventing or treating the typical end-organ damage caused by long-lasting and inadequately treated hypertension. In the past decade, it has been shown that microRNAs (miRs) are involved in several hypertension-related pathologies, such as cardiac hypertrophy and fibrosis, hypertensive heart failure, renal fibrosis, kidney failure, and, to a lesser extent, eye disease and hemorrhagic stroke. Whereas others extensively reviewed the role of miRs in atherosclerosis and vascular disease, this review focuses on their role in target organ damage during arterial hypertension. We emphasize the involvement of miRs in pathological end-organ remodeling processes and try to demonstrate some common miR signatures in distinct end organs. Hence, we aimed to provide proof of arterial hypertension being a systemic disease, similar to diabetes mellitus or metabolic syndrome. Furthermore, miRs that act on one particular process in different end organs are interesting therapeutic targets. Some future perspectives in miR research are highlighted with respect to novel therapeutic strategies in the cardiovascular field.
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subjectArterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - genetics ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; general categories: basic science ; genetics/genomics: gene expression/regulation ; heart/cardiac: failure ; Humans ; Hypertension - complications ; Hypertension - genetics ; Hypertensive Retinopathy - etiology ; Hypertensive Retinopathy - genetics ; Kidney Diseases - etiology ; Kidney Diseases - genetics ; kidney: chronic failure ; Medical sciences ; microRNA ; MicroRNAs - genetics ; Models, Genetic ; Risk Factors ; vascular biology: hypertrophy/remodeling
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6Clinical manifestations. Epidemiology. Investigative techniques. Etiology
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8genetics/genomics: gene expression/regulation
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11Hypertension - complications
12Hypertension - genetics
13Hypertensive Retinopathy - etiology
14Hypertensive Retinopathy - genetics
15Kidney Diseases - etiology
16Kidney Diseases - genetics
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22Risk Factors
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abstractEven in the new millennium, arterial hypertension remains a serious condition, with considerable morbidity and mortality worldwide. Crucial in managing the disease is not only lowering arterial blood pressure but also preventing or treating the typical end-organ damage caused by long-lasting and inadequately treated hypertension. In the past decade, it has been shown that microRNAs (miRs) are involved in several hypertension-related pathologies, such as cardiac hypertrophy and fibrosis, hypertensive heart failure, renal fibrosis, kidney failure, and, to a lesser extent, eye disease and hemorrhagic stroke. Whereas others extensively reviewed the role of miRs in atherosclerosis and vascular disease, this review focuses on their role in target organ damage during arterial hypertension. We emphasize the involvement of miRs in pathological end-organ remodeling processes and try to demonstrate some common miR signatures in distinct end organs. Hence, we aimed to provide proof of arterial hypertension being a systemic disease, similar to diabetes mellitus or metabolic syndrome. Furthermore, miRs that act on one particular process in different end organs are interesting therapeutic targets. Some future perspectives in miR research are highlighted with respect to novel therapeutic strategies in the cardiovascular field.
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