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The role of uric acid in the pathogenesis of human cardiovascular disease

Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies ha... Full description

Journal Title: Heart 2013-06, Vol.99 (11), p.759-766
Main Author: Kanbay, Mehmet
Other Authors: Segal, Mark , Afsar, Baris , Kang, Duk-Hee , Rodriguez-Iturbe, Bernardo , Johnson, Richard J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Quelle: Alma/SFX Local Collection
Publisher: England: BMJ Publishing Group Ltd and British Cardiovascular Society
ID: ISSN: 1355-6037
Link: https://www.ncbi.nlm.nih.gov/pubmed/23343689
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title: The role of uric acid in the pathogenesis of human cardiovascular disease
format: Article
creator:
  • Kanbay, Mehmet
  • Segal, Mark
  • Afsar, Baris
  • Kang, Duk-Hee
  • Rodriguez-Iturbe, Bernardo
  • Johnson, Richard J
subjects:
  • Abridged Index Medicus
  • Age
  • Alcohol use
  • Body mass index
  • Cardiovascular disease
  • Cardiovascular diseases
  • Cardiovascular Diseases - blood
  • Cardiovascular Diseases - etiology
  • Cardiovascular Diseases - physiopathology
  • Causes of
  • Complications and side effects
  • Coronary Artery Disease
  • Diabetes
  • Endothelium, Vascular - physiopathology
  • Family medical history
  • Fasting
  • Glucose
  • Heart Failure
  • Humans
  • Hypertension
  • Hyperuricemia
  • Hyperuricemia - blood
  • Hyperuricemia - complications
  • Hyperuricemia - physiopathology
  • Inflammation
  • Insulin
  • Lipids
  • Metabolism
  • Oxidative Stress
  • Rheumatism
  • Rodents
  • Studies
  • Uric acid
  • Uric Acid - blood
  • Vasoconstriction - physiology
  • Womens health
ispartof: Heart, 2013-06, Vol.99 (11), p.759-766
description: Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, as well as stroke and heart failure. Experimentally raising uric acid in animals increases blood pressure, and pilot studies suggest that lowering uric acid in humans can reduce blood pressure in hypertensive individuals. Uric acid may also have emerging roles in the pathogenesis of kidney disease, metabolic syndrome and diabetes. More studies need to be performed on the pathophysiology and clinical consequences of hyperuricaemia in cardiovascular disease.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1355-6037
fulltext: fulltext
issn:
  • 1355-6037
  • 1468-201X
url: Link


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descriptionHyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, as well as stroke and heart failure. Experimentally raising uric acid in animals increases blood pressure, and pilot studies suggest that lowering uric acid in humans can reduce blood pressure in hypertensive individuals. Uric acid may also have emerging roles in the pathogenesis of kidney disease, metabolic syndrome and diabetes. More studies need to be performed on the pathophysiology and clinical consequences of hyperuricaemia in cardiovascular disease.
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subjectAbridged Index Medicus ; Age ; Alcohol use ; Body mass index ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - physiopathology ; Causes of ; Complications and side effects ; Coronary Artery Disease ; Diabetes ; Endothelium, Vascular - physiopathology ; Family medical history ; Fasting ; Glucose ; Heart Failure ; Humans ; Hypertension ; Hyperuricemia ; Hyperuricemia - blood ; Hyperuricemia - complications ; Hyperuricemia - physiopathology ; Inflammation ; Insulin ; Lipids ; Metabolism ; Oxidative Stress ; Rheumatism ; Rodents ; Studies ; Uric acid ; Uric Acid - blood ; Vasoconstriction - physiology ; Womens health
ispartofHeart, 2013-06, Vol.99 (11), p.759-766
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abstractHyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, as well as stroke and heart failure. Experimentally raising uric acid in animals increases blood pressure, and pilot studies suggest that lowering uric acid in humans can reduce blood pressure in hypertensive individuals. Uric acid may also have emerging roles in the pathogenesis of kidney disease, metabolic syndrome and diabetes. More studies need to be performed on the pathophysiology and clinical consequences of hyperuricaemia in cardiovascular disease.
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