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Association of dilated retinal arteriolar caliber with early age-related macular degeneration: the Handan Eye Study

Background To identify factors associated with early age-related macular degeneration (AMD) in a rural Chinese population, with emphasis on retinal vessel caliber. Methods The study population comprised the 6,830 participants of the Handan Eye Study. All participants underwent digital retinal photog... Full description

Journal Title: Graefe's archive for clinical and experimental ophthalmology 2011-10-05, Vol.250 (5), p.741-749
Main Author: Yang, Ke
Other Authors: Zhan, Si Yan , Liang, Yuan Bo , Duan, Xinrong , Wang, Fenghua , Wong, Tien Yin , Sun, Lan Ping , Wang, Ning-Li
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Eye
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0721-832X
Link: https://www.ncbi.nlm.nih.gov/pubmed/21971892
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recordid: cdi_proquest_miscellaneous_1285086977
title: Association of dilated retinal arteriolar caliber with early age-related macular degeneration: the Handan Eye Study
format: Article
creator:
  • Yang, Ke
  • Zhan, Si Yan
  • Liang, Yuan Bo
  • Duan, Xinrong
  • Wang, Fenghua
  • Wong, Tien Yin
  • Sun, Lan Ping
  • Wang, Ning-Li
subjects:
  • Age
  • Analysis
  • Arterioles - pathology
  • Asian Continental Ancestry Group
  • Blood Pressure
  • Blood vessels
  • Body Constitution
  • Data processing
  • Diabetes
  • Diabetes mellitus
  • Dilatation, Pathologic
  • Eye
  • Female
  • Humans
  • Hypertension
  • Image Processing, Computer-Assisted
  • Macular degeneration
  • Macular Degeneration - diagnosis
  • Male
  • Medical colleges
  • Medical Ophthalmology
  • Medicine
  • Medicine & Public Health
  • Middle Aged
  • Models
  • Ophthalmology
  • Photography
  • Physiological aspects
  • Population studies
  • Public health
  • Retina
  • Retinal Artery - pathology
  • Retinal Drusen - diagnosis
  • Risk Factors
  • Rural Population
  • Smoking
ispartof: Graefe's archive for clinical and experimental ophthalmology, 2011-10-05, Vol.250 (5), p.741-749
description: Background To identify factors associated with early age-related macular degeneration (AMD) in a rural Chinese population, with emphasis on retinal vessel caliber. Methods The study population comprised the 6,830 participants of the Handan Eye Study. All participants underwent digital retinal photography of both eyes. Trained graders assessed the presence of AMD lesions. Arteriolar and venular diameters were measured with a specific computer-assisted program and were summarized as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Results The data for the 199 individuals with evaluable retinal photographs and early AMD and 400 age-matched individuals randomly selected from the group without AMD were analyzed. After adjusting for participants’ age, sex, smoking status, hypertension, diabetes, BMI, and CRVE, the multivariate adjusted model showed that a higher CRAE was significantly associated with early AMD (OR = 1.34; 95% CI: 1.05–1.71; p  = 0.020) and the presence of soft distinct drusen (OR = 1.32 (95% CI: 1.02–1.71, p  = 0.037). There were no significant associations between CRVE and early AMD. Conclusions Dilated retinal arteriolar caliber is associated with early AMD and soft distinct drusen in this population. We found no significant associations between CRAE and other characteristics of the retina related to AMD or between retinal venal caliber and early AMD. More research is needed to determine whether the difference between these results and those previously published stem from the rural living conditions of the participants or other factors.
language: eng
source:
identifier: ISSN: 0721-832X
fulltext: no_fulltext
issn:
  • 0721-832X
  • 1435-702X
url: Link


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titleAssociation of dilated retinal arteriolar caliber with early age-related macular degeneration: the Handan Eye Study
creatorYang, Ke ; Zhan, Si Yan ; Liang, Yuan Bo ; Duan, Xinrong ; Wang, Fenghua ; Wong, Tien Yin ; Sun, Lan Ping ; Wang, Ning-Li
creatorcontribYang, Ke ; Zhan, Si Yan ; Liang, Yuan Bo ; Duan, Xinrong ; Wang, Fenghua ; Wong, Tien Yin ; Sun, Lan Ping ; Wang, Ning-Li
descriptionBackground To identify factors associated with early age-related macular degeneration (AMD) in a rural Chinese population, with emphasis on retinal vessel caliber. Methods The study population comprised the 6,830 participants of the Handan Eye Study. All participants underwent digital retinal photography of both eyes. Trained graders assessed the presence of AMD lesions. Arteriolar and venular diameters were measured with a specific computer-assisted program and were summarized as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Results The data for the 199 individuals with evaluable retinal photographs and early AMD and 400 age-matched individuals randomly selected from the group without AMD were analyzed. After adjusting for participants’ age, sex, smoking status, hypertension, diabetes, BMI, and CRVE, the multivariate adjusted model showed that a higher CRAE was significantly associated with early AMD (OR = 1.34; 95% CI: 1.05–1.71; p  = 0.020) and the presence of soft distinct drusen (OR = 1.32 (95% CI: 1.02–1.71, p  = 0.037). There were no significant associations between CRVE and early AMD. Conclusions Dilated retinal arteriolar caliber is associated with early AMD and soft distinct drusen in this population. We found no significant associations between CRAE and other characteristics of the retina related to AMD or between retinal venal caliber and early AMD. More research is needed to determine whether the difference between these results and those previously published stem from the rural living conditions of the participants or other factors.
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subjectAge ; Analysis ; Arterioles - pathology ; Asian Continental Ancestry Group ; Blood Pressure ; Blood vessels ; Body Constitution ; Data processing ; Diabetes ; Diabetes mellitus ; Dilatation, Pathologic ; Eye ; Female ; Humans ; Hypertension ; Image Processing, Computer-Assisted ; Macular degeneration ; Macular Degeneration - diagnosis ; Male ; Medical colleges ; Medical Ophthalmology ; Medicine ; Medicine & Public Health ; Middle Aged ; Models ; Ophthalmology ; Photography ; Physiological aspects ; Population studies ; Public health ; Retina ; Retinal Artery - pathology ; Retinal Drusen - diagnosis ; Risk Factors ; Rural Population ; Smoking
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descriptionBackground To identify factors associated with early age-related macular degeneration (AMD) in a rural Chinese population, with emphasis on retinal vessel caliber. Methods The study population comprised the 6,830 participants of the Handan Eye Study. All participants underwent digital retinal photography of both eyes. Trained graders assessed the presence of AMD lesions. Arteriolar and venular diameters were measured with a specific computer-assisted program and were summarized as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Results The data for the 199 individuals with evaluable retinal photographs and early AMD and 400 age-matched individuals randomly selected from the group without AMD were analyzed. After adjusting for participants’ age, sex, smoking status, hypertension, diabetes, BMI, and CRVE, the multivariate adjusted model showed that a higher CRAE was significantly associated with early AMD (OR = 1.34; 95% CI: 1.05–1.71; p  = 0.020) and the presence of soft distinct drusen (OR = 1.32 (95% CI: 1.02–1.71, p  = 0.037). There were no significant associations between CRVE and early AMD. Conclusions Dilated retinal arteriolar caliber is associated with early AMD and soft distinct drusen in this population. We found no significant associations between CRAE and other characteristics of the retina related to AMD or between retinal venal caliber and early AMD. More research is needed to determine whether the difference between these results and those previously published stem from the rural living conditions of the participants or other factors.
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abstractBackground To identify factors associated with early age-related macular degeneration (AMD) in a rural Chinese population, with emphasis on retinal vessel caliber. Methods The study population comprised the 6,830 participants of the Handan Eye Study. All participants underwent digital retinal photography of both eyes. Trained graders assessed the presence of AMD lesions. Arteriolar and venular diameters were measured with a specific computer-assisted program and were summarized as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Results The data for the 199 individuals with evaluable retinal photographs and early AMD and 400 age-matched individuals randomly selected from the group without AMD were analyzed. After adjusting for participants’ age, sex, smoking status, hypertension, diabetes, BMI, and CRVE, the multivariate adjusted model showed that a higher CRAE was significantly associated with early AMD (OR = 1.34; 95% CI: 1.05–1.71; p  = 0.020) and the presence of soft distinct drusen (OR = 1.32 (95% CI: 1.02–1.71, p  = 0.037). There were no significant associations between CRVE and early AMD. Conclusions Dilated retinal arteriolar caliber is associated with early AMD and soft distinct drusen in this population. We found no significant associations between CRAE and other characteristics of the retina related to AMD or between retinal venal caliber and early AMD. More research is needed to determine whether the difference between these results and those previously published stem from the rural living conditions of the participants or other factors.
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doi10.1007/s00417-011-1824-4