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Regulation of intestinal epithelial permeability by tight junctions

The gastrointestinal epithelium forms the boundary between the body and external environment. It effectively provides a selective permeable barrier that limits the permeation of luminal noxious molecules, such as pathogens, toxins, and antigens, while allowing the appropriate absorption of nutrients... Full description

Journal Title: Cellular and molecular life sciences : CMLS 2012-07-11, Vol.70 (4), p.631-659
Main Author: Suzuki, Takuya
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Basel: SP Birkhäuser Verlag Basel
ID: ISSN: 1420-682X
Link: https://www.ncbi.nlm.nih.gov/pubmed/22782113
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recordid: cdi_proquest_miscellaneous_1282512652
title: Regulation of intestinal epithelial permeability by tight junctions
format: Article
creator:
  • Suzuki, Takuya
subjects:
  • Analysis
  • Animals
  • Biochemistry
  • Biomedical and Life Sciences
  • Biomedicine
  • Cell Biology
  • Cellular biology
  • Cytokines
  • Cytokines - immunology
  • Cytokines - metabolism
  • Digestive system
  • general
  • Humans
  • Immunology
  • Intercellular Signaling Peptides and Proteins - immunology
  • Intercellular Signaling Peptides and Proteins - metabolism
  • Intestinal Mucosa - immunology
  • Intestinal Mucosa - metabolism
  • Intestinal Mucosa - microbiology
  • Intestinal Mucosa - pathology
  • Life Sciences
  • Nutrients
  • Nutritional Physiological Phenomena
  • Pathology
  • Permeability
  • Review
  • Tight Junctions - immunology
  • Tight Junctions - metabolism
  • Tight Junctions - microbiology
  • Tight Junctions - pathology
ispartof: Cellular and molecular life sciences : CMLS, 2012-07-11, Vol.70 (4), p.631-659
description: The gastrointestinal epithelium forms the boundary between the body and external environment. It effectively provides a selective permeable barrier that limits the permeation of luminal noxious molecules, such as pathogens, toxins, and antigens, while allowing the appropriate absorption of nutrients and water. This selective permeable barrier is achieved by intercellular tight junction (TJ) structures, which regulate paracellular permeability. Disruption of the intestinal TJ barrier, followed by permeation of luminal noxious molecules, induces a perturbation of the mucosal immune system and inflammation, and can act as a trigger for the development of intestinal and systemic diseases. In this context, much effort has been taken to understand the roles of extracellular factors, including cytokines, pathogens, and food factors, for the regulation of the intestinal TJ barrier. Here, I discuss the regulation of the intestinal TJ barrier together with its implications for the pathogenesis of diseases.
language: eng
source:
identifier: ISSN: 1420-682X
fulltext: no_fulltext
issn:
  • 1420-682X
  • 1420-9071
url: Link


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descriptionThe gastrointestinal epithelium forms the boundary between the body and external environment. It effectively provides a selective permeable barrier that limits the permeation of luminal noxious molecules, such as pathogens, toxins, and antigens, while allowing the appropriate absorption of nutrients and water. This selective permeable barrier is achieved by intercellular tight junction (TJ) structures, which regulate paracellular permeability. Disruption of the intestinal TJ barrier, followed by permeation of luminal noxious molecules, induces a perturbation of the mucosal immune system and inflammation, and can act as a trigger for the development of intestinal and systemic diseases. In this context, much effort has been taken to understand the roles of extracellular factors, including cytokines, pathogens, and food factors, for the regulation of the intestinal TJ barrier. Here, I discuss the regulation of the intestinal TJ barrier together with its implications for the pathogenesis of diseases.
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subjectAnalysis ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cellular biology ; Cytokines ; Cytokines - immunology ; Cytokines - metabolism ; Digestive system ; general ; Humans ; Immunology ; Intercellular Signaling Peptides and Proteins - immunology ; Intercellular Signaling Peptides and Proteins - metabolism ; Intestinal Mucosa - immunology ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - microbiology ; Intestinal Mucosa - pathology ; Life Sciences ; Nutrients ; Nutritional Physiological Phenomena ; Pathology ; Permeability ; Review ; Tight Junctions - immunology ; Tight Junctions - metabolism ; Tight Junctions - microbiology ; Tight Junctions - pathology
ispartofCellular and molecular life sciences : CMLS, 2012-07-11, Vol.70 (4), p.631-659
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abstractThe gastrointestinal epithelium forms the boundary between the body and external environment. It effectively provides a selective permeable barrier that limits the permeation of luminal noxious molecules, such as pathogens, toxins, and antigens, while allowing the appropriate absorption of nutrients and water. This selective permeable barrier is achieved by intercellular tight junction (TJ) structures, which regulate paracellular permeability. Disruption of the intestinal TJ barrier, followed by permeation of luminal noxious molecules, induces a perturbation of the mucosal immune system and inflammation, and can act as a trigger for the development of intestinal and systemic diseases. In this context, much effort has been taken to understand the roles of extracellular factors, including cytokines, pathogens, and food factors, for the regulation of the intestinal TJ barrier. Here, I discuss the regulation of the intestinal TJ barrier together with its implications for the pathogenesis of diseases.
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doi10.1007/s00018-012-1070-x