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Omics and drug response

A new generation of technologies commonly named omics permits assessment of the entirety of the components of biological systems and produces an explosion of data and a major shift in our concepts of disease. These technologies will likely shape the future of health care. One aspect of these advance... Full description

Journal Title: Annual review of pharmacology and toxicology 2013, Vol.53 (1), p.475-502
Main Author: MEYER, Urs A
Other Authors: ZANGER, Ulrich M , SCHWAB, Matthias
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Palo Alto, CA: Annual Reviews
ID: ISSN: 0362-1642
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title: Omics and drug response
format: Article
creator:
  • MEYER, Urs A
  • ZANGER, Ulrich M
  • SCHWAB, Matthias
subjects:
  • Animals
  • Biological and medical sciences
  • General pharmacology
  • Genomics - methods
  • Humans
  • Medical sciences
  • Miscellaneous
  • Pharmacogenetics - methods
  • Pharmacology. Drug treatments
  • Precision Medicine - methods
ispartof: Annual review of pharmacology and toxicology, 2013, Vol.53 (1), p.475-502
description: A new generation of technologies commonly named omics permits assessment of the entirety of the components of biological systems and produces an explosion of data and a major shift in our concepts of disease. These technologies will likely shape the future of health care. One aspect of these advances is that the data generated document the uniqueness of each human being in regard to disease risk and treatment response. These developments have reemphasized the concept of personalized medicine. Here we review the impact of omics technologies on one key aspect of personalized medicine: the individual drug response. We describe how knowledge of different omics may affect treatment decisions, namely drug choice and drug dose, and how it can be used to improve clinical outcomes.
language: eng
source:
identifier: ISSN: 0362-1642
fulltext: no_fulltext
issn:
  • 0362-1642
  • 1545-4304
url: Link


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descriptionA new generation of technologies commonly named omics permits assessment of the entirety of the components of biological systems and produces an explosion of data and a major shift in our concepts of disease. These technologies will likely shape the future of health care. One aspect of these advances is that the data generated document the uniqueness of each human being in regard to disease risk and treatment response. These developments have reemphasized the concept of personalized medicine. Here we review the impact of omics technologies on one key aspect of personalized medicine: the individual drug response. We describe how knowledge of different omics may affect treatment decisions, namely drug choice and drug dose, and how it can be used to improve clinical outcomes.
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subjectAnimals ; Biological and medical sciences ; General pharmacology ; Genomics - methods ; Humans ; Medical sciences ; Miscellaneous ; Pharmacogenetics - methods ; Pharmacology. Drug treatments ; Precision Medicine - methods
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9Precision Medicine - methods
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abstractA new generation of technologies commonly named omics permits assessment of the entirety of the components of biological systems and produces an explosion of data and a major shift in our concepts of disease. These technologies will likely shape the future of health care. One aspect of these advances is that the data generated document the uniqueness of each human being in regard to disease risk and treatment response. These developments have reemphasized the concept of personalized medicine. Here we review the impact of omics technologies on one key aspect of personalized medicine: the individual drug response. We describe how knowledge of different omics may affect treatment decisions, namely drug choice and drug dose, and how it can be used to improve clinical outcomes.
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doi10.1146/annurev-pharmtox-010510-100502