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Association Between Metabolic Syndrome and Carotid Atherosclerosis: A Community-Based Study in Hong Kong

Background: Carotid atherosclerosis should not be neglected as a cause for stroke in China, despite its low prevalence. This study was performed to evaluate the association between ultrasonographic markers for different stages of carotid atherosclerosis and metabolic syndrome. Methods: This was a co... Full description

Journal Title: Metabolic syndrome and related disorders 2013-04-01, Vol.11 (2), p.19-114
Main Author: Leng, Xin Yi
Other Authors: Chen, Xiang Yan , Chook, Ping , Xiong, Li , Lin, Wen Hua , Liu, Jing Yi , Tomlinson, Brian , Thomas, G. Neil , Lam, Tai Hing , Lam, Karen S.L , Cheung, Bernard M.Y , Wong, Ka Sing
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Mary Ann Liebert, Inc
ID: ISSN: 1540-4196
Link: https://www.ncbi.nlm.nih.gov/pubmed/23350809
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title: Association Between Metabolic Syndrome and Carotid Atherosclerosis: A Community-Based Study in Hong Kong
format: Article
creator:
  • Leng, Xin Yi
  • Chen, Xiang Yan
  • Chook, Ping
  • Xiong, Li
  • Lin, Wen Hua
  • Liu, Jing Yi
  • Tomlinson, Brian
  • Thomas, G. Neil
  • Lam, Tai Hing
  • Lam, Karen S.L
  • Cheung, Bernard M.Y
  • Wong, Ka Sing
subjects:
  • Carotid Arteries - diagnostic imaging
  • Carotid Arteries - pathology
  • Carotid Artery Diseases - complications
  • Carotid Artery Diseases - diagnosis
  • Carotid Artery Diseases - epidemiology
  • Carotid Intima-Media Thickness
  • Carotid Stenosis - pathology
  • Female
  • Hong Kong - epidemiology
  • Humans
  • Male
  • Metabolic Syndrome - complications
  • Metabolic Syndrome - diagnosis
  • Metabolic Syndrome - epidemiology
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Original Articles
  • Prevalence
  • Prospective Studies
  • Risk Factors
  • Sex Factors
ispartof: Metabolic syndrome and related disorders, 2013-04-01, Vol.11 (2), p.19-114
description: Background: Carotid atherosclerosis should not be neglected as a cause for stroke in China, despite its low prevalence. This study was performed to evaluate the association between ultrasonographic markers for different stages of carotid atherosclerosis and metabolic syndrome. Methods: This was a community-based study in Hong Kong. Metabolic syndrome was defined as having three or more of the following conditions or receiving specific treatment for these conditions: Abdominal obesity, elevated triglycerides, low high-density lipoprotein cholesterol, hypertension, and impaired fasting blood glucose. All subjects underwent carotid duplex ultrasonography. Mean carotid intima media thickness (CIMT) of bilateral common carotid arteries was used as the CIMT value for a single subject. CIMT within the 4 th quartile was regarded as increased CIMT. Carotid plaque was defined as a focal CIMT of >1.5 mm. A carotid plaque obstructing ≥50% of vessel lumen was considered as carotid stenosis. Results : A total of 653 subjects (mean age 55.1±10.4; 47.2% male) were recruited. Metabolic syndrome was found in 188 (28.8%) subjects (30.8% in males and 27.0% in females). Mean CIMT was 0.74±0.12 mm. Increased CIMT, carotid plaque, and carotid stenosis were detected in 163 (25.0%), 95 (14.5%), and 6 (1.4%) subjects, respectively. In multivariate linear regression, CIMT significantly increased with increasing numbers of metabolic syndrome components ( P
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1540-4196
fulltext: fulltext
issn:
  • 1540-4196
  • 1557-8518
url: Link


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titleAssociation Between Metabolic Syndrome and Carotid Atherosclerosis: A Community-Based Study in Hong Kong
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creatorLeng, Xin Yi ; Chen, Xiang Yan ; Chook, Ping ; Xiong, Li ; Lin, Wen Hua ; Liu, Jing Yi ; Tomlinson, Brian ; Thomas, G. Neil ; Lam, Tai Hing ; Lam, Karen S.L ; Cheung, Bernard M.Y ; Wong, Ka Sing
creatorcontribLeng, Xin Yi ; Chen, Xiang Yan ; Chook, Ping ; Xiong, Li ; Lin, Wen Hua ; Liu, Jing Yi ; Tomlinson, Brian ; Thomas, G. Neil ; Lam, Tai Hing ; Lam, Karen S.L ; Cheung, Bernard M.Y ; Wong, Ka Sing
descriptionBackground: Carotid atherosclerosis should not be neglected as a cause for stroke in China, despite its low prevalence. This study was performed to evaluate the association between ultrasonographic markers for different stages of carotid atherosclerosis and metabolic syndrome. Methods: This was a community-based study in Hong Kong. Metabolic syndrome was defined as having three or more of the following conditions or receiving specific treatment for these conditions: Abdominal obesity, elevated triglycerides, low high-density lipoprotein cholesterol, hypertension, and impaired fasting blood glucose. All subjects underwent carotid duplex ultrasonography. Mean carotid intima media thickness (CIMT) of bilateral common carotid arteries was used as the CIMT value for a single subject. CIMT within the 4 th quartile was regarded as increased CIMT. Carotid plaque was defined as a focal CIMT of >1.5 mm. A carotid plaque obstructing ≥50% of vessel lumen was considered as carotid stenosis. Results : A total of 653 subjects (mean age 55.1±10.4; 47.2% male) were recruited. Metabolic syndrome was found in 188 (28.8%) subjects (30.8% in males and 27.0% in females). Mean CIMT was 0.74±0.12 mm. Increased CIMT, carotid plaque, and carotid stenosis were detected in 163 (25.0%), 95 (14.5%), and 6 (1.4%) subjects, respectively. In multivariate linear regression, CIMT significantly increased with increasing numbers of metabolic syndrome components ( P <0.001). In multivariate logistic regression analysis, metabolic syndrome was independently associated with increased CIMT [odds ratio (OR) 1.17; 95% confidence interval (CI) 1.11–2.64; P =0.014), but not presence of carotid plaque (OR 1.50; 95% CI 0.92–2.46; P =0.108). Conclusions : Metabolic syndrome may be independently associated with the early stage but not the later and advanced stages of carotid atherosclerosis in community residents in China.
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subjectCarotid Arteries - diagnostic imaging ; Carotid Arteries - pathology ; Carotid Artery Diseases - complications ; Carotid Artery Diseases - diagnosis ; Carotid Artery Diseases - epidemiology ; Carotid Intima-Media Thickness ; Carotid Stenosis - pathology ; Female ; Hong Kong - epidemiology ; Humans ; Male ; Metabolic Syndrome - complications ; Metabolic Syndrome - diagnosis ; Metabolic Syndrome - epidemiology ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Original Articles ; Prevalence ; Prospective Studies ; Risk Factors ; Sex Factors
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descriptionBackground: Carotid atherosclerosis should not be neglected as a cause for stroke in China, despite its low prevalence. This study was performed to evaluate the association between ultrasonographic markers for different stages of carotid atherosclerosis and metabolic syndrome. Methods: This was a community-based study in Hong Kong. Metabolic syndrome was defined as having three or more of the following conditions or receiving specific treatment for these conditions: Abdominal obesity, elevated triglycerides, low high-density lipoprotein cholesterol, hypertension, and impaired fasting blood glucose. All subjects underwent carotid duplex ultrasonography. Mean carotid intima media thickness (CIMT) of bilateral common carotid arteries was used as the CIMT value for a single subject. CIMT within the 4 th quartile was regarded as increased CIMT. Carotid plaque was defined as a focal CIMT of >1.5 mm. A carotid plaque obstructing ≥50% of vessel lumen was considered as carotid stenosis. Results : A total of 653 subjects (mean age 55.1±10.4; 47.2% male) were recruited. Metabolic syndrome was found in 188 (28.8%) subjects (30.8% in males and 27.0% in females). Mean CIMT was 0.74±0.12 mm. Increased CIMT, carotid plaque, and carotid stenosis were detected in 163 (25.0%), 95 (14.5%), and 6 (1.4%) subjects, respectively. In multivariate linear regression, CIMT significantly increased with increasing numbers of metabolic syndrome components ( P <0.001). In multivariate logistic regression analysis, metabolic syndrome was independently associated with increased CIMT [odds ratio (OR) 1.17; 95% confidence interval (CI) 1.11–2.64; P =0.014), but not presence of carotid plaque (OR 1.50; 95% CI 0.92–2.46; P =0.108). Conclusions : Metabolic syndrome may be independently associated with the early stage but not the later and advanced stages of carotid atherosclerosis in community residents in China.
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1Carotid Arteries - pathology
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13Metabolic Syndrome - epidemiology
14Middle Aged
15Multivariate Analysis
16Odds Ratio
17Original Articles
18Prevalence
19Prospective Studies
20Risk Factors
21Sex Factors
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abstractBackground: Carotid atherosclerosis should not be neglected as a cause for stroke in China, despite its low prevalence. This study was performed to evaluate the association between ultrasonographic markers for different stages of carotid atherosclerosis and metabolic syndrome. Methods: This was a community-based study in Hong Kong. Metabolic syndrome was defined as having three or more of the following conditions or receiving specific treatment for these conditions: Abdominal obesity, elevated triglycerides, low high-density lipoprotein cholesterol, hypertension, and impaired fasting blood glucose. All subjects underwent carotid duplex ultrasonography. Mean carotid intima media thickness (CIMT) of bilateral common carotid arteries was used as the CIMT value for a single subject. CIMT within the 4 th quartile was regarded as increased CIMT. Carotid plaque was defined as a focal CIMT of >1.5 mm. A carotid plaque obstructing ≥50% of vessel lumen was considered as carotid stenosis. Results : A total of 653 subjects (mean age 55.1±10.4; 47.2% male) were recruited. Metabolic syndrome was found in 188 (28.8%) subjects (30.8% in males and 27.0% in females). Mean CIMT was 0.74±0.12 mm. Increased CIMT, carotid plaque, and carotid stenosis were detected in 163 (25.0%), 95 (14.5%), and 6 (1.4%) subjects, respectively. In multivariate linear regression, CIMT significantly increased with increasing numbers of metabolic syndrome components ( P <0.001). In multivariate logistic regression analysis, metabolic syndrome was independently associated with increased CIMT [odds ratio (OR) 1.17; 95% confidence interval (CI) 1.11–2.64; P =0.014), but not presence of carotid plaque (OR 1.50; 95% CI 0.92–2.46; P =0.108). Conclusions : Metabolic syndrome may be independently associated with the early stage but not the later and advanced stages of carotid atherosclerosis in community residents in China.
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pmid23350809
doi10.1089/met.2012.0099
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