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Serum levels of 3-Epi-25-OH-D3 during Hypervitaminosis D in Clinical Practice

Context: Intoxication from vitamin D supplements has been rarely reported, but nowadays, it occurs more frequently. The presence of the C-3 epimer of 25-hydroxyvitamin D3 (3-epi-25-OH-D3) is highly prevalent in adults, although there is little information regarding its in vivo relevance, if any, esp... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2012, Vol.97 (12), p.E2266-E2270
Main Author: Granado-Lorencio, F
Other Authors: Blanco-Navarro, I , Pérez-Sacristán, B , Donoso-Navarro, E , Silvestre-Mardomingo, R
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Endocrine Society
ID: ISSN: 0021-972X
Link: https://www.ncbi.nlm.nih.gov/pubmed/23038681
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title: Serum levels of 3-Epi-25-OH-D3 during Hypervitaminosis D in Clinical Practice
format: Article
creator:
  • Granado-Lorencio, F
  • Blanco-Navarro, I
  • Pérez-Sacristán, B
  • Donoso-Navarro, E
  • Silvestre-Mardomingo, R
subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Chemical Analysis
  • Calcifediol - analogs & derivatives
  • Calcifediol - analysis
  • Calcifediol - blood
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nutrition Disorders - blood
  • Nutrition Disorders - therapy
  • Osmolar Concentration
  • Professional Practice
  • Vitamin D - analogs & derivatives
  • Vitamin D - blood
  • Vitamin D - metabolism
ispartof: The journal of clinical endocrinology and metabolism, 2012, Vol.97 (12), p.E2266-E2270
description: Context: Intoxication from vitamin D supplements has been rarely reported, but nowadays, it occurs more frequently. The presence of the C-3 epimer of 25-hydroxyvitamin D3 (3-epi-25-OH-D3) is highly prevalent in adults, although there is little information regarding its in vivo relevance, if any, especially under pathological conditions. Objective: Our aim was to assess the presence of the 3-epi-25-OH-D3 in serum samples displaying 25-OH-D3 concentrations indicative of hypervitaminosis D. Design, Setting, Patients, and Main Outcome Measure: A total of 58 samples displaying a wide range of concentrations of 25-OH-D3 (>64–439 ng/ml) by ultrafast liquid chromatography were consecutively recruited and reassessed for the presence of 3-epi-25-OH-D3 using a second chromatographic system. Data from additional biochemical tests performed as part of the patient evaluation were also recorded. Results: Mean relative contribution of 3-epi-25-OH-D3 was less than 4%, and concentrations ranged from 2–28.6 ng/ml. Serum levels of the C3 epimer, but not the relative contribution, correlate with serum 25-OH-D3. Overall, in subjects with 25-OH-D3 concentrations indicative of hypervitaminosis D, the presence of the C-3 epimer and its levels were apparently unrelated to age, serum markers of renal and liver function, acute-phase reactants, and the presence of hypercalcemia. 3-Epi-25-OH-D3 did not correlate with PTH, but subjects displaying PTH suppression (
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titleSerum levels of 3-Epi-25-OH-D3 during Hypervitaminosis D in Clinical Practice
creatorGranado-Lorencio, F ; Blanco-Navarro, I ; Pérez-Sacristán, B ; Donoso-Navarro, E ; Silvestre-Mardomingo, R
creatorcontribGranado-Lorencio, F ; Blanco-Navarro, I ; Pérez-Sacristán, B ; Donoso-Navarro, E ; Silvestre-Mardomingo, R
descriptionContext: Intoxication from vitamin D supplements has been rarely reported, but nowadays, it occurs more frequently. The presence of the C-3 epimer of 25-hydroxyvitamin D3 (3-epi-25-OH-D3) is highly prevalent in adults, although there is little information regarding its in vivo relevance, if any, especially under pathological conditions. Objective: Our aim was to assess the presence of the 3-epi-25-OH-D3 in serum samples displaying 25-OH-D3 concentrations indicative of hypervitaminosis D. Design, Setting, Patients, and Main Outcome Measure: A total of 58 samples displaying a wide range of concentrations of 25-OH-D3 (>64–439 ng/ml) by ultrafast liquid chromatography were consecutively recruited and reassessed for the presence of 3-epi-25-OH-D3 using a second chromatographic system. Data from additional biochemical tests performed as part of the patient evaluation were also recorded. Results: Mean relative contribution of 3-epi-25-OH-D3 was less than 4%, and concentrations ranged from 2–28.6 ng/ml. Serum levels of the C3 epimer, but not the relative contribution, correlate with serum 25-OH-D3. Overall, in subjects with 25-OH-D3 concentrations indicative of hypervitaminosis D, the presence of the C-3 epimer and its levels were apparently unrelated to age, serum markers of renal and liver function, acute-phase reactants, and the presence of hypercalcemia. 3-Epi-25-OH-D3 did not correlate with PTH, but subjects displaying PTH suppression (<14 pg/ml) showed higher concentrations of 3-epi-25-OH-D3. Conclusion: The relative contribution of 3-epi-25-D3 was not significantly altered during hypervitaminosis D, although the absolute levels reached in serum may be biologically relevant. From a clinical viewpoint, although the small size of the group may affect the lack of relationships, the presence of 3-epi-25-OH-D3 was apparently unrelated to serum markers of renal and liver function, acute-phase reactants, PTH, and the presence of hypercalcemia.
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subjectAdult ; Aged ; Aged, 80 and over ; Blood Chemical Analysis ; Calcifediol - analogs & derivatives ; Calcifediol - analysis ; Calcifediol - blood ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Nutrition Disorders - blood ; Nutrition Disorders - therapy ; Osmolar Concentration ; Professional Practice ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D - metabolism
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descriptionContext: Intoxication from vitamin D supplements has been rarely reported, but nowadays, it occurs more frequently. The presence of the C-3 epimer of 25-hydroxyvitamin D3 (3-epi-25-OH-D3) is highly prevalent in adults, although there is little information regarding its in vivo relevance, if any, especially under pathological conditions. Objective: Our aim was to assess the presence of the 3-epi-25-OH-D3 in serum samples displaying 25-OH-D3 concentrations indicative of hypervitaminosis D. Design, Setting, Patients, and Main Outcome Measure: A total of 58 samples displaying a wide range of concentrations of 25-OH-D3 (>64–439 ng/ml) by ultrafast liquid chromatography were consecutively recruited and reassessed for the presence of 3-epi-25-OH-D3 using a second chromatographic system. Data from additional biochemical tests performed as part of the patient evaluation were also recorded. Results: Mean relative contribution of 3-epi-25-OH-D3 was less than 4%, and concentrations ranged from 2–28.6 ng/ml. Serum levels of the C3 epimer, but not the relative contribution, correlate with serum 25-OH-D3. Overall, in subjects with 25-OH-D3 concentrations indicative of hypervitaminosis D, the presence of the C-3 epimer and its levels were apparently unrelated to age, serum markers of renal and liver function, acute-phase reactants, and the presence of hypercalcemia. 3-Epi-25-OH-D3 did not correlate with PTH, but subjects displaying PTH suppression (<14 pg/ml) showed higher concentrations of 3-epi-25-OH-D3. Conclusion: The relative contribution of 3-epi-25-D3 was not significantly altered during hypervitaminosis D, although the absolute levels reached in serum may be biologically relevant. From a clinical viewpoint, although the small size of the group may affect the lack of relationships, the presence of 3-epi-25-OH-D3 was apparently unrelated to serum markers of renal and liver function, acute-phase reactants, PTH, and the presence of hypercalcemia.
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abstractContext: Intoxication from vitamin D supplements has been rarely reported, but nowadays, it occurs more frequently. The presence of the C-3 epimer of 25-hydroxyvitamin D3 (3-epi-25-OH-D3) is highly prevalent in adults, although there is little information regarding its in vivo relevance, if any, especially under pathological conditions. Objective: Our aim was to assess the presence of the 3-epi-25-OH-D3 in serum samples displaying 25-OH-D3 concentrations indicative of hypervitaminosis D. Design, Setting, Patients, and Main Outcome Measure: A total of 58 samples displaying a wide range of concentrations of 25-OH-D3 (>64–439 ng/ml) by ultrafast liquid chromatography were consecutively recruited and reassessed for the presence of 3-epi-25-OH-D3 using a second chromatographic system. Data from additional biochemical tests performed as part of the patient evaluation were also recorded. Results: Mean relative contribution of 3-epi-25-OH-D3 was less than 4%, and concentrations ranged from 2–28.6 ng/ml. Serum levels of the C3 epimer, but not the relative contribution, correlate with serum 25-OH-D3. Overall, in subjects with 25-OH-D3 concentrations indicative of hypervitaminosis D, the presence of the C-3 epimer and its levels were apparently unrelated to age, serum markers of renal and liver function, acute-phase reactants, and the presence of hypercalcemia. 3-Epi-25-OH-D3 did not correlate with PTH, but subjects displaying PTH suppression (<14 pg/ml) showed higher concentrations of 3-epi-25-OH-D3. Conclusion: The relative contribution of 3-epi-25-D3 was not significantly altered during hypervitaminosis D, although the absolute levels reached in serum may be biologically relevant. From a clinical viewpoint, although the small size of the group may affect the lack of relationships, the presence of 3-epi-25-OH-D3 was apparently unrelated to serum markers of renal and liver function, acute-phase reactants, PTH, and the presence of hypercalcemia.
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pubEndocrine Society
pmid23038681
doi10.1210/jc.2012-2627