schliessen

Filtern

 

Bibliotheken

Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations

Summary Background Atherosclerosis is thought to be a disease of modern human beings and related to contemporary lifestyles. However, its prevalence before the modern era is unknown. We aimed to evaluate preindustrial populations for atherosclerosis. Methods We obtained whole body CT scans of 137 mu... Full description

Journal Title: The Lancet (British edition) 2013, Vol.381 (9873), p.1211-1222
Main Author: Thompson, Randall C, Prof
Other Authors: Allam, Adel H, Prof , Lombardi, Guido P, MD , Wann, L Samuel, MD , Sutherland, M Linda, MD , Sutherland, James D, MD , Soliman, Muhammad Al-Tohamy, PhD , Frohlich, Bruno, PhD , Mininberg, David T, MD , Monge, Janet M, PhD , Vallodolid, Clide M, BA , Cox, Samantha L, MS , Abd el-Maksoud, Gomaa, Prof , Badr, Ibrahim, PhD , Miyamoto, Michael I, MD , el-Halim Nur el-din, Abd, Prof , Narula, Jagat, Prof , Finch, Caleb E, Prof , Thomas, Gregory S, Prof
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Kidlington: Elsevier
ID: ISSN: 0140-6736
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1324960404
title: Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations
format: Article
creator:
  • Thompson, Randall C, Prof
  • Allam, Adel H, Prof
  • Lombardi, Guido P, MD
  • Wann, L Samuel, MD
  • Sutherland, M Linda, MD
  • Sutherland, James D, MD
  • Soliman, Muhammad Al-Tohamy, PhD
  • Frohlich, Bruno, PhD
  • Mininberg, David T, MD
  • Monge, Janet M, PhD
  • Vallodolid, Clide M, BA
  • Cox, Samantha L, MS
  • Abd el-Maksoud, Gomaa, Prof
  • Badr, Ibrahim, PhD
  • Miyamoto, Michael I, MD
  • el-Halim Nur el-din, Abd, Prof
  • Narula, Jagat, Prof
  • Finch, Caleb E, Prof
  • Thomas, Gregory S, Prof
subjects:
  • Abridged Index Medicus
  • Adult
  • Age Factors
  • Alaska - ethnology
  • Analysis
  • Art galleries & museums
  • Atherosclerosis
  • Atherosclerosis (general aspects, experimental research)
  • Atherosclerosis - ethnology
  • Atherosclerosis - history
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Cardiology. Vascular system
  • Colleges & universities
  • Coronary vessels
  • Demographic aspects
  • Egypt - ethnology
  • Female
  • General aspects
  • History, 15th Century
  • History, 16th Century
  • History, 17th Century
  • History, 18th Century
  • History, 19th Century
  • History, 20th Century
  • History, Ancient
  • History, Medieval
  • Humans
  • Internal Medicine
  • Male
  • Medical imaging
  • Medical sciences
  • Mummies
  • Mummies - pathology
  • Peru - ethnology
  • Scanners
  • Southwestern United States - ethnology
  • Tomography, X-Ray Computed
  • Vascular Calcification - ethnology
  • Vascular Calcification - history
ispartof: The Lancet (British edition), 2013, Vol.381 (9873), p.1211-1222
description: Summary Background Atherosclerosis is thought to be a disease of modern human beings and related to contemporary lifestyles. However, its prevalence before the modern era is unknown. We aimed to evaluate preindustrial populations for atherosclerosis. Methods We obtained whole body CT scans of 137 mummies from four different geographical regions or populations spanning more than 4000 years. Individuals from ancient Egypt, ancient Peru, the Ancestral Puebloans of southwest America, and the Unangan of the Aleutian Islands were imaged. Atherosclerosis was regarded as definite if a calcified plaque was seen in the wall of an artery and probable if calcifications were seen along the expected course of an artery. Findings Probable or definite atherosclerosis was noted in 47 (34%) of 137 mummies and in all four geographical populations: 29 (38%) of 76 ancient Egyptians, 13 (25%) of 51 ancient Peruvians, two (40%) of five Ancestral Puebloans, and three (60%) of five Unangan hunter gatherers (p=NS). Atherosclerosis was present in the aorta in 28 (20%) mummies, iliac or femoral arteries in 25 (18%), popliteal or tibial arteries in 25 (18%), carotid arteries in 17 (12%), and coronary arteries in six (4%). Of the five vascular beds examined, atherosclerosis was present in one to two beds in 34 (25%) mummies, in three to four beds in 11 (8%), and in all five vascular beds in two (1%). Age at time of death was positively correlated with atherosclerosis (mean age at death was 43 [SD 10] years for mummies with atherosclerosis vs 32 [15] years for those without; p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.7520697
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_1324960404
sourceformatXML
sourcesystemPC
galeidA333595180
sourcerecordidA333595180
originalsourceidFETCH-LOGICAL-1700t-774c988ae987bffdffebb466dc3295e29db51232562f9d402b5bcd3512f26a293
addsrcrecordideNqNkm1rFDEUhQdR7Fr9CUpAhApOzevMREFYilqh4AcV9lvIZJLd1NnJmDsj7L83s1u721K0BBK4POfcQzhZ9pzgU4JJ8fYbJhznRcmKE8JeF1jIKl88yGaElzwXvFw8zGbXyFH2BOASY8wT-Dg7ooxXshRslqn5sLIxgGmn2wPSJr2AeILRxuoIKDi0Gte6QysPQ4ibdyhJ0HmIIyAYxmYzES6MEenOeNsNqA_92OrBhw6eZo-cbsE-u3qPsx-fPn4_O88vvn7-cja_yEmJ8ZCXJTeyqrSVVVk71zhn65oXRWMYlcJS2dSCUEZFQZ1sOKa1qE3D0szRQlPJjrOTnW8fw6_RwqDWHoxtW93ZMIIijHJZYI55Ql_eQi9T-C6lmygmJSO02lNL3VrlOxeGqM1kquaCEiYrUpF_UowxIQWpcKJO76DSaezam9BZ59P8hu29BIcbXtwhUIeObw6AegTfWUgX-OVqgKUeAW4GuAd-uF7s8G15onWqj36t40YRrKa6qm1d1dTF9MlqW1e12Mfux3ptm2vV334m4NUVoMHo1sWpYrDnSlIKwUXi3t8KYPywbWD6B9_-N8aHndqmhv72NirT-s6nhT_txsK-HgqowjuTyYOwrcOC_QFk2RRd
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1323993128
display
typearticle
titleAtherosclerosis across 4000 years of human history: the Horus study of four ancient populations
sourceAlma/SFX Local Collection
creatorThompson, Randall C, Prof ; Allam, Adel H, Prof ; Lombardi, Guido P, MD ; Wann, L Samuel, MD ; Sutherland, M Linda, MD ; Sutherland, James D, MD ; Soliman, Muhammad Al-Tohamy, PhD ; Frohlich, Bruno, PhD ; Mininberg, David T, MD ; Monge, Janet M, PhD ; Vallodolid, Clide M, BA ; Cox, Samantha L, MS ; Abd el-Maksoud, Gomaa, Prof ; Badr, Ibrahim, PhD ; Miyamoto, Michael I, MD ; el-Halim Nur el-din, Abd, Prof ; Narula, Jagat, Prof ; Finch, Caleb E, Prof ; Thomas, Gregory S, Prof
creatorcontribThompson, Randall C, Prof ; Allam, Adel H, Prof ; Lombardi, Guido P, MD ; Wann, L Samuel, MD ; Sutherland, M Linda, MD ; Sutherland, James D, MD ; Soliman, Muhammad Al-Tohamy, PhD ; Frohlich, Bruno, PhD ; Mininberg, David T, MD ; Monge, Janet M, PhD ; Vallodolid, Clide M, BA ; Cox, Samantha L, MS ; Abd el-Maksoud, Gomaa, Prof ; Badr, Ibrahim, PhD ; Miyamoto, Michael I, MD ; el-Halim Nur el-din, Abd, Prof ; Narula, Jagat, Prof ; Finch, Caleb E, Prof ; Thomas, Gregory S, Prof
descriptionSummary Background Atherosclerosis is thought to be a disease of modern human beings and related to contemporary lifestyles. However, its prevalence before the modern era is unknown. We aimed to evaluate preindustrial populations for atherosclerosis. Methods We obtained whole body CT scans of 137 mummies from four different geographical regions or populations spanning more than 4000 years. Individuals from ancient Egypt, ancient Peru, the Ancestral Puebloans of southwest America, and the Unangan of the Aleutian Islands were imaged. Atherosclerosis was regarded as definite if a calcified plaque was seen in the wall of an artery and probable if calcifications were seen along the expected course of an artery. Findings Probable or definite atherosclerosis was noted in 47 (34%) of 137 mummies and in all four geographical populations: 29 (38%) of 76 ancient Egyptians, 13 (25%) of 51 ancient Peruvians, two (40%) of five Ancestral Puebloans, and three (60%) of five Unangan hunter gatherers (p=NS). Atherosclerosis was present in the aorta in 28 (20%) mummies, iliac or femoral arteries in 25 (18%), popliteal or tibial arteries in 25 (18%), carotid arteries in 17 (12%), and coronary arteries in six (4%). Of the five vascular beds examined, atherosclerosis was present in one to two beds in 34 (25%) mummies, in three to four beds in 11 (8%), and in all five vascular beds in two (1%). Age at time of death was positively correlated with atherosclerosis (mean age at death was 43 [SD 10] years for mummies with atherosclerosis vs 32 [15] years for those without; p<0·0001) and with the number of arterial beds involved (mean age was 32 [SD 15] years for mummies with no atherosclerosis, 42 [10] years for those with atherosclerosis in one or two beds, and 44 [8] years for those with atherosclerosis in three to five beds; p<0·0001). Interpretation Atherosclerosis was common in four preindustrial populations including preagricultural hunter-gatherers. Although commonly assumed to be a modern disease, the presence of atherosclerosis in premodern human beings raises the possibility of a more basic predisposition to the disease. Funding National Endowment for the Humanities, Paleocardiology Foundation, The National Bank of Egypt, Siemens, and St Luke's Hospital Foundation of Kansas City.
identifier
0ISSN: 0140-6736
1EISSN: 1474-547X
2DOI: 10.1016/S0140-6736(13)60598-X
3PMID: 23489753
4CODEN: LANCAO
languageeng
publisherKidlington: Elsevier
subjectAbridged Index Medicus ; Adult ; Age Factors ; Alaska - ethnology ; Analysis ; Art galleries & museums ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - ethnology ; Atherosclerosis - history ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Colleges & universities ; Coronary vessels ; Demographic aspects ; Egypt - ethnology ; Female ; General aspects ; History, 15th Century ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, Ancient ; History, Medieval ; Humans ; Internal Medicine ; Male ; Medical imaging ; Medical sciences ; Mummies ; Mummies - pathology ; Peru - ethnology ; Scanners ; Southwestern United States - ethnology ; Tomography, X-Ray Computed ; Vascular Calcification - ethnology ; Vascular Calcification - history
ispartofThe Lancet (British edition), 2013, Vol.381 (9873), p.1211-1222
rights
0Elsevier Ltd
12014 INIST-CNRS
2Copyright © 2013 Elsevier Ltd. All rights reserved.
3COPYRIGHT 2013 Elsevier B.V.
4Copyright Elsevier Limited Apr 6, 2013
lds50peer_reviewed
citedbyFETCH-LOGICAL-1700t-774c988ae987bffdffebb466dc3295e29db51232562f9d402b5bcd3512f26a293
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27175545$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23489753$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Thompson, Randall C, Prof
1Allam, Adel H, Prof
2Lombardi, Guido P, MD
3Wann, L Samuel, MD
4Sutherland, M Linda, MD
5Sutherland, James D, MD
6Soliman, Muhammad Al-Tohamy, PhD
7Frohlich, Bruno, PhD
8Mininberg, David T, MD
9Monge, Janet M, PhD
10Vallodolid, Clide M, BA
11Cox, Samantha L, MS
12Abd el-Maksoud, Gomaa, Prof
13Badr, Ibrahim, PhD
14Miyamoto, Michael I, MD
15el-Halim Nur el-din, Abd, Prof
16Narula, Jagat, Prof
17Finch, Caleb E, Prof
18Thomas, Gregory S, Prof
title
0Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations
1The Lancet (British edition)
addtitleLancet
descriptionSummary Background Atherosclerosis is thought to be a disease of modern human beings and related to contemporary lifestyles. However, its prevalence before the modern era is unknown. We aimed to evaluate preindustrial populations for atherosclerosis. Methods We obtained whole body CT scans of 137 mummies from four different geographical regions or populations spanning more than 4000 years. Individuals from ancient Egypt, ancient Peru, the Ancestral Puebloans of southwest America, and the Unangan of the Aleutian Islands were imaged. Atherosclerosis was regarded as definite if a calcified plaque was seen in the wall of an artery and probable if calcifications were seen along the expected course of an artery. Findings Probable or definite atherosclerosis was noted in 47 (34%) of 137 mummies and in all four geographical populations: 29 (38%) of 76 ancient Egyptians, 13 (25%) of 51 ancient Peruvians, two (40%) of five Ancestral Puebloans, and three (60%) of five Unangan hunter gatherers (p=NS). Atherosclerosis was present in the aorta in 28 (20%) mummies, iliac or femoral arteries in 25 (18%), popliteal or tibial arteries in 25 (18%), carotid arteries in 17 (12%), and coronary arteries in six (4%). Of the five vascular beds examined, atherosclerosis was present in one to two beds in 34 (25%) mummies, in three to four beds in 11 (8%), and in all five vascular beds in two (1%). Age at time of death was positively correlated with atherosclerosis (mean age at death was 43 [SD 10] years for mummies with atherosclerosis vs 32 [15] years for those without; p<0·0001) and with the number of arterial beds involved (mean age was 32 [SD 15] years for mummies with no atherosclerosis, 42 [10] years for those with atherosclerosis in one or two beds, and 44 [8] years for those with atherosclerosis in three to five beds; p<0·0001). Interpretation Atherosclerosis was common in four preindustrial populations including preagricultural hunter-gatherers. Although commonly assumed to be a modern disease, the presence of atherosclerosis in premodern human beings raises the possibility of a more basic predisposition to the disease. Funding National Endowment for the Humanities, Paleocardiology Foundation, The National Bank of Egypt, Siemens, and St Luke's Hospital Foundation of Kansas City.
subject
0Abridged Index Medicus
1Adult
2Age Factors
3Alaska - ethnology
4Analysis
5Art galleries & museums
6Atherosclerosis
7Atherosclerosis (general aspects, experimental research)
8Atherosclerosis - ethnology
9Atherosclerosis - history
10Biological and medical sciences
11Blood and lymphatic vessels
12Cardiology. Vascular system
13Colleges & universities
14Coronary vessels
15Demographic aspects
16Egypt - ethnology
17Female
18General aspects
19History, 15th Century
20History, 16th Century
21History, 17th Century
22History, 18th Century
23History, 19th Century
24History, 20th Century
25History, Ancient
26History, Medieval
27Humans
28Internal Medicine
29Male
30Medical imaging
31Medical sciences
32Mummies
33Mummies - pathology
34Peru - ethnology
35Scanners
36Southwestern United States - ethnology
37Tomography, X-Ray Computed
38Vascular Calcification - ethnology
39Vascular Calcification - history
issn
00140-6736
11474-547X
fulltexttrue
rsrctypearticle
creationdate2013
recordtypearticle
recordideNqNkm1rFDEUhQdR7Fr9CUpAhApOzevMREFYilqh4AcV9lvIZJLd1NnJmDsj7L83s1u721K0BBK4POfcQzhZ9pzgU4JJ8fYbJhznRcmKE8JeF1jIKl88yGaElzwXvFw8zGbXyFH2BOASY8wT-Dg7ooxXshRslqn5sLIxgGmn2wPSJr2AeILRxuoIKDi0Gte6QysPQ4ibdyhJ0HmIIyAYxmYzES6MEenOeNsNqA_92OrBhw6eZo-cbsE-u3qPsx-fPn4_O88vvn7-cja_yEmJ8ZCXJTeyqrSVVVk71zhn65oXRWMYlcJS2dSCUEZFQZ1sOKa1qE3D0szRQlPJjrOTnW8fw6_RwqDWHoxtW93ZMIIijHJZYI55Ql_eQi9T-C6lmygmJSO02lNL3VrlOxeGqM1kquaCEiYrUpF_UowxIQWpcKJO76DSaezam9BZ59P8hu29BIcbXtwhUIeObw6AegTfWUgX-OVqgKUeAW4GuAd-uF7s8G15onWqj36t40YRrKa6qm1d1dTF9MlqW1e12Mfux3ptm2vV334m4NUVoMHo1sWpYrDnSlIKwUXi3t8KYPywbWD6B9_-N8aHndqmhv72NirT-s6nhT_txsK-HgqowjuTyYOwrcOC_QFk2RRd
startdate2013
enddate2013
creator
0Thompson, Randall C, Prof
1Allam, Adel H, Prof
2Lombardi, Guido P, MD
3Wann, L Samuel, MD
4Sutherland, M Linda, MD
5Sutherland, James D, MD
6Soliman, Muhammad Al-Tohamy, PhD
7Frohlich, Bruno, PhD
8Mininberg, David T, MD
9Monge, Janet M, PhD
10Vallodolid, Clide M, BA
11Cox, Samantha L, MS
12Abd el-Maksoud, Gomaa, Prof
13Badr, Ibrahim, PhD
14Miyamoto, Michael I, MD
15el-Halim Nur el-din, Abd, Prof
16Narula, Jagat, Prof
17Finch, Caleb E, Prof
18Thomas, Gregory S, Prof
general
0Elsevier
1Elsevier B.V
2Elsevier Limited
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
9BKMMT
10BSHEE
110TT
120TZ
130U~
143V.
157QL
167QP
177RV
187TK
197U7
207U9
217X7
227XB
2388A
2488C
2588E
2688G
2788I
288AF
298AO
308C1
318C2
328FE
338FH
348FI
358FJ
368FK
378G5
38ABUWG
39AN0
40ASE
41AZQEC
42BBNVY
43BEC
44BENPR
45BHPHI
46C1K
47DWQXO
48FPQ
49FYUFA
50GHDGH
51GNUQQ
52GUQSH
53H94
54HCIFZ
55K6X
56K9-
57K9.
58KB0
59KB~
60LK8
61M0R
62M0S
63M0T
64M1P
65M2M
66M2O
67M2P
68M7N
69M7P
70MBDVC
71NAPCQ
72PQEST
73PQQKQ
74PQUKI
75Q9U
76S0X
777X8
sort
creationdate2013
titleAtherosclerosis across 4000 years of human history: the Horus study of four ancient populations
authorThompson, Randall C, Prof ; Allam, Adel H, Prof ; Lombardi, Guido P, MD ; Wann, L Samuel, MD ; Sutherland, M Linda, MD ; Sutherland, James D, MD ; Soliman, Muhammad Al-Tohamy, PhD ; Frohlich, Bruno, PhD ; Mininberg, David T, MD ; Monge, Janet M, PhD ; Vallodolid, Clide M, BA ; Cox, Samantha L, MS ; Abd el-Maksoud, Gomaa, Prof ; Badr, Ibrahim, PhD ; Miyamoto, Michael I, MD ; el-Halim Nur el-din, Abd, Prof ; Narula, Jagat, Prof ; Finch, Caleb E, Prof ; Thomas, Gregory S, Prof
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1700t-774c988ae987bffdffebb466dc3295e29db51232562f9d402b5bcd3512f26a293
rsrctypearticles
prefilterarticles
languageeng
creationdate2013
topic
0Abridged Index Medicus
1Adult
2Age Factors
3Alaska - ethnology
4Analysis
5Art galleries & museums
6Atherosclerosis
7Atherosclerosis (general aspects, experimental research)
8Atherosclerosis - ethnology
9Atherosclerosis - history
10Biological and medical sciences
11Blood and lymphatic vessels
12Cardiology. Vascular system
13Colleges & universities
14Coronary vessels
15Demographic aspects
16Egypt - ethnology
17Female
18General aspects
19History, 15th Century
20History, 16th Century
21History, 17th Century
22History, 18th Century
23History, 19th Century
24History, 20th Century
25History, Ancient
26History, Medieval
27Humans
28Internal Medicine
29Male
30Medical imaging
31Medical sciences
32Mummies
33Mummies - pathology
34Peru - ethnology
35Scanners
36Southwestern United States - ethnology
37Tomography, X-Ray Computed
38Vascular Calcification - ethnology
39Vascular Calcification - history
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Thompson, Randall C, Prof
1Allam, Adel H, Prof
2Lombardi, Guido P, MD
3Wann, L Samuel, MD
4Sutherland, M Linda, MD
5Sutherland, James D, MD
6Soliman, Muhammad Al-Tohamy, PhD
7Frohlich, Bruno, PhD
8Mininberg, David T, MD
9Monge, Janet M, PhD
10Vallodolid, Clide M, BA
11Cox, Samantha L, MS
12Abd el-Maksoud, Gomaa, Prof
13Badr, Ibrahim, PhD
14Miyamoto, Michael I, MD
15el-Halim Nur el-din, Abd, Prof
16Narula, Jagat, Prof
17Finch, Caleb E, Prof
18Thomas, Gregory S, Prof
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Gale General OneFile (A&I only)
9Academic OneFile (A&I only)
10News PRO
11Pharma and Biotech Premium PRO
12Global News & ABI/Inform Professional
13ProQuest Central (Corporate)
14Bacteriology Abstracts (Microbiology B)
15Calcium & Calcified Tissue Abstracts
16Nursing & Allied Health Database
17Neurosciences Abstracts
18Toxicology Abstracts
19Virology and AIDS Abstracts
20Health & Medical Collection
21ProQuest Central (purchase pre-March 2016)
22Biology Database (Alumni Edition)
23Healthcare Administration Database (Alumni)
24Medical Database (Alumni Edition)
25Psychology Database (Alumni)
26Science Database (Alumni Edition)
27STEM Database
28ProQuest Pharma Collection
29Public Health Database
30Lancet Titles
31ProQuest SciTech Collection
32ProQuest Natural Science Collection
33Hospital Premium Collection
34Hospital Premium Collection (Alumni Edition)
35ProQuest Central (Alumni) (purchase pre-March 2016)
36Research Library (Alumni Edition)
37ProQuest Central (Alumni Edition)
38British Nursing Database
39British Nursing Index
40ProQuest Central Essentials
41Biological Science Collection
42eLibrary
43ProQuest Central
44Natural Science Collection
45Environmental Sciences and Pollution Management
46ProQuest Central Korea
47British Nursing Index (BNI) (1985 to Present)
48Health Research Premium Collection
49Health Research Premium Collection (Alumni)
50ProQuest Central Student
51Research Library Prep
52AIDS and Cancer Research Abstracts
53SciTech Premium Collection
54British Nursing Index
55Consumer Health Database (Alumni Edition)
56ProQuest Health & Medical Complete (Alumni)
57Nursing & Allied Health Database (Alumni Edition)
58ProQuest Newsstand Professional
59ProQuest Biological Science Collection
60Consumer Health Database
61Health & Medical Collection (Alumni Edition)
62Healthcare Administration Database
63Medical Database
64Psychology Database
65Research Library
66Science Database
67Algology Mycology and Protozoology Abstracts (Microbiology C)
68Biological Science Database
69Research Library (Corporate)
70Nursing & Allied Health Premium
71ProQuest One Academic Eastern Edition
72ProQuest One Academic
73ProQuest One Academic UKI Edition
74ProQuest Central Basic
75SIRS Editorial
76MEDLINE - Academic
jtitleThe Lancet (British edition)
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Thompson, Randall C, Prof
1Allam, Adel H, Prof
2Lombardi, Guido P, MD
3Wann, L Samuel, MD
4Sutherland, M Linda, MD
5Sutherland, James D, MD
6Soliman, Muhammad Al-Tohamy, PhD
7Frohlich, Bruno, PhD
8Mininberg, David T, MD
9Monge, Janet M, PhD
10Vallodolid, Clide M, BA
11Cox, Samantha L, MS
12Abd el-Maksoud, Gomaa, Prof
13Badr, Ibrahim, PhD
14Miyamoto, Michael I, MD
15el-Halim Nur el-din, Abd, Prof
16Narula, Jagat, Prof
17Finch, Caleb E, Prof
18Thomas, Gregory S, Prof
formatjournal
genrearticle
ristypeJOUR
atitleAtherosclerosis across 4000 years of human history: the Horus study of four ancient populations
jtitleThe Lancet (British edition)
addtitleLancet
date2013
risdate2013
volume381
issue9873
spage1211
epage1222
pages1211-1222
issn0140-6736
eissn1474-547X
codenLANCAO
abstractSummary Background Atherosclerosis is thought to be a disease of modern human beings and related to contemporary lifestyles. However, its prevalence before the modern era is unknown. We aimed to evaluate preindustrial populations for atherosclerosis. Methods We obtained whole body CT scans of 137 mummies from four different geographical regions or populations spanning more than 4000 years. Individuals from ancient Egypt, ancient Peru, the Ancestral Puebloans of southwest America, and the Unangan of the Aleutian Islands were imaged. Atherosclerosis was regarded as definite if a calcified plaque was seen in the wall of an artery and probable if calcifications were seen along the expected course of an artery. Findings Probable or definite atherosclerosis was noted in 47 (34%) of 137 mummies and in all four geographical populations: 29 (38%) of 76 ancient Egyptians, 13 (25%) of 51 ancient Peruvians, two (40%) of five Ancestral Puebloans, and three (60%) of five Unangan hunter gatherers (p=NS). Atherosclerosis was present in the aorta in 28 (20%) mummies, iliac or femoral arteries in 25 (18%), popliteal or tibial arteries in 25 (18%), carotid arteries in 17 (12%), and coronary arteries in six (4%). Of the five vascular beds examined, atherosclerosis was present in one to two beds in 34 (25%) mummies, in three to four beds in 11 (8%), and in all five vascular beds in two (1%). Age at time of death was positively correlated with atherosclerosis (mean age at death was 43 [SD 10] years for mummies with atherosclerosis vs 32 [15] years for those without; p<0·0001) and with the number of arterial beds involved (mean age was 32 [SD 15] years for mummies with no atherosclerosis, 42 [10] years for those with atherosclerosis in one or two beds, and 44 [8] years for those with atherosclerosis in three to five beds; p<0·0001). Interpretation Atherosclerosis was common in four preindustrial populations including preagricultural hunter-gatherers. Although commonly assumed to be a modern disease, the presence of atherosclerosis in premodern human beings raises the possibility of a more basic predisposition to the disease. Funding National Endowment for the Humanities, Paleocardiology Foundation, The National Bank of Egypt, Siemens, and St Luke's Hospital Foundation of Kansas City.
copKidlington
pubElsevier
pmid23489753
doi10.1016/S0140-6736(13)60598-X