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Atherosclerosis is associated with multiple pathogenic mechanisms in HIV-infected antiretroviral-naive or treated individuals

HIV-infected patients have a greater burden of sub-clinical and clinical atherosclerotic disease compared to the general population. The primary objective of this study was to compare the relative roles of inflammation, endothelial alterations, and metabolic factors in the induction and maintenance... Full description

Journal Title: AIDS (London) 2013, Vol.27 (3), p.381-389
Main Author: PICONI, Stefania
Other Authors: PARISOTTO, Serena , TRABATTONI, Daria , CLERICI, Mario , RIZZARDINI, Giuliano , PASSERINI, Simone , MERAVIGLIA, Paola , SCHIAVINI, Monica , NIERO, Fosca , BIASIN, Mara , BONFANTI, Paolo , DELFINA RICCI, Elena
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
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title: Atherosclerosis is associated with multiple pathogenic mechanisms in HIV-infected antiretroviral-naive or treated individuals
format: Article
creator:
  • PICONI, Stefania
  • PARISOTTO, Serena
  • TRABATTONI, Daria
  • CLERICI, Mario
  • RIZZARDINI, Giuliano
  • PASSERINI, Simone
  • MERAVIGLIA, Paola
  • SCHIAVINI, Monica
  • NIERO, Fosca
  • BIASIN, Mara
  • BONFANTI, Paolo
  • DELFINA RICCI, Elena
subjects:
  • AIDS/HIV
  • Anti-HIV Agents - therapeutic use
  • Antibiotics. Antiinfectious agents. Antiparasitic agents
  • antiretroviral therapy
  • Antiviral agents
  • Apolipoprotein B
  • Arteriosclerosis
  • Atherogenesis
  • Atherosclerosis (general aspects, experimental research)
  • Atherosclerosis - drug therapy
  • Atherosclerosis - metabolism
  • Atherosclerosis - pathology
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Cardiology. Vascular system
  • Cardiovascular diseases
  • Carotid Intima-Media Thickness
  • CD4 antigen
  • CD4 Lymphocyte Count
  • Cholesterol
  • Cross-Sectional Studies
  • Disease Progression
  • HIV Infections - drug therapy
  • HIV Infections - metabolism
  • HIV Infections - pathology
  • Human immunodeficiency virus
  • Human viral diseases
  • Humans
  • Infection
  • Infectious diseases
  • Inflammation
  • Inflammation - pathology
  • Inflammatory diseases
  • Lipoproteins
  • Lipoproteins (low density)
  • Lipoproteins, LDL - metabolism
  • Longitudinal Studies
  • Male
  • Medical sciences
  • Middle Aged
  • Multivariate analysis
  • Nef protein
  • Pharmacology. Drug treatments
  • Protein transport
  • Reproducibility of Results
  • Risk Factors
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
ispartof: AIDS (London), 2013, Vol.27 (3), p.381-389
description: HIV-infected patients have a greater burden of sub-clinical and clinical atherosclerotic disease compared to the general population. The primary objective of this study was to compare the relative roles of inflammation, endothelial alterations, and metabolic factors in the induction and maintenance of atherosclerosis in antiretroviral therapy (ART)-treated or ART-naive patients. Cross-sectional study; 79 HIV-infected patients (55 ART-treated and 24 naive individuals) were consecutively enrolled. In both groups, nearly 50% of the individuals had a high cardiovascular risk (Framingham value >20%). Echo-Doppler [intima-media thickness (IMT)], inflammatory, thrombophilic, endothelial, metabolic indexes, and cholesterol efflux molecules were evaluated. Multivariate analysis adjusted for age, CD4 nadir, BMI, and Framingham's score were used to analyze the results. A complex pathogenesis drives atherogenesis in HIV infection. Thus, whereas inflammation could be responsible for this process in ART-naive individuals, metabolic factors [low-density lipoprotein (LDL), apolipoprotein B (ApoB), lipoprotein A] seem to play a more prevalent role in ART-treated patients. Notably, ABCA-1, an ATP-binding transporter cassette protein involved in cholesterol efflux, which is inhibited by Nef, is up-regulated in ART-treated individuals. Atherosclerosis in HIV infection results from the interaction of multiple factors: an inflammatory and HIV-driven disease could prevail in the absence of therapy; metabolic, non-inflammatory causes may be more important in patients undergoing therapy. Approaches to atherosclerotic disease in HIV infection should consider these differences.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleAtherosclerosis is associated with multiple pathogenic mechanisms in HIV-infected antiretroviral-naive or treated individuals
creatorPICONI, Stefania ; PARISOTTO, Serena ; TRABATTONI, Daria ; CLERICI, Mario ; RIZZARDINI, Giuliano ; PASSERINI, Simone ; MERAVIGLIA, Paola ; SCHIAVINI, Monica ; NIERO, Fosca ; BIASIN, Mara ; BONFANTI, Paolo ; DELFINA RICCI, Elena
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descriptionHIV-infected patients have a greater burden of sub-clinical and clinical atherosclerotic disease compared to the general population. The primary objective of this study was to compare the relative roles of inflammation, endothelial alterations, and metabolic factors in the induction and maintenance of atherosclerosis in antiretroviral therapy (ART)-treated or ART-naive patients. Cross-sectional study; 79 HIV-infected patients (55 ART-treated and 24 naive individuals) were consecutively enrolled. In both groups, nearly 50% of the individuals had a high cardiovascular risk (Framingham value >20%). Echo-Doppler [intima-media thickness (IMT)], inflammatory, thrombophilic, endothelial, metabolic indexes, and cholesterol efflux molecules were evaluated. Multivariate analysis adjusted for age, CD4 nadir, BMI, and Framingham's score were used to analyze the results. A complex pathogenesis drives atherogenesis in HIV infection. Thus, whereas inflammation could be responsible for this process in ART-naive individuals, metabolic factors [low-density lipoprotein (LDL), apolipoprotein B (ApoB), lipoprotein A] seem to play a more prevalent role in ART-treated patients. Notably, ABCA-1, an ATP-binding transporter cassette protein involved in cholesterol efflux, which is inhibited by Nef, is up-regulated in ART-treated individuals. Atherosclerosis in HIV infection results from the interaction of multiple factors: an inflammatory and HIV-driven disease could prevail in the absence of therapy; metabolic, non-inflammatory causes may be more important in patients undergoing therapy. Approaches to atherosclerotic disease in HIV infection should consider these differences.
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subjectAIDS/HIV ; Anti-HIV Agents - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; antiretroviral therapy ; Antiviral agents ; Apolipoprotein B ; Arteriosclerosis ; Atherogenesis ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - drug therapy ; Atherosclerosis - metabolism ; Atherosclerosis - pathology ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular diseases ; Carotid Intima-Media Thickness ; CD4 antigen ; CD4 Lymphocyte Count ; Cholesterol ; Cross-Sectional Studies ; Disease Progression ; HIV Infections - drug therapy ; HIV Infections - metabolism ; HIV Infections - pathology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infection ; Infectious diseases ; Inflammation ; Inflammation - pathology ; Inflammatory diseases ; Lipoproteins ; Lipoproteins (low density) ; Lipoproteins, LDL - metabolism ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Multivariate analysis ; Nef protein ; Pharmacology. Drug treatments ; Protein transport ; Reproducibility of Results ; Risk Factors ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids
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2TRABATTONI, Daria
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6MERAVIGLIA, Paola
7SCHIAVINI, Monica
8NIERO, Fosca
9BIASIN, Mara
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0Atherosclerosis is associated with multiple pathogenic mechanisms in HIV-infected antiretroviral-naive or treated individuals
1AIDS (London)
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descriptionHIV-infected patients have a greater burden of sub-clinical and clinical atherosclerotic disease compared to the general population. The primary objective of this study was to compare the relative roles of inflammation, endothelial alterations, and metabolic factors in the induction and maintenance of atherosclerosis in antiretroviral therapy (ART)-treated or ART-naive patients. Cross-sectional study; 79 HIV-infected patients (55 ART-treated and 24 naive individuals) were consecutively enrolled. In both groups, nearly 50% of the individuals had a high cardiovascular risk (Framingham value >20%). Echo-Doppler [intima-media thickness (IMT)], inflammatory, thrombophilic, endothelial, metabolic indexes, and cholesterol efflux molecules were evaluated. Multivariate analysis adjusted for age, CD4 nadir, BMI, and Framingham's score were used to analyze the results. A complex pathogenesis drives atherogenesis in HIV infection. Thus, whereas inflammation could be responsible for this process in ART-naive individuals, metabolic factors [low-density lipoprotein (LDL), apolipoprotein B (ApoB), lipoprotein A] seem to play a more prevalent role in ART-treated patients. Notably, ABCA-1, an ATP-binding transporter cassette protein involved in cholesterol efflux, which is inhibited by Nef, is up-regulated in ART-treated individuals. Atherosclerosis in HIV infection results from the interaction of multiple factors: an inflammatory and HIV-driven disease could prevail in the absence of therapy; metabolic, non-inflammatory causes may be more important in patients undergoing therapy. Approaches to atherosclerotic disease in HIV infection should consider these differences.
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0AIDS/HIV
1Anti-HIV Agents - therapeutic use
2Antibiotics. Antiinfectious agents. Antiparasitic agents
3antiretroviral therapy
4Antiviral agents
5Apolipoprotein B
6Arteriosclerosis
7Atherogenesis
8Atherosclerosis (general aspects, experimental research)
9Atherosclerosis - drug therapy
10Atherosclerosis - metabolism
11Atherosclerosis - pathology
12Biological and medical sciences
13Blood and lymphatic vessels
14Cardiology. Vascular system
15Cardiovascular diseases
16Carotid Intima-Media Thickness
17CD4 antigen
18CD4 Lymphocyte Count
19Cholesterol
20Cross-Sectional Studies
21Disease Progression
22HIV Infections - drug therapy
23HIV Infections - metabolism
24HIV Infections - pathology
25Human immunodeficiency virus
26Human viral diseases
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29Infectious diseases
30Inflammation
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39Middle Aged
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41Nef protein
42Pharmacology. Drug treatments
43Protein transport
44Reproducibility of Results
45Risk Factors
46Viral diseases
47Viral diseases of the lymphoid tissue and the blood. Aids
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7SCHIAVINI, Monica
8NIERO, Fosca
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titleAtherosclerosis is associated with multiple pathogenic mechanisms in HIV-infected antiretroviral-naive or treated individuals
authorPICONI, Stefania ; PARISOTTO, Serena ; TRABATTONI, Daria ; CLERICI, Mario ; RIZZARDINI, Giuliano ; PASSERINI, Simone ; MERAVIGLIA, Paola ; SCHIAVINI, Monica ; NIERO, Fosca ; BIASIN, Mara ; BONFANTI, Paolo ; DELFINA RICCI, Elena
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39Middle Aged
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42Pharmacology. Drug treatments
43Protein transport
44Reproducibility of Results
45Risk Factors
46Viral diseases
47Viral diseases of the lymphoid tissue and the blood. Aids
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atitleAtherosclerosis is associated with multiple pathogenic mechanisms in HIV-infected antiretroviral-naive or treated individuals
jtitleAIDS (London)
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date2013
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issue3
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pages381-389
issn0269-9370
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abstractHIV-infected patients have a greater burden of sub-clinical and clinical atherosclerotic disease compared to the general population. The primary objective of this study was to compare the relative roles of inflammation, endothelial alterations, and metabolic factors in the induction and maintenance of atherosclerosis in antiretroviral therapy (ART)-treated or ART-naive patients. Cross-sectional study; 79 HIV-infected patients (55 ART-treated and 24 naive individuals) were consecutively enrolled. In both groups, nearly 50% of the individuals had a high cardiovascular risk (Framingham value >20%). Echo-Doppler [intima-media thickness (IMT)], inflammatory, thrombophilic, endothelial, metabolic indexes, and cholesterol efflux molecules were evaluated. Multivariate analysis adjusted for age, CD4 nadir, BMI, and Framingham's score were used to analyze the results. A complex pathogenesis drives atherogenesis in HIV infection. Thus, whereas inflammation could be responsible for this process in ART-naive individuals, metabolic factors [low-density lipoprotein (LDL), apolipoprotein B (ApoB), lipoprotein A] seem to play a more prevalent role in ART-treated patients. Notably, ABCA-1, an ATP-binding transporter cassette protein involved in cholesterol efflux, which is inhibited by Nef, is up-regulated in ART-treated individuals. Atherosclerosis in HIV infection results from the interaction of multiple factors: an inflammatory and HIV-driven disease could prevail in the absence of therapy; metabolic, non-inflammatory causes may be more important in patients undergoing therapy. Approaches to atherosclerotic disease in HIV infection should consider these differences.
copHagerstown, MD
pubLippincott Williams & Wilkins
pmid23079800
doi10.1097/QAD.0b013e32835abcc9